Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism

Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the thera...
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Autor*in:	Paula Kielbik [verfasserIn] Jarosław Kaszewski [verfasserIn] Bartłomiej Dominiak [verfasserIn] Magdalena Damentko [verfasserIn] Izabela Serafińska [verfasserIn] Julita Rosowska [verfasserIn] Mikołaj A. Gralak [verfasserIn] Marcin Krajewski [verfasserIn] Bartłomiej S. Witkowski [verfasserIn] Zdzislaw Gajewski [verfasserIn] Marek Godlewski [verfasserIn] Michal M. Godlewski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping

Übergeordnetes Werk:	In: Nanoscale Research Letters - SpringerOpen, 2007, 14(2019), 1, Seite 13
Übergeordnetes Werk:	volume:14 ; year:2019 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1186/s11671-019-3217-2

Katalog-ID:	DOAJ014301040

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520			\|a Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required.
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allfields	10.1186/s11671-019-3217-2 doi (DE-627)DOAJ014301040 (DE-599)DOAJa5c784d2c41a47039850a281bed3b957 DE-627 ger DE-627 rakwb eng TA401-492 Paula Kielbik verfasserin aut Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials Jarosław Kaszewski verfasserin aut Bartłomiej Dominiak verfasserin aut Magdalena Damentko verfasserin aut Izabela Serafińska verfasserin aut Julita Rosowska verfasserin aut Mikołaj A. Gralak verfasserin aut Marcin Krajewski verfasserin aut Bartłomiej S. Witkowski verfasserin aut Zdzislaw Gajewski verfasserin aut Marek Godlewski verfasserin aut Michal M. Godlewski verfasserin aut In Nanoscale Research Letters SpringerOpen, 2007 14(2019), 1, Seite 13 (DE-627)518632474 (DE-600)2253244-4 1556276X nnns volume:14 year:2019 number:1 pages:13 https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 kostenfrei https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/toc/1931-7573 Journal toc kostenfrei https://doaj.org/toc/1556-276X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 13
spelling	10.1186/s11671-019-3217-2 doi (DE-627)DOAJ014301040 (DE-599)DOAJa5c784d2c41a47039850a281bed3b957 DE-627 ger DE-627 rakwb eng TA401-492 Paula Kielbik verfasserin aut Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials Jarosław Kaszewski verfasserin aut Bartłomiej Dominiak verfasserin aut Magdalena Damentko verfasserin aut Izabela Serafińska verfasserin aut Julita Rosowska verfasserin aut Mikołaj A. Gralak verfasserin aut Marcin Krajewski verfasserin aut Bartłomiej S. Witkowski verfasserin aut Zdzislaw Gajewski verfasserin aut Marek Godlewski verfasserin aut Michal M. Godlewski verfasserin aut In Nanoscale Research Letters SpringerOpen, 2007 14(2019), 1, Seite 13 (DE-627)518632474 (DE-600)2253244-4 1556276X nnns volume:14 year:2019 number:1 pages:13 https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 kostenfrei https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/toc/1931-7573 Journal toc kostenfrei https://doaj.org/toc/1556-276X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 13
allfields_unstemmed	10.1186/s11671-019-3217-2 doi (DE-627)DOAJ014301040 (DE-599)DOAJa5c784d2c41a47039850a281bed3b957 DE-627 ger DE-627 rakwb eng TA401-492 Paula Kielbik verfasserin aut Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials Jarosław Kaszewski verfasserin aut Bartłomiej Dominiak verfasserin aut Magdalena Damentko verfasserin aut Izabela Serafińska verfasserin aut Julita Rosowska verfasserin aut Mikołaj A. Gralak verfasserin aut Marcin Krajewski verfasserin aut Bartłomiej S. Witkowski verfasserin aut Zdzislaw Gajewski verfasserin aut Marek Godlewski verfasserin aut Michal M. Godlewski verfasserin aut In Nanoscale Research Letters SpringerOpen, 2007 14(2019), 1, Seite 13 (DE-627)518632474 (DE-600)2253244-4 1556276X nnns volume:14 year:2019 number:1 pages:13 https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 kostenfrei https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/toc/1931-7573 Journal toc kostenfrei https://doaj.org/toc/1556-276X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 13
allfieldsGer	10.1186/s11671-019-3217-2 doi (DE-627)DOAJ014301040 (DE-599)DOAJa5c784d2c41a47039850a281bed3b957 DE-627 ger DE-627 rakwb eng TA401-492 Paula Kielbik verfasserin aut Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials Jarosław Kaszewski verfasserin aut Bartłomiej Dominiak verfasserin aut Magdalena Damentko verfasserin aut Izabela Serafińska verfasserin aut Julita Rosowska verfasserin aut Mikołaj A. Gralak verfasserin aut Marcin Krajewski verfasserin aut Bartłomiej S. Witkowski verfasserin aut Zdzislaw Gajewski verfasserin aut Marek Godlewski verfasserin aut Michal M. Godlewski verfasserin aut In Nanoscale Research Letters SpringerOpen, 2007 14(2019), 1, Seite 13 (DE-627)518632474 (DE-600)2253244-4 1556276X nnns volume:14 year:2019 number:1 pages:13 https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 kostenfrei https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/toc/1931-7573 Journal toc kostenfrei https://doaj.org/toc/1556-276X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 13
allfieldsSound	10.1186/s11671-019-3217-2 doi (DE-627)DOAJ014301040 (DE-599)DOAJa5c784d2c41a47039850a281bed3b957 DE-627 ger DE-627 rakwb eng TA401-492 Paula Kielbik verfasserin aut Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials Jarosław Kaszewski verfasserin aut Bartłomiej Dominiak verfasserin aut Magdalena Damentko verfasserin aut Izabela Serafińska verfasserin aut Julita Rosowska verfasserin aut Mikołaj A. Gralak verfasserin aut Marcin Krajewski verfasserin aut Bartłomiej S. Witkowski verfasserin aut Zdzislaw Gajewski verfasserin aut Marek Godlewski verfasserin aut Michal M. Godlewski verfasserin aut In Nanoscale Research Letters SpringerOpen, 2007 14(2019), 1, Seite 13 (DE-627)518632474 (DE-600)2253244-4 1556276X nnns volume:14 year:2019 number:1 pages:13 https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 kostenfrei https://doi.org/10.1186/s11671-019-3217-2 kostenfrei https://doaj.org/toc/1931-7573 Journal toc kostenfrei https://doaj.org/toc/1556-276X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 13
language	English
source	In Nanoscale Research Letters 14(2019), 1, Seite 13 volume:14 year:2019 number:1 pages:13
sourceStr	In Nanoscale Research Letters 14(2019), 1, Seite 13 volume:14 year:2019 number:1 pages:13
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping Materials of engineering and construction. Mechanics of materials
isfreeaccess_bool	true
container_title	Nanoscale Research Letters
authorswithroles_txt_mv	Paula Kielbik @@aut@@ Jarosław Kaszewski @@aut@@ Bartłomiej Dominiak @@aut@@ Magdalena Damentko @@aut@@ Izabela Serafińska @@aut@@ Julita Rosowska @@aut@@ Mikołaj A. Gralak @@aut@@ Marcin Krajewski @@aut@@ Bartłomiej S. Witkowski @@aut@@ Zdzislaw Gajewski @@aut@@ Marek Godlewski @@aut@@ Michal M. Godlewski @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	518632474
id	DOAJ014301040
language_de	englisch
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callnumber-first	T - Technology
author	Paula Kielbik
spellingShingle	Paula Kielbik misc TA401-492 misc ZnO:Fe misc Nanoparticles misc Iron deficiency misc Iron delivery misc Iron doping misc Materials of engineering and construction. Mechanics of materials Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
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topic_title	TA401-492 Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism ZnO:Fe Nanoparticles Iron deficiency Iron delivery Iron doping
topic	misc TA401-492 misc ZnO:Fe misc Nanoparticles misc Iron deficiency misc Iron delivery misc Iron doping misc Materials of engineering and construction. Mechanics of materials
topic_unstemmed	misc TA401-492 misc ZnO:Fe misc Nanoparticles misc Iron deficiency misc Iron delivery misc Iron doping misc Materials of engineering and construction. Mechanics of materials
topic_browse	misc TA401-492 misc ZnO:Fe misc Nanoparticles misc Iron deficiency misc Iron delivery misc Iron doping misc Materials of engineering and construction. Mechanics of materials
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title	Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
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title_full	Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
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author_browse	Paula Kielbik Jarosław Kaszewski Bartłomiej Dominiak Magdalena Damentko Izabela Serafińska Julita Rosowska Mikołaj A. Gralak Marcin Krajewski Bartłomiej S. Witkowski Zdzislaw Gajewski Marek Godlewski Michal M. Godlewski
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title_sort	preliminary studies on biodegradable zinc oxide nanoparticles doped with fe as a potential form of iron delivery to the living organism
callnumber	TA401-492
title_auth	Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
abstract	Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required.
abstractGer	Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required.
abstract_unstemmed	Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required.
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title_short	Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
url	https://doi.org/10.1186/s11671-019-3217-2 https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 https://doaj.org/toc/1931-7573 https://doaj.org/toc/1556-276X
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Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism

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