A Historical Overview of Natural Products in Drug Discovery

Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of...
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Gespeichert in:

Autor*in:	Daniel A. Dias [verfasserIn] Sylvia Urban [verfasserIn] Ute Roessner [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	natural products secondary metabolites drug discovery bioactivity metabolomics dereplication, plants sponges algae fungi

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 2(2012), 2, Seite 303-336
Übergeordnetes Werk:	volume:2 ; year:2012 ; number:2 ; pages:303-336

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo2020303

Katalog-ID:	DOAJ014915766

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callnumber-first	Q - Science
author	Daniel A. Dias
spellingShingle	Daniel A. Dias misc QR1-502 misc natural products misc secondary metabolites misc drug discovery misc bioactivity misc metabolomics misc dereplication, plants misc sponges misc algae misc fungi misc Microbiology A Historical Overview of Natural Products in Drug Discovery
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topic_title	QR1-502 A Historical Overview of Natural Products in Drug Discovery natural products secondary metabolites drug discovery bioactivity metabolomics dereplication, plants sponges algae fungi
topic	misc QR1-502 misc natural products misc secondary metabolites misc drug discovery misc bioactivity misc metabolomics misc dereplication, plants misc sponges misc algae misc fungi misc Microbiology
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title	A Historical Overview of Natural Products in Drug Discovery
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title_sort	historical overview of natural products in drug discovery
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title_auth	A Historical Overview of Natural Products in Drug Discovery
abstract	Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
abstractGer	Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
abstract_unstemmed	Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.
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