The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially betw...
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| Autor*in: |
Thomas W Winkler [verfasserIn] Anne E Justice [verfasserIn] Mariaelisa Graff [verfasserIn] Llilda Barata [verfasserIn] Mary F Feitosa [verfasserIn] Su Chu [verfasserIn] Jacek Czajkowski [verfasserIn] Tõnu Esko [verfasserIn] Tove Fall [verfasserIn] Tuomas O Kilpeläinen [verfasserIn] Yingchang Lu [verfasserIn] Reedik Mägi [verfasserIn] Evelin Mihailov [verfasserIn] Tune H Pers [verfasserIn] Sina Rüeger [verfasserIn] Alexander Teumer [verfasserIn] Georg B Ehret [verfasserIn] Teresa Ferreira [verfasserIn] Nancy L Heard-Costa [verfasserIn] Juha Karjalainen [verfasserIn] Vasiliki Lagou [verfasserIn] Anubha Mahajan [verfasserIn] Michael D Neinast [verfasserIn] Inga Prokopenko [verfasserIn] Jeannette Simino [verfasserIn] Tanya M Teslovich [verfasserIn] Rick Jansen [verfasserIn] Harm-Jan Westra [verfasserIn] Charles C White [verfasserIn] Devin Absher [verfasserIn] Tarunveer S Ahluwalia [verfasserIn] Shafqat Ahmad [verfasserIn] Eva Albrecht [verfasserIn] Alexessander Couto Alves [verfasserIn] 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Jeffrey R O'Connell [verfasserIn] David Schlessinger [verfasserIn] David P Strachan [verfasserIn] Kari Stefansson [verfasserIn] Cornelia M van Duijn [verfasserIn] Joel N Hirschhorn [verfasserIn] Cecilia M Lindgren [verfasserIn] Iris M Heid [verfasserIn] Kari E North [verfasserIn] Ingrid B Borecki [verfasserIn] Zoltán Kutalik [verfasserIn] Ruth J F Loos [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
In: PLoS Genetics - Public Library of Science (PLoS), 2005, 11(2015), 10, p e1005378 |
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| Übergeordnetes Werk: |
volume:11 ; year:2015 ; number:10, p e1005378 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.1371/journal.pgen.1005378 |
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| Katalog-ID: |
DOAJ014082977 |
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| 100 | 0 | |a Thomas W Winkler |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. |
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| 520 | |a Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. | ||
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| 700 | 0 | |a Nigel W Rayner |e verfasserin |4 aut | |
| 700 | 0 | |a Frida Renström |e verfasserin |4 aut | |
| 700 | 0 | |a Federica Rizzi |e verfasserin |4 aut | |
| 700 | 0 | |a Lynda M Rose |e verfasserin |4 aut | |
| 700 | 0 | |a Kathy A Ryan |e verfasserin |4 aut | |
| 700 | 0 | |a Perttu Salo |e verfasserin |4 aut | |
| 700 | 0 | |a Serena Sanna |e verfasserin |4 aut | |
| 700 | 0 | |a Hubert Scharnagl |e verfasserin |4 aut | |
| 700 | 0 | |a Jianxin Shi |e verfasserin |4 aut | |
| 700 | 0 | |a Albert Vernon Smith |e verfasserin |4 aut | |
| 700 | 0 | |a Lorraine Southam |e verfasserin |4 aut | |
| 700 | 0 | |a Alena Stančáková |e verfasserin |4 aut | |
| 700 | 0 | |a Valgerdur Steinthorsdottir |e verfasserin |4 aut | |
| 700 | 0 | |a Rona J Strawbridge |e verfasserin |4 aut | |
| 700 | 0 | |a Yun Ju Sung |e verfasserin |4 aut | |
| 700 | 0 | |a Ioanna Tachmazidou |e verfasserin |4 aut | |
| 700 | 0 | |a Toshiko Tanaka |e verfasserin |4 aut | |
| 700 | 0 | |a Gudmar Thorleifsson |e verfasserin |4 aut | |
| 700 | 0 | |a Stella Trompet |e verfasserin |4 aut | |
| 700 | 0 | |a Natalia Pervjakova |e verfasserin |4 aut | |
| 700 | 0 | |a Jonathan P Tyrer |e verfasserin |4 aut | |
| 700 | 0 | |a Liesbeth Vandenput |e verfasserin |4 aut | |
| 700 | 0 | |a Sander W van der Laan |e verfasserin |4 aut | |
| 700 | 0 | |a Nathalie van der Velde |e verfasserin |4 aut | |
| 700 | 0 | |a Jessica van Setten |e verfasserin |4 aut | |
| 700 | 0 | |a Jana V van Vliet-Ostaptchouk |e verfasserin |4 aut | |
| 700 | 0 | |a Niek Verweij |e verfasserin |4 aut | |
| 700 | 0 | |a Efthymia Vlachopoulou |e verfasserin |4 aut | |
| 700 | 0 | |a Lindsay L Waite |e verfasserin |4 aut | |
| 700 | 0 | |a Sophie R Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Zhaoming Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Sarah H Wild |e verfasserin |4 aut | |
| 700 | 0 | |a Christina Willenborg |e verfasserin |4 aut | |
| 700 | 0 | |a James F Wilson |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew Wong |e verfasserin |4 aut | |
| 700 | 0 | |a Jian Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Loïc Yengo |e verfasserin |4 aut | |
| 700 | 0 | |a Laura M Yerges-Armstrong |e verfasserin |4 aut | |
| 700 | 0 | |a Lei Yu |e verfasserin |4 aut | |
| 700 | 0 | |a Weihua Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Jing Hua Zhao |e verfasserin |4 aut | |
| 700 | 0 | |a Ehm A Andersson |e verfasserin |4 aut | |
| 700 | 0 | |a Stephan J L Bakker |e verfasserin |4 aut | |
| 700 | 0 | |a Damiano Baldassarre |e verfasserin |4 aut | |
| 700 | 0 | |a Karina Banasik |e verfasserin |4 aut | |
| 700 | 0 | |a Matteo Barcella |e verfasserin |4 aut | |
| 700 | 0 | |a Cristina Barlassina |e verfasserin |4 aut | |
| 700 | 0 | |a Claire Bellis |e verfasserin |4 aut | |
| 700 | 0 | |a Paola Benaglio |e verfasserin |4 aut | |
| 700 | 0 | |a John Blangero |e verfasserin |4 aut | |
| 700 | 0 | |a Matthias Blüher |e verfasserin |4 aut | |
| 700 | 0 | |a Fabrice Bonnet |e verfasserin |4 aut | |
| 700 | 0 | |a Lori L Bonnycastle |e verfasserin |4 aut | |
| 700 | 0 | |a Heather A Boyd |e verfasserin |4 aut | |
| 700 | 0 | |a Marcel Bruinenberg |e verfasserin |4 aut | |
| 700 | 0 | |a Aron S Buchman |e verfasserin |4 aut | |
| 700 | 0 | |a Harry Campbell |e verfasserin |4 aut | |
| 700 | 0 | |a Yii-Der Ida Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Peter S Chines |e verfasserin |4 aut | |
| 700 | 0 | |a Simone Claudi-Boehm |e verfasserin |4 aut | |
| 700 | 0 | |a John Cole |e verfasserin |4 aut | |
| 700 | 0 | |a Francis S Collins |e verfasserin |4 aut | |
| 700 | 0 | |a Eco J C de Geus |e verfasserin |4 aut | |
| 700 | 0 | |a Lisette C P G M de Groot |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Dimitriou |e verfasserin |4 aut | |
| 700 | 0 | |a Jubao Duan |e verfasserin |4 aut | |
| 700 | 0 | |a Stefan Enroth |e verfasserin |4 aut | |
| 700 | 0 | |a Elodie Eury |e verfasserin |4 aut | |
| 700 | 0 | |a Aliki-Eleni Farmaki |e verfasserin |4 aut | |
| 700 | 0 | |a Nita G Forouhi |e verfasserin |4 aut | |
| 700 | 0 | |a Nele Friedrich |e verfasserin |4 aut | |
| 700 | 0 | |a Pablo V Gejman |e verfasserin |4 aut | |
| 700 | 0 | |a Bruna Gigante |e verfasserin |4 aut | |
| 700 | 0 | |a Nicola Glorioso |e verfasserin |4 aut | |
| 700 | 0 | |a Alan S Go |e verfasserin |4 aut | |
| 700 | 0 | |a Omri Gottesman |e verfasserin |4 aut | |
| 700 | 0 | |a Jürgen Gräßler |e verfasserin |4 aut | |
| 700 | 0 | |a Harald Grallert |e verfasserin |4 aut | |
| 700 | 0 | |a Niels Grarup |e verfasserin |4 aut | |
| 700 | 0 | |a Yu-Mei Gu |e verfasserin |4 aut | |
| 700 | 0 | |a Linda Broer |e verfasserin |4 aut | |
| 700 | 0 | |a Annelies C Ham |e verfasserin |4 aut | |
| 700 | 0 | |a Torben Hansen |e verfasserin |4 aut | |
| 700 | 0 | |a Tamara B Harris |e verfasserin |4 aut | |
| 700 | 0 | |a Catharina A Hartman |e verfasserin |4 aut | |
| 700 | 0 | |a Maija Hassinen |e verfasserin |4 aut | |
| 700 | 0 | |a Nicholas Hastie |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew T Hattersley |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew C Heath |e verfasserin |4 aut | |
| 700 | 0 | |a Anjali K Henders |e verfasserin |4 aut | |
| 700 | 0 | |a Dena Hernandez |e verfasserin |4 aut | |
| 700 | 0 | |a Hans Hillege |e verfasserin |4 aut | |
| 700 | 0 | |a Oddgeir Holmen |e verfasserin |4 aut | |
| 700 | 0 | |a Kees G Hovingh |e verfasserin |4 aut | |
| 700 | 0 | |a Jennie Hui |e verfasserin |4 aut | |
| 700 | 0 | |a Lise L Husemoen |e verfasserin |4 aut | |
| 700 | 0 | |a Nina Hutri-Kähönen |e verfasserin |4 aut | |
| 700 | 0 | |a Pirro G Hysi |e verfasserin |4 aut | |
| 700 | 0 | |a Thomas Illig |e verfasserin |4 aut | |
| 700 | 0 | |a Philip L De Jager |e verfasserin |4 aut | |
| 700 | 0 | |a Shapour Jalilzadeh |e verfasserin |4 aut | |
| 700 | 0 | |a Torben Jørgensen |e verfasserin |4 aut | |
| 700 | 0 | |a J Wouter Jukema |e verfasserin |4 aut | |
| 700 | 0 | |a Markus Juonala |e verfasserin |4 aut | |
| 700 | 0 | |a Stavroula Kanoni |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Karaleftheri |e verfasserin |4 aut | |
| 700 | 0 | |a Kay Tee Khaw |e verfasserin |4 aut | |
| 700 | 0 | |a Leena Kinnunen |e verfasserin |4 aut | |
| 700 | 0 | |a Steven J Kittner |e verfasserin |4 aut | |
| 700 | 0 | |a Wolfgang Koenig |e verfasserin |4 aut | |
| 700 | 0 | |a Ivana Kolcic |e verfasserin |4 aut | |
| 700 | 0 | |a Peter Kovacs |e verfasserin |4 aut | |
| 700 | 0 | |a Nikolaj T Krarup |e verfasserin |4 aut | |
| 700 | 0 | |a Wolfgang Kratzer |e verfasserin |4 aut | |
| 700 | 0 | |a Janine Krüger |e verfasserin |4 aut | |
| 700 | 0 | |a Diana Kuh |e verfasserin |4 aut | |
| 700 | 0 | |a Meena Kumari |e verfasserin |4 aut | |
| 700 | 0 | |a Theodosios Kyriakou |e verfasserin |4 aut | |
| 700 | 0 | |a Claudia Langenberg |e verfasserin |4 aut | |
| 700 | 0 | |a Lars Lannfelt |e verfasserin |4 aut | |
| 700 | 0 | |a Chiara Lanzani |e verfasserin |4 aut | |
| 700 | 0 | |a Vaneet Lotay |e verfasserin |4 aut | |
| 700 | 0 | |a Lenore J Launer |e verfasserin |4 aut | |
| 700 | 0 | |a Karin Leander |e verfasserin |4 aut | |
| 700 | 0 | |a Jaana Lindström |e verfasserin |4 aut | |
| 700 | 0 | |a Allan Linneberg |e verfasserin |4 aut | |
| 700 | 0 | |a Yan-Ping Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Stéphane Lobbens |e verfasserin |4 aut | |
| 700 | 0 | |a Robert Luben |e verfasserin |4 aut | |
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| 700 | 0 | |a Satu Männistö |e verfasserin |4 aut | |
| 700 | 0 | |a Patrik K Magnusson |e verfasserin |4 aut | |
| 700 | 0 | |a Wendy L McArdle |e verfasserin |4 aut | |
| 700 | 0 | |a Cristina Menni |e verfasserin |4 aut | |
| 700 | 0 | |a Sigrun Merger |e verfasserin |4 aut | |
| 700 | 0 | |a Lili Milani |e verfasserin |4 aut | |
| 700 | 0 | |a Grant W Montgomery |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew P Morris |e verfasserin |4 aut | |
| 700 | 0 | |a Narisu Narisu |e verfasserin |4 aut | |
| 700 | 0 | |a Mari Nelis |e verfasserin |4 aut | |
| 700 | 0 | |a Ken K Ong |e verfasserin |4 aut | |
| 700 | 0 | |a Aarno Palotie |e verfasserin |4 aut | |
| 700 | 0 | |a Louis Pérusse |e verfasserin |4 aut | |
| 700 | 0 | |a Irene Pichler |e verfasserin |4 aut | |
| 700 | 0 | |a Maria G Pilia |e verfasserin |4 aut | |
| 700 | 0 | |a Anneli Pouta |e verfasserin |4 aut | |
| 700 | 0 | |a Myriam Rheinberger |e verfasserin |4 aut | |
| 700 | 0 | |a Rasmus Ribel-Madsen |e verfasserin |4 aut | |
| 700 | 0 | |a Marcus Richards |e verfasserin |4 aut | |
| 700 | 0 | |a Kenneth M Rice |e verfasserin |4 aut | |
| 700 | 0 | |a Treva K Rice |e verfasserin |4 aut | |
| 700 | 0 | |a Carlo Rivolta |e verfasserin |4 aut | |
| 700 | 0 | |a Veikko Salomaa |e verfasserin |4 aut | |
| 700 | 0 | |a Alan R Sanders |e verfasserin |4 aut | |
| 700 | 0 | |a Mark A Sarzynski |e verfasserin |4 aut | |
| 700 | 0 | |a Salome Scholtens |e verfasserin |4 aut | |
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| 700 | 0 | |a William R Scott |e verfasserin |4 aut | |
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| 700 | 0 | |a P Eline Slagboom |e verfasserin |4 aut | |
| 700 | 0 | |a Jan H Smit |e verfasserin |4 aut | |
| 700 | 0 | |a Thomas H Sparsø |e verfasserin |4 aut | |
| 700 | 0 | |a Kathleen Stirrups |e verfasserin |4 aut | |
| 700 | 0 | |a Ronald P Stolk |e verfasserin |4 aut | |
| 700 | 0 | |a Heather M Stringham |e verfasserin |4 aut | |
| 700 | 0 | |a Morris A Swertz |e verfasserin |4 aut | |
| 700 | 0 | |a Amy J Swift |e verfasserin |4 aut | |
| 700 | 0 | |a Ann-Christine Syvänen |e verfasserin |4 aut | |
| 700 | 0 | |a Sian-Tsung Tan |e verfasserin |4 aut | |
| 700 | 0 | |a Barbara Thorand |e verfasserin |4 aut | |
| 700 | 0 | |a Anke Tönjes |e verfasserin |4 aut | |
| 700 | 0 | |a Angelo Tremblay |e verfasserin |4 aut | |
| 700 | 0 | |a Emmanouil Tsafantakis |e verfasserin |4 aut | |
| 700 | 0 | |a Peter J van der Most |e verfasserin |4 aut | |
| 700 | 0 | |a Uwe Völker |e verfasserin |4 aut | |
| 700 | 0 | |a Marie-Claude Vohl |e verfasserin |4 aut | |
| 700 | 0 | |a Judith M Vonk |e verfasserin |4 aut | |
| 700 | 0 | |a Melanie Waldenberger |e verfasserin |4 aut | |
| 700 | 0 | |a Ryan W Walker |e verfasserin |4 aut | |
| 700 | 0 | |a Roman Wennauer |e verfasserin |4 aut | |
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| 700 | 0 | |a Gonneke Willemsen |e verfasserin |4 aut | |
| 700 | 0 | |a Tom Wilsgaard |e verfasserin |4 aut | |
| 700 | 0 | |a Alan F Wright |e verfasserin |4 aut | |
| 700 | 0 | |a M Carola Zillikens |e verfasserin |4 aut | |
| 700 | 0 | |a Suzanne C van Dijk |e verfasserin |4 aut | |
| 700 | 0 | |a Natasja M van Schoor |e verfasserin |4 aut | |
| 700 | 0 | |a Folkert W Asselbergs |e verfasserin |4 aut | |
| 700 | 0 | |a Paul I W de Bakker |e verfasserin |4 aut | |
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| 700 | 0 | |a David A Bennett |e verfasserin |4 aut | |
| 700 | 0 | |a Richard N Bergman |e verfasserin |4 aut | |
| 700 | 0 | |a Sven Bergmann |e verfasserin |4 aut | |
| 700 | 0 | |a Carsten A Böger |e verfasserin |4 aut | |
| 700 | 0 | |a Bernhard O Boehm |e verfasserin |4 aut | |
| 700 | 0 | |a Eric Boerwinkle |e verfasserin |4 aut | |
| 700 | 0 | |a Dorret I Boomsma |e verfasserin |4 aut | |
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| 700 | 0 | |a Erwin P Bottinger |e verfasserin |4 aut | |
| 700 | 0 | |a Claude Bouchard |e verfasserin |4 aut | |
| 700 | 0 | |a John C Chambers |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen J Chanock |e verfasserin |4 aut | |
| 700 | 0 | |a Daniel I Chasman |e verfasserin |4 aut | |
| 700 | 0 | |a Francesco Cucca |e verfasserin |4 aut | |
| 700 | 0 | |a Daniele Cusi |e verfasserin |4 aut | |
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| 700 | 0 | |a Johan G Eriksson |e verfasserin |4 aut | |
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| 700 | 0 | |a Ulf de Faire |e verfasserin |4 aut | |
| 700 | 0 | |a Martin Farrall |e verfasserin |4 aut | |
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| 700 | 0 | |a Per Hall |e verfasserin |4 aut | |
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| 700 | 0 | |a Markku Heliövaara |e verfasserin |4 aut | |
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| 700 | 0 | |a Aroon Hingorani |e verfasserin |4 aut | |
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| 700 | 0 | |a Heikki V Huikuri |e verfasserin |4 aut | |
| 700 | 0 | |a Kristian Hveem |e verfasserin |4 aut | |
| 700 | 0 | |a Alan L James |e verfasserin |4 aut | |
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| 700 | 0 | |a Antti Jula |e verfasserin |4 aut | |
| 700 | 0 | |a Mika Kähönen |e verfasserin |4 aut | |
| 700 | 0 | |a Eero Kajantie |e verfasserin |4 aut | |
| 700 | 0 | |a Sekar Kathiresan |e verfasserin |4 aut | |
| 700 | 0 | |a Lambertus A L M Kiemeney |e verfasserin |4 aut | |
| 700 | 0 | |a Mika Kivimaki |e verfasserin |4 aut | |
| 700 | 0 | |a Paul B Knekt |e verfasserin |4 aut | |
| 700 | 0 | |a Heikki A Koistinen |e verfasserin |4 aut | |
| 700 | 0 | |a Jaspal S Kooner |e verfasserin |4 aut | |
| 700 | 0 | |a Seppo Koskinen |e verfasserin |4 aut | |
| 700 | 0 | |a Johanna Kuusisto |e verfasserin |4 aut | |
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| 700 | 0 | |a Timo A Lakka |e verfasserin |4 aut | |
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| 700 | 0 | |a Douglas F Levinson |e verfasserin |4 aut | |
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| 700 | 0 | |a Arthur W Musk |e verfasserin |4 aut | |
| 700 | 0 | |a Markku S Nieminen |e verfasserin |4 aut | |
| 700 | 0 | |a Inger Njølstad |e verfasserin |4 aut | |
| 700 | 0 | |a Claes Ohlsson |e verfasserin |4 aut | |
| 700 | 0 | |a Albertine J Oldehinkel |e verfasserin |4 aut | |
| 700 | 0 | |a Ben A Oostra |e verfasserin |4 aut | |
| 700 | 0 | |a Lyle J Palmer |e verfasserin |4 aut | |
| 700 | 0 | |a James S Pankow |e verfasserin |4 aut | |
| 700 | 0 | |a Gerard Pasterkamp |e verfasserin |4 aut | |
| 700 | 0 | |a Nancy L Pedersen |e verfasserin |4 aut | |
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| 700 | 0 | |a Ozren Polašek |e verfasserin |4 aut | |
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| 700 | 0 | |a Bruce M Psaty |e verfasserin |4 aut | |
| 700 | 0 | |a Lu Qi |e verfasserin |4 aut | |
| 700 | 0 | |a Thomas Quertermous |e verfasserin |4 aut | |
| 700 | 0 | |a Olli T Raitakari |e verfasserin |4 aut | |
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| 700 | 0 | |a Rainer Rauramaa |e verfasserin |4 aut | |
| 700 | 0 | |a Paul M Ridker |e verfasserin |4 aut | |
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| 700 | 0 | |a Jerome I Rotter |e verfasserin |4 aut | |
| 700 | 0 | |a Igor Rudan |e verfasserin |4 aut | |
| 700 | 0 | |a Hester M den Ruijter |e verfasserin |4 aut | |
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| 700 | 0 | |a Naveed Sattar |e verfasserin |4 aut | |
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| 700 | 0 | |a Alan R Shuldiner |e verfasserin |4 aut | |
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| 700 | 0 | |a Tim D Spector |e verfasserin |4 aut | |
| 700 | 0 | |a Jan A Staessen |e verfasserin |4 aut | |
| 700 | 0 | |a Bandinelli Stefania |e verfasserin |4 aut | |
| 700 | 0 | |a Unnur Thorsteinsdottir |e verfasserin |4 aut | |
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| 700 | 0 | |a Elena Tremoli |e verfasserin |4 aut | |
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| 700 | 0 | |a André G Uitterlinden |e verfasserin |4 aut | |
| 700 | 0 | |a Matti Uusitupa |e verfasserin |4 aut | |
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| 700 | 0 | |a Sita H Vermeulen |e verfasserin |4 aut | |
| 700 | 0 | |a Jorma S Viikari |e verfasserin |4 aut | |
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| 700 | 0 | |a Henry Völzke |e verfasserin |4 aut | |
| 700 | 0 | |a Peter Vollenweider |e verfasserin |4 aut | |
| 700 | 0 | |a Gérard Waeber |e verfasserin |4 aut | |
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| 700 | 0 | |a Henri Wallaschofski |e verfasserin |4 aut | |
| 700 | 0 | |a Nicholas J Wareham |e verfasserin |4 aut | |
| 700 | 0 | |a Hugh Watkins |e verfasserin |4 aut | |
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10.1371/journal.pgen.1005378 doi (DE-627)DOAJ014082977 (DE-599)DOAJffdbcee3ab414e498706575063e26ecf DE-627 ger DE-627 rakwb eng QH426-470 Thomas W Winkler verfasserin aut The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. Genetics Anne E Justice verfasserin aut Mariaelisa Graff verfasserin aut Llilda Barata verfasserin aut Mary F Feitosa verfasserin aut Su Chu verfasserin aut Jacek Czajkowski verfasserin aut Tõnu Esko verfasserin aut Tove Fall verfasserin aut Tuomas O Kilpeläinen verfasserin aut Yingchang Lu verfasserin aut Reedik Mägi verfasserin aut Evelin Mihailov verfasserin aut Tune H Pers verfasserin aut Sina Rüeger verfasserin aut Alexander Teumer verfasserin aut Georg B Ehret verfasserin aut Teresa Ferreira verfasserin aut Nancy L Heard-Costa verfasserin aut Juha Karjalainen verfasserin aut Vasiliki Lagou verfasserin aut Anubha Mahajan verfasserin aut Michael D Neinast verfasserin aut Inga Prokopenko verfasserin aut Jeannette Simino verfasserin aut Tanya M Teslovich verfasserin aut Rick Jansen verfasserin aut Harm-Jan Westra verfasserin aut Charles C White verfasserin aut Devin Absher verfasserin aut Tarunveer S Ahluwalia verfasserin aut Shafqat Ahmad verfasserin aut Eva Albrecht verfasserin aut Alexessander Couto Alves verfasserin aut Jennifer L Bragg-Gresham verfasserin aut Anton J M de Craen verfasserin aut Joshua C Bis verfasserin aut Amélie Bonnefond verfasserin aut Gabrielle Boucher verfasserin aut Gemma Cadby verfasserin aut Yu-Ching Cheng verfasserin aut Charleston W K Chiang verfasserin aut Graciela Delgado verfasserin aut Ayse Demirkan verfasserin aut Nicole Dueker verfasserin aut Niina Eklund verfasserin aut Gudny Eiriksdottir verfasserin aut Joel Eriksson verfasserin aut Bjarke Feenstra verfasserin aut Krista Fischer verfasserin aut Francesca Frau verfasserin aut Tessel E Galesloot verfasserin aut Frank Geller verfasserin aut Anuj Goel verfasserin aut Mathias Gorski verfasserin aut Tanja B Grammer verfasserin aut Stefan Gustafsson verfasserin aut Saskia Haitjema verfasserin aut Jouke-Jan Hottenga verfasserin aut Jennifer E Huffman verfasserin aut Anne U Jackson verfasserin aut Kevin B Jacobs verfasserin aut Åsa Johansson verfasserin aut Marika Kaakinen verfasserin aut Marcus E Kleber verfasserin aut Jari Lahti verfasserin aut Irene Mateo Leach verfasserin aut Benjamin Lehne verfasserin aut Youfang Liu verfasserin aut Ken Sin Lo verfasserin aut Mattias Lorentzon verfasserin aut Jian'an Luan verfasserin aut Pamela A F Madden verfasserin aut Massimo Mangino verfasserin aut Barbara McKnight verfasserin aut Carolina Medina-Gomez verfasserin aut Keri L Monda verfasserin aut May E Montasser verfasserin aut Gabriele Müller verfasserin aut Martina Müller-Nurasyid verfasserin aut Ilja M Nolte verfasserin aut Kalliope Panoutsopoulou verfasserin aut Laura Pascoe verfasserin aut Lavinia Paternoster verfasserin aut Nigel W Rayner verfasserin aut Frida Renström verfasserin aut Federica Rizzi verfasserin aut Lynda M Rose verfasserin aut Kathy A Ryan verfasserin aut Perttu Salo verfasserin aut Serena Sanna verfasserin aut Hubert Scharnagl verfasserin aut Jianxin Shi verfasserin aut Albert Vernon Smith verfasserin aut Lorraine Southam verfasserin aut Alena Stančáková verfasserin aut Valgerdur Steinthorsdottir verfasserin aut Rona J Strawbridge verfasserin aut Yun Ju Sung verfasserin aut Ioanna Tachmazidou verfasserin aut Toshiko Tanaka verfasserin aut Gudmar Thorleifsson verfasserin aut Stella Trompet verfasserin aut Natalia Pervjakova verfasserin aut Jonathan P Tyrer verfasserin aut Liesbeth Vandenput verfasserin aut Sander W van der Laan verfasserin aut Nathalie van der Velde verfasserin aut Jessica van Setten verfasserin aut Jana V van Vliet-Ostaptchouk verfasserin aut Niek Verweij verfasserin aut Efthymia Vlachopoulou verfasserin aut Lindsay L Waite verfasserin aut Sophie R Wang verfasserin aut Zhaoming Wang verfasserin aut Sarah H Wild verfasserin aut Christina Willenborg verfasserin aut James F Wilson verfasserin aut Andrew Wong verfasserin aut Jian Yang verfasserin aut Loïc Yengo verfasserin aut Laura M Yerges-Armstrong verfasserin aut Lei Yu verfasserin aut Weihua Zhang verfasserin aut Jing Hua Zhao verfasserin aut Ehm A 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Montgomery verfasserin aut Andrew P Morris verfasserin aut Narisu Narisu verfasserin aut Mari Nelis verfasserin aut Ken K Ong verfasserin aut Aarno Palotie verfasserin aut Louis Pérusse verfasserin aut Irene Pichler verfasserin aut Maria G Pilia verfasserin aut Anneli Pouta verfasserin aut Myriam Rheinberger verfasserin aut Rasmus Ribel-Madsen verfasserin aut Marcus Richards verfasserin aut Kenneth M Rice verfasserin aut Treva K Rice verfasserin aut Carlo Rivolta verfasserin aut Veikko Salomaa verfasserin aut Alan R Sanders verfasserin aut Mark A Sarzynski verfasserin aut Salome Scholtens verfasserin aut Robert A Scott verfasserin aut William R Scott verfasserin aut Sylvain Sebert verfasserin aut Sebanti Sengupta verfasserin aut Bengt Sennblad verfasserin aut Thomas Seufferlein verfasserin aut Angela Silveira verfasserin aut P Eline Slagboom verfasserin aut Jan H Smit verfasserin aut Thomas H Sparsø verfasserin aut Kathleen Stirrups verfasserin aut Ronald P Stolk verfasserin aut Heather M Stringham verfasserin aut Morris A Swertz verfasserin aut Amy J Swift verfasserin aut Ann-Christine Syvänen verfasserin aut Sian-Tsung Tan verfasserin aut Barbara Thorand verfasserin aut Anke Tönjes verfasserin aut Angelo Tremblay verfasserin aut Emmanouil Tsafantakis verfasserin aut Peter J van der Most verfasserin aut Uwe Völker verfasserin aut Marie-Claude Vohl verfasserin aut Judith M Vonk verfasserin aut Melanie Waldenberger verfasserin aut Ryan W Walker verfasserin aut Roman Wennauer verfasserin aut Elisabeth Widén verfasserin aut Gonneke Willemsen verfasserin aut Tom Wilsgaard verfasserin aut Alan F Wright verfasserin aut M Carola Zillikens verfasserin aut Suzanne C van Dijk verfasserin aut Natasja M van Schoor verfasserin aut Folkert W Asselbergs verfasserin aut Paul I W de Bakker verfasserin aut Jacques S Beckmann verfasserin aut John Beilby verfasserin aut David A Bennett verfasserin aut Richard N Bergman verfasserin aut Sven Bergmann verfasserin aut Carsten A Böger verfasserin aut Bernhard O Boehm verfasserin aut Eric Boerwinkle verfasserin aut Dorret I Boomsma verfasserin aut Stefan R Bornstein verfasserin aut Erwin P Bottinger verfasserin aut Claude Bouchard verfasserin aut John C Chambers verfasserin aut Stephen J Chanock verfasserin aut Daniel I Chasman verfasserin aut Francesco Cucca verfasserin aut Daniele Cusi verfasserin aut George Dedoussis verfasserin aut Jeanette Erdmann verfasserin aut Johan G Eriksson verfasserin aut Denis A Evans verfasserin aut Ulf de Faire verfasserin aut Martin Farrall verfasserin aut Luigi Ferrucci verfasserin aut Ian Ford verfasserin aut Lude Franke verfasserin aut Paul W Franks verfasserin aut Philippe Froguel verfasserin aut Ron T Gansevoort verfasserin aut Christian Gieger verfasserin aut Henrik Grönberg verfasserin aut Vilmundur Gudnason verfasserin aut Ulf Gyllensten verfasserin aut Per Hall verfasserin aut Anders Hamsten verfasserin aut Pim van der Harst verfasserin aut Caroline Hayward verfasserin aut Markku Heliövaara verfasserin aut Christian Hengstenberg verfasserin aut Andrew A Hicks verfasserin aut Aroon Hingorani verfasserin aut Albert Hofman verfasserin aut Frank Hu verfasserin aut Heikki V Huikuri verfasserin aut Kristian Hveem verfasserin aut Alan L James verfasserin aut Joanne M Jordan verfasserin aut Antti Jula verfasserin aut Mika Kähönen verfasserin aut Eero Kajantie verfasserin aut Sekar Kathiresan verfasserin aut Lambertus A L M Kiemeney verfasserin aut Mika Kivimaki verfasserin aut Paul B Knekt verfasserin aut Heikki A Koistinen verfasserin aut Jaspal S Kooner verfasserin aut Seppo Koskinen verfasserin aut Johanna Kuusisto verfasserin aut Winfried Maerz verfasserin aut Nicholas G Martin verfasserin aut Markku Laakso verfasserin aut Timo A Lakka verfasserin aut Terho Lehtimäki verfasserin aut Guillaume Lettre verfasserin aut Douglas F Levinson verfasserin aut Lars Lind verfasserin aut Marja-Liisa Lokki verfasserin aut Pekka Mäntyselkä verfasserin aut Mads Melbye verfasserin aut Andres Metspalu verfasserin aut Braxton D Mitchell verfasserin aut Frans L Moll verfasserin aut Jeffrey C Murray verfasserin aut Arthur W Musk verfasserin aut Markku S Nieminen verfasserin aut Inger Njølstad verfasserin aut Claes Ohlsson verfasserin aut Albertine J Oldehinkel verfasserin aut Ben A Oostra verfasserin aut Lyle J Palmer verfasserin aut James S Pankow verfasserin aut Gerard Pasterkamp verfasserin aut Nancy L Pedersen verfasserin aut Oluf Pedersen verfasserin aut Brenda W Penninx verfasserin aut Markus Perola verfasserin aut Annette Peters verfasserin aut Ozren Polašek verfasserin aut Peter P Pramstaller verfasserin aut Bruce M Psaty verfasserin aut Lu Qi verfasserin aut Thomas Quertermous verfasserin aut Olli T Raitakari verfasserin aut Tuomo Rankinen verfasserin aut Rainer Rauramaa verfasserin aut Paul M Ridker verfasserin aut John D Rioux verfasserin aut Fernando Rivadeneira verfasserin aut Jerome I Rotter verfasserin aut Igor Rudan verfasserin aut Hester M den Ruijter verfasserin aut Juha Saltevo verfasserin aut Naveed Sattar verfasserin aut Heribert Schunkert verfasserin aut Peter E H Schwarz verfasserin aut Alan R Shuldiner verfasserin aut Juha Sinisalo verfasserin aut Harold Snieder verfasserin aut Thorkild I A Sørensen verfasserin aut Tim D Spector verfasserin aut Jan A Staessen verfasserin aut Bandinelli Stefania verfasserin aut Unnur Thorsteinsdottir verfasserin aut Michael Stumvoll verfasserin aut Jean-Claude Tardif verfasserin aut Elena Tremoli verfasserin aut Jaakko Tuomilehto verfasserin aut André G Uitterlinden verfasserin aut Matti Uusitupa verfasserin aut André L M Verbeek verfasserin aut Sita H Vermeulen verfasserin aut Jorma S Viikari verfasserin aut Veronique Vitart verfasserin aut Henry Völzke verfasserin aut Peter Vollenweider verfasserin aut Gérard Waeber verfasserin aut Mark Walker verfasserin aut Henri Wallaschofski verfasserin aut Nicholas J Wareham verfasserin aut Hugh Watkins verfasserin aut Eleftheria Zeggini verfasserin aut CHARGE Consortium verfasserin aut DIAGRAM Consortium verfasserin aut GLGC Consortium verfasserin aut Global-BPGen Consortium verfasserin aut ICBP Consortium verfasserin aut MAGIC Consortium verfasserin aut Aravinda Chakravarti verfasserin aut Deborah J Clegg verfasserin aut L Adrienne Cupples verfasserin aut Penny Gordon-Larsen verfasserin aut Cashell E Jaquish verfasserin aut D C Rao verfasserin aut Goncalo R Abecasis verfasserin aut Themistocles L Assimes verfasserin aut Inês Barroso verfasserin aut Sonja I Berndt verfasserin aut Michael Boehnke verfasserin aut Panos Deloukas verfasserin aut Caroline S Fox verfasserin aut Leif C Groop verfasserin aut David J Hunter verfasserin aut Erik Ingelsson verfasserin aut Robert C Kaplan verfasserin aut Mark I McCarthy verfasserin aut Karen L Mohlke verfasserin aut Jeffrey R O'Connell verfasserin aut David Schlessinger verfasserin aut David P Strachan verfasserin aut Kari Stefansson verfasserin aut Cornelia M van Duijn verfasserin aut Joel N Hirschhorn verfasserin aut Cecilia M Lindgren verfasserin aut Iris M Heid verfasserin aut Kari E North verfasserin aut Ingrid B Borecki verfasserin aut Zoltán Kutalik verfasserin aut Ruth J F Loos verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 11(2015), 10, p e1005378 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:11 year:2015 number:10, p e1005378 https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/article/ffdbcee3ab414e498706575063e26ecf kostenfrei https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 10, p e1005378 |
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10.1371/journal.pgen.1005378 doi (DE-627)DOAJ014082977 (DE-599)DOAJffdbcee3ab414e498706575063e26ecf DE-627 ger DE-627 rakwb eng QH426-470 Thomas W Winkler verfasserin aut The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. Genetics Anne E Justice verfasserin aut Mariaelisa Graff verfasserin aut Llilda Barata verfasserin aut Mary F Feitosa verfasserin aut Su Chu verfasserin aut Jacek Czajkowski verfasserin aut Tõnu Esko verfasserin aut Tove Fall verfasserin aut Tuomas O Kilpeläinen verfasserin aut Yingchang Lu verfasserin aut Reedik Mägi verfasserin aut Evelin Mihailov verfasserin aut Tune H Pers verfasserin aut Sina Rüeger verfasserin aut Alexander Teumer verfasserin aut Georg B Ehret verfasserin aut Teresa Ferreira verfasserin aut Nancy L Heard-Costa verfasserin aut Juha Karjalainen verfasserin aut Vasiliki Lagou verfasserin aut Anubha Mahajan verfasserin aut Michael D Neinast verfasserin aut Inga Prokopenko verfasserin aut Jeannette Simino verfasserin aut Tanya M Teslovich verfasserin aut Rick Jansen verfasserin aut Harm-Jan Westra verfasserin aut Charles C White verfasserin aut Devin Absher verfasserin aut Tarunveer S Ahluwalia verfasserin aut Shafqat Ahmad verfasserin aut Eva Albrecht verfasserin aut Alexessander Couto Alves verfasserin aut Jennifer L Bragg-Gresham verfasserin aut Anton J M de Craen verfasserin aut Joshua C Bis verfasserin aut Amélie Bonnefond verfasserin aut Gabrielle Boucher verfasserin aut Gemma Cadby verfasserin aut Yu-Ching Cheng verfasserin aut Charleston W K Chiang verfasserin aut Graciela Delgado verfasserin aut Ayse Demirkan verfasserin aut Nicole Dueker verfasserin aut Niina Eklund verfasserin aut Gudny Eiriksdottir verfasserin aut Joel Eriksson verfasserin aut Bjarke Feenstra verfasserin aut Krista Fischer verfasserin aut Francesca Frau verfasserin aut Tessel E Galesloot verfasserin aut Frank Geller verfasserin aut Anuj Goel verfasserin aut Mathias Gorski verfasserin aut Tanja B Grammer verfasserin aut Stefan Gustafsson verfasserin aut Saskia Haitjema verfasserin aut Jouke-Jan Hottenga verfasserin aut Jennifer E Huffman verfasserin aut Anne U Jackson verfasserin aut Kevin B Jacobs verfasserin aut Åsa Johansson verfasserin aut Marika Kaakinen verfasserin aut Marcus E Kleber verfasserin aut Jari Lahti verfasserin aut Irene Mateo Leach verfasserin aut Benjamin Lehne verfasserin aut Youfang Liu verfasserin aut Ken Sin Lo verfasserin aut Mattias Lorentzon verfasserin aut Jian'an Luan verfasserin aut Pamela A F Madden verfasserin aut Massimo Mangino verfasserin aut Barbara McKnight verfasserin aut Carolina Medina-Gomez verfasserin aut Keri L Monda verfasserin aut May E Montasser verfasserin aut Gabriele Müller verfasserin aut Martina Müller-Nurasyid verfasserin aut Ilja M Nolte verfasserin aut Kalliope Panoutsopoulou verfasserin aut Laura Pascoe verfasserin aut Lavinia Paternoster verfasserin aut Nigel W Rayner verfasserin aut Frida Renström verfasserin aut Federica Rizzi verfasserin aut Lynda M Rose verfasserin aut Kathy A Ryan verfasserin aut Perttu Salo verfasserin aut Serena Sanna verfasserin aut Hubert Scharnagl verfasserin aut Jianxin Shi verfasserin aut Albert Vernon Smith verfasserin aut Lorraine Southam verfasserin aut Alena Stančáková verfasserin aut Valgerdur Steinthorsdottir verfasserin aut Rona J Strawbridge verfasserin aut Yun Ju Sung verfasserin aut Ioanna Tachmazidou verfasserin aut Toshiko Tanaka verfasserin aut Gudmar Thorleifsson verfasserin aut Stella Trompet verfasserin aut Natalia Pervjakova verfasserin aut Jonathan P Tyrer verfasserin aut Liesbeth Vandenput verfasserin aut Sander W van der Laan verfasserin aut Nathalie van der Velde verfasserin aut Jessica van Setten verfasserin aut Jana V van Vliet-Ostaptchouk verfasserin aut Niek Verweij verfasserin aut Efthymia Vlachopoulou verfasserin aut Lindsay L Waite verfasserin aut Sophie R Wang verfasserin aut Zhaoming Wang verfasserin aut Sarah H Wild verfasserin aut Christina Willenborg verfasserin aut James F Wilson verfasserin aut Andrew Wong verfasserin aut Jian Yang verfasserin aut Loïc Yengo verfasserin aut Laura M Yerges-Armstrong verfasserin aut Lei Yu verfasserin aut Weihua Zhang verfasserin aut Jing Hua Zhao verfasserin aut Ehm A Andersson verfasserin aut Stephan J L Bakker verfasserin aut Damiano Baldassarre verfasserin aut Karina Banasik verfasserin aut Matteo Barcella verfasserin aut Cristina Barlassina verfasserin aut Claire Bellis verfasserin aut Paola Benaglio verfasserin aut John Blangero verfasserin aut Matthias Blüher verfasserin aut Fabrice Bonnet verfasserin aut Lori L Bonnycastle verfasserin aut Heather A Boyd verfasserin aut Marcel Bruinenberg verfasserin aut Aron S Buchman verfasserin aut Harry Campbell verfasserin aut Yii-Der Ida Chen verfasserin aut Peter S Chines verfasserin aut Simone Claudi-Boehm verfasserin aut John Cole verfasserin aut Francis S Collins verfasserin aut Eco J C de Geus verfasserin aut Lisette C P G M de Groot verfasserin aut Maria Dimitriou verfasserin aut Jubao Duan verfasserin aut Stefan Enroth verfasserin aut Elodie Eury verfasserin aut Aliki-Eleni Farmaki verfasserin aut Nita G Forouhi verfasserin aut Nele Friedrich verfasserin aut Pablo V Gejman verfasserin aut Bruna Gigante verfasserin aut Nicola Glorioso verfasserin aut Alan S Go verfasserin aut Omri Gottesman verfasserin aut Jürgen Gräßler verfasserin aut Harald Grallert verfasserin aut Niels Grarup verfasserin aut Yu-Mei Gu verfasserin aut Linda Broer verfasserin aut Annelies C Ham verfasserin aut Torben Hansen verfasserin aut Tamara B Harris verfasserin aut Catharina A Hartman verfasserin aut Maija Hassinen verfasserin aut Nicholas Hastie verfasserin aut Andrew T Hattersley verfasserin aut Andrew C Heath verfasserin aut Anjali K Henders verfasserin aut Dena Hernandez verfasserin aut Hans Hillege verfasserin aut Oddgeir Holmen verfasserin aut Kees G Hovingh verfasserin aut Jennie Hui verfasserin aut Lise L Husemoen verfasserin aut Nina Hutri-Kähönen verfasserin aut Pirro G Hysi verfasserin aut Thomas Illig verfasserin aut Philip L De Jager verfasserin aut Shapour Jalilzadeh verfasserin aut Torben Jørgensen verfasserin aut J Wouter Jukema verfasserin aut Markus Juonala verfasserin aut Stavroula Kanoni verfasserin aut Maria Karaleftheri verfasserin aut Kay Tee Khaw verfasserin aut Leena Kinnunen verfasserin aut Steven J Kittner verfasserin aut Wolfgang Koenig verfasserin aut Ivana Kolcic verfasserin aut Peter Kovacs verfasserin aut Nikolaj T Krarup verfasserin aut Wolfgang Kratzer verfasserin aut Janine Krüger verfasserin aut Diana Kuh verfasserin aut Meena Kumari verfasserin aut Theodosios Kyriakou verfasserin aut Claudia Langenberg verfasserin aut Lars Lannfelt verfasserin aut Chiara Lanzani verfasserin aut Vaneet Lotay verfasserin aut Lenore J Launer verfasserin aut Karin Leander verfasserin aut Jaana Lindström verfasserin aut Allan Linneberg verfasserin aut Yan-Ping Liu verfasserin aut Stéphane Lobbens verfasserin aut Robert Luben verfasserin aut Valeriya Lyssenko verfasserin aut Satu Männistö verfasserin aut Patrik K Magnusson verfasserin aut Wendy L McArdle verfasserin aut Cristina Menni verfasserin aut Sigrun Merger verfasserin aut Lili Milani verfasserin aut Grant W Montgomery verfasserin aut Andrew P Morris verfasserin aut Narisu Narisu verfasserin aut Mari Nelis verfasserin aut Ken K Ong verfasserin aut Aarno Palotie verfasserin aut Louis Pérusse verfasserin aut Irene Pichler verfasserin aut Maria G Pilia verfasserin aut Anneli Pouta verfasserin aut Myriam Rheinberger verfasserin aut Rasmus Ribel-Madsen verfasserin aut Marcus Richards verfasserin aut Kenneth M Rice verfasserin aut Treva K Rice verfasserin aut Carlo Rivolta verfasserin aut Veikko Salomaa verfasserin aut Alan R Sanders verfasserin aut Mark A Sarzynski verfasserin aut Salome Scholtens verfasserin aut Robert A Scott verfasserin aut William R Scott verfasserin aut Sylvain Sebert verfasserin aut Sebanti Sengupta verfasserin aut Bengt Sennblad verfasserin aut Thomas Seufferlein verfasserin aut Angela Silveira verfasserin aut P Eline Slagboom verfasserin aut Jan H Smit verfasserin aut Thomas H Sparsø verfasserin aut Kathleen Stirrups verfasserin aut Ronald P Stolk verfasserin aut Heather M Stringham verfasserin aut Morris A Swertz verfasserin aut Amy J Swift verfasserin aut Ann-Christine Syvänen verfasserin aut Sian-Tsung Tan verfasserin aut Barbara Thorand verfasserin aut Anke Tönjes verfasserin aut Angelo Tremblay verfasserin aut Emmanouil Tsafantakis verfasserin aut Peter J van der Most verfasserin aut Uwe Völker verfasserin aut Marie-Claude Vohl verfasserin aut Judith M Vonk verfasserin aut Melanie Waldenberger verfasserin aut Ryan W Walker verfasserin aut Roman Wennauer verfasserin aut Elisabeth Widén verfasserin aut Gonneke Willemsen verfasserin aut Tom Wilsgaard verfasserin aut Alan F Wright verfasserin aut M Carola Zillikens verfasserin aut Suzanne C van Dijk verfasserin aut Natasja M van Schoor verfasserin aut Folkert W Asselbergs verfasserin aut Paul I W de Bakker verfasserin aut Jacques S Beckmann verfasserin aut John Beilby verfasserin aut David A Bennett verfasserin aut Richard N Bergman verfasserin aut Sven Bergmann verfasserin aut Carsten A Böger verfasserin aut Bernhard O Boehm verfasserin aut Eric Boerwinkle verfasserin aut Dorret I Boomsma verfasserin aut Stefan R Bornstein verfasserin aut Erwin P Bottinger verfasserin aut Claude Bouchard verfasserin aut John C Chambers verfasserin aut Stephen J Chanock verfasserin aut Daniel I Chasman verfasserin aut Francesco Cucca verfasserin aut Daniele Cusi verfasserin aut George Dedoussis verfasserin aut Jeanette Erdmann verfasserin aut Johan G Eriksson verfasserin aut Denis A Evans verfasserin aut Ulf de Faire verfasserin aut Martin Farrall verfasserin aut Luigi Ferrucci verfasserin aut Ian Ford verfasserin aut Lude Franke verfasserin aut Paul W Franks verfasserin aut Philippe Froguel verfasserin aut Ron T Gansevoort verfasserin aut Christian Gieger verfasserin aut Henrik Grönberg verfasserin aut Vilmundur Gudnason verfasserin aut Ulf Gyllensten verfasserin aut Per Hall verfasserin aut Anders Hamsten verfasserin aut Pim van der Harst verfasserin aut Caroline Hayward verfasserin aut Markku Heliövaara verfasserin aut Christian Hengstenberg verfasserin aut Andrew A Hicks verfasserin aut Aroon Hingorani verfasserin aut Albert Hofman verfasserin aut Frank Hu verfasserin aut Heikki V Huikuri verfasserin aut Kristian Hveem verfasserin aut Alan L James verfasserin aut Joanne M Jordan verfasserin aut Antti Jula verfasserin aut Mika Kähönen verfasserin aut Eero Kajantie verfasserin aut Sekar Kathiresan verfasserin aut Lambertus A L M Kiemeney verfasserin aut Mika Kivimaki verfasserin aut Paul B Knekt verfasserin aut Heikki A Koistinen verfasserin aut Jaspal S Kooner verfasserin aut Seppo Koskinen verfasserin aut Johanna Kuusisto verfasserin aut Winfried Maerz verfasserin aut Nicholas G Martin verfasserin aut Markku Laakso verfasserin aut Timo A Lakka verfasserin aut Terho Lehtimäki verfasserin aut Guillaume Lettre verfasserin aut Douglas F Levinson verfasserin aut Lars Lind verfasserin aut Marja-Liisa Lokki verfasserin aut Pekka Mäntyselkä verfasserin aut Mads Melbye verfasserin aut Andres Metspalu verfasserin aut Braxton D Mitchell verfasserin aut Frans L Moll verfasserin aut Jeffrey C Murray verfasserin aut Arthur W Musk verfasserin aut Markku S Nieminen verfasserin aut Inger Njølstad verfasserin aut Claes Ohlsson verfasserin aut Albertine J Oldehinkel verfasserin aut Ben A Oostra verfasserin aut Lyle J Palmer verfasserin aut James S Pankow verfasserin aut Gerard Pasterkamp verfasserin aut Nancy L Pedersen verfasserin aut Oluf Pedersen verfasserin aut Brenda W Penninx verfasserin aut Markus Perola verfasserin aut Annette Peters verfasserin aut Ozren Polašek verfasserin aut Peter P Pramstaller verfasserin aut Bruce M Psaty verfasserin aut Lu Qi verfasserin aut Thomas Quertermous verfasserin aut Olli T Raitakari verfasserin aut Tuomo Rankinen verfasserin aut Rainer Rauramaa verfasserin aut Paul M Ridker verfasserin aut John D Rioux verfasserin aut Fernando Rivadeneira verfasserin aut Jerome I Rotter verfasserin aut Igor Rudan verfasserin aut Hester M den Ruijter verfasserin aut Juha Saltevo verfasserin aut Naveed Sattar verfasserin aut Heribert Schunkert verfasserin aut Peter E H Schwarz verfasserin aut Alan R Shuldiner verfasserin aut Juha Sinisalo verfasserin aut Harold Snieder verfasserin aut Thorkild I A Sørensen verfasserin aut Tim D Spector verfasserin aut Jan A Staessen verfasserin aut Bandinelli Stefania verfasserin aut Unnur Thorsteinsdottir verfasserin aut Michael Stumvoll verfasserin aut Jean-Claude Tardif verfasserin aut Elena Tremoli verfasserin aut Jaakko Tuomilehto verfasserin aut André G Uitterlinden verfasserin aut Matti Uusitupa verfasserin aut André L M Verbeek verfasserin aut Sita H Vermeulen verfasserin aut Jorma S Viikari verfasserin aut Veronique Vitart verfasserin aut Henry Völzke verfasserin aut Peter Vollenweider verfasserin aut Gérard Waeber verfasserin aut Mark Walker verfasserin aut Henri Wallaschofski verfasserin aut Nicholas J Wareham verfasserin aut Hugh Watkins verfasserin aut Eleftheria Zeggini verfasserin aut CHARGE Consortium verfasserin aut DIAGRAM Consortium verfasserin aut GLGC Consortium verfasserin aut Global-BPGen Consortium verfasserin aut ICBP Consortium verfasserin aut MAGIC Consortium verfasserin aut Aravinda Chakravarti verfasserin aut Deborah J Clegg verfasserin aut L Adrienne Cupples verfasserin aut Penny Gordon-Larsen verfasserin aut Cashell E Jaquish verfasserin aut D C Rao verfasserin aut Goncalo R Abecasis verfasserin aut Themistocles L Assimes verfasserin aut Inês Barroso verfasserin aut Sonja I Berndt verfasserin aut Michael Boehnke verfasserin aut Panos Deloukas verfasserin aut Caroline S Fox verfasserin aut Leif C Groop verfasserin aut David J Hunter verfasserin aut Erik Ingelsson verfasserin aut Robert C Kaplan verfasserin aut Mark I McCarthy verfasserin aut Karen L Mohlke verfasserin aut Jeffrey R O'Connell verfasserin aut David Schlessinger verfasserin aut David P Strachan verfasserin aut Kari Stefansson verfasserin aut Cornelia M van Duijn verfasserin aut Joel N Hirschhorn verfasserin aut Cecilia M Lindgren verfasserin aut Iris M Heid verfasserin aut Kari E North verfasserin aut Ingrid B Borecki verfasserin aut Zoltán Kutalik verfasserin aut Ruth J F Loos verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 11(2015), 10, p e1005378 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:11 year:2015 number:10, p e1005378 https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/article/ffdbcee3ab414e498706575063e26ecf kostenfrei https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 10, p e1005378 |
| allfields_unstemmed |
10.1371/journal.pgen.1005378 doi (DE-627)DOAJ014082977 (DE-599)DOAJffdbcee3ab414e498706575063e26ecf DE-627 ger DE-627 rakwb eng QH426-470 Thomas W Winkler verfasserin aut The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. Genetics Anne E Justice verfasserin aut Mariaelisa Graff verfasserin aut Llilda Barata verfasserin aut Mary F Feitosa verfasserin aut Su Chu verfasserin aut Jacek Czajkowski verfasserin aut Tõnu Esko verfasserin aut Tove Fall verfasserin aut Tuomas O Kilpeläinen verfasserin aut Yingchang Lu verfasserin aut Reedik Mägi verfasserin aut Evelin Mihailov verfasserin aut Tune H Pers verfasserin aut Sina Rüeger verfasserin aut Alexander Teumer verfasserin aut Georg B Ehret verfasserin aut Teresa Ferreira verfasserin aut Nancy L Heard-Costa verfasserin aut Juha Karjalainen verfasserin aut Vasiliki Lagou verfasserin aut Anubha Mahajan verfasserin aut Michael D Neinast verfasserin aut Inga Prokopenko verfasserin aut Jeannette Simino verfasserin aut Tanya M Teslovich verfasserin aut Rick Jansen verfasserin aut Harm-Jan Westra verfasserin aut Charles C White verfasserin aut Devin Absher verfasserin aut Tarunveer S Ahluwalia verfasserin aut Shafqat Ahmad verfasserin aut Eva Albrecht verfasserin aut Alexessander Couto Alves verfasserin aut Jennifer L Bragg-Gresham verfasserin aut Anton J M de Craen verfasserin aut Joshua C Bis verfasserin aut Amélie Bonnefond verfasserin aut Gabrielle Boucher verfasserin aut Gemma Cadby verfasserin aut Yu-Ching Cheng verfasserin aut Charleston W K Chiang verfasserin aut Graciela Delgado verfasserin aut Ayse Demirkan verfasserin aut Nicole Dueker verfasserin aut Niina Eklund verfasserin aut Gudny Eiriksdottir verfasserin aut Joel Eriksson verfasserin aut Bjarke Feenstra verfasserin aut Krista Fischer verfasserin aut Francesca Frau verfasserin aut Tessel E Galesloot verfasserin aut Frank Geller verfasserin aut Anuj Goel verfasserin aut Mathias Gorski verfasserin aut Tanja B Grammer verfasserin aut Stefan Gustafsson verfasserin aut Saskia Haitjema verfasserin aut Jouke-Jan Hottenga verfasserin aut Jennifer E Huffman verfasserin aut Anne U Jackson verfasserin aut Kevin B Jacobs verfasserin aut Åsa Johansson verfasserin aut Marika Kaakinen verfasserin aut Marcus E Kleber verfasserin aut Jari Lahti verfasserin aut Irene Mateo Leach verfasserin aut Benjamin Lehne verfasserin aut Youfang Liu verfasserin aut Ken Sin Lo verfasserin aut Mattias Lorentzon verfasserin aut Jian'an Luan verfasserin aut Pamela A F Madden verfasserin aut Massimo Mangino verfasserin aut Barbara McKnight verfasserin aut Carolina Medina-Gomez verfasserin aut Keri L Monda verfasserin aut May E Montasser verfasserin aut Gabriele Müller verfasserin aut Martina Müller-Nurasyid verfasserin aut Ilja M Nolte verfasserin aut Kalliope Panoutsopoulou verfasserin aut Laura Pascoe verfasserin aut Lavinia Paternoster verfasserin aut Nigel W Rayner verfasserin aut Frida Renström verfasserin aut Federica Rizzi verfasserin aut Lynda M Rose verfasserin aut Kathy A Ryan verfasserin aut Perttu Salo verfasserin aut Serena Sanna verfasserin aut Hubert Scharnagl verfasserin aut Jianxin Shi verfasserin aut Albert Vernon Smith verfasserin aut Lorraine Southam verfasserin aut Alena Stančáková verfasserin aut Valgerdur Steinthorsdottir verfasserin aut Rona J Strawbridge verfasserin aut Yun Ju Sung verfasserin aut Ioanna Tachmazidou verfasserin aut Toshiko Tanaka verfasserin aut Gudmar Thorleifsson verfasserin aut Stella Trompet verfasserin aut Natalia Pervjakova verfasserin aut Jonathan P Tyrer verfasserin aut Liesbeth Vandenput verfasserin aut Sander W van der Laan verfasserin aut Nathalie van der Velde verfasserin aut Jessica van Setten verfasserin aut Jana V van Vliet-Ostaptchouk verfasserin aut Niek Verweij verfasserin aut Efthymia Vlachopoulou verfasserin aut Lindsay L Waite verfasserin aut Sophie R Wang verfasserin aut Zhaoming Wang verfasserin aut Sarah H Wild verfasserin aut Christina Willenborg verfasserin aut James F Wilson verfasserin aut Andrew Wong verfasserin aut Jian Yang verfasserin aut Loïc Yengo verfasserin aut Laura M Yerges-Armstrong verfasserin aut Lei Yu verfasserin aut Weihua Zhang verfasserin aut Jing Hua Zhao verfasserin aut Ehm A Andersson verfasserin aut Stephan J L Bakker verfasserin aut Damiano Baldassarre verfasserin aut Karina Banasik verfasserin aut Matteo Barcella verfasserin aut Cristina Barlassina verfasserin aut Claire Bellis verfasserin aut Paola Benaglio verfasserin aut John Blangero verfasserin aut Matthias Blüher verfasserin aut Fabrice Bonnet verfasserin aut Lori L Bonnycastle verfasserin aut Heather A Boyd verfasserin aut Marcel Bruinenberg verfasserin aut Aron S Buchman verfasserin aut Harry Campbell verfasserin aut Yii-Der Ida Chen verfasserin aut Peter S Chines verfasserin aut Simone Claudi-Boehm verfasserin aut John Cole verfasserin aut Francis S Collins verfasserin aut Eco J C de Geus verfasserin aut Lisette C P G M de Groot verfasserin aut Maria Dimitriou verfasserin aut Jubao Duan verfasserin aut Stefan Enroth verfasserin aut Elodie Eury verfasserin aut Aliki-Eleni Farmaki verfasserin aut Nita G Forouhi verfasserin aut Nele Friedrich verfasserin aut Pablo V Gejman verfasserin aut Bruna Gigante verfasserin aut Nicola Glorioso verfasserin aut Alan S Go verfasserin aut Omri Gottesman verfasserin aut Jürgen Gräßler verfasserin aut Harald Grallert verfasserin aut Niels Grarup verfasserin aut Yu-Mei Gu verfasserin aut Linda Broer verfasserin aut Annelies C Ham verfasserin aut Torben Hansen verfasserin aut Tamara B Harris verfasserin aut Catharina A Hartman verfasserin aut Maija Hassinen verfasserin aut Nicholas Hastie verfasserin aut Andrew T Hattersley verfasserin aut Andrew C Heath verfasserin aut Anjali K Henders verfasserin aut Dena Hernandez verfasserin aut Hans Hillege verfasserin aut Oddgeir Holmen verfasserin aut Kees G Hovingh verfasserin aut Jennie Hui verfasserin aut Lise L Husemoen verfasserin aut Nina Hutri-Kähönen verfasserin aut Pirro G Hysi verfasserin aut Thomas Illig verfasserin aut Philip L De Jager verfasserin aut Shapour Jalilzadeh verfasserin aut Torben Jørgensen verfasserin aut J Wouter Jukema verfasserin aut Markus Juonala verfasserin aut Stavroula Kanoni verfasserin aut Maria Karaleftheri verfasserin aut Kay Tee Khaw verfasserin aut Leena Kinnunen verfasserin aut Steven J Kittner verfasserin aut Wolfgang Koenig verfasserin aut Ivana Kolcic verfasserin aut Peter Kovacs verfasserin aut Nikolaj T Krarup verfasserin aut Wolfgang Kratzer verfasserin aut Janine Krüger verfasserin aut Diana Kuh verfasserin aut Meena Kumari verfasserin aut Theodosios Kyriakou verfasserin aut Claudia Langenberg verfasserin aut Lars Lannfelt verfasserin aut Chiara Lanzani verfasserin aut Vaneet Lotay verfasserin aut Lenore J Launer verfasserin aut Karin Leander verfasserin aut Jaana Lindström verfasserin aut Allan Linneberg verfasserin aut Yan-Ping Liu verfasserin aut Stéphane Lobbens verfasserin aut Robert Luben verfasserin aut Valeriya Lyssenko verfasserin aut Satu Männistö verfasserin aut Patrik K Magnusson verfasserin aut Wendy L McArdle verfasserin aut Cristina Menni verfasserin aut Sigrun Merger verfasserin aut Lili Milani verfasserin aut Grant W Montgomery verfasserin aut Andrew P Morris verfasserin aut Narisu Narisu verfasserin aut Mari Nelis verfasserin aut Ken K Ong verfasserin aut Aarno Palotie verfasserin aut Louis Pérusse verfasserin aut Irene Pichler verfasserin aut Maria G Pilia verfasserin aut Anneli Pouta verfasserin aut Myriam Rheinberger verfasserin aut Rasmus Ribel-Madsen verfasserin aut Marcus Richards verfasserin aut Kenneth M Rice verfasserin aut Treva K Rice verfasserin aut Carlo Rivolta verfasserin aut Veikko Salomaa verfasserin aut Alan R Sanders verfasserin aut Mark A Sarzynski verfasserin aut Salome Scholtens verfasserin aut Robert A Scott verfasserin aut William R Scott verfasserin aut Sylvain Sebert verfasserin aut Sebanti Sengupta verfasserin aut Bengt Sennblad verfasserin aut Thomas Seufferlein verfasserin aut Angela Silveira verfasserin aut P Eline Slagboom verfasserin aut Jan H Smit verfasserin aut Thomas H Sparsø verfasserin aut Kathleen Stirrups verfasserin aut Ronald P Stolk verfasserin aut Heather M Stringham verfasserin aut Morris A Swertz verfasserin aut Amy J Swift verfasserin aut Ann-Christine Syvänen verfasserin aut Sian-Tsung Tan verfasserin aut Barbara Thorand verfasserin aut Anke Tönjes verfasserin aut Angelo Tremblay verfasserin aut Emmanouil Tsafantakis verfasserin aut Peter J van der Most verfasserin aut Uwe Völker verfasserin aut Marie-Claude Vohl verfasserin aut Judith M Vonk verfasserin aut Melanie Waldenberger verfasserin aut Ryan W Walker verfasserin aut Roman Wennauer verfasserin aut Elisabeth Widén verfasserin aut Gonneke Willemsen verfasserin aut Tom Wilsgaard verfasserin aut Alan F Wright verfasserin aut M Carola Zillikens verfasserin aut Suzanne C van Dijk verfasserin aut Natasja M van Schoor verfasserin aut Folkert W Asselbergs verfasserin aut Paul I W de Bakker verfasserin aut Jacques S Beckmann verfasserin aut John Beilby verfasserin aut David A Bennett verfasserin aut Richard N Bergman verfasserin aut Sven Bergmann verfasserin aut Carsten A Böger verfasserin aut Bernhard O Boehm verfasserin aut Eric Boerwinkle verfasserin aut Dorret I Boomsma verfasserin aut Stefan R Bornstein verfasserin aut Erwin P Bottinger verfasserin aut Claude Bouchard verfasserin aut John C Chambers verfasserin aut Stephen J Chanock verfasserin aut Daniel I Chasman verfasserin aut Francesco Cucca verfasserin aut Daniele Cusi verfasserin aut George Dedoussis verfasserin aut Jeanette Erdmann verfasserin aut Johan G Eriksson verfasserin aut Denis A Evans verfasserin aut Ulf de Faire verfasserin aut Martin Farrall verfasserin aut Luigi Ferrucci verfasserin aut Ian Ford verfasserin aut Lude Franke verfasserin aut Paul W Franks verfasserin aut Philippe Froguel verfasserin aut Ron T Gansevoort verfasserin aut Christian Gieger verfasserin aut Henrik Grönberg verfasserin aut Vilmundur Gudnason verfasserin aut Ulf Gyllensten verfasserin aut Per Hall verfasserin aut Anders Hamsten verfasserin aut Pim van der Harst verfasserin aut Caroline Hayward verfasserin aut Markku Heliövaara verfasserin aut Christian Hengstenberg verfasserin aut Andrew A Hicks verfasserin aut Aroon Hingorani verfasserin aut Albert Hofman verfasserin aut Frank Hu verfasserin aut Heikki V Huikuri verfasserin aut Kristian Hveem verfasserin aut Alan L James verfasserin aut Joanne M Jordan verfasserin aut Antti Jula verfasserin aut Mika Kähönen verfasserin aut Eero Kajantie verfasserin aut Sekar Kathiresan verfasserin aut Lambertus A L M Kiemeney verfasserin aut Mika Kivimaki verfasserin aut Paul B Knekt verfasserin aut Heikki A Koistinen verfasserin aut Jaspal S Kooner verfasserin aut Seppo Koskinen verfasserin aut Johanna Kuusisto verfasserin aut Winfried Maerz verfasserin aut Nicholas G Martin verfasserin aut Markku Laakso verfasserin aut Timo A Lakka verfasserin aut Terho Lehtimäki verfasserin aut Guillaume Lettre verfasserin aut Douglas F Levinson verfasserin aut Lars Lind verfasserin aut Marja-Liisa Lokki verfasserin aut Pekka Mäntyselkä verfasserin aut Mads Melbye verfasserin aut Andres Metspalu verfasserin aut Braxton D Mitchell verfasserin aut Frans L Moll verfasserin aut Jeffrey C Murray verfasserin aut Arthur W Musk verfasserin aut Markku S Nieminen verfasserin aut Inger Njølstad verfasserin aut Claes Ohlsson verfasserin aut Albertine J Oldehinkel verfasserin aut Ben A Oostra verfasserin aut Lyle J Palmer verfasserin aut James S Pankow verfasserin aut Gerard Pasterkamp verfasserin aut Nancy L Pedersen verfasserin aut Oluf Pedersen verfasserin aut Brenda W Penninx verfasserin aut Markus Perola verfasserin aut Annette Peters verfasserin aut Ozren Polašek verfasserin aut Peter P Pramstaller verfasserin aut Bruce M Psaty verfasserin aut Lu Qi verfasserin aut Thomas Quertermous verfasserin aut Olli T Raitakari verfasserin aut Tuomo Rankinen verfasserin aut Rainer Rauramaa verfasserin aut Paul M Ridker verfasserin aut John D Rioux verfasserin aut Fernando Rivadeneira verfasserin aut Jerome I Rotter verfasserin aut Igor Rudan verfasserin aut Hester M den Ruijter verfasserin aut Juha Saltevo verfasserin aut Naveed Sattar verfasserin aut Heribert Schunkert verfasserin aut Peter E H Schwarz verfasserin aut Alan R Shuldiner verfasserin aut Juha Sinisalo verfasserin aut Harold Snieder verfasserin aut Thorkild I A Sørensen verfasserin aut Tim D Spector verfasserin aut Jan A Staessen verfasserin aut Bandinelli Stefania verfasserin aut Unnur Thorsteinsdottir verfasserin aut Michael Stumvoll verfasserin aut Jean-Claude Tardif verfasserin aut Elena Tremoli verfasserin aut Jaakko Tuomilehto verfasserin aut André G Uitterlinden verfasserin aut Matti Uusitupa verfasserin aut André L M Verbeek verfasserin aut Sita H Vermeulen verfasserin aut Jorma S Viikari verfasserin aut Veronique Vitart verfasserin aut Henry Völzke verfasserin aut Peter Vollenweider verfasserin aut Gérard Waeber verfasserin aut Mark Walker verfasserin aut Henri Wallaschofski verfasserin aut Nicholas J Wareham verfasserin aut Hugh Watkins verfasserin aut Eleftheria Zeggini verfasserin aut CHARGE Consortium verfasserin aut DIAGRAM Consortium verfasserin aut GLGC Consortium verfasserin aut Global-BPGen Consortium verfasserin aut ICBP Consortium verfasserin aut MAGIC Consortium verfasserin aut Aravinda Chakravarti verfasserin aut Deborah J Clegg verfasserin aut L Adrienne Cupples verfasserin aut Penny Gordon-Larsen verfasserin aut Cashell E Jaquish verfasserin aut D C Rao verfasserin aut Goncalo R Abecasis verfasserin aut Themistocles L Assimes verfasserin aut Inês Barroso verfasserin aut Sonja I Berndt verfasserin aut Michael Boehnke verfasserin aut Panos Deloukas verfasserin aut Caroline S Fox verfasserin aut Leif C Groop verfasserin aut David J Hunter verfasserin aut Erik Ingelsson verfasserin aut Robert C Kaplan verfasserin aut Mark I McCarthy verfasserin aut Karen L Mohlke verfasserin aut Jeffrey R O'Connell verfasserin aut David Schlessinger verfasserin aut David P Strachan verfasserin aut Kari Stefansson verfasserin aut Cornelia M van Duijn verfasserin aut Joel N Hirschhorn verfasserin aut Cecilia M Lindgren verfasserin aut Iris M Heid verfasserin aut Kari E North verfasserin aut Ingrid B Borecki verfasserin aut Zoltán Kutalik verfasserin aut Ruth J F Loos verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 11(2015), 10, p e1005378 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:11 year:2015 number:10, p e1005378 https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/article/ffdbcee3ab414e498706575063e26ecf kostenfrei https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 10, p e1005378 |
| allfieldsGer |
10.1371/journal.pgen.1005378 doi (DE-627)DOAJ014082977 (DE-599)DOAJffdbcee3ab414e498706575063e26ecf DE-627 ger DE-627 rakwb eng QH426-470 Thomas W Winkler verfasserin aut The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. Genetics Anne E Justice verfasserin aut Mariaelisa Graff verfasserin aut Llilda Barata verfasserin aut Mary F Feitosa verfasserin aut Su Chu verfasserin aut Jacek Czajkowski verfasserin aut Tõnu Esko verfasserin aut Tove Fall verfasserin aut Tuomas O Kilpeläinen verfasserin aut Yingchang Lu verfasserin aut Reedik Mägi verfasserin aut Evelin Mihailov verfasserin aut Tune H Pers verfasserin aut Sina Rüeger verfasserin aut Alexander Teumer verfasserin aut Georg B Ehret verfasserin aut Teresa Ferreira verfasserin aut Nancy L Heard-Costa verfasserin aut Juha Karjalainen verfasserin aut Vasiliki Lagou verfasserin aut Anubha Mahajan verfasserin aut Michael D Neinast verfasserin aut Inga Prokopenko verfasserin aut Jeannette Simino verfasserin aut Tanya M Teslovich verfasserin aut Rick Jansen verfasserin aut Harm-Jan Westra verfasserin aut Charles C White verfasserin aut Devin Absher verfasserin aut Tarunveer S Ahluwalia verfasserin aut Shafqat Ahmad verfasserin aut Eva Albrecht verfasserin aut Alexessander Couto Alves verfasserin aut Jennifer L Bragg-Gresham verfasserin aut Anton J M de Craen verfasserin aut Joshua C Bis verfasserin aut Amélie Bonnefond verfasserin aut Gabrielle Boucher verfasserin aut Gemma Cadby verfasserin aut Yu-Ching Cheng verfasserin aut Charleston W K Chiang verfasserin aut Graciela Delgado verfasserin aut Ayse Demirkan verfasserin aut Nicole Dueker verfasserin aut Niina Eklund verfasserin aut Gudny Eiriksdottir verfasserin aut Joel Eriksson verfasserin aut Bjarke Feenstra verfasserin aut Krista Fischer verfasserin aut Francesca Frau verfasserin aut Tessel E Galesloot verfasserin aut Frank Geller verfasserin aut Anuj Goel verfasserin aut Mathias Gorski verfasserin aut Tanja B Grammer verfasserin aut Stefan Gustafsson verfasserin aut Saskia Haitjema verfasserin aut Jouke-Jan Hottenga verfasserin aut Jennifer E Huffman verfasserin aut Anne U Jackson verfasserin aut Kevin B Jacobs verfasserin aut Åsa Johansson verfasserin aut Marika Kaakinen verfasserin aut Marcus E Kleber verfasserin aut Jari Lahti verfasserin aut Irene Mateo Leach verfasserin aut Benjamin Lehne verfasserin aut Youfang Liu verfasserin aut Ken Sin Lo verfasserin aut Mattias Lorentzon verfasserin aut Jian'an Luan verfasserin aut Pamela A F Madden verfasserin aut Massimo Mangino verfasserin aut Barbara McKnight verfasserin aut Carolina Medina-Gomez verfasserin aut Keri L Monda verfasserin aut May E Montasser verfasserin aut Gabriele Müller verfasserin aut Martina Müller-Nurasyid verfasserin aut Ilja M Nolte verfasserin aut Kalliope Panoutsopoulou verfasserin aut Laura Pascoe verfasserin aut Lavinia Paternoster verfasserin aut Nigel W Rayner verfasserin aut Frida Renström verfasserin aut Federica Rizzi verfasserin aut Lynda M Rose verfasserin aut Kathy A Ryan verfasserin aut Perttu Salo verfasserin aut Serena Sanna verfasserin aut Hubert Scharnagl verfasserin aut Jianxin Shi verfasserin aut Albert Vernon Smith verfasserin aut Lorraine Southam verfasserin aut Alena Stančáková verfasserin aut Valgerdur Steinthorsdottir verfasserin aut Rona J Strawbridge verfasserin aut Yun Ju Sung verfasserin aut Ioanna Tachmazidou verfasserin aut Toshiko Tanaka verfasserin aut Gudmar Thorleifsson verfasserin aut Stella Trompet verfasserin aut Natalia Pervjakova verfasserin aut Jonathan P Tyrer verfasserin aut Liesbeth Vandenput verfasserin aut Sander W van der Laan verfasserin aut Nathalie van der Velde verfasserin aut Jessica van Setten verfasserin aut Jana V van Vliet-Ostaptchouk verfasserin aut Niek Verweij verfasserin aut Efthymia Vlachopoulou verfasserin aut Lindsay L Waite verfasserin aut Sophie R Wang verfasserin aut Zhaoming Wang verfasserin aut Sarah H Wild verfasserin aut Christina Willenborg verfasserin aut James F Wilson verfasserin aut Andrew Wong verfasserin aut Jian Yang verfasserin aut Loïc Yengo verfasserin aut Laura M Yerges-Armstrong verfasserin aut Lei Yu verfasserin aut Weihua Zhang verfasserin aut Jing Hua Zhao verfasserin aut Ehm A Andersson verfasserin aut Stephan J L Bakker verfasserin aut Damiano Baldassarre verfasserin aut Karina Banasik verfasserin aut Matteo Barcella verfasserin aut Cristina Barlassina verfasserin aut Claire Bellis verfasserin aut Paola Benaglio verfasserin aut John Blangero verfasserin aut Matthias Blüher verfasserin aut Fabrice Bonnet verfasserin aut Lori L Bonnycastle verfasserin aut Heather A Boyd verfasserin aut Marcel Bruinenberg verfasserin aut Aron S Buchman verfasserin aut Harry Campbell verfasserin aut Yii-Der Ida Chen verfasserin aut Peter S Chines verfasserin aut Simone Claudi-Boehm verfasserin aut John Cole verfasserin aut Francis S Collins verfasserin aut Eco J C de Geus verfasserin aut Lisette C P G M de Groot verfasserin aut Maria Dimitriou verfasserin aut Jubao Duan verfasserin aut Stefan Enroth verfasserin aut Elodie Eury verfasserin aut Aliki-Eleni Farmaki verfasserin aut Nita G Forouhi verfasserin aut Nele Friedrich verfasserin aut Pablo V Gejman verfasserin aut Bruna Gigante verfasserin aut Nicola Glorioso verfasserin aut Alan S Go verfasserin aut Omri Gottesman verfasserin aut Jürgen Gräßler verfasserin aut Harald Grallert verfasserin aut Niels Grarup verfasserin aut Yu-Mei Gu verfasserin aut Linda Broer verfasserin aut Annelies C Ham verfasserin aut Torben Hansen verfasserin aut Tamara B Harris verfasserin aut Catharina A Hartman verfasserin aut Maija Hassinen verfasserin aut Nicholas Hastie verfasserin aut Andrew T Hattersley verfasserin aut Andrew C Heath verfasserin aut Anjali K Henders verfasserin aut Dena Hernandez verfasserin aut Hans Hillege verfasserin aut Oddgeir Holmen verfasserin aut Kees G Hovingh verfasserin aut Jennie Hui verfasserin aut Lise L Husemoen verfasserin aut Nina Hutri-Kähönen verfasserin aut Pirro G Hysi verfasserin aut Thomas Illig verfasserin aut Philip L De Jager verfasserin aut Shapour Jalilzadeh verfasserin aut Torben Jørgensen verfasserin aut J Wouter Jukema verfasserin aut Markus Juonala verfasserin aut Stavroula Kanoni verfasserin aut Maria Karaleftheri verfasserin aut Kay Tee Khaw verfasserin aut Leena Kinnunen verfasserin aut Steven J Kittner verfasserin aut Wolfgang Koenig verfasserin aut Ivana Kolcic verfasserin aut Peter Kovacs verfasserin aut Nikolaj T Krarup verfasserin aut Wolfgang Kratzer verfasserin aut Janine Krüger verfasserin aut Diana Kuh verfasserin aut Meena Kumari verfasserin aut Theodosios Kyriakou verfasserin aut Claudia Langenberg verfasserin aut Lars Lannfelt verfasserin aut Chiara Lanzani verfasserin aut Vaneet Lotay verfasserin aut Lenore J Launer verfasserin aut Karin Leander verfasserin aut Jaana Lindström verfasserin aut Allan Linneberg verfasserin aut Yan-Ping Liu verfasserin aut Stéphane Lobbens verfasserin aut Robert Luben verfasserin aut Valeriya Lyssenko verfasserin aut Satu Männistö verfasserin aut Patrik K Magnusson verfasserin aut Wendy L McArdle verfasserin aut Cristina Menni verfasserin aut Sigrun Merger verfasserin aut Lili Milani verfasserin aut Grant W Montgomery verfasserin aut Andrew P Morris verfasserin aut Narisu Narisu verfasserin aut Mari Nelis verfasserin aut Ken K Ong verfasserin aut Aarno Palotie verfasserin aut Louis Pérusse verfasserin aut Irene Pichler verfasserin aut Maria G Pilia verfasserin aut Anneli Pouta verfasserin aut Myriam Rheinberger verfasserin aut Rasmus Ribel-Madsen verfasserin aut Marcus Richards verfasserin aut Kenneth M Rice verfasserin aut Treva K Rice verfasserin aut Carlo Rivolta verfasserin aut Veikko Salomaa verfasserin aut Alan R Sanders verfasserin aut Mark A Sarzynski verfasserin aut Salome Scholtens verfasserin aut Robert A Scott verfasserin aut William R Scott verfasserin aut Sylvain Sebert verfasserin aut Sebanti Sengupta verfasserin aut Bengt Sennblad verfasserin aut Thomas Seufferlein verfasserin aut Angela Silveira verfasserin aut P Eline Slagboom verfasserin aut Jan H Smit verfasserin aut Thomas H Sparsø verfasserin aut Kathleen Stirrups verfasserin aut Ronald P Stolk verfasserin aut Heather M Stringham verfasserin aut Morris A Swertz verfasserin aut Amy J Swift verfasserin aut Ann-Christine Syvänen verfasserin aut Sian-Tsung Tan verfasserin aut Barbara Thorand verfasserin aut Anke Tönjes verfasserin aut Angelo Tremblay verfasserin aut Emmanouil Tsafantakis verfasserin aut Peter J van der Most verfasserin aut Uwe Völker verfasserin aut Marie-Claude Vohl verfasserin aut Judith M Vonk verfasserin aut Melanie Waldenberger verfasserin aut Ryan W Walker verfasserin aut Roman Wennauer verfasserin aut Elisabeth Widén verfasserin aut Gonneke Willemsen verfasserin aut Tom Wilsgaard verfasserin aut Alan F Wright verfasserin aut M Carola Zillikens verfasserin aut Suzanne C van Dijk verfasserin aut Natasja M van Schoor verfasserin aut Folkert W Asselbergs verfasserin aut Paul I W de Bakker verfasserin aut Jacques S Beckmann verfasserin aut John Beilby verfasserin aut David A Bennett verfasserin aut Richard N Bergman verfasserin aut Sven Bergmann verfasserin aut Carsten A Böger verfasserin aut Bernhard O Boehm verfasserin aut Eric Boerwinkle verfasserin aut Dorret I Boomsma verfasserin aut Stefan R Bornstein verfasserin aut Erwin P Bottinger verfasserin aut Claude Bouchard verfasserin aut John C Chambers verfasserin aut Stephen J Chanock verfasserin aut Daniel I Chasman verfasserin aut Francesco Cucca verfasserin aut Daniele Cusi verfasserin aut George Dedoussis verfasserin aut Jeanette Erdmann verfasserin aut Johan G Eriksson verfasserin aut Denis A Evans verfasserin aut Ulf de Faire verfasserin aut Martin Farrall verfasserin aut Luigi Ferrucci verfasserin aut Ian Ford verfasserin aut Lude Franke verfasserin aut Paul W Franks verfasserin aut Philippe Froguel verfasserin aut Ron T Gansevoort verfasserin aut Christian Gieger verfasserin aut Henrik Grönberg verfasserin aut Vilmundur Gudnason verfasserin aut Ulf Gyllensten verfasserin aut Per Hall verfasserin aut Anders Hamsten verfasserin aut Pim van der Harst verfasserin aut Caroline Hayward verfasserin aut Markku Heliövaara verfasserin aut Christian Hengstenberg verfasserin aut Andrew A Hicks verfasserin aut Aroon Hingorani verfasserin aut Albert Hofman verfasserin aut Frank Hu verfasserin aut Heikki V Huikuri verfasserin aut Kristian Hveem verfasserin aut Alan L James verfasserin aut Joanne M Jordan verfasserin aut Antti Jula verfasserin aut Mika Kähönen verfasserin aut Eero Kajantie verfasserin aut Sekar Kathiresan verfasserin aut Lambertus A L M Kiemeney verfasserin aut Mika Kivimaki verfasserin aut Paul B Knekt verfasserin aut Heikki A Koistinen verfasserin aut Jaspal S Kooner verfasserin aut Seppo Koskinen verfasserin aut Johanna Kuusisto verfasserin aut Winfried Maerz verfasserin aut Nicholas G Martin verfasserin aut Markku Laakso verfasserin aut Timo A Lakka verfasserin aut Terho Lehtimäki verfasserin aut Guillaume Lettre verfasserin aut Douglas F Levinson verfasserin aut Lars Lind verfasserin aut Marja-Liisa Lokki verfasserin aut Pekka Mäntyselkä verfasserin aut Mads Melbye verfasserin aut Andres Metspalu verfasserin aut Braxton D Mitchell verfasserin aut Frans L Moll verfasserin aut Jeffrey C Murray verfasserin aut Arthur W Musk verfasserin aut Markku S Nieminen verfasserin aut Inger Njølstad verfasserin aut Claes Ohlsson verfasserin aut Albertine J Oldehinkel verfasserin aut Ben A Oostra verfasserin aut Lyle J Palmer verfasserin aut James S Pankow verfasserin aut Gerard Pasterkamp verfasserin aut Nancy L Pedersen verfasserin aut Oluf Pedersen verfasserin aut Brenda W Penninx verfasserin aut Markus Perola verfasserin aut Annette Peters verfasserin aut Ozren Polašek verfasserin aut Peter P Pramstaller verfasserin aut Bruce M Psaty verfasserin aut Lu Qi verfasserin aut Thomas Quertermous verfasserin aut Olli T Raitakari verfasserin aut Tuomo Rankinen verfasserin aut Rainer Rauramaa verfasserin aut Paul M Ridker verfasserin aut John D Rioux verfasserin aut Fernando Rivadeneira verfasserin aut Jerome I Rotter verfasserin aut Igor Rudan verfasserin aut Hester M den Ruijter verfasserin aut Juha Saltevo verfasserin aut Naveed Sattar verfasserin aut Heribert Schunkert verfasserin aut Peter E H Schwarz verfasserin aut Alan R Shuldiner verfasserin aut Juha Sinisalo verfasserin aut Harold Snieder verfasserin aut Thorkild I A Sørensen verfasserin aut Tim D Spector verfasserin aut Jan A Staessen verfasserin aut Bandinelli Stefania verfasserin aut Unnur Thorsteinsdottir verfasserin aut Michael Stumvoll verfasserin aut Jean-Claude Tardif verfasserin aut Elena Tremoli verfasserin aut Jaakko Tuomilehto verfasserin aut André G Uitterlinden verfasserin aut Matti Uusitupa verfasserin aut André L M Verbeek verfasserin aut Sita H Vermeulen verfasserin aut Jorma S Viikari verfasserin aut Veronique Vitart verfasserin aut Henry Völzke verfasserin aut Peter Vollenweider verfasserin aut Gérard Waeber verfasserin aut Mark Walker verfasserin aut Henri Wallaschofski verfasserin aut Nicholas J Wareham verfasserin aut Hugh Watkins verfasserin aut Eleftheria Zeggini verfasserin aut CHARGE Consortium verfasserin aut DIAGRAM Consortium verfasserin aut GLGC Consortium verfasserin aut Global-BPGen Consortium verfasserin aut ICBP Consortium verfasserin aut MAGIC Consortium verfasserin aut Aravinda Chakravarti verfasserin aut Deborah J Clegg verfasserin aut L Adrienne Cupples verfasserin aut Penny Gordon-Larsen verfasserin aut Cashell E Jaquish verfasserin aut D C Rao verfasserin aut Goncalo R Abecasis verfasserin aut Themistocles L Assimes verfasserin aut Inês Barroso verfasserin aut Sonja I Berndt verfasserin aut Michael Boehnke verfasserin aut Panos Deloukas verfasserin aut Caroline S Fox verfasserin aut Leif C Groop verfasserin aut David J Hunter verfasserin aut Erik Ingelsson verfasserin aut Robert C Kaplan verfasserin aut Mark I McCarthy verfasserin aut Karen L Mohlke verfasserin aut Jeffrey R O'Connell verfasserin aut David Schlessinger verfasserin aut David P Strachan verfasserin aut Kari Stefansson verfasserin aut Cornelia M van Duijn verfasserin aut Joel N Hirschhorn verfasserin aut Cecilia M Lindgren verfasserin aut Iris M Heid verfasserin aut Kari E North verfasserin aut Ingrid B Borecki verfasserin aut Zoltán Kutalik verfasserin aut Ruth J F Loos verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 11(2015), 10, p e1005378 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:11 year:2015 number:10, p e1005378 https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/article/ffdbcee3ab414e498706575063e26ecf kostenfrei https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 10, p e1005378 |
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10.1371/journal.pgen.1005378 doi (DE-627)DOAJ014082977 (DE-599)DOAJffdbcee3ab414e498706575063e26ecf DE-627 ger DE-627 rakwb eng QH426-470 Thomas W Winkler verfasserin aut The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. Genetics Anne E Justice verfasserin aut Mariaelisa Graff verfasserin aut Llilda Barata verfasserin aut Mary F Feitosa verfasserin aut Su Chu verfasserin aut Jacek Czajkowski verfasserin aut Tõnu Esko verfasserin aut Tove Fall verfasserin aut Tuomas O Kilpeläinen verfasserin aut Yingchang Lu verfasserin aut Reedik Mägi verfasserin aut Evelin Mihailov verfasserin aut Tune H Pers verfasserin aut Sina Rüeger verfasserin aut Alexander Teumer verfasserin aut Georg B Ehret verfasserin aut Teresa Ferreira verfasserin aut Nancy L Heard-Costa verfasserin aut Juha Karjalainen verfasserin aut Vasiliki Lagou verfasserin aut Anubha Mahajan verfasserin aut Michael D Neinast verfasserin aut Inga Prokopenko verfasserin aut Jeannette Simino verfasserin aut Tanya M Teslovich verfasserin aut Rick Jansen verfasserin aut Harm-Jan Westra verfasserin aut Charles C White verfasserin aut Devin Absher verfasserin aut Tarunveer S Ahluwalia verfasserin aut Shafqat Ahmad verfasserin aut Eva Albrecht verfasserin aut Alexessander Couto Alves verfasserin aut Jennifer L Bragg-Gresham verfasserin aut Anton J M de Craen verfasserin aut Joshua C Bis verfasserin aut Amélie Bonnefond verfasserin aut Gabrielle Boucher verfasserin aut Gemma Cadby verfasserin aut Yu-Ching Cheng verfasserin aut Charleston W K Chiang verfasserin aut Graciela Delgado verfasserin aut Ayse Demirkan verfasserin aut Nicole Dueker verfasserin aut Niina Eklund verfasserin aut Gudny Eiriksdottir verfasserin aut Joel Eriksson verfasserin aut Bjarke Feenstra verfasserin aut Krista Fischer verfasserin aut Francesca Frau verfasserin aut Tessel E Galesloot verfasserin aut Frank Geller verfasserin aut Anuj Goel verfasserin aut Mathias Gorski verfasserin aut Tanja B Grammer verfasserin aut Stefan Gustafsson verfasserin aut Saskia Haitjema verfasserin aut Jouke-Jan Hottenga verfasserin aut Jennifer E Huffman verfasserin aut Anne U Jackson verfasserin aut Kevin B Jacobs verfasserin aut Åsa Johansson verfasserin aut Marika Kaakinen verfasserin aut Marcus E Kleber verfasserin aut Jari Lahti verfasserin aut Irene Mateo Leach verfasserin aut Benjamin Lehne verfasserin aut Youfang Liu verfasserin aut Ken Sin Lo verfasserin aut Mattias Lorentzon verfasserin aut Jian'an Luan verfasserin aut Pamela A F Madden verfasserin aut Massimo Mangino verfasserin aut Barbara McKnight verfasserin aut Carolina Medina-Gomez verfasserin aut Keri L Monda verfasserin aut May E Montasser verfasserin aut Gabriele Müller verfasserin aut Martina Müller-Nurasyid verfasserin aut Ilja M Nolte verfasserin aut Kalliope Panoutsopoulou verfasserin aut Laura Pascoe verfasserin aut Lavinia Paternoster verfasserin aut Nigel W Rayner verfasserin aut Frida Renström verfasserin aut Federica Rizzi verfasserin aut Lynda M Rose verfasserin aut Kathy A Ryan verfasserin aut Perttu Salo verfasserin aut Serena Sanna verfasserin aut Hubert Scharnagl verfasserin aut Jianxin Shi verfasserin aut Albert Vernon Smith verfasserin aut Lorraine Southam verfasserin aut Alena Stančáková verfasserin aut Valgerdur Steinthorsdottir verfasserin aut Rona J Strawbridge verfasserin aut Yun Ju Sung verfasserin aut Ioanna Tachmazidou verfasserin aut Toshiko Tanaka verfasserin aut Gudmar Thorleifsson verfasserin aut Stella Trompet verfasserin aut Natalia Pervjakova verfasserin aut Jonathan P Tyrer verfasserin aut Liesbeth Vandenput verfasserin aut Sander W van der Laan verfasserin aut Nathalie van der Velde verfasserin aut Jessica van Setten verfasserin aut Jana V van Vliet-Ostaptchouk verfasserin aut Niek Verweij verfasserin aut Efthymia Vlachopoulou verfasserin aut Lindsay L Waite verfasserin aut Sophie R Wang verfasserin aut Zhaoming Wang verfasserin aut Sarah H Wild verfasserin aut Christina Willenborg verfasserin aut James F Wilson verfasserin aut Andrew Wong verfasserin aut Jian Yang verfasserin aut Loïc Yengo verfasserin aut Laura M Yerges-Armstrong verfasserin aut Lei Yu verfasserin aut Weihua Zhang verfasserin aut Jing Hua Zhao verfasserin aut Ehm A Andersson verfasserin aut Stephan J L Bakker verfasserin aut Damiano Baldassarre verfasserin aut Karina Banasik verfasserin aut Matteo Barcella verfasserin aut Cristina Barlassina verfasserin aut Claire Bellis verfasserin aut Paola Benaglio verfasserin aut John Blangero verfasserin aut Matthias Blüher verfasserin aut Fabrice Bonnet verfasserin aut Lori L Bonnycastle verfasserin aut Heather A Boyd verfasserin aut Marcel Bruinenberg verfasserin aut Aron S Buchman verfasserin aut Harry Campbell verfasserin aut Yii-Der Ida Chen verfasserin aut Peter S Chines verfasserin aut Simone Claudi-Boehm verfasserin aut John Cole verfasserin aut Francis S Collins verfasserin aut Eco J C de Geus verfasserin aut Lisette C P G M de Groot verfasserin aut Maria Dimitriou verfasserin aut Jubao Duan verfasserin aut Stefan Enroth verfasserin aut Elodie Eury verfasserin aut Aliki-Eleni Farmaki verfasserin aut Nita G Forouhi verfasserin aut Nele Friedrich verfasserin aut Pablo V Gejman verfasserin aut Bruna Gigante verfasserin aut Nicola Glorioso verfasserin aut Alan S Go verfasserin aut Omri Gottesman verfasserin aut Jürgen Gräßler verfasserin aut Harald Grallert verfasserin aut Niels Grarup verfasserin aut Yu-Mei Gu verfasserin aut Linda Broer verfasserin aut Annelies C Ham verfasserin aut Torben Hansen verfasserin aut Tamara B Harris verfasserin aut Catharina A Hartman verfasserin aut Maija Hassinen verfasserin aut Nicholas Hastie verfasserin aut Andrew T Hattersley verfasserin aut Andrew C Heath verfasserin aut Anjali K Henders verfasserin aut Dena Hernandez verfasserin aut Hans Hillege verfasserin aut Oddgeir Holmen verfasserin aut Kees G Hovingh verfasserin aut Jennie Hui verfasserin aut Lise L Husemoen verfasserin aut Nina Hutri-Kähönen verfasserin aut Pirro G Hysi verfasserin aut Thomas Illig verfasserin aut Philip L De Jager verfasserin aut Shapour Jalilzadeh verfasserin aut Torben Jørgensen verfasserin aut J Wouter Jukema verfasserin aut Markus Juonala verfasserin aut Stavroula Kanoni verfasserin aut Maria Karaleftheri verfasserin aut Kay Tee Khaw verfasserin aut Leena Kinnunen verfasserin aut Steven J Kittner verfasserin aut Wolfgang Koenig verfasserin aut Ivana Kolcic verfasserin aut Peter Kovacs verfasserin aut Nikolaj T Krarup verfasserin aut Wolfgang Kratzer verfasserin aut Janine Krüger verfasserin aut Diana Kuh verfasserin aut Meena Kumari verfasserin aut Theodosios Kyriakou verfasserin aut Claudia Langenberg verfasserin aut Lars Lannfelt verfasserin aut Chiara Lanzani verfasserin aut Vaneet Lotay verfasserin aut Lenore J Launer verfasserin aut Karin Leander verfasserin aut Jaana Lindström verfasserin aut Allan Linneberg verfasserin aut Yan-Ping Liu verfasserin aut Stéphane Lobbens verfasserin aut Robert Luben verfasserin aut Valeriya Lyssenko verfasserin aut Satu Männistö verfasserin aut Patrik K Magnusson verfasserin aut Wendy L McArdle verfasserin aut Cristina Menni verfasserin aut Sigrun Merger verfasserin aut Lili Milani verfasserin aut Grant W 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M den Ruijter verfasserin aut Juha Saltevo verfasserin aut Naveed Sattar verfasserin aut Heribert Schunkert verfasserin aut Peter E H Schwarz verfasserin aut Alan R Shuldiner verfasserin aut Juha Sinisalo verfasserin aut Harold Snieder verfasserin aut Thorkild I A Sørensen verfasserin aut Tim D Spector verfasserin aut Jan A Staessen verfasserin aut Bandinelli Stefania verfasserin aut Unnur Thorsteinsdottir verfasserin aut Michael Stumvoll verfasserin aut Jean-Claude Tardif verfasserin aut Elena Tremoli verfasserin aut Jaakko Tuomilehto verfasserin aut André G Uitterlinden verfasserin aut Matti Uusitupa verfasserin aut André L M Verbeek verfasserin aut Sita H Vermeulen verfasserin aut Jorma S Viikari verfasserin aut Veronique Vitart verfasserin aut Henry Völzke verfasserin aut Peter Vollenweider verfasserin aut Gérard Waeber verfasserin aut Mark Walker verfasserin aut Henri Wallaschofski verfasserin aut Nicholas J Wareham verfasserin aut Hugh Watkins verfasserin aut Eleftheria Zeggini verfasserin aut CHARGE Consortium verfasserin aut DIAGRAM Consortium verfasserin aut GLGC Consortium verfasserin aut Global-BPGen Consortium verfasserin aut ICBP Consortium verfasserin aut MAGIC Consortium verfasserin aut Aravinda Chakravarti verfasserin aut Deborah J Clegg verfasserin aut L Adrienne Cupples verfasserin aut Penny Gordon-Larsen verfasserin aut Cashell E Jaquish verfasserin aut D C Rao verfasserin aut Goncalo R Abecasis verfasserin aut Themistocles L Assimes verfasserin aut Inês Barroso verfasserin aut Sonja I Berndt verfasserin aut Michael Boehnke verfasserin aut Panos Deloukas verfasserin aut Caroline S Fox verfasserin aut Leif C Groop verfasserin aut David J Hunter verfasserin aut Erik Ingelsson verfasserin aut Robert C Kaplan verfasserin aut Mark I McCarthy verfasserin aut Karen L Mohlke verfasserin aut Jeffrey R O'Connell verfasserin aut David Schlessinger verfasserin aut David P Strachan verfasserin aut Kari Stefansson verfasserin aut Cornelia M van Duijn verfasserin aut Joel N Hirschhorn verfasserin aut Cecilia M Lindgren verfasserin aut Iris M Heid verfasserin aut Kari E North verfasserin aut Ingrid B Borecki verfasserin aut Zoltán Kutalik verfasserin aut Ruth J F Loos verfasserin aut In PLoS Genetics Public Library of Science (PLoS), 2005 11(2015), 10, p e1005378 (DE-627)485248026 (DE-600)2186725-2 15537404 nnns volume:11 year:2015 number:10, p e1005378 https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/article/ffdbcee3ab414e498706575063e26ecf kostenfrei https://doi.org/10.1371/journal.pgen.1005378 kostenfrei https://doaj.org/toc/1553-7390 Journal toc kostenfrei https://doaj.org/toc/1553-7404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 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In PLoS Genetics 11(2015), 10, p e1005378 volume:11 year:2015 number:10, p e1005378 |
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Thomas W Winkler @@aut@@ Anne E Justice @@aut@@ Mariaelisa Graff @@aut@@ Llilda Barata @@aut@@ Mary F Feitosa @@aut@@ Su Chu @@aut@@ Jacek Czajkowski @@aut@@ Tõnu Esko @@aut@@ Tove Fall @@aut@@ Tuomas O Kilpeläinen @@aut@@ Yingchang Lu @@aut@@ Reedik Mägi @@aut@@ Evelin Mihailov @@aut@@ Tune H Pers @@aut@@ Sina Rüeger @@aut@@ Alexander Teumer @@aut@@ Georg B Ehret @@aut@@ Teresa Ferreira @@aut@@ Nancy L Heard-Costa @@aut@@ Juha Karjalainen @@aut@@ Vasiliki Lagou @@aut@@ Anubha Mahajan @@aut@@ Michael D Neinast @@aut@@ Inga Prokopenko @@aut@@ Jeannette Simino @@aut@@ Tanya M Teslovich @@aut@@ Rick Jansen @@aut@@ Harm-Jan Westra @@aut@@ Charles C White @@aut@@ Devin Absher @@aut@@ Tarunveer S Ahluwalia @@aut@@ Shafqat Ahmad @@aut@@ Eva Albrecht @@aut@@ Alexessander Couto Alves @@aut@@ Jennifer L Bragg-Gresham @@aut@@ Anton J M de Craen @@aut@@ Joshua C Bis @@aut@@ Amélie Bonnefond @@aut@@ Gabrielle Boucher @@aut@@ Gemma Cadby @@aut@@ Yu-Ching Cheng @@aut@@ Charleston W K Chiang @@aut@@ Graciela Delgado @@aut@@ Ayse Demirkan @@aut@@ Nicole Dueker @@aut@@ Niina Eklund @@aut@@ Gudny Eiriksdottir @@aut@@ Joel Eriksson @@aut@@ Bjarke Feenstra @@aut@@ Krista Fischer @@aut@@ Francesca Frau @@aut@@ Tessel E Galesloot @@aut@@ Frank Geller @@aut@@ Anuj Goel @@aut@@ Mathias Gorski @@aut@@ Tanja B Grammer @@aut@@ Stefan Gustafsson @@aut@@ Saskia Haitjema @@aut@@ Jouke-Jan Hottenga @@aut@@ Jennifer E Huffman @@aut@@ Anne U Jackson @@aut@@ Kevin B Jacobs @@aut@@ Åsa Johansson @@aut@@ Marika Kaakinen @@aut@@ Marcus E Kleber @@aut@@ Jari Lahti @@aut@@ Irene Mateo Leach @@aut@@ Benjamin Lehne @@aut@@ Youfang Liu @@aut@@ Ken Sin Lo @@aut@@ Mattias Lorentzon @@aut@@ Jian'an Luan @@aut@@ Pamela A F Madden @@aut@@ Massimo Mangino @@aut@@ Barbara McKnight @@aut@@ Carolina Medina-Gomez @@aut@@ Keri L Monda @@aut@@ May E Montasser @@aut@@ Gabriele Müller @@aut@@ Martina Müller-Nurasyid @@aut@@ Ilja M Nolte @@aut@@ Kalliope Panoutsopoulou @@aut@@ Laura Pascoe @@aut@@ Lavinia Paternoster @@aut@@ Nigel W Rayner @@aut@@ Frida Renström @@aut@@ Federica Rizzi @@aut@@ Lynda M Rose @@aut@@ Kathy A Ryan @@aut@@ Perttu Salo @@aut@@ Serena Sanna @@aut@@ Hubert Scharnagl @@aut@@ Jianxin Shi @@aut@@ Albert Vernon Smith @@aut@@ Lorraine Southam @@aut@@ Alena Stančáková @@aut@@ Valgerdur Steinthorsdottir @@aut@@ Rona J Strawbridge @@aut@@ Yun Ju Sung @@aut@@ Ioanna Tachmazidou @@aut@@ Toshiko Tanaka @@aut@@ Gudmar Thorleifsson @@aut@@ Stella Trompet @@aut@@ Natalia Pervjakova @@aut@@ Jonathan P Tyrer @@aut@@ Liesbeth Vandenput @@aut@@ Sander W van der Laan @@aut@@ Nathalie van der Velde @@aut@@ Jessica van Setten @@aut@@ Jana V van Vliet-Ostaptchouk @@aut@@ Niek Verweij @@aut@@ Efthymia Vlachopoulou @@aut@@ Lindsay L Waite @@aut@@ Sophie R Wang @@aut@@ Zhaoming Wang @@aut@@ Sarah H Wild @@aut@@ Christina Willenborg @@aut@@ James F Wilson @@aut@@ Andrew Wong @@aut@@ Jian Yang @@aut@@ Loïc Yengo @@aut@@ Laura M Yerges-Armstrong @@aut@@ Lei Yu @@aut@@ Weihua Zhang @@aut@@ Jing Hua Zhao @@aut@@ Ehm A Andersson @@aut@@ Stephan J L Bakker @@aut@@ Damiano Baldassarre @@aut@@ Karina Banasik @@aut@@ Matteo Barcella @@aut@@ Cristina Barlassina @@aut@@ Claire Bellis @@aut@@ Paola Benaglio @@aut@@ John Blangero @@aut@@ Matthias Blüher @@aut@@ Fabrice Bonnet @@aut@@ Lori L Bonnycastle @@aut@@ Heather A Boyd @@aut@@ Marcel Bruinenberg @@aut@@ Aron S Buchman @@aut@@ Harry Campbell @@aut@@ Yii-Der Ida Chen @@aut@@ Peter S Chines @@aut@@ Simone Claudi-Boehm @@aut@@ John Cole @@aut@@ Francis S Collins @@aut@@ Eco J C de Geus @@aut@@ Lisette C P G M de Groot @@aut@@ Maria Dimitriou @@aut@@ Jubao Duan @@aut@@ Stefan Enroth @@aut@@ Elodie Eury @@aut@@ Aliki-Eleni Farmaki @@aut@@ Nita G Forouhi @@aut@@ Nele Friedrich @@aut@@ Pablo V Gejman @@aut@@ Bruna Gigante @@aut@@ Nicola Glorioso @@aut@@ Alan S Go @@aut@@ Omri Gottesman @@aut@@ Jürgen Gräßler @@aut@@ Harald Grallert @@aut@@ Niels Grarup @@aut@@ Yu-Mei Gu @@aut@@ Linda Broer @@aut@@ Annelies C Ham @@aut@@ Torben Hansen @@aut@@ Tamara B Harris @@aut@@ Catharina A Hartman @@aut@@ Maija Hassinen @@aut@@ Nicholas Hastie @@aut@@ Andrew T Hattersley @@aut@@ Andrew C Heath @@aut@@ Anjali K Henders @@aut@@ Dena Hernandez @@aut@@ Hans Hillege @@aut@@ Oddgeir Holmen @@aut@@ Kees G Hovingh @@aut@@ Jennie Hui @@aut@@ Lise L Husemoen @@aut@@ Nina Hutri-Kähönen @@aut@@ Pirro G Hysi @@aut@@ Thomas Illig @@aut@@ Philip L De Jager @@aut@@ Shapour Jalilzadeh @@aut@@ Torben Jørgensen @@aut@@ J Wouter Jukema @@aut@@ Markus Juonala @@aut@@ Stavroula Kanoni @@aut@@ Maria Karaleftheri @@aut@@ Kay Tee Khaw @@aut@@ Leena Kinnunen @@aut@@ Steven J Kittner @@aut@@ Wolfgang Koenig @@aut@@ Ivana Kolcic @@aut@@ Peter Kovacs @@aut@@ Nikolaj T Krarup @@aut@@ Wolfgang Kratzer @@aut@@ Janine Krüger @@aut@@ Diana Kuh @@aut@@ Meena Kumari @@aut@@ Theodosios Kyriakou @@aut@@ Claudia Langenberg @@aut@@ Lars Lannfelt @@aut@@ Chiara Lanzani @@aut@@ Vaneet Lotay @@aut@@ Lenore J Launer @@aut@@ Karin Leander @@aut@@ Jaana Lindström @@aut@@ Allan Linneberg @@aut@@ Yan-Ping Liu @@aut@@ Stéphane Lobbens @@aut@@ Robert Luben @@aut@@ Valeriya Lyssenko @@aut@@ Satu Männistö @@aut@@ Patrik K Magnusson @@aut@@ Wendy L McArdle @@aut@@ Cristina Menni @@aut@@ Sigrun Merger @@aut@@ Lili Milani @@aut@@ Grant W Montgomery @@aut@@ Andrew P Morris @@aut@@ Narisu Narisu @@aut@@ Mari Nelis @@aut@@ Ken K Ong @@aut@@ Aarno Palotie @@aut@@ Louis Pérusse @@aut@@ Irene Pichler @@aut@@ Maria G Pilia @@aut@@ Anneli Pouta @@aut@@ Myriam Rheinberger @@aut@@ Rasmus Ribel-Madsen @@aut@@ Marcus Richards @@aut@@ Kenneth M Rice @@aut@@ Treva K Rice @@aut@@ Carlo Rivolta @@aut@@ Veikko Salomaa @@aut@@ Alan R Sanders @@aut@@ Mark A Sarzynski @@aut@@ Salome Scholtens @@aut@@ Robert A Scott @@aut@@ William R Scott @@aut@@ Sylvain Sebert @@aut@@ Sebanti Sengupta @@aut@@ Bengt Sennblad @@aut@@ Thomas Seufferlein @@aut@@ Angela Silveira @@aut@@ P Eline Slagboom @@aut@@ Jan H Smit @@aut@@ Thomas H Sparsø @@aut@@ Kathleen Stirrups @@aut@@ Ronald P Stolk @@aut@@ Heather M Stringham @@aut@@ Morris A Swertz @@aut@@ Amy J Swift @@aut@@ Ann-Christine Syvänen @@aut@@ Sian-Tsung Tan @@aut@@ Barbara Thorand @@aut@@ Anke Tönjes @@aut@@ Angelo Tremblay @@aut@@ Emmanouil Tsafantakis @@aut@@ Peter J van der Most @@aut@@ Uwe Völker @@aut@@ Marie-Claude Vohl @@aut@@ Judith M Vonk @@aut@@ Melanie Waldenberger @@aut@@ Ryan W Walker @@aut@@ Roman Wennauer @@aut@@ Elisabeth Widén @@aut@@ Gonneke Willemsen @@aut@@ Tom Wilsgaard @@aut@@ Alan F Wright @@aut@@ M Carola Zillikens @@aut@@ Suzanne C van Dijk @@aut@@ Natasja M van Schoor @@aut@@ Folkert W Asselbergs @@aut@@ Paul I W de Bakker @@aut@@ Jacques S Beckmann @@aut@@ John Beilby @@aut@@ David A Bennett @@aut@@ Richard N Bergman @@aut@@ Sven Bergmann @@aut@@ Carsten A Böger @@aut@@ Bernhard O Boehm @@aut@@ Eric Boerwinkle @@aut@@ Dorret I Boomsma @@aut@@ Stefan R Bornstein @@aut@@ Erwin P Bottinger @@aut@@ Claude Bouchard @@aut@@ John C Chambers @@aut@@ Stephen J Chanock @@aut@@ Daniel I Chasman @@aut@@ Francesco Cucca @@aut@@ Daniele Cusi @@aut@@ George Dedoussis @@aut@@ Jeanette Erdmann @@aut@@ Johan G Eriksson @@aut@@ Denis A Evans @@aut@@ Ulf de Faire @@aut@@ Martin Farrall @@aut@@ Luigi Ferrucci @@aut@@ Ian Ford @@aut@@ Lude Franke @@aut@@ Paul W Franks @@aut@@ Philippe Froguel @@aut@@ Ron T Gansevoort @@aut@@ Christian Gieger @@aut@@ Henrik Grönberg @@aut@@ Vilmundur Gudnason @@aut@@ Ulf Gyllensten @@aut@@ Per Hall @@aut@@ Anders Hamsten @@aut@@ Pim van der Harst @@aut@@ Caroline Hayward @@aut@@ Markku Heliövaara @@aut@@ Christian Hengstenberg @@aut@@ Andrew A Hicks @@aut@@ Aroon Hingorani @@aut@@ Albert Hofman @@aut@@ Frank Hu @@aut@@ Heikki V Huikuri @@aut@@ Kristian Hveem @@aut@@ Alan L James @@aut@@ Joanne M Jordan @@aut@@ Antti Jula @@aut@@ Mika Kähönen @@aut@@ Eero Kajantie @@aut@@ Sekar Kathiresan @@aut@@ Lambertus A L M Kiemeney @@aut@@ Mika Kivimaki @@aut@@ Paul B Knekt @@aut@@ Heikki A Koistinen @@aut@@ Jaspal S Kooner @@aut@@ Seppo Koskinen @@aut@@ Johanna Kuusisto @@aut@@ Winfried Maerz @@aut@@ Nicholas G Martin @@aut@@ Markku Laakso @@aut@@ Timo A Lakka @@aut@@ Terho Lehtimäki @@aut@@ Guillaume Lettre @@aut@@ Douglas F Levinson @@aut@@ Lars Lind @@aut@@ Marja-Liisa Lokki @@aut@@ Pekka Mäntyselkä @@aut@@ Mads Melbye @@aut@@ Andres Metspalu @@aut@@ Braxton D Mitchell @@aut@@ Frans L Moll @@aut@@ Jeffrey C Murray @@aut@@ Arthur W Musk @@aut@@ Markku S Nieminen @@aut@@ Inger Njølstad @@aut@@ Claes Ohlsson @@aut@@ Albertine J Oldehinkel @@aut@@ Ben A Oostra @@aut@@ Lyle J Palmer @@aut@@ James S Pankow @@aut@@ Gerard Pasterkamp @@aut@@ Nancy L Pedersen @@aut@@ Oluf Pedersen @@aut@@ Brenda W Penninx @@aut@@ Markus Perola @@aut@@ Annette Peters @@aut@@ Ozren Polašek @@aut@@ Peter P Pramstaller @@aut@@ Bruce M Psaty @@aut@@ Lu Qi @@aut@@ Thomas Quertermous @@aut@@ Olli T Raitakari @@aut@@ Tuomo Rankinen @@aut@@ Rainer Rauramaa @@aut@@ Paul M Ridker @@aut@@ John D Rioux @@aut@@ Fernando Rivadeneira @@aut@@ Jerome I Rotter @@aut@@ Igor Rudan @@aut@@ Hester M den Ruijter @@aut@@ Juha Saltevo @@aut@@ Naveed Sattar @@aut@@ Heribert Schunkert @@aut@@ Peter E H Schwarz @@aut@@ Alan R Shuldiner @@aut@@ Juha Sinisalo @@aut@@ Harold Snieder @@aut@@ Thorkild I A Sørensen @@aut@@ Tim D Spector @@aut@@ Jan A Staessen @@aut@@ Bandinelli Stefania @@aut@@ Unnur Thorsteinsdottir @@aut@@ Michael Stumvoll @@aut@@ Jean-Claude Tardif @@aut@@ Elena Tremoli @@aut@@ Jaakko Tuomilehto @@aut@@ André G Uitterlinden @@aut@@ Matti Uusitupa @@aut@@ André L M Verbeek @@aut@@ Sita H Vermeulen @@aut@@ Jorma S Viikari @@aut@@ Veronique Vitart @@aut@@ Henry Völzke @@aut@@ Peter Vollenweider @@aut@@ Gérard Waeber @@aut@@ Mark Walker @@aut@@ Henri Wallaschofski @@aut@@ Nicholas J Wareham @@aut@@ Hugh Watkins @@aut@@ Eleftheria Zeggini @@aut@@ CHARGE Consortium @@aut@@ DIAGRAM Consortium @@aut@@ GLGC Consortium @@aut@@ Global-BPGen Consortium @@aut@@ ICBP Consortium @@aut@@ MAGIC Consortium @@aut@@ Aravinda Chakravarti @@aut@@ Deborah J Clegg @@aut@@ L Adrienne Cupples @@aut@@ Penny Gordon-Larsen @@aut@@ Cashell E Jaquish @@aut@@ D C Rao @@aut@@ Goncalo R Abecasis @@aut@@ Themistocles L Assimes @@aut@@ Inês Barroso @@aut@@ Sonja I Berndt @@aut@@ Michael Boehnke @@aut@@ Panos Deloukas @@aut@@ Caroline S Fox @@aut@@ Leif C Groop @@aut@@ David J Hunter @@aut@@ Erik Ingelsson @@aut@@ Robert C Kaplan @@aut@@ Mark I McCarthy @@aut@@ Karen L Mohlke @@aut@@ Jeffrey R O'Connell @@aut@@ David Schlessinger @@aut@@ David P Strachan @@aut@@ Kari Stefansson @@aut@@ Cornelia M van Duijn @@aut@@ Joel N Hirschhorn @@aut@@ Cecilia M Lindgren @@aut@@ Iris M Heid @@aut@@ Kari E North @@aut@@ Ingrid B Borecki @@aut@@ Zoltán Kutalik @@aut@@ Ruth J F Loos @@aut@@ |
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englisch |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ014082977</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310063304.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1371/journal.pgen.1005378</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ014082977</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJffdbcee3ab414e498706575063e26ecf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Thomas W Winkler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anne E Justice</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariaelisa Graff</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Llilda Barata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary F Feitosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Su 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ind2=" "><subfield code="a">Catharina A Hartman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maija Hassinen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicholas Hastie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew T Hattersley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew C Heath</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anjali K Henders</subfield><subfield code="e">verfasserin</subfield><subfield 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Männistö</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patrik K Magnusson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wendy L McArdle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristina Menni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sigrun Merger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lili Milani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing 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influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study |
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. |
| abstract |
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. |
| abstractGer |
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. |
| abstract_unstemmed |
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape. |
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. |
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Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini CHARGE Consortium DIAGRAM Consortium GLGC Consortium Global-BPGen Consortium ICBP Consortium MAGIC Consortium Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N 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Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini CHARGE Consortium DIAGRAM Consortium GLGC Consortium Global-BPGen Consortium ICBP Consortium MAGIC Consortium Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos |
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10.1371/journal.pgen.1005378 |
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2024-07-03T21:10:22.885Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ014082977</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310063304.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1371/journal.pgen.1005378</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ014082977</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJffdbcee3ab414e498706575063e26ecf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Thomas W Winkler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men <50y, women ≤50y, women <50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. 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