Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults

Damage to the fornix leads to significant memory impairment and executive dysfunction and is associated with dementia risk. We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older ad...
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Autor*in:	Patcharaporn Srisaikaew [verfasserIn] Nahathai Wongpakaran [verfasserIn] Nicole D. Anderson [verfasserIn] J. Jean Chen [verfasserIn] Suchart Kothan [verfasserIn] Pairada Varnado [verfasserIn] Kittisak Unsrisong [verfasserIn] Pasuk Mahakkanukrauh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	non-amnestic mild cognitive impairment (n-aMCI) fornix diffusion tensor imaging (DTI) fractional anisotropy (FA) fiber tract length (FTL) cognitive performance

Übergeordnetes Werk:	In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 12(2020)
Übergeordnetes Werk:	volume:12 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnagi.2020.594002

Katalog-ID:	DOAJ01349872X

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callnumber-first	R - Medicine
author	Patcharaporn Srisaikaew
spellingShingle	Patcharaporn Srisaikaew misc RC321-571 misc non-amnestic mild cognitive impairment (n-aMCI) misc fornix misc diffusion tensor imaging (DTI) misc fractional anisotropy (FA) misc fiber tract length (FTL) misc cognitive performance misc Neurosciences. Biological psychiatry. Neuropsychiatry Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults
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topic_title	RC321-571 Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults non-amnestic mild cognitive impairment (n-aMCI) fornix diffusion tensor imaging (DTI) fractional anisotropy (FA) fiber tract length (FTL) cognitive performance
topic	misc RC321-571 misc non-amnestic mild cognitive impairment (n-aMCI) misc fornix misc diffusion tensor imaging (DTI) misc fractional anisotropy (FA) misc fiber tract length (FTL) misc cognitive performance misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc non-amnestic mild cognitive impairment (n-aMCI) misc fornix misc diffusion tensor imaging (DTI) misc fractional anisotropy (FA) misc fiber tract length (FTL) misc cognitive performance misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc non-amnestic mild cognitive impairment (n-aMCI) misc fornix misc diffusion tensor imaging (DTI) misc fractional anisotropy (FA) misc fiber tract length (FTL) misc cognitive performance misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults
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title_full	Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults
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author_browse	Patcharaporn Srisaikaew Nahathai Wongpakaran Nicole D. Anderson J. Jean Chen Suchart Kothan Pairada Varnado Kittisak Unsrisong Pasuk Mahakkanukrauh
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title_sort	fornix integrity is differently associated with cognition in healthy aging and non-amnestic mild cognitive impairment: a pilot diffusion tensor imaging study in thai older adults
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title_auth	Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults
abstract	Damage to the fornix leads to significant memory impairment and executive dysfunction and is associated with dementia risk. We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older adult controls (HCs) and 17 subjects with non-amnestic MCI (n-aMCI) were analyzed. Diffusion tensor imaging (DTI) at 1.5 Tesla MRI was performed to enable manual tracing of the fornix and calculation of DTI parameters. Higher fractional anisotropy of body and column of the fornix was associated with better executive functioning and memory, more strongly in the HC than in the n-aMCI group. Fornix fiber tract length (FTL) was associated with better executive function, more strongly in the n-aMCI than in the HC group, and with better memory, more strongly in the HC than in the n-aMCI group. These results highlight a decline in the contributions of the fornix to cognition in n-aMCI and suggest that maintenance of fornix FTL is essential for sustaining executive functioning in people with n-aMCI.
abstractGer	Damage to the fornix leads to significant memory impairment and executive dysfunction and is associated with dementia risk. We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older adult controls (HCs) and 17 subjects with non-amnestic MCI (n-aMCI) were analyzed. Diffusion tensor imaging (DTI) at 1.5 Tesla MRI was performed to enable manual tracing of the fornix and calculation of DTI parameters. Higher fractional anisotropy of body and column of the fornix was associated with better executive functioning and memory, more strongly in the HC than in the n-aMCI group. Fornix fiber tract length (FTL) was associated with better executive function, more strongly in the n-aMCI than in the HC group, and with better memory, more strongly in the HC than in the n-aMCI group. These results highlight a decline in the contributions of the fornix to cognition in n-aMCI and suggest that maintenance of fornix FTL is essential for sustaining executive functioning in people with n-aMCI.
abstract_unstemmed	Damage to the fornix leads to significant memory impairment and executive dysfunction and is associated with dementia risk. We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older adult controls (HCs) and 17 subjects with non-amnestic MCI (n-aMCI) were analyzed. Diffusion tensor imaging (DTI) at 1.5 Tesla MRI was performed to enable manual tracing of the fornix and calculation of DTI parameters. Higher fractional anisotropy of body and column of the fornix was associated with better executive functioning and memory, more strongly in the HC than in the n-aMCI group. Fornix fiber tract length (FTL) was associated with better executive function, more strongly in the n-aMCI than in the HC group, and with better memory, more strongly in the HC than in the n-aMCI group. These results highlight a decline in the contributions of the fornix to cognition in n-aMCI and suggest that maintenance of fornix FTL is essential for sustaining executive functioning in people with n-aMCI.
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title_short	Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults
url	https://doi.org/10.3389/fnagi.2020.594002 https://doaj.org/article/b9cddf25b84f437792bbe011494ba1f1 https://www.frontiersin.org/articles/10.3389/fnagi.2020.594002/full https://doaj.org/toc/1663-4365
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up_date	2024-07-03T17:58:06.656Z
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We sought to identify if fornix integrity and fiber length are disrupted in mild cognitive impairment (MCI) and how they associate with cognition. Data from 14 healthy older adult controls (HCs) and 17 subjects with non-amnestic MCI (n-aMCI) were analyzed. Diffusion tensor imaging (DTI) at 1.5 Tesla MRI was performed to enable manual tracing of the fornix and calculation of DTI parameters. Higher fractional anisotropy of body and column of the fornix was associated with better executive functioning and memory, more strongly in the HC than in the n-aMCI group. Fornix fiber tract length (FTL) was associated with better executive function, more strongly in the n-aMCI than in the HC group, and with better memory, more strongly in the HC than in the n-aMCI group. 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Fornix Integrity Is Differently Associated With Cognition in Healthy Aging and Non-amnestic Mild Cognitive Impairment: A Pilot Diffusion Tensor Imaging Study in Thai Older Adults

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