TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma

Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells...
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Gespeichert in:

Autor*in:	Fan Yang [verfasserIn] Ziqing Zeng [verfasserIn] Jing Li [verfasserIn] Xiubao Ren [verfasserIn] Feng Wei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	HNSCC TIM-3 CEACAM1 TILs prognosis

Übergeordnetes Werk:	In: Frontiers in Molecular Biosciences - Frontiers Media S.A., 2015, 8(2021)
Übergeordnetes Werk:	volume:8 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmolb.2021.619765

Katalog-ID:	DOAJ015151905

Internformat


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520			\|a Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.
650		4	\|a HNSCC
650		4	\|a TIM-3
650		4	\|a CEACAM1
650		4	\|a TILs
650		4	\|a prognosis
653		0	\|a Biology (General)
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allfields	10.3389/fmolb.2021.619765 doi (DE-627)DOAJ015151905 (DE-599)DOAJe8619bad42654c20b8a6baa291cb215a DE-627 ger DE-627 rakwb eng QH301-705.5 Fan Yang verfasserin aut TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma. HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General) Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.619765 kostenfrei https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
spelling	10.3389/fmolb.2021.619765 doi (DE-627)DOAJ015151905 (DE-599)DOAJe8619bad42654c20b8a6baa291cb215a DE-627 ger DE-627 rakwb eng QH301-705.5 Fan Yang verfasserin aut TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma. HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General) Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.619765 kostenfrei https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfields_unstemmed	10.3389/fmolb.2021.619765 doi (DE-627)DOAJ015151905 (DE-599)DOAJe8619bad42654c20b8a6baa291cb215a DE-627 ger DE-627 rakwb eng QH301-705.5 Fan Yang verfasserin aut TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma. HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General) Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.619765 kostenfrei https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsGer	10.3389/fmolb.2021.619765 doi (DE-627)DOAJ015151905 (DE-599)DOAJe8619bad42654c20b8a6baa291cb215a DE-627 ger DE-627 rakwb eng QH301-705.5 Fan Yang verfasserin aut TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma. HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General) Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.619765 kostenfrei https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsSound	10.3389/fmolb.2021.619765 doi (DE-627)DOAJ015151905 (DE-599)DOAJe8619bad42654c20b8a6baa291cb215a DE-627 ger DE-627 rakwb eng QH301-705.5 Fan Yang verfasserin aut TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma. HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General) Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Fan Yang verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Ziqing Zeng verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Jing Li verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Xiubao Ren verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut Feng Wei verfasserin aut In Frontiers in Molecular Biosciences Frontiers Media S.A., 2015 8(2021) (DE-627)820039691 (DE-600)2814330-9 2296889X nnns volume:8 year:2021 https://doi.org/10.3389/fmolb.2021.619765 kostenfrei https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a kostenfrei https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full kostenfrei https://doaj.org/toc/2296-889X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
language	English
source	In Frontiers in Molecular Biosciences 8(2021) volume:8 year:2021
sourceStr	In Frontiers in Molecular Biosciences 8(2021) volume:8 year:2021
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	HNSCC TIM-3 CEACAM1 TILs prognosis Biology (General)
isfreeaccess_bool	true
container_title	Frontiers in Molecular Biosciences
authorswithroles_txt_mv	Fan Yang @@aut@@ Ziqing Zeng @@aut@@ Jing Li @@aut@@ Xiubao Ren @@aut@@ Feng Wei @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	820039691
id	DOAJ015151905
language_de	englisch
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Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p &lt; 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. 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callnumber-first	Q - Science
author	Fan Yang
spellingShingle	Fan Yang misc QH301-705.5 misc HNSCC misc TIM-3 misc CEACAM1 misc TILs misc prognosis misc Biology (General) TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma
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topic_title	QH301-705.5 TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma HNSCC TIM-3 CEACAM1 TILs prognosis
topic	misc QH301-705.5 misc HNSCC misc TIM-3 misc CEACAM1 misc TILs misc prognosis misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc HNSCC misc TIM-3 misc CEACAM1 misc TILs misc prognosis misc Biology (General)
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title	TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma
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title_full	TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma
author_sort	Fan Yang
journal	Frontiers in Molecular Biosciences
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author_browse	Fan Yang Ziqing Zeng Jing Li Xiubao Ren Feng Wei
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title_sort	tim-3 and ceacam1 are prognostic factors in head and neck squamous cell carcinoma
callnumber	QH301-705.5
title_auth	TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma
abstract	Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.
abstractGer	Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.
abstract_unstemmed	Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a new immune checkpoint molecule which plays important and complex roles in regulating immune responses and in inducing immune tolerance. TIM-3 is expressed on activated T cells and its signaling on cytotoxic T cells leads to T cell exhaustion which is mediated by carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and neck squamous cell carcinoma (HNSCC) specimens, linked to detailed outcome, clinic-pathological parameters. Here we reported scores and absolute counts of TIM-3+/CEACAM1+ TILs, and evaluated the expression of CEACAM1 on tumor tissues.Results: The results showed that more TIM-3+ TILs infiltration correlated with poorer overall survival (p < 0.001), as did the presence of CEACAM1 on cancer cells (p < 0.001) and CEACAM1+ TILs in tumor microenvironment (p = 0.015). Multivariate Cox regression analysis revealed that high TIM-3+ TILs may be considered as an independent prognostic factor of poor disease outcome (hazard ratio, 2.066; 95% confidence interval, 1.027–4.159; p = 0.042), as well as cancer cells expressed CEACAM1 level (hazard ratio, 5.885; 95% confidence interval, 2.832–12.230; p < 0.001).Conclusion: Our results indicate that expression of TIM-3 and CEACAM1 may represent a highly dysfunctional population of T cells. Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.
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title_short	TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma
url	https://doi.org/10.3389/fmolb.2021.619765 https://doaj.org/article/e8619bad42654c20b8a6baa291cb215a https://www.frontiersin.org/articles/10.3389/fmolb.2021.619765/full https://doaj.org/toc/2296-889X
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author2	Fan Yang Ziqing Zeng Jing Li Xiubao Ren Feng Wei
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up_date	2024-07-04T01:48:48.307Z
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