Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a fo...
Ausführliche Beschreibung
Autor*in: |
Giuseppe Delvecchio [verfasserIn] Eleonora Maggioni [verfasserIn] Alessandro Pigoni [verfasserIn] B. Crespo-Facorro [verfasserIn] Igor Nenadić [verfasserIn] Francesco Benedetti [verfasserIn] Christian Gaser [verfasserIn] Heinrich Sauer [verfasserIn] Roberto Roiz-Santiañez [verfasserIn] Sara Poletti [verfasserIn] Maria G. Rossetti [verfasserIn] Marcella Bellani [verfasserIn] Cinzia Perlini [verfasserIn] Mirella Ruggeri [verfasserIn] Vaibhav A. Diwadkar [verfasserIn] Paolo Brambilla [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 13(2021) |
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Übergeordnetes Werk: |
volume:13 ; year:2021 |
Links: |
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DOI / URN: |
10.3389/fnagi.2021.622054 |
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Katalog-ID: |
DOAJ013497294 |
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10.3389/fnagi.2021.622054 doi (DE-627)DOAJ013497294 (DE-599)DOAJ6f78e7af416d442185082c41ba8b45fe DE-627 ger DE-627 rakwb eng RC321-571 Giuseppe Delvecchio verfasserin aut Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. sex differences sexual dimorphism aging healthy individuals magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry Eleonora Maggioni verfasserin aut Alessandro Pigoni verfasserin aut B. Crespo-Facorro verfasserin aut B. Crespo-Facorro verfasserin aut Igor Nenadić verfasserin aut Francesco Benedetti verfasserin aut Christian Gaser verfasserin aut Heinrich Sauer verfasserin aut Roberto Roiz-Santiañez verfasserin aut Roberto Roiz-Santiañez verfasserin aut Sara Poletti verfasserin aut Maria G. Rossetti verfasserin aut Maria G. Rossetti verfasserin aut Marcella Bellani verfasserin aut Cinzia Perlini verfasserin aut Mirella Ruggeri verfasserin aut Vaibhav A. Diwadkar verfasserin aut Paolo Brambilla verfasserin aut Paolo Brambilla verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 13(2021) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:13 year:2021 https://doi.org/10.3389/fnagi.2021.622054 kostenfrei https://doaj.org/article/6f78e7af416d442185082c41ba8b45fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2021.622054/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 |
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10.3389/fnagi.2021.622054 doi (DE-627)DOAJ013497294 (DE-599)DOAJ6f78e7af416d442185082c41ba8b45fe DE-627 ger DE-627 rakwb eng RC321-571 Giuseppe Delvecchio verfasserin aut Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. sex differences sexual dimorphism aging healthy individuals magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry Eleonora Maggioni verfasserin aut Alessandro Pigoni verfasserin aut B. Crespo-Facorro verfasserin aut B. Crespo-Facorro verfasserin aut Igor Nenadić verfasserin aut Francesco Benedetti verfasserin aut Christian Gaser verfasserin aut Heinrich Sauer verfasserin aut Roberto Roiz-Santiañez verfasserin aut Roberto Roiz-Santiañez verfasserin aut Sara Poletti verfasserin aut Maria G. Rossetti verfasserin aut Maria G. Rossetti verfasserin aut Marcella Bellani verfasserin aut Cinzia Perlini verfasserin aut Mirella Ruggeri verfasserin aut Vaibhav A. Diwadkar verfasserin aut Paolo Brambilla verfasserin aut Paolo Brambilla verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 13(2021) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:13 year:2021 https://doi.org/10.3389/fnagi.2021.622054 kostenfrei https://doaj.org/article/6f78e7af416d442185082c41ba8b45fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2021.622054/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 |
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10.3389/fnagi.2021.622054 doi (DE-627)DOAJ013497294 (DE-599)DOAJ6f78e7af416d442185082c41ba8b45fe DE-627 ger DE-627 rakwb eng RC321-571 Giuseppe Delvecchio verfasserin aut Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. sex differences sexual dimorphism aging healthy individuals magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry Eleonora Maggioni verfasserin aut Alessandro Pigoni verfasserin aut B. Crespo-Facorro verfasserin aut B. Crespo-Facorro verfasserin aut Igor Nenadić verfasserin aut Francesco Benedetti verfasserin aut Christian Gaser verfasserin aut Heinrich Sauer verfasserin aut Roberto Roiz-Santiañez verfasserin aut Roberto Roiz-Santiañez verfasserin aut Sara Poletti verfasserin aut Maria G. Rossetti verfasserin aut Maria G. Rossetti verfasserin aut Marcella Bellani verfasserin aut Cinzia Perlini verfasserin aut Mirella Ruggeri verfasserin aut Vaibhav A. Diwadkar verfasserin aut Paolo Brambilla verfasserin aut Paolo Brambilla verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 13(2021) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:13 year:2021 https://doi.org/10.3389/fnagi.2021.622054 kostenfrei https://doaj.org/article/6f78e7af416d442185082c41ba8b45fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnagi.2021.622054/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 |
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Giuseppe Delvecchio Eleonora Maggioni Alessandro Pigoni B. Crespo-Facorro Igor Nenadić Francesco Benedetti Christian Gaser Heinrich Sauer Roberto Roiz-Santiañez Sara Poletti Maria G. Rossetti Marcella Bellani Cinzia Perlini Mirella Ruggeri Vaibhav A. Diwadkar Paolo Brambilla |
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sexual regional dimorphism of post-adolescent and middle age brain maturation. a multi-center 3t mri study |
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Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
abstract |
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. |
abstractGer |
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. |
abstract_unstemmed |
Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes. |
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title_short |
Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study |
url |
https://doi.org/10.3389/fnagi.2021.622054 https://doaj.org/article/6f78e7af416d442185082c41ba8b45fe https://www.frontiersin.org/articles/10.3389/fnagi.2021.622054/full https://doaj.org/toc/1663-4365 |
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Eleonora Maggioni Alessandro Pigoni B. Crespo-Facorro Igor Nenadić Francesco Benedetti Christian Gaser Heinrich Sauer Roberto Roiz-Santiañez Sara Poletti Maria G. Rossetti Marcella Bellani Cinzia Perlini Mirella Ruggeri Vaibhav A. Diwadkar Paolo Brambilla |
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