Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia

Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE)...
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Autor*in:	Song Cao [verfasserIn] Dexin Zhang [verfasserIn] Jie Yuan [verfasserIn] Wenwen Deng [verfasserIn] Song Wen [verfasserIn] Bangyong Qin [verfasserIn] Ying Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Journal of International Medical Research - SAGE Publishing, 2015, 48(2020)
Übergeordnetes Werk:	volume:48 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/0300060520929582

Katalog-ID:	DOAJ014613050

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520			\|a Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin.
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allfields	10.1177/0300060520929582 doi (DE-627)DOAJ014613050 (DE-599)DOAJd5c2f19213c2442ead1ccf656805b6ae DE-627 ger DE-627 rakwb eng R5-920 Song Cao verfasserin aut Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin. Medicine (General) Dexin Zhang verfasserin aut Jie Yuan verfasserin aut Wenwen Deng verfasserin aut Song Wen verfasserin aut Bangyong Qin verfasserin aut Ying Li verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae kostenfrei https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
spelling	10.1177/0300060520929582 doi (DE-627)DOAJ014613050 (DE-599)DOAJd5c2f19213c2442ead1ccf656805b6ae DE-627 ger DE-627 rakwb eng R5-920 Song Cao verfasserin aut Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin. Medicine (General) Dexin Zhang verfasserin aut Jie Yuan verfasserin aut Wenwen Deng verfasserin aut Song Wen verfasserin aut Bangyong Qin verfasserin aut Ying Li verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae kostenfrei https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfields_unstemmed	10.1177/0300060520929582 doi (DE-627)DOAJ014613050 (DE-599)DOAJd5c2f19213c2442ead1ccf656805b6ae DE-627 ger DE-627 rakwb eng R5-920 Song Cao verfasserin aut Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin. Medicine (General) Dexin Zhang verfasserin aut Jie Yuan verfasserin aut Wenwen Deng verfasserin aut Song Wen verfasserin aut Bangyong Qin verfasserin aut Ying Li verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae kostenfrei https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfieldsGer	10.1177/0300060520929582 doi (DE-627)DOAJ014613050 (DE-599)DOAJd5c2f19213c2442ead1ccf656805b6ae DE-627 ger DE-627 rakwb eng R5-920 Song Cao verfasserin aut Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin. Medicine (General) Dexin Zhang verfasserin aut Jie Yuan verfasserin aut Wenwen Deng verfasserin aut Song Wen verfasserin aut Bangyong Qin verfasserin aut Ying Li verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae kostenfrei https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfieldsSound	10.1177/0300060520929582 doi (DE-627)DOAJ014613050 (DE-599)DOAJd5c2f19213c2442ead1ccf656805b6ae DE-627 ger DE-627 rakwb eng R5-920 Song Cao verfasserin aut Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin. Medicine (General) Dexin Zhang verfasserin aut Jie Yuan verfasserin aut Wenwen Deng verfasserin aut Song Wen verfasserin aut Bangyong Qin verfasserin aut Ying Li verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae kostenfrei https://doi.org/10.1177/0300060520929582 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
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Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. 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callnumber-first	R - Medicine
author	Song Cao
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topic_title	R5-920 Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
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title	Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
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title_full	Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
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title_sort	inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
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title_auth	Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
abstract	Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin.
abstractGer	Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin.
abstract_unstemmed	Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays. Conclusions Expression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin.
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title_short	Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia
url	https://doi.org/10.1177/0300060520929582 https://doaj.org/article/d5c2f19213c2442ead1ccf656805b6ae https://doaj.org/toc/1473-2300
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Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia

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