Regional balance between glutamate+glutamine and GABA+ in the resting human brain

Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Adam Steel [verfasserIn] Mark Mikkelsen [verfasserIn] Richard A.E. Edden [verfasserIn] Caroline E. Robertson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	GABA Glutamate MRS Excitation Inhibition

Übergeordnetes Werk:	In: NeuroImage - Elsevier, 2020, 220(2020), Seite 117112-
Übergeordnetes Werk:	volume:220 ; year:2020 ; pages:117112-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.neuroimage.2020.117112

Katalog-ID:	DOAJ015298264

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callnumber-first	R - Medicine
author	Adam Steel
spellingShingle	Adam Steel misc RC321-571 misc GABA misc Glutamate misc MRS misc Excitation misc Inhibition misc Neurosciences. Biological psychiatry. Neuropsychiatry Regional balance between glutamate+glutamine and GABA+ in the resting human brain
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topic_title	RC321-571 Regional balance between glutamate+glutamine and GABA+ in the resting human brain GABA Glutamate MRS Excitation Inhibition
topic	misc RC321-571 misc GABA misc Glutamate misc MRS misc Excitation misc Inhibition misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Regional balance between glutamate+glutamine and GABA+ in the resting human brain
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title_full	Regional balance between glutamate+glutamine and GABA+ in the resting human brain
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author_browse	Adam Steel Mark Mikkelsen Richard A.E. Edden Caroline E. Robertson
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title_sort	regional balance between glutamate+glutamine and gaba+ in the resting human brain
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title_auth	Regional balance between glutamate+glutamine and GABA+ in the resting human brain
abstract	Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neurotransmitters are measured in vivo using magnetic resonance spectroscopy (MRS). However, despite the central importance of E/I balance to theories of brain function, a relationship between regional glutamate and GABA levels in the human brain has not been shown. We addressed this question in a large corpus of edited MRS data collected at 19 different sites (n = 220). Consistent with the notion of E/I balance, we found that levels of glutamate+glutamine (Glx) and GABA+ were highly correlated (R = 0.52, p = 2.86 x 10−14). This relationship held when controlling for site, scanner vendor, and demographics. Controlling for neurochemicals associated with neuronal density and metabolism (i.e. N-acetylaspartate and creatine) significantly reduced the correlation between GABA+ and Glx, suggesting that the levels of GABA+ and Glx may be critically linked to regional metabolism. These results are consistent with the notion that excitation and inhibition are balanced in the human brain.
abstractGer	Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neurotransmitters are measured in vivo using magnetic resonance spectroscopy (MRS). However, despite the central importance of E/I balance to theories of brain function, a relationship between regional glutamate and GABA levels in the human brain has not been shown. We addressed this question in a large corpus of edited MRS data collected at 19 different sites (n = 220). Consistent with the notion of E/I balance, we found that levels of glutamate+glutamine (Glx) and GABA+ were highly correlated (R = 0.52, p = 2.86 x 10−14). This relationship held when controlling for site, scanner vendor, and demographics. Controlling for neurochemicals associated with neuronal density and metabolism (i.e. N-acetylaspartate and creatine) significantly reduced the correlation between GABA+ and Glx, suggesting that the levels of GABA+ and Glx may be critically linked to regional metabolism. These results are consistent with the notion that excitation and inhibition are balanced in the human brain.
abstract_unstemmed	Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neurotransmitters are measured in vivo using magnetic resonance spectroscopy (MRS). However, despite the central importance of E/I balance to theories of brain function, a relationship between regional glutamate and GABA levels in the human brain has not been shown. We addressed this question in a large corpus of edited MRS data collected at 19 different sites (n = 220). Consistent with the notion of E/I balance, we found that levels of glutamate+glutamine (Glx) and GABA+ were highly correlated (R = 0.52, p = 2.86 x 10−14). This relationship held when controlling for site, scanner vendor, and demographics. Controlling for neurochemicals associated with neuronal density and metabolism (i.e. N-acetylaspartate and creatine) significantly reduced the correlation between GABA+ and Glx, suggesting that the levels of GABA+ and Glx may be critically linked to regional metabolism. These results are consistent with the notion that excitation and inhibition are balanced in the human brain.
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title_short	Regional balance between glutamate+glutamine and GABA+ in the resting human brain
url	https://doi.org/10.1016/j.neuroimage.2020.117112 https://doaj.org/article/8daffe00ab374b55bc5a944e541f5e61 http://www.sciencedirect.com/science/article/pii/S105381192030598X https://doaj.org/toc/1095-9572
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up_date	2024-07-03T14:09:19.186Z
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Regional balance between glutamate+glutamine and GABA+ in the resting human brain

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