Extracellular trap can be trained as a memory response

Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding o...
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Gespeichert in:

Autor*in:	Yu Gao [verfasserIn] Jian-Gang Zhang [verfasserIn] Zhen-Zhen Liu [verfasserIn] Ke Ma [verfasserIn] Xiao-Qi Lin [verfasserIn] Jia-Bao Zhang [verfasserIn] Wei Chen [verfasserIn] Yong-Jun Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Extracellular trap trained immunity trained memory innate immune memory response antimicrobial

Übergeordnetes Werk:	In: Virulence - Taylor & Francis Group, 2018, 13(2022), 1, Seite 471-482
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:471-482

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21505594.2022.2046950

Katalog-ID:	DOAJ015377237

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520			\|a Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders.
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allfields	10.1080/21505594.2022.2046950 doi (DE-627)DOAJ015377237 (DE-599)DOAJ3e4449e95b1d49ebb6ae596c09129d4a DE-627 ger DE-627 rakwb eng RC109-216 Yu Gao verfasserin aut Extracellular trap can be trained as a memory response 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders. Extracellular trap trained immunity trained memory innate immune memory response antimicrobial Infectious and parasitic diseases Jian-Gang Zhang verfasserin aut Zhen-Zhen Liu verfasserin aut Ke Ma verfasserin aut Xiao-Qi Lin verfasserin aut Jia-Bao Zhang verfasserin aut Wei Chen verfasserin aut Yong-Jun Yang verfasserin aut In Virulence Taylor & Francis Group, 2018 13(2022), 1, Seite 471-482 (DE-627)689717296 (DE-600)2657572-3 21505608 nnns volume:13 year:2022 number:1 pages:471-482 https://doi.org/10.1080/21505594.2022.2046950 kostenfrei https://doaj.org/article/3e4449e95b1d49ebb6ae596c09129d4a kostenfrei https://www.tandfonline.com/doi/10.1080/21505594.2022.2046950 kostenfrei https://doaj.org/toc/2150-5594 Journal toc kostenfrei https://doaj.org/toc/2150-5608 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 1 471-482
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allfieldsSound	10.1080/21505594.2022.2046950 doi (DE-627)DOAJ015377237 (DE-599)DOAJ3e4449e95b1d49ebb6ae596c09129d4a DE-627 ger DE-627 rakwb eng RC109-216 Yu Gao verfasserin aut Extracellular trap can be trained as a memory response 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders. Extracellular trap trained immunity trained memory innate immune memory response antimicrobial Infectious and parasitic diseases Jian-Gang Zhang verfasserin aut Zhen-Zhen Liu verfasserin aut Ke Ma verfasserin aut Xiao-Qi Lin verfasserin aut Jia-Bao Zhang verfasserin aut Wei Chen verfasserin aut Yong-Jun Yang verfasserin aut In Virulence Taylor & Francis Group, 2018 13(2022), 1, Seite 471-482 (DE-627)689717296 (DE-600)2657572-3 21505608 nnns volume:13 year:2022 number:1 pages:471-482 https://doi.org/10.1080/21505594.2022.2046950 kostenfrei https://doaj.org/article/3e4449e95b1d49ebb6ae596c09129d4a kostenfrei https://www.tandfonline.com/doi/10.1080/21505594.2022.2046950 kostenfrei https://doaj.org/toc/2150-5594 Journal toc kostenfrei https://doaj.org/toc/2150-5608 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 1 471-482
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callnumber-first	R - Medicine
author	Yu Gao
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topic_title	RC109-216 Extracellular trap can be trained as a memory response Extracellular trap trained immunity trained memory innate immune memory response antimicrobial
topic	misc RC109-216 misc Extracellular trap misc trained immunity misc trained memory misc innate immune misc memory response misc antimicrobial misc Infectious and parasitic diseases
topic_unstemmed	misc RC109-216 misc Extracellular trap misc trained immunity misc trained memory misc innate immune misc memory response misc antimicrobial misc Infectious and parasitic diseases
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title	Extracellular trap can be trained as a memory response
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title_full	Extracellular trap can be trained as a memory response
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title_sort	extracellular trap can be trained as a memory response
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title_auth	Extracellular trap can be trained as a memory response
abstract	Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders.
abstractGer	Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders.
abstract_unstemmed	Extracellular trap (ET) appears as a double-edged sword for the host since it participates in host immune defense by entrapping pathogens, while excessive ET release also contributes to various diseases progression including atherosclerosis, cancer, and autoimmune disorders. A better understanding of ET formation and regulation will be beneficial for developing strategies for infection control and ET-associated disease treatment. There is some evidence indicating that prior infection can enhance extracellular killing. Neutrophils from cancer or sepsis are predisposed to generate ET. It is reasonable to suspect that ET may be trained to form as a memory response, just like cytokine memory response termed “trained immunity.” The mice were intraperitoneally injected with heat-killed Candida albicans (HK-C. albicans), 3 days later bone marrow-derived macrophages (BMDM) were isolated and challenged with Clostridium perfringens as a second stimulation. We found that HK-C. albicans priming enhanced ET formation upon Clostridium perfringens infection, accompanied by increased extracellular killing capacity. Mannan priming also enhanced ET formation. Since ETs memory was induced in chicken PBMC, ETs memory may be evolutionarily conserved. Moreover, mTOR was required for ETs memory response. Collectively, this study showed that ETs can be trained as a memory response and indicated that memory property of ETs should be considered during the understanding of recurrent infection and ET-associated disorders.
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title_short	Extracellular trap can be trained as a memory response
url	https://doi.org/10.1080/21505594.2022.2046950 https://doaj.org/article/3e4449e95b1d49ebb6ae596c09129d4a https://www.tandfonline.com/doi/10.1080/21505594.2022.2046950 https://doaj.org/toc/2150-5594 https://doaj.org/toc/2150-5608
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author2	Jian-Gang Zhang Zhen-Zhen Liu Ke Ma Xiao-Qi Lin Jia-Bao Zhang Wei Chen Yong-Jun Yang
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up_date	2024-07-03T14:38:12.170Z
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