Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau

To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Olga Kurskaya [verfasserIn] Elena Prokopyeva [verfasserIn] Hongtao Bi [verfasserIn] Ivan Sobolev [verfasserIn] Tatyana Murashkina [verfasserIn] Alexander Shestopalov [verfasserIn] Lixin Wei [verfasserIn] Kirill Sharshov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	extract

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 14(2022), 2, p 360
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:2, p 360

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v14020360

Katalog-ID:	DOAJ013955314

Internformat


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520			\|a To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
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Indexfelder

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publishDate	2022
allfields	10.3390/v14020360 doi (DE-627)DOAJ013955314 (DE-599)DOAJ9c0872502ef1471383e368c2b804ac5e DE-627 ger DE-627 rakwb eng QR1-502 Olga Kurskaya verfasserin aut Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs. extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology Elena Prokopyeva verfasserin aut Hongtao Bi verfasserin aut Ivan Sobolev verfasserin aut Tatyana Murashkina verfasserin aut Alexander Shestopalov verfasserin aut Lixin Wei verfasserin aut Kirill Sharshov verfasserin aut In Viruses MDPI AG, 2009 14(2022), 2, p 360 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:2, p 360 https://doi.org/10.3390/v14020360 kostenfrei https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e kostenfrei https://www.mdpi.com/1999-4915/14/2/360 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 2, p 360
spelling	10.3390/v14020360 doi (DE-627)DOAJ013955314 (DE-599)DOAJ9c0872502ef1471383e368c2b804ac5e DE-627 ger DE-627 rakwb eng QR1-502 Olga Kurskaya verfasserin aut Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs. extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology Elena Prokopyeva verfasserin aut Hongtao Bi verfasserin aut Ivan Sobolev verfasserin aut Tatyana Murashkina verfasserin aut Alexander Shestopalov verfasserin aut Lixin Wei verfasserin aut Kirill Sharshov verfasserin aut In Viruses MDPI AG, 2009 14(2022), 2, p 360 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:2, p 360 https://doi.org/10.3390/v14020360 kostenfrei https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e kostenfrei https://www.mdpi.com/1999-4915/14/2/360 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 2, p 360
allfields_unstemmed	10.3390/v14020360 doi (DE-627)DOAJ013955314 (DE-599)DOAJ9c0872502ef1471383e368c2b804ac5e DE-627 ger DE-627 rakwb eng QR1-502 Olga Kurskaya verfasserin aut Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs. extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology Elena Prokopyeva verfasserin aut Hongtao Bi verfasserin aut Ivan Sobolev verfasserin aut Tatyana Murashkina verfasserin aut Alexander Shestopalov verfasserin aut Lixin Wei verfasserin aut Kirill Sharshov verfasserin aut In Viruses MDPI AG, 2009 14(2022), 2, p 360 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:2, p 360 https://doi.org/10.3390/v14020360 kostenfrei https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e kostenfrei https://www.mdpi.com/1999-4915/14/2/360 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 2, p 360
allfieldsGer	10.3390/v14020360 doi (DE-627)DOAJ013955314 (DE-599)DOAJ9c0872502ef1471383e368c2b804ac5e DE-627 ger DE-627 rakwb eng QR1-502 Olga Kurskaya verfasserin aut Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs. extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology Elena Prokopyeva verfasserin aut Hongtao Bi verfasserin aut Ivan Sobolev verfasserin aut Tatyana Murashkina verfasserin aut Alexander Shestopalov verfasserin aut Lixin Wei verfasserin aut Kirill Sharshov verfasserin aut In Viruses MDPI AG, 2009 14(2022), 2, p 360 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:2, p 360 https://doi.org/10.3390/v14020360 kostenfrei https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e kostenfrei https://www.mdpi.com/1999-4915/14/2/360 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 2, p 360
allfieldsSound	10.3390/v14020360 doi (DE-627)DOAJ013955314 (DE-599)DOAJ9c0872502ef1471383e368c2b804ac5e DE-627 ger DE-627 rakwb eng QR1-502 Olga Kurskaya verfasserin aut Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs. extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology Elena Prokopyeva verfasserin aut Hongtao Bi verfasserin aut Ivan Sobolev verfasserin aut Tatyana Murashkina verfasserin aut Alexander Shestopalov verfasserin aut Lixin Wei verfasserin aut Kirill Sharshov verfasserin aut In Viruses MDPI AG, 2009 14(2022), 2, p 360 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:2, p 360 https://doi.org/10.3390/v14020360 kostenfrei https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e kostenfrei https://www.mdpi.com/1999-4915/14/2/360 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 2, p 360
language	English
source	In Viruses 14(2022), 2, p 360 volume:14 year:2022 number:2, p 360
sourceStr	In Viruses 14(2022), 2, p 360 volume:14 year:2022 number:2, p 360
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i< Microbiology
isfreeaccess_bool	true
container_title	Viruses
authorswithroles_txt_mv	Olga Kurskaya @@aut@@ Elena Prokopyeva @@aut@@ Hongtao Bi @@aut@@ Ivan Sobolev @@aut@@ Tatyana Murashkina @@aut@@ Alexander Shestopalov @@aut@@ Lixin Wei @@aut@@ Kirill Sharshov @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	609775871
id	DOAJ013955314
language_de	englisch
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callnumber-first	Q - Science
author	Olga Kurskaya
spellingShingle	Olga Kurskaya misc QR1-502 misc extract misc <i<A. sativa</i< misc <i<H. vulgare</i< misc <i<H. rhamnoides</i< misc <i<L. ruthenicum</i< misc <i<N. tangutorum</i< misc Microbiology Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
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topic_title	QR1-502 Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau extract <i<A. sativa</i< <i<H. vulgare</i< <i<H. rhamnoides</i< <i<L. ruthenicum</i< <i<N. tangutorum</i<
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title	Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
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author_browse	Olga Kurskaya Elena Prokopyeva Hongtao Bi Ivan Sobolev Tatyana Murashkina Alexander Shestopalov Lixin Wei Kirill Sharshov
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title_sort	anti-influenza activity of medicinal material extracts from qinghai–tibet plateau
callnumber	QR1-502
title_auth	Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
abstract	To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
abstractGer	To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
abstract_unstemmed	To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (<i<Avena sativa</i< L., <i<Hordeum vulgare</i< Linn. var. nudum Hook. f., <i<Hippophae rhamnoides</i< Linn., <i<Lycium ruthenicum</i< Murr., <i<Nitraria tangutorum</i< Bobr., <i<Nitraria tangutorum</i< Bobr. by-products, <i<Potentilla anserina</i< L., <i<Cladina rangiferina</i< (L.) Nyl., and <i<Armillaria luteo-virens</i<) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 μg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (<i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i<) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom <i<A. luteo-virens</i<. These extracts significantly reduced the infectivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 μg/mL. Two extracts (<i<N. tangutorum</i< by-products and <i<P. anserina</i<) had no A/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of <i<N. tangutorum</i< and <i<N. tangutorum</i< by-products exhibited different anti-influenza effects. The results suggest that extracts of <i<A. sativa</i<, <i<H. vulgare</i<, <i<H. rhamnoides</i<, <i<L. ruthenicum</i<, <i<N. tangutorum</i<, <i<C. rangiferina</i<, and <i<A. luteo-virens</i< contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
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title_short	Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
url	https://doi.org/10.3390/v14020360 https://doaj.org/article/9c0872502ef1471383e368c2b804ac5e https://www.mdpi.com/1999-4915/14/2/360 https://doaj.org/toc/1999-4915
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Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau

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