Intercellular Communication between Hepatic Cells in Liver Diseases
Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contai...
Ausführliche Beschreibung
Autor*in: |
Keisaku Sato [verfasserIn] Lindsey Kennedy [verfasserIn] Suthat Liangpunsakul [verfasserIn] Praveen Kusumanchi [verfasserIn] Zhihong Yang [verfasserIn] Fanyin Meng [verfasserIn] Shannon Glaser [verfasserIn] Heather Francis [verfasserIn] Gianfranco Alpini [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 9, p 2180 |
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Übergeordnetes Werk: |
volume:20 ; year:2019 ; number:9, p 2180 |
Links: |
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DOI / URN: |
10.3390/ijms20092180 |
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Katalog-ID: |
DOAJ014355736 |
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10.3390/ijms20092180 doi (DE-627)DOAJ014355736 (DE-599)DOAJ792b64b236cc4a21bb306e677f7d8a81 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Keisaku Sato verfasserin aut Intercellular Communication between Hepatic Cells in Liver Diseases 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target. liver fibrosis extracellular vesicles hepatocytes macrophages Biology (General) Chemistry Lindsey Kennedy verfasserin aut Suthat Liangpunsakul verfasserin aut Praveen Kusumanchi verfasserin aut Zhihong Yang verfasserin aut Fanyin Meng verfasserin aut Shannon Glaser verfasserin aut Heather Francis verfasserin aut Gianfranco Alpini verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 9, p 2180 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:9, p 2180 https://doi.org/10.3390/ijms20092180 kostenfrei https://doaj.org/article/792b64b236cc4a21bb306e677f7d8a81 kostenfrei https://www.mdpi.com/1422-0067/20/9/2180 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 9, p 2180 |
allfieldsSound |
10.3390/ijms20092180 doi (DE-627)DOAJ014355736 (DE-599)DOAJ792b64b236cc4a21bb306e677f7d8a81 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Keisaku Sato verfasserin aut Intercellular Communication between Hepatic Cells in Liver Diseases 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target. liver fibrosis extracellular vesicles hepatocytes macrophages Biology (General) Chemistry Lindsey Kennedy verfasserin aut Suthat Liangpunsakul verfasserin aut Praveen Kusumanchi verfasserin aut Zhihong Yang verfasserin aut Fanyin Meng verfasserin aut Shannon Glaser verfasserin aut Heather Francis verfasserin aut Gianfranco Alpini verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 9, p 2180 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:9, p 2180 https://doi.org/10.3390/ijms20092180 kostenfrei https://doaj.org/article/792b64b236cc4a21bb306e677f7d8a81 kostenfrei https://www.mdpi.com/1422-0067/20/9/2180 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 9, p 2180 |
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Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target. |
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Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target. |
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Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target. |
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