Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice

The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surf...
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Autor*in:	Kyu Yun Chai [verfasserIn] Mi-Sun Song [verfasserIn] Thuy Thi Thu Nguyen [verfasserIn] Duckhee Lee [verfasserIn] Hee Min Hwang [verfasserIn] Jun Seo Park [verfasserIn] Kwang-Hyun Park [verfasserIn] Seon Il Jang [verfasserIn] Ji Ye Mok [verfasserIn] In Hwa Jeon [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 17(2012), 3, Seite 2992-3007
Übergeordnetes Werk:	volume:17 ; year:2012 ; number:3 ; pages:2992-3007

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules17032992

Katalog-ID:	DOAJ014717646

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spelling	10.3390/molecules17032992 doi (DE-627)DOAJ014717646 (DE-599)DOAJbe63205dcd1248b88465d65f28895084 DE-627 ger DE-627 rakwb eng QD241-441 Kyu Yun Chai verfasserin aut Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent. dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing Organic chemistry Mi-Sun Song verfasserin aut Thuy Thi Thu Nguyen verfasserin aut Duckhee Lee verfasserin aut Hee Min Hwang verfasserin aut Jun Seo Park verfasserin aut Kwang-Hyun Park verfasserin aut Seon Il Jang verfasserin aut Ji Ye Mok verfasserin aut In Hwa Jeon verfasserin aut In Molecules MDPI AG, 2003 17(2012), 3, Seite 2992-3007 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:3 pages:2992-3007 https://doi.org/10.3390/molecules17032992 kostenfrei https://doaj.org/article/be63205dcd1248b88465d65f28895084 kostenfrei http://www.mdpi.com/1420-3049/17/3/2992/ kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 3 2992-3007
allfields_unstemmed	10.3390/molecules17032992 doi (DE-627)DOAJ014717646 (DE-599)DOAJbe63205dcd1248b88465d65f28895084 DE-627 ger DE-627 rakwb eng QD241-441 Kyu Yun Chai verfasserin aut Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent. dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing Organic chemistry Mi-Sun Song verfasserin aut Thuy Thi Thu Nguyen verfasserin aut Duckhee Lee verfasserin aut Hee Min Hwang verfasserin aut Jun Seo Park verfasserin aut Kwang-Hyun Park verfasserin aut Seon Il Jang verfasserin aut Ji Ye Mok verfasserin aut In Hwa Jeon verfasserin aut In Molecules MDPI AG, 2003 17(2012), 3, Seite 2992-3007 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:3 pages:2992-3007 https://doi.org/10.3390/molecules17032992 kostenfrei https://doaj.org/article/be63205dcd1248b88465d65f28895084 kostenfrei http://www.mdpi.com/1420-3049/17/3/2992/ kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 3 2992-3007
allfieldsGer	10.3390/molecules17032992 doi (DE-627)DOAJ014717646 (DE-599)DOAJbe63205dcd1248b88465d65f28895084 DE-627 ger DE-627 rakwb eng QD241-441 Kyu Yun Chai verfasserin aut Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent. dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing Organic chemistry Mi-Sun Song verfasserin aut Thuy Thi Thu Nguyen verfasserin aut Duckhee Lee verfasserin aut Hee Min Hwang verfasserin aut Jun Seo Park verfasserin aut Kwang-Hyun Park verfasserin aut Seon Il Jang verfasserin aut Ji Ye Mok verfasserin aut In Hwa Jeon verfasserin aut In Molecules MDPI AG, 2003 17(2012), 3, Seite 2992-3007 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:3 pages:2992-3007 https://doi.org/10.3390/molecules17032992 kostenfrei https://doaj.org/article/be63205dcd1248b88465d65f28895084 kostenfrei http://www.mdpi.com/1420-3049/17/3/2992/ kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 3 2992-3007
allfieldsSound	10.3390/molecules17032992 doi (DE-627)DOAJ014717646 (DE-599)DOAJbe63205dcd1248b88465d65f28895084 DE-627 ger DE-627 rakwb eng QD241-441 Kyu Yun Chai verfasserin aut Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent. dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing Organic chemistry Mi-Sun Song verfasserin aut Thuy Thi Thu Nguyen verfasserin aut Duckhee Lee verfasserin aut Hee Min Hwang verfasserin aut Jun Seo Park verfasserin aut Kwang-Hyun Park verfasserin aut Seon Il Jang verfasserin aut Ji Ye Mok verfasserin aut In Hwa Jeon verfasserin aut In Molecules MDPI AG, 2003 17(2012), 3, Seite 2992-3007 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:3 pages:2992-3007 https://doi.org/10.3390/molecules17032992 kostenfrei https://doaj.org/article/be63205dcd1248b88465d65f28895084 kostenfrei http://www.mdpi.com/1420-3049/17/3/2992/ kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 3 2992-3007
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callnumber-first	Q - Science
author	Kyu Yun Chai
spellingShingle	Kyu Yun Chai misc QD241-441 misc dibutyryl chitin misc nanofiber membrane misc electrospinning misc hairless mice misc wound healing misc Organic chemistry Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice
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topic_title	QD241-441 Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice dibutyryl chitin nanofiber membrane electrospinning hairless mice wound healing
topic	misc QD241-441 misc dibutyryl chitin misc nanofiber membrane misc electrospinning misc hairless mice misc wound healing misc Organic chemistry
topic_unstemmed	misc QD241-441 misc dibutyryl chitin misc nanofiber membrane misc electrospinning misc hairless mice misc wound healing misc Organic chemistry
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title	Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice
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title_full	Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice
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title_sort	effect of electrospun non-woven mats of dibutyryl chitin/poly(lactic acid) blends on wound healing in hairless mice
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title_auth	Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice
abstract	The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent.
abstractGer	The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent.
abstract_unstemmed	The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent.
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title_short	Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice
url	https://doi.org/10.3390/molecules17032992 https://doaj.org/article/be63205dcd1248b88465d65f28895084 http://www.mdpi.com/1420-3049/17/3/2992/ https://doaj.org/toc/1420-3049
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up_date	2024-07-04T00:12:59.957Z
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The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in a dose dependent way. Furthermore, DBCNFM notably increased the expression of the type 1 collagen and filaggrin. 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Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice

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