Genome-wide association study identifies four loci associated with eruption of permanent teeth.

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, ana...
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Autor*in:	Frank Geller [verfasserIn] Bjarke Feenstra [verfasserIn] Hao Zhang [verfasserIn] John R Shaffer [verfasserIn] Thomas Hansen [verfasserIn] Ann-Louise Esserlind [verfasserIn] Heather A Boyd [verfasserIn] Ellen A Nohr [verfasserIn] Nicholas J Timpson [verfasserIn] Ghazaleh Fatemifar [verfasserIn] Lavinia Paternoster [verfasserIn] David M Evans [verfasserIn] Robert J Weyant [verfasserIn] Steven M Levy [verfasserIn] Mark Lathrop [verfasserIn] George Davey Smith [verfasserIn] Jeffrey C Murray [verfasserIn] Jes Olesen [verfasserIn] Thomas Werge [verfasserIn] Mary L Marazita [verfasserIn] Thorkild I A Sørensen [verfasserIn] Mads Melbye [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: PLoS Genetics - Public Library of Science (PLoS), 2005, 7(2011), 9, p e1002275
Übergeordnetes Werk:	volume:7 ; year:2011 ; number:9, p e1002275

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.pgen.1002275

Katalog-ID:	DOAJ013852876

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520			\|a The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles.
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allfields	10.1371/journal.pgen.1002275 doi (DE-627)DOAJ013852876 (DE-599)DOAJa8b61a457e72496e9bde799f37085a3b DE-627 ger DE-627 rakwb eng QH426-470 Frank Geller verfasserin aut Genome-wide association study identifies four loci associated with eruption of permanent teeth. 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. Genetics Bjarke Feenstra verfasserin aut Hao Zhang verfasserin aut John R Shaffer verfasserin aut Thomas Hansen verfasserin aut Ann-Louise Esserlind verfasserin aut Heather A Boyd verfasserin aut Ellen A Nohr verfasserin aut Nicholas J Timpson verfasserin aut Ghazaleh Fatemifar verfasserin aut Lavinia Paternoster verfasserin aut David M Evans verfasserin aut Robert J Weyant verfasserin aut Steven M Levy verfasserin aut Mark Lathrop verfasserin aut George Davey Smith verfasserin aut Jeffrey C Murray verfasserin aut Jes Olesen verfasserin aut Thomas Werge verfasserin aut Mary L Marazita verfasserin aut Thorkild I A Sørensen verfasserin aut Mads Melbye verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 7(2011), 9, p e1002275 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:7 year:2011 number:9, p e1002275 https://doi.org/10.1371/journal.pgen.1002275 kostenfrei https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2011 9, p e1002275
spelling	10.1371/journal.pgen.1002275 doi (DE-627)DOAJ013852876 (DE-599)DOAJa8b61a457e72496e9bde799f37085a3b DE-627 ger DE-627 rakwb eng QH426-470 Frank Geller verfasserin aut Genome-wide association study identifies four loci associated with eruption of permanent teeth. 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. Genetics Bjarke Feenstra verfasserin aut Hao Zhang verfasserin aut John R Shaffer verfasserin aut Thomas Hansen verfasserin aut Ann-Louise Esserlind verfasserin aut Heather A Boyd verfasserin aut Ellen A Nohr verfasserin aut Nicholas J Timpson verfasserin aut Ghazaleh Fatemifar verfasserin aut Lavinia Paternoster verfasserin aut David M Evans verfasserin aut Robert J Weyant verfasserin aut Steven M Levy verfasserin aut Mark Lathrop verfasserin aut George Davey Smith verfasserin aut Jeffrey C Murray verfasserin aut Jes Olesen verfasserin aut Thomas Werge verfasserin aut Mary L Marazita verfasserin aut Thorkild I A Sørensen verfasserin aut Mads Melbye verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 7(2011), 9, p e1002275 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:7 year:2011 number:9, p e1002275 https://doi.org/10.1371/journal.pgen.1002275 kostenfrei https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2011 9, p e1002275
allfields_unstemmed	10.1371/journal.pgen.1002275 doi (DE-627)DOAJ013852876 (DE-599)DOAJa8b61a457e72496e9bde799f37085a3b DE-627 ger DE-627 rakwb eng QH426-470 Frank Geller verfasserin aut Genome-wide association study identifies four loci associated with eruption of permanent teeth. 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. Genetics Bjarke Feenstra verfasserin aut Hao Zhang verfasserin aut John R Shaffer verfasserin aut Thomas Hansen verfasserin aut Ann-Louise Esserlind verfasserin aut Heather A Boyd verfasserin aut Ellen A Nohr verfasserin aut Nicholas J Timpson verfasserin aut Ghazaleh Fatemifar verfasserin aut Lavinia Paternoster verfasserin aut David M Evans verfasserin aut Robert J Weyant verfasserin aut Steven M Levy verfasserin aut Mark Lathrop verfasserin aut George Davey Smith verfasserin aut Jeffrey C Murray verfasserin aut Jes Olesen verfasserin aut Thomas Werge verfasserin aut Mary L Marazita verfasserin aut Thorkild I A Sørensen verfasserin aut Mads Melbye verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 7(2011), 9, p e1002275 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:7 year:2011 number:9, p e1002275 https://doi.org/10.1371/journal.pgen.1002275 kostenfrei https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2011 9, p e1002275
allfieldsGer	10.1371/journal.pgen.1002275 doi (DE-627)DOAJ013852876 (DE-599)DOAJa8b61a457e72496e9bde799f37085a3b DE-627 ger DE-627 rakwb eng QH426-470 Frank Geller verfasserin aut Genome-wide association study identifies four loci associated with eruption of permanent teeth. 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. Genetics Bjarke Feenstra verfasserin aut Hao Zhang verfasserin aut John R Shaffer verfasserin aut Thomas Hansen verfasserin aut Ann-Louise Esserlind verfasserin aut Heather A Boyd verfasserin aut Ellen A Nohr verfasserin aut Nicholas J Timpson verfasserin aut Ghazaleh Fatemifar verfasserin aut Lavinia Paternoster verfasserin aut David M Evans verfasserin aut Robert J Weyant verfasserin aut Steven M Levy verfasserin aut Mark Lathrop verfasserin aut George Davey Smith verfasserin aut Jeffrey C Murray verfasserin aut Jes Olesen verfasserin aut Thomas Werge verfasserin aut Mary L Marazita verfasserin aut Thorkild I A Sørensen verfasserin aut Mads Melbye verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 7(2011), 9, p e1002275 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:7 year:2011 number:9, p e1002275 https://doi.org/10.1371/journal.pgen.1002275 kostenfrei https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2011 9, p e1002275
allfieldsSound	10.1371/journal.pgen.1002275 doi (DE-627)DOAJ013852876 (DE-599)DOAJa8b61a457e72496e9bde799f37085a3b DE-627 ger DE-627 rakwb eng QH426-470 Frank Geller verfasserin aut Genome-wide association study identifies four loci associated with eruption of permanent teeth. 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. Genetics Bjarke Feenstra verfasserin aut Hao Zhang verfasserin aut John R Shaffer verfasserin aut Thomas Hansen verfasserin aut Ann-Louise Esserlind verfasserin aut Heather A Boyd verfasserin aut Ellen A Nohr verfasserin aut Nicholas J Timpson verfasserin aut Ghazaleh Fatemifar verfasserin aut Lavinia Paternoster verfasserin aut David M Evans verfasserin aut Robert J Weyant verfasserin aut Steven M Levy verfasserin aut Mark Lathrop verfasserin aut George Davey Smith verfasserin aut Jeffrey C Murray verfasserin aut Jes Olesen verfasserin aut Thomas Werge verfasserin aut Mary L Marazita verfasserin aut Thorkild I A Sørensen verfasserin aut Mads Melbye verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 7(2011), 9, p e1002275 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:7 year:2011 number:9, p e1002275 https://doi.org/10.1371/journal.pgen.1002275 kostenfrei https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2011 9, p e1002275
language	English
source	In PLoS Genetics 7(2011), 9, p e1002275 volume:7 year:2011 number:9, p e1002275
sourceStr	In PLoS Genetics 7(2011), 9, p e1002275 volume:7 year:2011 number:9, p e1002275
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
isfreeaccess_bool	true
container_title	PLoS Genetics
authorswithroles_txt_mv	Frank Geller @@aut@@ Bjarke Feenstra @@aut@@ Hao Zhang @@aut@@ John R Shaffer @@aut@@ Thomas Hansen @@aut@@ Ann-Louise Esserlind @@aut@@ Heather A Boyd @@aut@@ Ellen A Nohr @@aut@@ Nicholas J Timpson @@aut@@ Ghazaleh Fatemifar @@aut@@ Lavinia Paternoster @@aut@@ David M Evans @@aut@@ Robert J Weyant @@aut@@ Steven M Levy @@aut@@ Mark Lathrop @@aut@@ George Davey Smith @@aut@@ Jeffrey C Murray @@aut@@ Jes Olesen @@aut@@ Thomas Werge @@aut@@ Mary L Marazita @@aut@@ Thorkild I A Sørensen @@aut@@ Mads Melbye @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	485248026
id	DOAJ013852876
language_de	englisch
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author	Frank Geller
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topic_title	QH426-470 Genome-wide association study identifies four loci associated with eruption of permanent teeth
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title	Genome-wide association study identifies four loci associated with eruption of permanent teeth.
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title_sort	genome-wide association study identifies four loci associated with eruption of permanent teeth
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title_auth	Genome-wide association study identifies four loci associated with eruption of permanent teeth.
abstract	The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles.
abstractGer	The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles.
abstract_unstemmed	The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10(-8) and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10(-11). Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles.
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title_short	Genome-wide association study identifies four loci associated with eruption of permanent teeth.
url	https://doi.org/10.1371/journal.pgen.1002275 https://doaj.org/article/a8b61a457e72496e9bde799f37085a3b https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931568/?tool=EBI https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404
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Genome-wide association study identifies four loci associated with eruption of permanent teeth.

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