Immunopharmacological aspects of the cytokine system
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biolog...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
A. S. Simbirtsev [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; Russisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: Бюллетень сибирской медицины - Siberian State Medical University (Tomsk), 2016, 18(2019), 1, Seite 84-95 |
|---|---|
| Übergeordnetes Werk: |
volume:18 ; year:2019 ; number:1 ; pages:84-95 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.20538/1682-0363-2019-1-84-95 |
|---|
| Katalog-ID: |
DOAJ014393859 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ014393859 | ||
| 003 | DE-627 | ||
| 005 | 20230410115635.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230226s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.20538/1682-0363-2019-1-84-95 |2 doi | |
| 035 | |a (DE-627)DOAJ014393859 | ||
| 035 | |a (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a rus | ||
| 100 | 0 | |a A. S. Simbirtsev |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Immunopharmacological aspects of the cytokine system |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. | ||
| 650 | 4 | |a цитокины | |
| 650 | 4 | |a цитокиновая регуляция | |
| 650 | 4 | |a цитокиновая терапия | |
| 650 | 4 | |a иммунофармакология | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 773 | 0 | 8 | |i In |t Бюллетень сибирской медицины |d Siberian State Medical University (Tomsk), 2016 |g 18(2019), 1, Seite 84-95 |w (DE-627)1760628204 |x 18193684 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2019 |g number:1 |g pages:84-95 |
| 856 | 4 | 0 | |u https://doi.org/10.20538/1682-0363-2019-1-84-95 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 |z kostenfrei |
| 856 | 4 | 0 | |u https://bulletin.ssmu.ru/jour/article/view/2173 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1682-0363 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1819-3684 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2019 |e 1 |h 84-95 | ||
| author_variant |
a s s ass |
|---|---|
| matchkey_str |
article:18193684:2019----::muohraooiaapcsfh |
| hierarchy_sort_str |
2019 |
| publishDate |
2019 |
| allfields |
10.20538/1682-0363-2019-1-84-95 doi (DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 DE-627 ger DE-627 rakwb eng rus A. S. Simbirtsev verfasserin aut Immunopharmacological aspects of the cytokine system 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 18(2019), 1, Seite 84-95 (DE-627)1760628204 18193684 nnns volume:18 year:2019 number:1 pages:84-95 https://doi.org/10.20538/1682-0363-2019-1-84-95 kostenfrei https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 kostenfrei https://bulletin.ssmu.ru/jour/article/view/2173 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 84-95 |
| spelling |
10.20538/1682-0363-2019-1-84-95 doi (DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 DE-627 ger DE-627 rakwb eng rus A. S. Simbirtsev verfasserin aut Immunopharmacological aspects of the cytokine system 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 18(2019), 1, Seite 84-95 (DE-627)1760628204 18193684 nnns volume:18 year:2019 number:1 pages:84-95 https://doi.org/10.20538/1682-0363-2019-1-84-95 kostenfrei https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 kostenfrei https://bulletin.ssmu.ru/jour/article/view/2173 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 84-95 |
| allfields_unstemmed |
10.20538/1682-0363-2019-1-84-95 doi (DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 DE-627 ger DE-627 rakwb eng rus A. S. Simbirtsev verfasserin aut Immunopharmacological aspects of the cytokine system 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 18(2019), 1, Seite 84-95 (DE-627)1760628204 18193684 nnns volume:18 year:2019 number:1 pages:84-95 https://doi.org/10.20538/1682-0363-2019-1-84-95 kostenfrei https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 kostenfrei https://bulletin.ssmu.ru/jour/article/view/2173 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 84-95 |
| allfieldsGer |
10.20538/1682-0363-2019-1-84-95 doi (DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 DE-627 ger DE-627 rakwb eng rus A. S. Simbirtsev verfasserin aut Immunopharmacological aspects of the cytokine system 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 18(2019), 1, Seite 84-95 (DE-627)1760628204 18193684 nnns volume:18 year:2019 number:1 pages:84-95 https://doi.org/10.20538/1682-0363-2019-1-84-95 kostenfrei https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 kostenfrei https://bulletin.ssmu.ru/jour/article/view/2173 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 84-95 |
| allfieldsSound |
10.20538/1682-0363-2019-1-84-95 doi (DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 DE-627 ger DE-627 rakwb eng rus A. S. Simbirtsev verfasserin aut Immunopharmacological aspects of the cytokine system 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 18(2019), 1, Seite 84-95 (DE-627)1760628204 18193684 nnns volume:18 year:2019 number:1 pages:84-95 https://doi.org/10.20538/1682-0363-2019-1-84-95 kostenfrei https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 kostenfrei https://bulletin.ssmu.ru/jour/article/view/2173 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 84-95 |
| language |
English Russian |
| source |
In Бюллетень сибирской медицины 18(2019), 1, Seite 84-95 volume:18 year:2019 number:1 pages:84-95 |
| sourceStr |
In Бюллетень сибирской медицины 18(2019), 1, Seite 84-95 volume:18 year:2019 number:1 pages:84-95 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология Medicine R |
| isfreeaccess_bool |
true |
| container_title |
Бюллетень сибирской медицины |
| authorswithroles_txt_mv |
A. S. Simbirtsev @@aut@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
| hierarchy_top_id |
1760628204 |
| id |
DOAJ014393859 |
| language_de |
englisch russisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ014393859</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230410115635.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.20538/1682-0363-2019-1-84-95</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ014393859</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">rus</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">A. S. Simbirtsev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Immunopharmacological aspects of the cytokine system</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокины</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокиновая регуляция</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокиновая терапия</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">иммунофармакология</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Бюллетень сибирской медицины</subfield><subfield code="d">Siberian State Medical University (Tomsk), 2016</subfield><subfield code="g">18(2019), 1, Seite 84-95</subfield><subfield code="w">(DE-627)1760628204</subfield><subfield code="x">18193684</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:84-95</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.20538/1682-0363-2019-1-84-95</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://bulletin.ssmu.ru/jour/article/view/2173</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1682-0363</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1819-3684</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="h">84-95</subfield></datafield></record></collection>
|
| author |
A. S. Simbirtsev |
| spellingShingle |
A. S. Simbirtsev misc цитокины misc цитокиновая регуляция misc цитокиновая терапия misc иммунофармакология misc Medicine misc R Immunopharmacological aspects of the cytokine system |
| authorStr |
A. S. Simbirtsev |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)1760628204 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
DOAJ |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
18193684 |
| topic_title |
Immunopharmacological aspects of the cytokine system цитокины цитокиновая регуляция цитокиновая терапия иммунофармакология |
| topic |
misc цитокины misc цитокиновая регуляция misc цитокиновая терапия misc иммунофармакология misc Medicine misc R |
| topic_unstemmed |
misc цитокины misc цитокиновая регуляция misc цитокиновая терапия misc иммунофармакология misc Medicine misc R |
| topic_browse |
misc цитокины misc цитокиновая регуляция misc цитокиновая терапия misc иммунофармакология misc Medicine misc R |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Бюллетень сибирской медицины |
| hierarchy_parent_id |
1760628204 |
| hierarchy_top_title |
Бюллетень сибирской медицины |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)1760628204 |
| title |
Immunopharmacological aspects of the cytokine system |
| ctrlnum |
(DE-627)DOAJ014393859 (DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530 |
| title_full |
Immunopharmacological aspects of the cytokine system |
| author_sort |
A. S. Simbirtsev |
| journal |
Бюллетень сибирской медицины |
| journalStr |
Бюллетень сибирской медицины |
| lang_code |
eng rus |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| container_start_page |
84 |
| author_browse |
A. S. Simbirtsev |
| container_volume |
18 |
| format_se |
Elektronische Aufsätze |
| author-letter |
A. S. Simbirtsev |
| doi_str_mv |
10.20538/1682-0363-2019-1-84-95 |
| title_sort |
immunopharmacological aspects of the cytokine system |
| title_auth |
Immunopharmacological aspects of the cytokine system |
| abstract |
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. |
| abstractGer |
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. |
| abstract_unstemmed |
Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ |
| container_issue |
1 |
| title_short |
Immunopharmacological aspects of the cytokine system |
| url |
https://doi.org/10.20538/1682-0363-2019-1-84-95 https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530 https://bulletin.ssmu.ru/jour/article/view/2173 https://doaj.org/toc/1682-0363 https://doaj.org/toc/1819-3684 |
| remote_bool |
true |
| ppnlink |
1760628204 |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.20538/1682-0363-2019-1-84-95 |
| up_date |
2024-07-03T22:48:40.583Z |
| _version_ |
1803599919803531264 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ014393859</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230410115635.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.20538/1682-0363-2019-1-84-95</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ014393859</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5ba50cdd5a65436e936818c233bc7530</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">rus</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">A. S. Simbirtsev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Immunopharmacological aspects of the cytokine system</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Cytokines represent a unique family of endogenous polypeptide mediators of intercellular interaction. From an immunopharmacological point of view cytokines can be marked out as a new, separate immunoregulatory molecule system and have some common biochemical properties and pleiotropic type of biological activity. In the cytokine regulatory system both reduction and elevation of cytokine levels can cause pathology. Several endogenous systems exist to control cytokine elevation and prevent tissue pathology. When synthesized simultaneously, cytokines form a cytokine chain. Deletion of any unit of this chain leads to the break in the formation of immunopathology. Cytokines as therapeutic preparations have evident advantages but also some limitations such as pharmacokinetics with short circulation period, adverse effects due to pleiotropic mode of action, and injectable drug forms. Rational design for clinical cytokine application could be linked with the development of prolonged and local drug forms or personalized cytokine therapy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокины</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокиновая регуляция</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">цитокиновая терапия</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">иммунофармакология</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Бюллетень сибирской медицины</subfield><subfield code="d">Siberian State Medical University (Tomsk), 2016</subfield><subfield code="g">18(2019), 1, Seite 84-95</subfield><subfield code="w">(DE-627)1760628204</subfield><subfield code="x">18193684</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:84-95</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.20538/1682-0363-2019-1-84-95</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5ba50cdd5a65436e936818c233bc7530</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://bulletin.ssmu.ru/jour/article/view/2173</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1682-0363</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1819-3684</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="h">84-95</subfield></datafield></record></collection>
|
| score |
7.3985004 |