Longitudinal characteristics of cytokine profiles in the peripheral blood of COVID-19 and bacterial pneumonia patients
Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from...
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| Autor*in: |
Luo Siwei, Yao Yachao, Zhong Limei, Hu Liangshan, Xiao Wei, Fang Xiaolin, Cao Donglin [verfasserIn] |
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E-Artikel |
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| Sprache: |
Chinesisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Xin yixue - Editorial Office of Journal of New Medicine, 2022, 53(2022), 5, Seite 372-378 |
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| Übergeordnetes Werk: |
volume:53 ; year:2022 ; number:5 ; pages:372-378 |
| Links: |
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| DOI / URN: |
10.3969/j.issn.0253-9802.2022.05.014 |
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DOAJ014362422 |
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| 520 | |a Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from mild COVID-19 patients （COVID-19 group）, bacterial pneumonia patients （bacterial pneumonia group）, and healthy controls （healthy control group）, respectively. The expression profile of 48 cytokines was determined to clarify the differences among three groups. The expression levels of 48 cytokines at different time points were measured in serum samples from 10 patients with COVID-19 to analyze their correlation with clinical features and disease progression. Results In the comparation between the COVID-19 group and the bacterial pneumonia group, the expression levels of MIF, GROα, GM-CSF and TNF-β were upregulated in COVID-19 patients（all P < 0.05）, whereas those of IL-10, IL-18, IL-2Rα and MIG were upregulated in patients with bacterial pneumonia（all P < 0.05）. The expression level of M-CSF was significantly downregulated in COVID-19 patients at the second week of hospitalization. The changes in the expression level of MCP-1 were consistent with the nucleic acid test results of COVID-19 patients. Conclusions The cytokine profiles differ between patients with COVID-19 and bacterial pneumonia. In addition, M-CSF and MCP-1 play critical roles in the progression of COVID-19. | ||
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10.3969/j.issn.0253-9802.2022.05.014 doi (DE-627)DOAJ014362422 (DE-599)DOAJ68a6bc8b1a124601865106e1046c1bf6 DE-627 ger DE-627 rakwb chi Luo Siwei, Yao Yachao, Zhong Limei, Hu Liangshan, Xiao Wei, Fang Xiaolin, Cao Donglin verfasserin aut Longitudinal characteristics of cytokine profiles in the peripheral blood of COVID-19 and bacterial pneumonia patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from mild COVID-19 patients （COVID-19 group）, bacterial pneumonia patients （bacterial pneumonia group）, and healthy controls （healthy control group）, respectively. The expression profile of 48 cytokines was determined to clarify the differences among three groups. The expression levels of 48 cytokines at different time points were measured in serum samples from 10 patients with COVID-19 to analyze their correlation with clinical features and disease progression. Results In the comparation between the COVID-19 group and the bacterial pneumonia group, the expression levels of MIF, GROα, GM-CSF and TNF-β were upregulated in COVID-19 patients（all P < 0.05）, whereas those of IL-10, IL-18, IL-2Rα and MIG were upregulated in patients with bacterial pneumonia（all P < 0.05）. The expression level of M-CSF was significantly downregulated in COVID-19 patients at the second week of hospitalization. The changes in the expression level of MCP-1 were consistent with the nucleic acid test results of COVID-19 patients. Conclusions The cytokine profiles differ between patients with COVID-19 and bacterial pneumonia. In addition, M-CSF and MCP-1 play critical roles in the progression of COVID-19. |covid-19|bacterial pneumonia|cytokine|profile Medicine R In Xin yixue Editorial Office of Journal of New Medicine, 2022 53(2022), 5, Seite 372-378 (DE-627)DOAJ000152676 02539802 nnns volume:53 year:2022 number:5 pages:372-378 https://doi.org/10.3969/j.issn.0253-9802.2022.05.014 kostenfrei https://doaj.org/article/68a6bc8b1a124601865106e1046c1bf6 kostenfrei https://www.xinyixue.cn/fileup/0253-9802/PDF/1655097958974-1078989333.pdf kostenfrei https://doaj.org/toc/0253-9802 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 53 2022 5 372-378 |
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Luo Siwei, Yao Yachao, Zhong Limei, Hu Liangshan, Xiao Wei, Fang Xiaolin, Cao Donglin |
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10.3969/j.issn.0253-9802.2022.05.014 |
| title_sort |
longitudinal characteristics of cytokine profiles in the peripheral blood of covid-19 and bacterial pneumonia patients |
| title_auth |
Longitudinal characteristics of cytokine profiles in the peripheral blood of COVID-19 and bacterial pneumonia patients |
| abstract |
Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from mild COVID-19 patients （COVID-19 group）, bacterial pneumonia patients （bacterial pneumonia group）, and healthy controls （healthy control group）, respectively. The expression profile of 48 cytokines was determined to clarify the differences among three groups. The expression levels of 48 cytokines at different time points were measured in serum samples from 10 patients with COVID-19 to analyze their correlation with clinical features and disease progression. Results In the comparation between the COVID-19 group and the bacterial pneumonia group, the expression levels of MIF, GROα, GM-CSF and TNF-β were upregulated in COVID-19 patients（all P < 0.05）, whereas those of IL-10, IL-18, IL-2Rα and MIG were upregulated in patients with bacterial pneumonia（all P < 0.05）. The expression level of M-CSF was significantly downregulated in COVID-19 patients at the second week of hospitalization. The changes in the expression level of MCP-1 were consistent with the nucleic acid test results of COVID-19 patients. Conclusions The cytokine profiles differ between patients with COVID-19 and bacterial pneumonia. In addition, M-CSF and MCP-1 play critical roles in the progression of COVID-19. |
| abstractGer |
Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from mild COVID-19 patients （COVID-19 group）, bacterial pneumonia patients （bacterial pneumonia group）, and healthy controls （healthy control group）, respectively. The expression profile of 48 cytokines was determined to clarify the differences among three groups. The expression levels of 48 cytokines at different time points were measured in serum samples from 10 patients with COVID-19 to analyze their correlation with clinical features and disease progression. Results In the comparation between the COVID-19 group and the bacterial pneumonia group, the expression levels of MIF, GROα, GM-CSF and TNF-β were upregulated in COVID-19 patients（all P < 0.05）, whereas those of IL-10, IL-18, IL-2Rα and MIG were upregulated in patients with bacterial pneumonia（all P < 0.05）. The expression level of M-CSF was significantly downregulated in COVID-19 patients at the second week of hospitalization. The changes in the expression level of MCP-1 were consistent with the nucleic acid test results of COVID-19 patients. Conclusions The cytokine profiles differ between patients with COVID-19 and bacterial pneumonia. In addition, M-CSF and MCP-1 play critical roles in the progression of COVID-19. |
| abstract_unstemmed |
Objective To investigate the differences of cytokine profiles between patients with novel COVID-19 and bacterial pneumonia, unravel the immunopathological mechanism of COVID-19, and provide evidence for new therapeutic targets in COVID-19. Methods In this study, 15 serum samples were collected from mild COVID-19 patients （COVID-19 group）, bacterial pneumonia patients （bacterial pneumonia group）, and healthy controls （healthy control group）, respectively. The expression profile of 48 cytokines was determined to clarify the differences among three groups. The expression levels of 48 cytokines at different time points were measured in serum samples from 10 patients with COVID-19 to analyze their correlation with clinical features and disease progression. Results In the comparation between the COVID-19 group and the bacterial pneumonia group, the expression levels of MIF, GROα, GM-CSF and TNF-β were upregulated in COVID-19 patients（all P < 0.05）, whereas those of IL-10, IL-18, IL-2Rα and MIG were upregulated in patients with bacterial pneumonia（all P < 0.05）. The expression level of M-CSF was significantly downregulated in COVID-19 patients at the second week of hospitalization. The changes in the expression level of MCP-1 were consistent with the nucleic acid test results of COVID-19 patients. Conclusions The cytokine profiles differ between patients with COVID-19 and bacterial pneumonia. In addition, M-CSF and MCP-1 play critical roles in the progression of COVID-19. |
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Longitudinal characteristics of cytokine profiles in the peripheral blood of COVID-19 and bacterial pneumonia patients |
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https://doi.org/10.3969/j.issn.0253-9802.2022.05.014 https://doaj.org/article/68a6bc8b1a124601865106e1046c1bf6 https://www.xinyixue.cn/fileup/0253-9802/PDF/1655097958974-1078989333.pdf https://doaj.org/toc/0253-9802 |
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2024-07-03T22:39:03.750Z |
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