Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells ex vivo. These models have been emerging over the past decade and have...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Florian Tran [verfasserIn] Christine Klein [verfasserIn] Alexander Arlt [verfasserIn] Simon Imm [verfasserIn] Evelyn Knappe [verfasserIn] Alison Simmons [verfasserIn] Philip Rosenstiel [verfasserIn] Philip Seibler [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	stem cell cancer precision medicine co-culture host-microbe immune-epithelial interactions

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2020.573562

Katalog-ID:	DOAJ013489607

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callnumber-first	R - Medicine
author	Florian Tran
spellingShingle	Florian Tran misc RC581-607 misc stem cell misc cancer misc precision medicine misc co-culture misc host-microbe misc immune-epithelial interactions misc Immunologic diseases. Allergy Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
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topic_title	RC581-607 Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet? stem cell cancer precision medicine co-culture host-microbe immune-epithelial interactions
topic	misc RC581-607 misc stem cell misc cancer misc precision medicine misc co-culture misc host-microbe misc immune-epithelial interactions misc Immunologic diseases. Allergy
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title	Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
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title_sort	stem cells and organoid technology in precision medicine in inflammation: are we there yet?
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title_auth	Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
abstract	Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells ex vivo. These models have been emerging over the past decade and have been used to reconstruct the respective organ-specific physiology and pathology, at an unsurpassed depth. In cancer research, patient-derived cancer organoids opened new perspectives in predicting therapy response and provided novel insights into tumour biology. In precision medicine of chronic inflammatory disorders, stem-cell based organoid models are currently being evaluated in pre-clinical pharmacodynamic studies (clinical studies in a dish) and are employed in clinical studies, e.g., by re-transplanting autologous epithelial organoids to re-establish intestinal barrier integrity. A particularly exciting feature of iPSC systems is their ability to provide insights into organ systems and inflammatory disease processes, which cannot be monitored with clinical biopsies, such as immune reactions in neurodegenerative disorders. Refinement of differentiation protocols, and next-generation co-culturing methods, aimed at generating self-organised, complex tissues in vitro, will be the next logical steps. In this mini-review, we critically discuss the current state-of-the-art stem cell and organoid technologies, as well as their future impact, potential and promises in combating immune-mediated chronic diseases.
abstractGer	Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells ex vivo. These models have been emerging over the past decade and have been used to reconstruct the respective organ-specific physiology and pathology, at an unsurpassed depth. In cancer research, patient-derived cancer organoids opened new perspectives in predicting therapy response and provided novel insights into tumour biology. In precision medicine of chronic inflammatory disorders, stem-cell based organoid models are currently being evaluated in pre-clinical pharmacodynamic studies (clinical studies in a dish) and are employed in clinical studies, e.g., by re-transplanting autologous epithelial organoids to re-establish intestinal barrier integrity. A particularly exciting feature of iPSC systems is their ability to provide insights into organ systems and inflammatory disease processes, which cannot be monitored with clinical biopsies, such as immune reactions in neurodegenerative disorders. Refinement of differentiation protocols, and next-generation co-culturing methods, aimed at generating self-organised, complex tissues in vitro, will be the next logical steps. In this mini-review, we critically discuss the current state-of-the-art stem cell and organoid technologies, as well as their future impact, potential and promises in combating immune-mediated chronic diseases.
abstract_unstemmed	Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cells ex vivo. These models have been emerging over the past decade and have been used to reconstruct the respective organ-specific physiology and pathology, at an unsurpassed depth. In cancer research, patient-derived cancer organoids opened new perspectives in predicting therapy response and provided novel insights into tumour biology. In precision medicine of chronic inflammatory disorders, stem-cell based organoid models are currently being evaluated in pre-clinical pharmacodynamic studies (clinical studies in a dish) and are employed in clinical studies, e.g., by re-transplanting autologous epithelial organoids to re-establish intestinal barrier integrity. A particularly exciting feature of iPSC systems is their ability to provide insights into organ systems and inflammatory disease processes, which cannot be monitored with clinical biopsies, such as immune reactions in neurodegenerative disorders. Refinement of differentiation protocols, and next-generation co-culturing methods, aimed at generating self-organised, complex tissues in vitro, will be the next logical steps. In this mini-review, we critically discuss the current state-of-the-art stem cell and organoid technologies, as well as their future impact, potential and promises in combating immune-mediated chronic diseases.
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title_short	Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
url	https://doi.org/10.3389/fimmu.2020.573562 https://doaj.org/article/a98f95e7d3c54acfaf498dbdf52ed0ed https://www.frontiersin.org/articles/10.3389/fimmu.2020.573562/full https://doaj.org/toc/1664-3224
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up_date	2024-07-03T17:55:14.662Z
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