Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR

The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosi...
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Autor*in:	Ming-Lun Yeh [verfasserIn] Po-Cheng Liang [verfasserIn] Pei-Chien Tsai [verfasserIn] Shu-Chi Wang [verfasserIn] Jennifer Leong [verfasserIn] Eiichi Ogawa [verfasserIn] Dae Won Jun [verfasserIn] Cheng-Hao Tseng [verfasserIn] Charles Landis [verfasserIn] Yasuhito Tanaka [verfasserIn] Chung-Feng Huang [verfasserIn] Jun Hayashi [verfasserIn] Yao-Chun Hsu [verfasserIn] Jee-Fu Huang [verfasserIn] Chia-Yen Dai [verfasserIn] Wan-Long Chuang [verfasserIn] Mindie H. Nguyen [verfasserIn] Ming-Lung Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 14, p 3455
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:14, p 3455

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13143455

Katalog-ID:	DOAJ015151824

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allfields	10.3390/cancers13143455 doi (DE-627)DOAJ015151824 (DE-599)DOAJeed7a681b0af4d1ba0cd0f9ffa99e31a DE-627 ger DE-627 rakwb eng RC254-282 Ming-Lun Yeh verfasserin aut Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Po-Cheng Liang verfasserin aut Pei-Chien Tsai verfasserin aut Shu-Chi Wang verfasserin aut Jennifer Leong verfasserin aut Eiichi Ogawa verfasserin aut Dae Won Jun verfasserin aut Cheng-Hao Tseng verfasserin aut Charles Landis verfasserin aut Yasuhito Tanaka verfasserin aut Chung-Feng Huang verfasserin aut Jun Hayashi verfasserin aut Yao-Chun Hsu verfasserin aut Jee-Fu Huang verfasserin aut Chia-Yen Dai verfasserin aut Wan-Long Chuang verfasserin aut Mindie H. Nguyen verfasserin aut Ming-Lung Yu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 14, p 3455 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:14, p 3455 https://doi.org/10.3390/cancers13143455 kostenfrei https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a kostenfrei https://www.mdpi.com/2072-6694/13/14/3455 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 14, p 3455
spelling	10.3390/cancers13143455 doi (DE-627)DOAJ015151824 (DE-599)DOAJeed7a681b0af4d1ba0cd0f9ffa99e31a DE-627 ger DE-627 rakwb eng RC254-282 Ming-Lun Yeh verfasserin aut Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Po-Cheng Liang verfasserin aut Pei-Chien Tsai verfasserin aut Shu-Chi Wang verfasserin aut Jennifer Leong verfasserin aut Eiichi Ogawa verfasserin aut Dae Won Jun verfasserin aut Cheng-Hao Tseng verfasserin aut Charles Landis verfasserin aut Yasuhito Tanaka verfasserin aut Chung-Feng Huang verfasserin aut Jun Hayashi verfasserin aut Yao-Chun Hsu verfasserin aut Jee-Fu Huang verfasserin aut Chia-Yen Dai verfasserin aut Wan-Long Chuang verfasserin aut Mindie H. Nguyen verfasserin aut Ming-Lung Yu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 14, p 3455 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:14, p 3455 https://doi.org/10.3390/cancers13143455 kostenfrei https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a kostenfrei https://www.mdpi.com/2072-6694/13/14/3455 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 14, p 3455
allfields_unstemmed	10.3390/cancers13143455 doi (DE-627)DOAJ015151824 (DE-599)DOAJeed7a681b0af4d1ba0cd0f9ffa99e31a DE-627 ger DE-627 rakwb eng RC254-282 Ming-Lun Yeh verfasserin aut Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Po-Cheng Liang verfasserin aut Pei-Chien Tsai verfasserin aut Shu-Chi Wang verfasserin aut Jennifer Leong verfasserin aut Eiichi Ogawa verfasserin aut Dae Won Jun verfasserin aut Cheng-Hao Tseng verfasserin aut Charles Landis verfasserin aut Yasuhito Tanaka verfasserin aut Chung-Feng Huang verfasserin aut Jun Hayashi verfasserin aut Yao-Chun Hsu verfasserin aut Jee-Fu Huang verfasserin aut Chia-Yen Dai verfasserin aut Wan-Long Chuang verfasserin aut Mindie H. Nguyen verfasserin aut Ming-Lung Yu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 14, p 3455 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:14, p 3455 https://doi.org/10.3390/cancers13143455 kostenfrei https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a kostenfrei https://www.mdpi.com/2072-6694/13/14/3455 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 14, p 3455
allfieldsGer	10.3390/cancers13143455 doi (DE-627)DOAJ015151824 (DE-599)DOAJeed7a681b0af4d1ba0cd0f9ffa99e31a DE-627 ger DE-627 rakwb eng RC254-282 Ming-Lun Yeh verfasserin aut Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Po-Cheng Liang verfasserin aut Pei-Chien Tsai verfasserin aut Shu-Chi Wang verfasserin aut Jennifer Leong verfasserin aut Eiichi Ogawa verfasserin aut Dae Won Jun verfasserin aut Cheng-Hao Tseng verfasserin aut Charles Landis verfasserin aut Yasuhito Tanaka verfasserin aut Chung-Feng Huang verfasserin aut Jun Hayashi verfasserin aut Yao-Chun Hsu verfasserin aut Jee-Fu Huang verfasserin aut Chia-Yen Dai verfasserin aut Wan-Long Chuang verfasserin aut Mindie H. Nguyen verfasserin aut Ming-Lung Yu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 14, p 3455 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:14, p 3455 https://doi.org/10.3390/cancers13143455 kostenfrei https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a kostenfrei https://www.mdpi.com/2072-6694/13/14/3455 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 14, p 3455
allfieldsSound	10.3390/cancers13143455 doi (DE-627)DOAJ015151824 (DE-599)DOAJeed7a681b0af4d1ba0cd0f9ffa99e31a DE-627 ger DE-627 rakwb eng RC254-282 Ming-Lun Yeh verfasserin aut Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Po-Cheng Liang verfasserin aut Pei-Chien Tsai verfasserin aut Shu-Chi Wang verfasserin aut Jennifer Leong verfasserin aut Eiichi Ogawa verfasserin aut Dae Won Jun verfasserin aut Cheng-Hao Tseng verfasserin aut Charles Landis verfasserin aut Yasuhito Tanaka verfasserin aut Chung-Feng Huang verfasserin aut Jun Hayashi verfasserin aut Yao-Chun Hsu verfasserin aut Jee-Fu Huang verfasserin aut Chia-Yen Dai verfasserin aut Wan-Long Chuang verfasserin aut Mindie H. Nguyen verfasserin aut Ming-Lung Yu verfasserin aut In Cancers MDPI AG, 2010 13(2021), 14, p 3455 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:14, p 3455 https://doi.org/10.3390/cancers13143455 kostenfrei https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a kostenfrei https://www.mdpi.com/2072-6694/13/14/3455 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 14, p 3455
language	English
source	In Cancers 13(2021), 14, p 3455 volume:13 year:2021 number:14, p 3455
sourceStr	In Cancers 13(2021), 14, p 3455 volume:13 year:2021 number:14, p 3455
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Ming-Lun Yeh @@aut@@ Po-Cheng Liang @@aut@@ Pei-Chien Tsai @@aut@@ Shu-Chi Wang @@aut@@ Jennifer Leong @@aut@@ Eiichi Ogawa @@aut@@ Dae Won Jun @@aut@@ Cheng-Hao Tseng @@aut@@ Charles Landis @@aut@@ Yasuhito Tanaka @@aut@@ Chung-Feng Huang @@aut@@ Jun Hayashi @@aut@@ Yao-Chun Hsu @@aut@@ Jee-Fu Huang @@aut@@ Chia-Yen Dai @@aut@@ Wan-Long Chuang @@aut@@ Mindie H. Nguyen @@aut@@ Ming-Lung Yu @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ015151824
language_de	englisch
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callnumber-first	R - Medicine
author	Ming-Lun Yeh
spellingShingle	Ming-Lun Yeh misc RC254-282 misc hepatitis C virus misc chronic hepatitis C misc hepatocellular carcinoma misc viremia misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
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topic_title	RC254-282 Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR hepatitis C virus chronic hepatitis C hepatocellular carcinoma viremia survival
topic	misc RC254-282 misc hepatitis C virus misc chronic hepatitis C misc hepatocellular carcinoma misc viremia misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc hepatitis C virus misc chronic hepatitis C misc hepatocellular carcinoma misc viremia misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc hepatitis C virus misc chronic hepatitis C misc hepatocellular carcinoma misc viremia misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
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title_full	Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
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author_browse	Ming-Lun Yeh Po-Cheng Liang Pei-Chien Tsai Shu-Chi Wang Jennifer Leong Eiichi Ogawa Dae Won Jun Cheng-Hao Tseng Charles Landis Yasuhito Tanaka Chung-Feng Huang Jun Hayashi Yao-Chun Hsu Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Mindie H. Nguyen Ming-Lung Yu
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title_sort	characteristics and survival outcomes of hepatocellular carcinoma developed after hcv svr
callnumber	RC254-282
title_auth	Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
abstract	The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival.
abstractGer	The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival.
abstract_unstemmed	The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, <i<p</i< < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (<i<p</i< < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival.
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title_short	Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
url	https://doi.org/10.3390/cancers13143455 https://doaj.org/article/eed7a681b0af4d1ba0cd0f9ffa99e31a https://www.mdpi.com/2072-6694/13/14/3455 https://doaj.org/toc/2072-6694
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Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR

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