Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solutio...
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Autor*in:	Inês M. Gonçalves [verfasserIn] Violeta Carvalho [verfasserIn] Raquel O. Rodrigues [verfasserIn] Diana Pinho [verfasserIn] Senhorinha F. C. F. Teixeira [verfasserIn] Ana Moita [verfasserIn] Takeshi Hori [verfasserIn] Hirokazu Kaji [verfasserIn] Rui Lima [verfasserIn] Graça Minas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	cancer cells hard tissues and organs organoids microfluidics organ-on-a-chip microbioreactor

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 4, p 935
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:4, p 935

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14040935

Katalog-ID:	DOAJ014058014

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spelling	10.3390/cancers14040935 doi (DE-627)DOAJ014058014 (DE-599)DOAJ3163ff7a7cec441d9ed4a1a38f2e22a9 DE-627 ger DE-627 rakwb eng RC254-282 Inês M. Gonçalves verfasserin aut Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays. cancer cells hard tissues and organs organoids microfluidics organ-on-a-chip microbioreactor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Violeta Carvalho verfasserin aut Raquel O. Rodrigues verfasserin aut Diana Pinho verfasserin aut Senhorinha F. C. F. Teixeira verfasserin aut Ana Moita verfasserin aut Takeshi Hori verfasserin aut Hirokazu Kaji verfasserin aut Rui Lima verfasserin aut Graça Minas verfasserin aut In Cancers MDPI AG, 2010 14(2022), 4, p 935 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:4, p 935 https://doi.org/10.3390/cancers14040935 kostenfrei https://doaj.org/article/3163ff7a7cec441d9ed4a1a38f2e22a9 kostenfrei https://www.mdpi.com/2072-6694/14/4/935 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 4, p 935
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allfieldsSound	10.3390/cancers14040935 doi (DE-627)DOAJ014058014 (DE-599)DOAJ3163ff7a7cec441d9ed4a1a38f2e22a9 DE-627 ger DE-627 rakwb eng RC254-282 Inês M. Gonçalves verfasserin aut Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays. cancer cells hard tissues and organs organoids microfluidics organ-on-a-chip microbioreactor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Violeta Carvalho verfasserin aut Raquel O. Rodrigues verfasserin aut Diana Pinho verfasserin aut Senhorinha F. C. F. Teixeira verfasserin aut Ana Moita verfasserin aut Takeshi Hori verfasserin aut Hirokazu Kaji verfasserin aut Rui Lima verfasserin aut Graça Minas verfasserin aut In Cancers MDPI AG, 2010 14(2022), 4, p 935 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:14 year:2022 number:4, p 935 https://doi.org/10.3390/cancers14040935 kostenfrei https://doaj.org/article/3163ff7a7cec441d9ed4a1a38f2e22a9 kostenfrei https://www.mdpi.com/2072-6694/14/4/935 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 4, p 935
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author	Inês M. Gonçalves
spellingShingle	Inês M. Gonçalves misc RC254-282 misc cancer cells misc hard tissues and organs misc organoids misc microfluidics misc organ-on-a-chip misc microbioreactor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review
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topic_title	RC254-282 Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review cancer cells hard tissues and organs organoids microfluidics organ-on-a-chip microbioreactor
topic	misc RC254-282 misc cancer cells misc hard tissues and organs misc organoids misc microfluidics misc organ-on-a-chip misc microbioreactor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc cancer cells misc hard tissues and organs misc organoids misc microfluidics misc organ-on-a-chip misc microbioreactor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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abstract	The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays.
abstractGer	The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays.
abstract_unstemmed	The development of cancer models that rectify the simplicity of monolayer or static cell cultures physiologic microenvironment and, at the same time, replicate the human system more accurately than animal models has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. Nevertheless, few studies used patient cells for the drug screening assays.
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Organ-on-a-chip (OoC) devices are a solution that has been explored over the last decade. The combination of microfluidics and cell culture allows the design of a dynamic microenvironment suitable for the evaluation of treatments’ efficacy and effects, closer to the response observed in patients. This systematic review sums the studies from the last decade, where OoC with cancer cell cultures were used for drug screening assays. The studies were selected from three databases and analyzed following the research guidelines for systematic reviews proposed by PRISMA. In the selected studies, several types of cancer cells were evaluated, and the majority of treatments tested were standard chemotherapeutic drugs. Some studies reported higher drug resistance of the cultures on the OoC devices than on 2D cultures, which indicates the better resemblance to in vivo conditions of the former. Several studies also included the replication of the microvasculature or the combination of different cell cultures. The presence of vasculature can influence positively or negatively the drug efficacy since it contributes to a greater diffusion of the drug and also oxygen and nutrients. Co-cultures with liver cells contributed to the evaluation of the systemic toxicity of some drugs metabolites. 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Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

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