Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine

Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related...
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Autor*in:	Pierfrancesco Franco [verfasserIn] Fiorenza De Rose [verfasserIn] Maria Carmen De Santis [verfasserIn] Nadia Pasinetti [verfasserIn] Valentina Lancellotta [verfasserIn] Bruno Meduri [verfasserIn] Icro Meattini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Clinical and Translational Radiation Oncology - Elsevier, 2017, 21(2020), Seite 112-119
Übergeordnetes Werk:	volume:21 ; year:2020 ; pages:112-119

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ctro.2020.02.003

Katalog-ID:	DOAJ015187624

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653		0	\|a Medical physics. Medical radiology. Nuclear medicine
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.1016/j.ctro.2020.02.003 doi (DE-627)DOAJ015187624 (DE-599)DOAJ30bfc3c370a2406ba37a38620acf45f6 DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierfrancesco Franco verfasserin aut Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fiorenza De Rose verfasserin aut Maria Carmen De Santis verfasserin aut Nadia Pasinetti verfasserin aut Valentina Lancellotta verfasserin aut Bruno Meduri verfasserin aut Icro Meattini verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 21(2020), Seite 112-119 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:21 year:2020 pages:112-119 https://doi.org/10.1016/j.ctro.2020.02.003 kostenfrei https://doaj.org/article/30bfc3c370a2406ba37a38620acf45f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300094 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2020 112-119
spelling	10.1016/j.ctro.2020.02.003 doi (DE-627)DOAJ015187624 (DE-599)DOAJ30bfc3c370a2406ba37a38620acf45f6 DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierfrancesco Franco verfasserin aut Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fiorenza De Rose verfasserin aut Maria Carmen De Santis verfasserin aut Nadia Pasinetti verfasserin aut Valentina Lancellotta verfasserin aut Bruno Meduri verfasserin aut Icro Meattini verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 21(2020), Seite 112-119 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:21 year:2020 pages:112-119 https://doi.org/10.1016/j.ctro.2020.02.003 kostenfrei https://doaj.org/article/30bfc3c370a2406ba37a38620acf45f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300094 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2020 112-119
allfields_unstemmed	10.1016/j.ctro.2020.02.003 doi (DE-627)DOAJ015187624 (DE-599)DOAJ30bfc3c370a2406ba37a38620acf45f6 DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierfrancesco Franco verfasserin aut Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fiorenza De Rose verfasserin aut Maria Carmen De Santis verfasserin aut Nadia Pasinetti verfasserin aut Valentina Lancellotta verfasserin aut Bruno Meduri verfasserin aut Icro Meattini verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 21(2020), Seite 112-119 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:21 year:2020 pages:112-119 https://doi.org/10.1016/j.ctro.2020.02.003 kostenfrei https://doaj.org/article/30bfc3c370a2406ba37a38620acf45f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300094 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2020 112-119
allfieldsGer	10.1016/j.ctro.2020.02.003 doi (DE-627)DOAJ015187624 (DE-599)DOAJ30bfc3c370a2406ba37a38620acf45f6 DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierfrancesco Franco verfasserin aut Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fiorenza De Rose verfasserin aut Maria Carmen De Santis verfasserin aut Nadia Pasinetti verfasserin aut Valentina Lancellotta verfasserin aut Bruno Meduri verfasserin aut Icro Meattini verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 21(2020), Seite 112-119 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:21 year:2020 pages:112-119 https://doi.org/10.1016/j.ctro.2020.02.003 kostenfrei https://doaj.org/article/30bfc3c370a2406ba37a38620acf45f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300094 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2020 112-119
allfieldsSound	10.1016/j.ctro.2020.02.003 doi (DE-627)DOAJ015187624 (DE-599)DOAJ30bfc3c370a2406ba37a38620acf45f6 DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierfrancesco Franco verfasserin aut Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Fiorenza De Rose verfasserin aut Maria Carmen De Santis verfasserin aut Nadia Pasinetti verfasserin aut Valentina Lancellotta verfasserin aut Bruno Meduri verfasserin aut Icro Meattini verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 21(2020), Seite 112-119 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:21 year:2020 pages:112-119 https://doi.org/10.1016/j.ctro.2020.02.003 kostenfrei https://doaj.org/article/30bfc3c370a2406ba37a38620acf45f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300094 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2020 112-119
language	English
source	In Clinical and Translational Radiation Oncology 21(2020), Seite 112-119 volume:21 year:2020 pages:112-119
sourceStr	In Clinical and Translational Radiation Oncology 21(2020), Seite 112-119 volume:21 year:2020 pages:112-119
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Clinical and Translational Radiation Oncology
authorswithroles_txt_mv	Pierfrancesco Franco @@aut@@ Fiorenza De Rose @@aut@@ Maria Carmen De Santis @@aut@@ Nadia Pasinetti @@aut@@ Valentina Lancellotta @@aut@@ Bruno Meduri @@aut@@ Icro Meattini @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	880788097
id	DOAJ015187624
language_de	englisch
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spellingShingle	Pierfrancesco Franco misc R895-920 misc RC254-282 misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
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topic_title	R895-920 RC254-282 Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
topic	misc R895-920 misc RC254-282 misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
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title_full	Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
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title_sort	omission of postoperative radiation after breast conserving surgery: a progressive paradigm shift towards precision medicine
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title_auth	Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
abstract	Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology
abstractGer	Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology
abstract_unstemmed	Radiation therapy is a standard therapeutic option in the post-operative setting for early breast cancer patients after breast conserving surgery, providing a substantial benefit in reducing the risk of local relapse with a consequent survival gain. Nevertheless, the reduction in the burden related to treatment is becoming crucial in modern oncology for both local and systemic therapies and investigational efforts are being put forward by radiations oncologists to identify a subset of women at very low risk to be potentially omitted from post-operative irradiation after breast conservation. Clinical factors, classical pathological parameters and new predictive scores derived from gene expression and next generation sequencing techniques are being integrated in the quest toward a reliable low-risk profile for breast cancer patients. We herein provide a comprehensive overview on the topic. Keywords: Radiotherapy omission, Breast cancer, Breast conserving surgery, Low risk, Endocrine therapy, Whole breast irradiation, Partial breast irradiation, Elderly, Radiation oncology
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title_short	Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine
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Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine

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