Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology f...
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Autor*in:	Lisa A. Stott [verfasserIn] Cheryl A. Brighton [verfasserIn] Jason Brown [verfasserIn] Richard Mould [verfasserIn] Kirstie A. Bennett [verfasserIn] Robert Newman [verfasserIn] Heather Currinn [verfasserIn] Flavia Autore [verfasserIn] Alicia P. Higueruelo [verfasserIn] Benjamin G. Tehan [verfasserIn] Cliona MacSweeney [verfasserIn] Michael A. O'Brien [verfasserIn] Steve P. Watson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	GPR52 Inverse agonist Cannabidiol CBD O-1918

Übergeordnetes Werk:	In: Heliyon - Elsevier, 2016, 7(2021), 6, Seite e07201-
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:6 ; pages:e07201-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.heliyon.2021.e07201

Katalog-ID:	DOAJ015048624

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520			\|a The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.
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publishDate	2021
allfields	10.1016/j.heliyon.2021.e07201 doi (DE-627)DOAJ015048624 (DE-599)DOAJ9ab0b310527d4fceba02192d55edbff1 DE-627 ger DE-627 rakwb eng Q1-390 H1-99 Lisa A. Stott verfasserin aut Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General) Cheryl A. Brighton verfasserin aut Jason Brown verfasserin aut Richard Mould verfasserin aut Kirstie A. Bennett verfasserin aut Robert Newman verfasserin aut Heather Currinn verfasserin aut Flavia Autore verfasserin aut Alicia P. Higueruelo verfasserin aut Benjamin G. Tehan verfasserin aut Cliona MacSweeney verfasserin aut Michael A. O'Brien verfasserin aut Steve P. Watson verfasserin aut In Heliyon Elsevier, 2016 7(2021), 6, Seite e07201- (DE-627)835893197 (DE-600)2835763-2 24058440 nnns volume:7 year:2021 number:6 pages:e07201- https://doi.org/10.1016/j.heliyon.2021.e07201 kostenfrei https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405844021013049 kostenfrei https://doaj.org/toc/2405-8440 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2021 6 e07201-
spelling	10.1016/j.heliyon.2021.e07201 doi (DE-627)DOAJ015048624 (DE-599)DOAJ9ab0b310527d4fceba02192d55edbff1 DE-627 ger DE-627 rakwb eng Q1-390 H1-99 Lisa A. Stott verfasserin aut Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General) Cheryl A. Brighton verfasserin aut Jason Brown verfasserin aut Richard Mould verfasserin aut Kirstie A. Bennett verfasserin aut Robert Newman verfasserin aut Heather Currinn verfasserin aut Flavia Autore verfasserin aut Alicia P. Higueruelo verfasserin aut Benjamin G. Tehan verfasserin aut Cliona MacSweeney verfasserin aut Michael A. O'Brien verfasserin aut Steve P. Watson verfasserin aut In Heliyon Elsevier, 2016 7(2021), 6, Seite e07201- (DE-627)835893197 (DE-600)2835763-2 24058440 nnns volume:7 year:2021 number:6 pages:e07201- https://doi.org/10.1016/j.heliyon.2021.e07201 kostenfrei https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405844021013049 kostenfrei https://doaj.org/toc/2405-8440 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2021 6 e07201-
allfields_unstemmed	10.1016/j.heliyon.2021.e07201 doi (DE-627)DOAJ015048624 (DE-599)DOAJ9ab0b310527d4fceba02192d55edbff1 DE-627 ger DE-627 rakwb eng Q1-390 H1-99 Lisa A. Stott verfasserin aut Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General) Cheryl A. Brighton verfasserin aut Jason Brown verfasserin aut Richard Mould verfasserin aut Kirstie A. Bennett verfasserin aut Robert Newman verfasserin aut Heather Currinn verfasserin aut Flavia Autore verfasserin aut Alicia P. Higueruelo verfasserin aut Benjamin G. Tehan verfasserin aut Cliona MacSweeney verfasserin aut Michael A. O'Brien verfasserin aut Steve P. Watson verfasserin aut In Heliyon Elsevier, 2016 7(2021), 6, Seite e07201- (DE-627)835893197 (DE-600)2835763-2 24058440 nnns volume:7 year:2021 number:6 pages:e07201- https://doi.org/10.1016/j.heliyon.2021.e07201 kostenfrei https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405844021013049 kostenfrei https://doaj.org/toc/2405-8440 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2021 6 e07201-
allfieldsGer	10.1016/j.heliyon.2021.e07201 doi (DE-627)DOAJ015048624 (DE-599)DOAJ9ab0b310527d4fceba02192d55edbff1 DE-627 ger DE-627 rakwb eng Q1-390 H1-99 Lisa A. Stott verfasserin aut Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General) Cheryl A. Brighton verfasserin aut Jason Brown verfasserin aut Richard Mould verfasserin aut Kirstie A. Bennett verfasserin aut Robert Newman verfasserin aut Heather Currinn verfasserin aut Flavia Autore verfasserin aut Alicia P. Higueruelo verfasserin aut Benjamin G. Tehan verfasserin aut Cliona MacSweeney verfasserin aut Michael A. O'Brien verfasserin aut Steve P. Watson verfasserin aut In Heliyon Elsevier, 2016 7(2021), 6, Seite e07201- (DE-627)835893197 (DE-600)2835763-2 24058440 nnns volume:7 year:2021 number:6 pages:e07201- https://doi.org/10.1016/j.heliyon.2021.e07201 kostenfrei https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405844021013049 kostenfrei https://doaj.org/toc/2405-8440 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2021 6 e07201-
allfieldsSound	10.1016/j.heliyon.2021.e07201 doi (DE-627)DOAJ015048624 (DE-599)DOAJ9ab0b310527d4fceba02192d55edbff1 DE-627 ger DE-627 rakwb eng Q1-390 H1-99 Lisa A. Stott verfasserin aut Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General) Cheryl A. Brighton verfasserin aut Jason Brown verfasserin aut Richard Mould verfasserin aut Kirstie A. Bennett verfasserin aut Robert Newman verfasserin aut Heather Currinn verfasserin aut Flavia Autore verfasserin aut Alicia P. Higueruelo verfasserin aut Benjamin G. Tehan verfasserin aut Cliona MacSweeney verfasserin aut Michael A. O'Brien verfasserin aut Steve P. Watson verfasserin aut In Heliyon Elsevier, 2016 7(2021), 6, Seite e07201- (DE-627)835893197 (DE-600)2835763-2 24058440 nnns volume:7 year:2021 number:6 pages:e07201- https://doi.org/10.1016/j.heliyon.2021.e07201 kostenfrei https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405844021013049 kostenfrei https://doaj.org/toc/2405-8440 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2021 6 e07201-
language	English
source	In Heliyon 7(2021), 6, Seite e07201- volume:7 year:2021 number:6 pages:e07201-
sourceStr	In Heliyon 7(2021), 6, Seite e07201- volume:7 year:2021 number:6 pages:e07201-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	GPR52 Inverse agonist Cannabidiol CBD O-1918 Science (General) Social sciences (General)
isfreeaccess_bool	true
container_title	Heliyon
authorswithroles_txt_mv	Lisa A. Stott @@aut@@ Cheryl A. Brighton @@aut@@ Jason Brown @@aut@@ Richard Mould @@aut@@ Kirstie A. Bennett @@aut@@ Robert Newman @@aut@@ Heather Currinn @@aut@@ Flavia Autore @@aut@@ Alicia P. Higueruelo @@aut@@ Benjamin G. Tehan @@aut@@ Cliona MacSweeney @@aut@@ Michael A. O'Brien @@aut@@ Steve P. Watson @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	835893197
id	DOAJ015048624
language_de	englisch
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callnumber-first	Q - Science
author	Lisa A. Stott
spellingShingle	Lisa A. Stott misc Q1-390 misc H1-99 misc GPR52 misc Inverse agonist misc Cannabidiol misc CBD misc O-1918 misc Science (General) misc Social sciences (General) Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
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topic_title	Q1-390 H1-99 Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 GPR52 Inverse agonist Cannabidiol CBD O-1918
topic	misc Q1-390 misc H1-99 misc GPR52 misc Inverse agonist misc Cannabidiol misc CBD misc O-1918 misc Science (General) misc Social sciences (General)
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title	Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
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title_full	Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
author_sort	Lisa A. Stott
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author_browse	Lisa A. Stott Cheryl A. Brighton Jason Brown Richard Mould Kirstie A. Bennett Robert Newman Heather Currinn Flavia Autore Alicia P. Higueruelo Benjamin G. Tehan Cliona MacSweeney Michael A. O'Brien Steve P. Watson
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title_sort	characterisation of inverse agonism of the orphan-g protein-coupled receptor gpr52 by cannabinoid ligands cannabidiol and o-1918
callnumber	Q1-390
title_auth	Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
abstract	The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.
abstractGer	The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.
abstract_unstemmed	The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.
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title_short	Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
url	https://doi.org/10.1016/j.heliyon.2021.e07201 https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1 http://www.sciencedirect.com/science/article/pii/S2405844021013049 https://doaj.org/toc/2405-8440
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up_date	2024-07-04T01:25:52.880Z
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Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

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