Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial

Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or addin...
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Autor*in:	Vaibhav Tiwari [verfasserIn] Arpita Ray Chaudhary [verfasserIn] Sanjay Dasgupta [verfasserIn] Smita Divyaveer [verfasserIn] Raju Kumar Sahu [verfasserIn] Atanu Pal [verfasserIn] Rajib Mondal [verfasserIn] Kapiljit Chakravarty [verfasserIn] Asit Kumar Mandal [verfasserIn] Dipankar Sircar [verfasserIn] Rajendra Pandey [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers

Übergeordnetes Werk:	In: Indian Journal of Nephrology - Wolters Kluwer Medknow Publications, 2017, 31(2021), 1, Seite 9-15
Übergeordnetes Werk:	volume:31 ; year:2021 ; number:1 ; pages:9-15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/ijn.IJN_322_19

Katalog-ID:	DOAJ015131955

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245	1	0	\|a Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
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520			\|a Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives.
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653		0	\|a Diseases of the genitourinary system. Urology
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allfields	10.4103/ijn.IJN_322_19 doi (DE-627)DOAJ015131955 (DE-599)DOAJd2aead54502a492baa33dbd68a25b6d5 DE-627 ger DE-627 rakwb eng RC870-923 Vaibhav Tiwari verfasserin aut Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology Arpita Ray Chaudhary verfasserin aut Sanjay Dasgupta verfasserin aut Smita Divyaveer verfasserin aut Raju Kumar Sahu verfasserin aut Atanu Pal verfasserin aut Rajib Mondal verfasserin aut Kapiljit Chakravarty verfasserin aut Asit Kumar Mandal verfasserin aut Dipankar Sircar verfasserin aut Rajendra Pandey verfasserin aut In Indian Journal of Nephrology Wolters Kluwer Medknow Publications, 2017 31(2021), 1, Seite 9-15 (DE-627)378569988 (DE-600)2134388-3 19983662 nnns volume:31 year:2021 number:1 pages:9-15 https://doi.org/10.4103/ijn.IJN_322_19 kostenfrei https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 kostenfrei http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari kostenfrei https://doaj.org/toc/0971-4065 Journal toc kostenfrei https://doaj.org/toc/1998-3662 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2021 1 9-15
spelling	10.4103/ijn.IJN_322_19 doi (DE-627)DOAJ015131955 (DE-599)DOAJd2aead54502a492baa33dbd68a25b6d5 DE-627 ger DE-627 rakwb eng RC870-923 Vaibhav Tiwari verfasserin aut Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology Arpita Ray Chaudhary verfasserin aut Sanjay Dasgupta verfasserin aut Smita Divyaveer verfasserin aut Raju Kumar Sahu verfasserin aut Atanu Pal verfasserin aut Rajib Mondal verfasserin aut Kapiljit Chakravarty verfasserin aut Asit Kumar Mandal verfasserin aut Dipankar Sircar verfasserin aut Rajendra Pandey verfasserin aut In Indian Journal of Nephrology Wolters Kluwer Medknow Publications, 2017 31(2021), 1, Seite 9-15 (DE-627)378569988 (DE-600)2134388-3 19983662 nnns volume:31 year:2021 number:1 pages:9-15 https://doi.org/10.4103/ijn.IJN_322_19 kostenfrei https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 kostenfrei http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari kostenfrei https://doaj.org/toc/0971-4065 Journal toc kostenfrei https://doaj.org/toc/1998-3662 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2021 1 9-15
allfields_unstemmed	10.4103/ijn.IJN_322_19 doi (DE-627)DOAJ015131955 (DE-599)DOAJd2aead54502a492baa33dbd68a25b6d5 DE-627 ger DE-627 rakwb eng RC870-923 Vaibhav Tiwari verfasserin aut Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology Arpita Ray Chaudhary verfasserin aut Sanjay Dasgupta verfasserin aut Smita Divyaveer verfasserin aut Raju Kumar Sahu verfasserin aut Atanu Pal verfasserin aut Rajib Mondal verfasserin aut Kapiljit Chakravarty verfasserin aut Asit Kumar Mandal verfasserin aut Dipankar Sircar verfasserin aut Rajendra Pandey verfasserin aut In Indian Journal of Nephrology Wolters Kluwer Medknow Publications, 2017 31(2021), 1, Seite 9-15 (DE-627)378569988 (DE-600)2134388-3 19983662 nnns volume:31 year:2021 number:1 pages:9-15 https://doi.org/10.4103/ijn.IJN_322_19 kostenfrei https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 kostenfrei http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari kostenfrei https://doaj.org/toc/0971-4065 Journal toc kostenfrei https://doaj.org/toc/1998-3662 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2021 1 9-15
allfieldsGer	10.4103/ijn.IJN_322_19 doi (DE-627)DOAJ015131955 (DE-599)DOAJd2aead54502a492baa33dbd68a25b6d5 DE-627 ger DE-627 rakwb eng RC870-923 Vaibhav Tiwari verfasserin aut Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology Arpita Ray Chaudhary verfasserin aut Sanjay Dasgupta verfasserin aut Smita Divyaveer verfasserin aut Raju Kumar Sahu verfasserin aut Atanu Pal verfasserin aut Rajib Mondal verfasserin aut Kapiljit Chakravarty verfasserin aut Asit Kumar Mandal verfasserin aut Dipankar Sircar verfasserin aut Rajendra Pandey verfasserin aut In Indian Journal of Nephrology Wolters Kluwer Medknow Publications, 2017 31(2021), 1, Seite 9-15 (DE-627)378569988 (DE-600)2134388-3 19983662 nnns volume:31 year:2021 number:1 pages:9-15 https://doi.org/10.4103/ijn.IJN_322_19 kostenfrei https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 kostenfrei http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari kostenfrei https://doaj.org/toc/0971-4065 Journal toc kostenfrei https://doaj.org/toc/1998-3662 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2021 1 9-15
allfieldsSound	10.4103/ijn.IJN_322_19 doi (DE-627)DOAJ015131955 (DE-599)DOAJd2aead54502a492baa33dbd68a25b6d5 DE-627 ger DE-627 rakwb eng RC870-923 Vaibhav Tiwari verfasserin aut Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives. abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology Arpita Ray Chaudhary verfasserin aut Sanjay Dasgupta verfasserin aut Smita Divyaveer verfasserin aut Raju Kumar Sahu verfasserin aut Atanu Pal verfasserin aut Rajib Mondal verfasserin aut Kapiljit Chakravarty verfasserin aut Asit Kumar Mandal verfasserin aut Dipankar Sircar verfasserin aut Rajendra Pandey verfasserin aut In Indian Journal of Nephrology Wolters Kluwer Medknow Publications, 2017 31(2021), 1, Seite 9-15 (DE-627)378569988 (DE-600)2134388-3 19983662 nnns volume:31 year:2021 number:1 pages:9-15 https://doi.org/10.4103/ijn.IJN_322_19 kostenfrei https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 kostenfrei http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari kostenfrei https://doaj.org/toc/0971-4065 Journal toc kostenfrei https://doaj.org/toc/1998-3662 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2021 1 9-15
language	English
source	In Indian Journal of Nephrology 31(2021), 1, Seite 9-15 volume:31 year:2021 number:1 pages:9-15
sourceStr	In Indian Journal of Nephrology 31(2021), 1, Seite 9-15 volume:31 year:2021 number:1 pages:9-15
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers Diseases of the genitourinary system. Urology
isfreeaccess_bool	true
container_title	Indian Journal of Nephrology
authorswithroles_txt_mv	Vaibhav Tiwari @@aut@@ Arpita Ray Chaudhary @@aut@@ Sanjay Dasgupta @@aut@@ Smita Divyaveer @@aut@@ Raju Kumar Sahu @@aut@@ Atanu Pal @@aut@@ Rajib Mondal @@aut@@ Kapiljit Chakravarty @@aut@@ Asit Kumar Mandal @@aut@@ Dipankar Sircar @@aut@@ Rajendra Pandey @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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language_de	englisch
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Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. 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callnumber-first	R - Medicine
author	Vaibhav Tiwari
spellingShingle	Vaibhav Tiwari misc RC870-923 misc abpm misc antihypertensives misc chronic kidney disease misc dippers misc hypertension misc nocturnal hypertension misc non-dippers misc Diseases of the genitourinary system. Urology Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
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topic_title	RC870-923 Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial abpm antihypertensives chronic kidney disease dippers hypertension nocturnal hypertension non-dippers
topic	misc RC870-923 misc abpm misc antihypertensives misc chronic kidney disease misc dippers misc hypertension misc nocturnal hypertension misc non-dippers misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc abpm misc antihypertensives misc chronic kidney disease misc dippers misc hypertension misc nocturnal hypertension misc non-dippers misc Diseases of the genitourinary system. Urology
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title	Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
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title_full	Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
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author_browse	Vaibhav Tiwari Arpita Ray Chaudhary Sanjay Dasgupta Smita Divyaveer Raju Kumar Sahu Atanu Pal Rajib Mondal Kapiljit Chakravarty Asit Kumar Mandal Dipankar Sircar Rajendra Pandey
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title_sort	effect of chronotherapy of antihypertensives in chronic kidney disease: a randomized control trial
callnumber	RC870-923
title_auth	Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
abstract	Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives.
abstractGer	Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives.
abstract_unstemmed	Introduction: There is a higher prevalence of non-dipping pattern in hypertensive chronic kidney disease (CKD) patients. Nocturnal hypertension has been shown to predict cardiovascular mortality and morbidity and is often superior to daytime blood pressure. We studied the effect of shifting or adding antihypertensive to night time on blood pressure profile of CKD III-IV patients. Methods: In this single-center, prospective, randomized controlled trial, eligible participants were adults from eastern India aged 18–65 years with CKD stages 3 and 4, with a non-dipping pattern on ambulatory blood pressure monitor (ABPM). The intervention group received all the antihypertensives in the night time whereas the standard care group continued to take the medication in the morning. Both groups were followed up for 1 year. The primary outcome was the number of patients changed from non-dippers to dippers in the standard care group and intervention group. Secondary outcomes included a change in estimated glomerular filtration rate (eGFR) and change in the cardiac structure. Results: 39 patients in the intervention group and 36 patients in the standard care group were analyzed. 10 patients (26%) reverted to dipping pattern in the intervention group as compared to none in the standard care group. Mean changes in eGFR were −2.55 and −0.18 mL/min/1.73 m2 in the standard care and intervention group at the end of the study, respectively. Between-group difference in eGFR was significant at 1 year (5.22 [95% CI, 4.3–6.1] ml/min/1.73 m2); (P = 0.03). The cardiac structure showed no significant changes in either group. Conclusions: Bedtime administration of antihypertensives reverted non-dippers to dippers and slowed the decline in eGFR in CKD stages 3 and 4 compared to morning administration of antihypertensives.
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title_short	Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial
url	https://doi.org/10.4103/ijn.IJN_322_19 https://doaj.org/article/d2aead54502a492baa33dbd68a25b6d5 http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=9;epage=15;aulast=Tiwari https://doaj.org/toc/0971-4065 https://doaj.org/toc/1998-3662
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Effect of chronotherapy of antihypertensives in chronic kidney disease: A randomized control trial

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