Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI

Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women...
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Autor*in:	Shweta Khandelwal [verfasserIn] Dimple Kondal [verfasserIn] Monica Chaudhry [verfasserIn] Kamal Patil [verfasserIn] Mallaiah Kenchaveeraiah Swamy [verfasserIn] Gangubai Pujeri [verfasserIn] Swati Babu Mane [verfasserIn] Yashaswi Kudachi [verfasserIn] Ruby Gupta [verfasserIn] Usha Ramakrishnan [verfasserIn] Aryeh D. Stein [verfasserIn] Dorairaj Prabhakaran [verfasserIn] Nikhil Tandon [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 13(2021), 3, p 730
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:3, p 730

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu13030730

Katalog-ID:	DOAJ014246120

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520			\|a Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.
650		4	\|a docosahexaenoic acid (DHA)
650		4	\|a long chain omega-3 fatty acids
650		4	\|a maternal supplementation
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650		4	\|a anthropometry
650		4	\|a birth weight
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allfields	10.3390/nu13030730 doi (DE-627)DOAJ014246120 (DE-599)DOAJe43758673ce54797983acc22b977adce DE-627 ger DE-627 rakwb eng TX341-641 Shweta Khandelwal verfasserin aut Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply Dimple Kondal verfasserin aut Monica Chaudhry verfasserin aut Kamal Patil verfasserin aut Mallaiah Kenchaveeraiah Swamy verfasserin aut Gangubai Pujeri verfasserin aut Swati Babu Mane verfasserin aut Yashaswi Kudachi verfasserin aut Ruby Gupta verfasserin aut Usha Ramakrishnan verfasserin aut Aryeh D. Stein verfasserin aut Dorairaj Prabhakaran verfasserin aut Nikhil Tandon verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 3, p 730 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:3, p 730 https://doi.org/10.3390/nu13030730 kostenfrei https://doaj.org/article/e43758673ce54797983acc22b977adce kostenfrei https://www.mdpi.com/2072-6643/13/3/730 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 730
spelling	10.3390/nu13030730 doi (DE-627)DOAJ014246120 (DE-599)DOAJe43758673ce54797983acc22b977adce DE-627 ger DE-627 rakwb eng TX341-641 Shweta Khandelwal verfasserin aut Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply Dimple Kondal verfasserin aut Monica Chaudhry verfasserin aut Kamal Patil verfasserin aut Mallaiah Kenchaveeraiah Swamy verfasserin aut Gangubai Pujeri verfasserin aut Swati Babu Mane verfasserin aut Yashaswi Kudachi verfasserin aut Ruby Gupta verfasserin aut Usha Ramakrishnan verfasserin aut Aryeh D. Stein verfasserin aut Dorairaj Prabhakaran verfasserin aut Nikhil Tandon verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 3, p 730 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:3, p 730 https://doi.org/10.3390/nu13030730 kostenfrei https://doaj.org/article/e43758673ce54797983acc22b977adce kostenfrei https://www.mdpi.com/2072-6643/13/3/730 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 730
allfields_unstemmed	10.3390/nu13030730 doi (DE-627)DOAJ014246120 (DE-599)DOAJe43758673ce54797983acc22b977adce DE-627 ger DE-627 rakwb eng TX341-641 Shweta Khandelwal verfasserin aut Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply Dimple Kondal verfasserin aut Monica Chaudhry verfasserin aut Kamal Patil verfasserin aut Mallaiah Kenchaveeraiah Swamy verfasserin aut Gangubai Pujeri verfasserin aut Swati Babu Mane verfasserin aut Yashaswi Kudachi verfasserin aut Ruby Gupta verfasserin aut Usha Ramakrishnan verfasserin aut Aryeh D. Stein verfasserin aut Dorairaj Prabhakaran verfasserin aut Nikhil Tandon verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 3, p 730 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:3, p 730 https://doi.org/10.3390/nu13030730 kostenfrei https://doaj.org/article/e43758673ce54797983acc22b977adce kostenfrei https://www.mdpi.com/2072-6643/13/3/730 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 730
allfieldsGer	10.3390/nu13030730 doi (DE-627)DOAJ014246120 (DE-599)DOAJe43758673ce54797983acc22b977adce DE-627 ger DE-627 rakwb eng TX341-641 Shweta Khandelwal verfasserin aut Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply Dimple Kondal verfasserin aut Monica Chaudhry verfasserin aut Kamal Patil verfasserin aut Mallaiah Kenchaveeraiah Swamy verfasserin aut Gangubai Pujeri verfasserin aut Swati Babu Mane verfasserin aut Yashaswi Kudachi verfasserin aut Ruby Gupta verfasserin aut Usha Ramakrishnan verfasserin aut Aryeh D. Stein verfasserin aut Dorairaj Prabhakaran verfasserin aut Nikhil Tandon verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 3, p 730 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:3, p 730 https://doi.org/10.3390/nu13030730 kostenfrei https://doaj.org/article/e43758673ce54797983acc22b977adce kostenfrei https://www.mdpi.com/2072-6643/13/3/730 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 730
allfieldsSound	10.3390/nu13030730 doi (DE-627)DOAJ014246120 (DE-599)DOAJe43758673ce54797983acc22b977adce DE-627 ger DE-627 rakwb eng TX341-641 Shweta Khandelwal verfasserin aut Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply Dimple Kondal verfasserin aut Monica Chaudhry verfasserin aut Kamal Patil verfasserin aut Mallaiah Kenchaveeraiah Swamy verfasserin aut Gangubai Pujeri verfasserin aut Swati Babu Mane verfasserin aut Yashaswi Kudachi verfasserin aut Ruby Gupta verfasserin aut Usha Ramakrishnan verfasserin aut Aryeh D. Stein verfasserin aut Dorairaj Prabhakaran verfasserin aut Nikhil Tandon verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 3, p 730 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:3, p 730 https://doi.org/10.3390/nu13030730 kostenfrei https://doaj.org/article/e43758673ce54797983acc22b977adce kostenfrei https://www.mdpi.com/2072-6643/13/3/730 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 3, p 730
language	English
source	In Nutrients 13(2021), 3, p 730 volume:13 year:2021 number:3, p 730
sourceStr	In Nutrients 13(2021), 3, p 730 volume:13 year:2021 number:3, p 730
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Nutrients
authorswithroles_txt_mv	Shweta Khandelwal @@aut@@ Dimple Kondal @@aut@@ Monica Chaudhry @@aut@@ Kamal Patil @@aut@@ Mallaiah Kenchaveeraiah Swamy @@aut@@ Gangubai Pujeri @@aut@@ Swati Babu Mane @@aut@@ Yashaswi Kudachi @@aut@@ Ruby Gupta @@aut@@ Usha Ramakrishnan @@aut@@ Aryeh D. Stein @@aut@@ Dorairaj Prabhakaran @@aut@@ Nikhil Tandon @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	610604155
id	DOAJ014246120
language_de	englisch
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callnumber-first	T - Technology
author	Shweta Khandelwal
spellingShingle	Shweta Khandelwal misc TX341-641 misc docosahexaenoic acid (DHA) misc long chain omega-3 fatty acids misc maternal supplementation misc pregnancy outcomes misc anthropometry misc birth weight misc Nutrition. Foods and food supply Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
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topic_title	TX341-641 Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI docosahexaenoic acid (DHA) long chain omega-3 fatty acids maternal supplementation pregnancy outcomes anthropometry birth weight
topic	misc TX341-641 misc docosahexaenoic acid (DHA) misc long chain omega-3 fatty acids misc maternal supplementation misc pregnancy outcomes misc anthropometry misc birth weight misc Nutrition. Foods and food supply
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title	Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
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title_full	Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
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author_browse	Shweta Khandelwal Dimple Kondal Monica Chaudhry Kamal Patil Mallaiah Kenchaveeraiah Swamy Gangubai Pujeri Swati Babu Mane Yashaswi Kudachi Ruby Gupta Usha Ramakrishnan Aryeh D. Stein Dorairaj Prabhakaran Nikhil Tandon
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title_sort	prenatal maternal docosahexaenoic acid (dha) supplementation and newborn anthropometry in india: findings from dhani
callnumber	TX341-641
title_auth	Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
abstract	Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.
abstractGer	Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.
abstract_unstemmed	Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; <i<n</i< = 478 and placebo; <i<n</i< = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, <i<p</i< = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, <i<p</i< = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, <i<p</i< = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, <i<p</i< = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.
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title_short	Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
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Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI

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