Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis

Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect o...
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Autor*in:	Louise Lönndahl [verfasserIn] Mikael Holst [verfasserIn] Maria Bradley [verfasserIn] Hassan Killasli [verfasserIn] Johan Heilborn [verfasserIn] Martin A. Hall [verfasserIn] Elvar Theodorsson [verfasserIn] Jadwiga Holmberg [verfasserIn] Klas Nordlind [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP

Übergeordnetes Werk:	In: Acta Dermato-Venereologica - Medical Journals Sweden, 2011, 98(2017), 3, Seite 324-328
Übergeordnetes Werk:	volume:98 ; year:2017 ; number:3 ; pages:324-328

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2340/00015555-2852

Katalog-ID:	DOAJ01451754X

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520			\|a Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group.
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publishDate	2017
allfields	10.2340/00015555-2852 doi (DE-627)DOAJ01451754X (DE-599)DOAJ46fb949dc53349c6a7e46b390e4b644a DE-627 ger DE-627 rakwb eng RL1-803 Louise Lönndahl verfasserin aut Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group. anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology Mikael Holst verfasserin aut Maria Bradley verfasserin aut Hassan Killasli verfasserin aut Johan Heilborn verfasserin aut Martin A. Hall verfasserin aut Elvar Theodorsson verfasserin aut Jadwiga Holmberg verfasserin aut Klas Nordlind verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2017), 3, Seite 324-328 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2017 number:3 pages:324-328 https://doi.org/10.2340/00015555-2852 kostenfrei https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2017 3 324-328
spelling	10.2340/00015555-2852 doi (DE-627)DOAJ01451754X (DE-599)DOAJ46fb949dc53349c6a7e46b390e4b644a DE-627 ger DE-627 rakwb eng RL1-803 Louise Lönndahl verfasserin aut Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group. anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology Mikael Holst verfasserin aut Maria Bradley verfasserin aut Hassan Killasli verfasserin aut Johan Heilborn verfasserin aut Martin A. Hall verfasserin aut Elvar Theodorsson verfasserin aut Jadwiga Holmberg verfasserin aut Klas Nordlind verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2017), 3, Seite 324-328 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2017 number:3 pages:324-328 https://doi.org/10.2340/00015555-2852 kostenfrei https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2017 3 324-328
allfields_unstemmed	10.2340/00015555-2852 doi (DE-627)DOAJ01451754X (DE-599)DOAJ46fb949dc53349c6a7e46b390e4b644a DE-627 ger DE-627 rakwb eng RL1-803 Louise Lönndahl verfasserin aut Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group. anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology Mikael Holst verfasserin aut Maria Bradley verfasserin aut Hassan Killasli verfasserin aut Johan Heilborn verfasserin aut Martin A. Hall verfasserin aut Elvar Theodorsson verfasserin aut Jadwiga Holmberg verfasserin aut Klas Nordlind verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2017), 3, Seite 324-328 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2017 number:3 pages:324-328 https://doi.org/10.2340/00015555-2852 kostenfrei https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2017 3 324-328
allfieldsGer	10.2340/00015555-2852 doi (DE-627)DOAJ01451754X (DE-599)DOAJ46fb949dc53349c6a7e46b390e4b644a DE-627 ger DE-627 rakwb eng RL1-803 Louise Lönndahl verfasserin aut Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group. anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology Mikael Holst verfasserin aut Maria Bradley verfasserin aut Hassan Killasli verfasserin aut Johan Heilborn verfasserin aut Martin A. Hall verfasserin aut Elvar Theodorsson verfasserin aut Jadwiga Holmberg verfasserin aut Klas Nordlind verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2017), 3, Seite 324-328 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2017 number:3 pages:324-328 https://doi.org/10.2340/00015555-2852 kostenfrei https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2017 3 324-328
allfieldsSound	10.2340/00015555-2852 doi (DE-627)DOAJ01451754X (DE-599)DOAJ46fb949dc53349c6a7e46b390e4b644a DE-627 ger DE-627 rakwb eng RL1-803 Louise Lönndahl verfasserin aut Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group. anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology Mikael Holst verfasserin aut Maria Bradley verfasserin aut Hassan Killasli verfasserin aut Johan Heilborn verfasserin aut Martin A. Hall verfasserin aut Elvar Theodorsson verfasserin aut Jadwiga Holmberg verfasserin aut Klas Nordlind verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2017), 3, Seite 324-328 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2017 number:3 pages:324-328 https://doi.org/10.2340/00015555-2852 kostenfrei https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2017 3 324-328
language	English
source	In Acta Dermato-Venereologica 98(2017), 3, Seite 324-328 volume:98 year:2017 number:3 pages:324-328
sourceStr	In Acta Dermato-Venereologica 98(2017), 3, Seite 324-328 volume:98 year:2017 number:3 pages:324-328
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP Dermatology
isfreeaccess_bool	true
container_title	Acta Dermato-Venereologica
authorswithroles_txt_mv	Louise Lönndahl @@aut@@ Mikael Holst @@aut@@ Maria Bradley @@aut@@ Hassan Killasli @@aut@@ Johan Heilborn @@aut@@ Martin A. Hall @@aut@@ Elvar Theodorsson @@aut@@ Jadwiga Holmberg @@aut@@ Klas Nordlind @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	302725431
id	DOAJ01451754X
language_de	englisch
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callnumber-first	R - Medicine
author	Louise Lönndahl
spellingShingle	Louise Lönndahl misc RL1-803 misc anxiety misc atopicdermatitis misc aprepitant misc depression misc neurokinin1receptor misc pruritus misc SCORAD misc substanceP misc Dermatology Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
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topic_title	RL1-803 Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis anxiety atopicdermatitis aprepitant depression neurokinin1receptor pruritus SCORAD substanceP
topic	misc RL1-803 misc anxiety misc atopicdermatitis misc aprepitant misc depression misc neurokinin1receptor misc pruritus misc SCORAD misc substanceP misc Dermatology
topic_unstemmed	misc RL1-803 misc anxiety misc atopicdermatitis misc aprepitant misc depression misc neurokinin1receptor misc pruritus misc SCORAD misc substanceP misc Dermatology
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title	Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
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title_full	Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
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author_browse	Louise Lönndahl Mikael Holst Maria Bradley Hassan Killasli Johan Heilborn Martin A. Hall Elvar Theodorsson Jadwiga Holmberg Klas Nordlind
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title_sort	substance p antagonist aprepitant shows no additive effect compared with standardized topical treatment alone in patients with atopic dermatitis
callnumber	RL1-803
title_auth	Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
abstract	Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group.
abstractGer	Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group.
abstract_unstemmed	Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment group (n = 19) received 80 mg/day aprepitant for 7 days as a supplement to standardized topical treatment with a moderately strong steroid and a moisturizer. The control group (n = 20) received topical treatment alone. Patients were monitored for the extent of the disease (using SCORing of Atopic Dermatitis; SCORAD), pruritus, and scratching movements. In both the aprepitant-treated and the control groups there was a decrease in SCORAD, pruritus and scratching movements. However, there was no significant additional improvement in any of these parameters in the aprepitant-treated group compared with the control group.
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title_short	Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
url	https://doi.org/10.2340/00015555-2852 https://doaj.org/article/46fb949dc53349c6a7e46b390e4b644a https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2852 https://doaj.org/toc/0001-5555 https://doaj.org/toc/1651-2057
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