The effect of Vitamin D in multiple sclerosis: An updated review

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reporte...
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Gespeichert in:

Autor*in:	Amal Mohammad Alkhotani [verfasserIn] Mawddah Hassan Faqeeh [verfasserIn] Raghad Sameer Aldoobi [verfasserIn] Ghofran Essam Sheikh [verfasserIn] Rama Hassan Halabi [verfasserIn] Wasan Khalid Alsharif [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	dose duration multiple sclerosis side effects supplement vitamin d

Übergeordnetes Werk:	In: Saudi Journal for Health Sciences - Wolters Kluwer Medknow Publications, 2018, 10(2021), 3, Seite 149-154
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:3 ; pages:149-154

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/sjhs.sjhs_70_21

Katalog-ID:	DOAJ014069075

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allfields	10.4103/sjhs.sjhs_70_21 doi (DE-627)DOAJ014069075 (DE-599)DOAJ59e5115b243e46e4a4595751fbe25848 DE-627 ger DE-627 rakwb eng Amal Mohammad Alkhotani verfasserin aut The effect of Vitamin D in multiple sclerosis: An updated review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements. dose duration multiple sclerosis side effects supplement vitamin d Medicine R Mawddah Hassan Faqeeh verfasserin aut Raghad Sameer Aldoobi verfasserin aut Ghofran Essam Sheikh verfasserin aut Rama Hassan Halabi verfasserin aut Wasan Khalid Alsharif verfasserin aut In Saudi Journal for Health Sciences Wolters Kluwer Medknow Publications, 2018 10(2021), 3, Seite 149-154 (DE-627)749504439 (DE-600)2719553-3 22780521 nnns volume:10 year:2021 number:3 pages:149-154 https://doi.org/10.4103/sjhs.sjhs_70_21 kostenfrei https://doaj.org/article/59e5115b243e46e4a4595751fbe25848 kostenfrei http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=3;spage=149;epage=154;aulast=Alkhotani kostenfrei https://doaj.org/toc/2278-0521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3 149-154
spelling	10.4103/sjhs.sjhs_70_21 doi (DE-627)DOAJ014069075 (DE-599)DOAJ59e5115b243e46e4a4595751fbe25848 DE-627 ger DE-627 rakwb eng Amal Mohammad Alkhotani verfasserin aut The effect of Vitamin D in multiple sclerosis: An updated review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements. dose duration multiple sclerosis side effects supplement vitamin d Medicine R Mawddah Hassan Faqeeh verfasserin aut Raghad Sameer Aldoobi verfasserin aut Ghofran Essam Sheikh verfasserin aut Rama Hassan Halabi verfasserin aut Wasan Khalid Alsharif verfasserin aut In Saudi Journal for Health Sciences Wolters Kluwer Medknow Publications, 2018 10(2021), 3, Seite 149-154 (DE-627)749504439 (DE-600)2719553-3 22780521 nnns volume:10 year:2021 number:3 pages:149-154 https://doi.org/10.4103/sjhs.sjhs_70_21 kostenfrei https://doaj.org/article/59e5115b243e46e4a4595751fbe25848 kostenfrei http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=3;spage=149;epage=154;aulast=Alkhotani kostenfrei https://doaj.org/toc/2278-0521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3 149-154
allfields_unstemmed	10.4103/sjhs.sjhs_70_21 doi (DE-627)DOAJ014069075 (DE-599)DOAJ59e5115b243e46e4a4595751fbe25848 DE-627 ger DE-627 rakwb eng Amal Mohammad Alkhotani verfasserin aut The effect of Vitamin D in multiple sclerosis: An updated review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements. dose duration multiple sclerosis side effects supplement vitamin d Medicine R Mawddah Hassan Faqeeh verfasserin aut Raghad Sameer Aldoobi verfasserin aut Ghofran Essam Sheikh verfasserin aut Rama Hassan Halabi verfasserin aut Wasan Khalid Alsharif verfasserin aut In Saudi Journal for Health Sciences Wolters Kluwer Medknow Publications, 2018 10(2021), 3, Seite 149-154 (DE-627)749504439 (DE-600)2719553-3 22780521 nnns volume:10 year:2021 number:3 pages:149-154 https://doi.org/10.4103/sjhs.sjhs_70_21 kostenfrei https://doaj.org/article/59e5115b243e46e4a4595751fbe25848 kostenfrei http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=3;spage=149;epage=154;aulast=Alkhotani kostenfrei https://doaj.org/toc/2278-0521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3 149-154
allfieldsGer	10.4103/sjhs.sjhs_70_21 doi (DE-627)DOAJ014069075 (DE-599)DOAJ59e5115b243e46e4a4595751fbe25848 DE-627 ger DE-627 rakwb eng Amal Mohammad Alkhotani verfasserin aut The effect of Vitamin D in multiple sclerosis: An updated review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements. dose duration multiple sclerosis side effects supplement vitamin d Medicine R Mawddah Hassan Faqeeh verfasserin aut Raghad Sameer Aldoobi verfasserin aut Ghofran Essam Sheikh verfasserin aut Rama Hassan Halabi verfasserin aut Wasan Khalid Alsharif verfasserin aut In Saudi Journal for Health Sciences Wolters Kluwer Medknow Publications, 2018 10(2021), 3, Seite 149-154 (DE-627)749504439 (DE-600)2719553-3 22780521 nnns volume:10 year:2021 number:3 pages:149-154 https://doi.org/10.4103/sjhs.sjhs_70_21 kostenfrei https://doaj.org/article/59e5115b243e46e4a4595751fbe25848 kostenfrei http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=3;spage=149;epage=154;aulast=Alkhotani kostenfrei https://doaj.org/toc/2278-0521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3 149-154
allfieldsSound	10.4103/sjhs.sjhs_70_21 doi (DE-627)DOAJ014069075 (DE-599)DOAJ59e5115b243e46e4a4595751fbe25848 DE-627 ger DE-627 rakwb eng Amal Mohammad Alkhotani verfasserin aut The effect of Vitamin D in multiple sclerosis: An updated review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements. dose duration multiple sclerosis side effects supplement vitamin d Medicine R Mawddah Hassan Faqeeh verfasserin aut Raghad Sameer Aldoobi verfasserin aut Ghofran Essam Sheikh verfasserin aut Rama Hassan Halabi verfasserin aut Wasan Khalid Alsharif verfasserin aut In Saudi Journal for Health Sciences Wolters Kluwer Medknow Publications, 2018 10(2021), 3, Seite 149-154 (DE-627)749504439 (DE-600)2719553-3 22780521 nnns volume:10 year:2021 number:3 pages:149-154 https://doi.org/10.4103/sjhs.sjhs_70_21 kostenfrei https://doaj.org/article/59e5115b243e46e4a4595751fbe25848 kostenfrei http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2021;volume=10;issue=3;spage=149;epage=154;aulast=Alkhotani kostenfrei https://doaj.org/toc/2278-0521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3 149-154
language	English
source	In Saudi Journal for Health Sciences 10(2021), 3, Seite 149-154 volume:10 year:2021 number:3 pages:149-154
sourceStr	In Saudi Journal for Health Sciences 10(2021), 3, Seite 149-154 volume:10 year:2021 number:3 pages:149-154
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	dose duration multiple sclerosis side effects supplement vitamin d Medicine R
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container_title	Saudi Journal for Health Sciences
authorswithroles_txt_mv	Amal Mohammad Alkhotani @@aut@@ Mawddah Hassan Faqeeh @@aut@@ Raghad Sameer Aldoobi @@aut@@ Ghofran Essam Sheikh @@aut@@ Rama Hassan Halabi @@aut@@ Wasan Khalid Alsharif @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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language_de	englisch
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author	Amal Mohammad Alkhotani
spellingShingle	Amal Mohammad Alkhotani misc dose misc duration misc multiple sclerosis misc side effects misc supplement misc vitamin d misc Medicine misc R The effect of Vitamin D in multiple sclerosis: An updated review
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topic_title	The effect of Vitamin D in multiple sclerosis: An updated review dose duration multiple sclerosis side effects supplement vitamin d
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title	The effect of Vitamin D in multiple sclerosis: An updated review
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title_full	The effect of Vitamin D in multiple sclerosis: An updated review
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author_browse	Amal Mohammad Alkhotani Mawddah Hassan Faqeeh Raghad Sameer Aldoobi Ghofran Essam Sheikh Rama Hassan Halabi Wasan Khalid Alsharif
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title_sort	effect of vitamin d in multiple sclerosis: an updated review
title_auth	The effect of Vitamin D in multiple sclerosis: An updated review
abstract	Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements.
abstractGer	Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements.
abstract_unstemmed	Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. The pathophysiology of MS has been correlated with low serum Vitamin D levels as one of the risk factors. However, limited evidence of the specific role of Vitamin D in managing MS cases has been reported. A literature search was performed in October 22, 2019, on PubMed database using search terms: “multiple sclerosis,” “Vitamin D,” “deficiency,” “therapeutic use,” “administration and dosage,” and “adverse effects.” Eligibility criteria: All study designs written in English language, applied on human, in the previous 0 years, related to the research question, a clinical diagnosis of MS and interventions containing Vitamin D supplementation (Vitamin D3 or calcitriol). Fourteen articles matched the criteria and were included in this review article. In this review article, we are discussing the effectiveness of Vitamin D supplementation in MS patients, the ideal dose, the duration of treatment, and to highlight the main adverse effects of the supplements.
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title_short	The effect of Vitamin D in multiple sclerosis: An updated review
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