The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is sc...
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Autor*in:	Chen Tang [verfasserIn] Hanxiang Jiang [verfasserIn] Bin Zhao [verfasserIn] Yi Lin [verfasserIn] Shengnan Lin [verfasserIn] Tianmu Chen [verfasserIn] Yanhua Su [verfasserIn] Yiqin Zhang [verfasserIn] Lina Zhou [verfasserIn] Lianmeng Li [verfasserIn] Jincheng Lin [verfasserIn] Zhonghua Lu [verfasserIn] Yao Wang [verfasserIn] Zeyu Zhao [verfasserIn] Longjian Liu [verfasserIn] Yuxin Wang [verfasserIn] Jie Zhang [verfasserIn] Heqing Shen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Ageing Bilirubin Cohort study Hypertension

Übergeordnetes Werk:	In: Journal of Translational Medicine - BMC, 2003, 20(2022), 1, Seite 16
Übergeordnetes Werk:	volume:20 ; year:2022 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12967-022-03309-7

Katalog-ID:	DOAJ015407101

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520			\|a Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.
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allfields	10.1186/s12967-022-03309-7 doi (DE-627)DOAJ015407101 (DE-599)DOAJaa02167d15c64acf9fcad3c1f4ce95db DE-627 ger DE-627 rakwb eng Chen Tang verfasserin aut The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated. Ageing Bilirubin Cohort study Hypertension Medicine R Hanxiang Jiang verfasserin aut Bin Zhao verfasserin aut Yi Lin verfasserin aut Shengnan Lin verfasserin aut Tianmu Chen verfasserin aut Yanhua Su verfasserin aut Yiqin Zhang verfasserin aut Lina Zhou verfasserin aut Lianmeng Li verfasserin aut Jincheng Lin verfasserin aut Zhonghua Lu verfasserin aut Yao Wang verfasserin aut Zeyu Zhao verfasserin aut Longjian Liu verfasserin aut Yuxin Wang verfasserin aut Jie Zhang verfasserin aut Heqing Shen verfasserin aut In Journal of Translational Medicine BMC, 2003 20(2022), 1, Seite 16 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:20 year:2022 number:1 pages:16 https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db kostenfrei https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 16
spelling	10.1186/s12967-022-03309-7 doi (DE-627)DOAJ015407101 (DE-599)DOAJaa02167d15c64acf9fcad3c1f4ce95db DE-627 ger DE-627 rakwb eng Chen Tang verfasserin aut The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated. Ageing Bilirubin Cohort study Hypertension Medicine R Hanxiang Jiang verfasserin aut Bin Zhao verfasserin aut Yi Lin verfasserin aut Shengnan Lin verfasserin aut Tianmu Chen verfasserin aut Yanhua Su verfasserin aut Yiqin Zhang verfasserin aut Lina Zhou verfasserin aut Lianmeng Li verfasserin aut Jincheng Lin verfasserin aut Zhonghua Lu verfasserin aut Yao Wang verfasserin aut Zeyu Zhao verfasserin aut Longjian Liu verfasserin aut Yuxin Wang verfasserin aut Jie Zhang verfasserin aut Heqing Shen verfasserin aut In Journal of Translational Medicine BMC, 2003 20(2022), 1, Seite 16 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:20 year:2022 number:1 pages:16 https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db kostenfrei https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 16
allfields_unstemmed	10.1186/s12967-022-03309-7 doi (DE-627)DOAJ015407101 (DE-599)DOAJaa02167d15c64acf9fcad3c1f4ce95db DE-627 ger DE-627 rakwb eng Chen Tang verfasserin aut The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated. Ageing Bilirubin Cohort study Hypertension Medicine R Hanxiang Jiang verfasserin aut Bin Zhao verfasserin aut Yi Lin verfasserin aut Shengnan Lin verfasserin aut Tianmu Chen verfasserin aut Yanhua Su verfasserin aut Yiqin Zhang verfasserin aut Lina Zhou verfasserin aut Lianmeng Li verfasserin aut Jincheng Lin verfasserin aut Zhonghua Lu verfasserin aut Yao Wang verfasserin aut Zeyu Zhao verfasserin aut Longjian Liu verfasserin aut Yuxin Wang verfasserin aut Jie Zhang verfasserin aut Heqing Shen verfasserin aut In Journal of Translational Medicine BMC, 2003 20(2022), 1, Seite 16 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:20 year:2022 number:1 pages:16 https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db kostenfrei https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 16
allfieldsGer	10.1186/s12967-022-03309-7 doi (DE-627)DOAJ015407101 (DE-599)DOAJaa02167d15c64acf9fcad3c1f4ce95db DE-627 ger DE-627 rakwb eng Chen Tang verfasserin aut The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated. Ageing Bilirubin Cohort study Hypertension Medicine R Hanxiang Jiang verfasserin aut Bin Zhao verfasserin aut Yi Lin verfasserin aut Shengnan Lin verfasserin aut Tianmu Chen verfasserin aut Yanhua Su verfasserin aut Yiqin Zhang verfasserin aut Lina Zhou verfasserin aut Lianmeng Li verfasserin aut Jincheng Lin verfasserin aut Zhonghua Lu verfasserin aut Yao Wang verfasserin aut Zeyu Zhao verfasserin aut Longjian Liu verfasserin aut Yuxin Wang verfasserin aut Jie Zhang verfasserin aut Heqing Shen verfasserin aut In Journal of Translational Medicine BMC, 2003 20(2022), 1, Seite 16 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:20 year:2022 number:1 pages:16 https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db kostenfrei https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 16
allfieldsSound	10.1186/s12967-022-03309-7 doi (DE-627)DOAJ015407101 (DE-599)DOAJaa02167d15c64acf9fcad3c1f4ce95db DE-627 ger DE-627 rakwb eng Chen Tang verfasserin aut The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated. Ageing Bilirubin Cohort study Hypertension Medicine R Hanxiang Jiang verfasserin aut Bin Zhao verfasserin aut Yi Lin verfasserin aut Shengnan Lin verfasserin aut Tianmu Chen verfasserin aut Yanhua Su verfasserin aut Yiqin Zhang verfasserin aut Lina Zhou verfasserin aut Lianmeng Li verfasserin aut Jincheng Lin verfasserin aut Zhonghua Lu verfasserin aut Yao Wang verfasserin aut Zeyu Zhao verfasserin aut Longjian Liu verfasserin aut Yuxin Wang verfasserin aut Jie Zhang verfasserin aut Heqing Shen verfasserin aut In Journal of Translational Medicine BMC, 2003 20(2022), 1, Seite 16 (DE-627)369084136 (DE-600)2118570-0 14795876 nnns volume:20 year:2022 number:1 pages:16 https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db kostenfrei https://doi.org/10.1186/s12967-022-03309-7 kostenfrei https://doaj.org/toc/1479-5876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 16
language	English
source	In Journal of Translational Medicine 20(2022), 1, Seite 16 volume:20 year:2022 number:1 pages:16
sourceStr	In Journal of Translational Medicine 20(2022), 1, Seite 16 volume:20 year:2022 number:1 pages:16
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Ageing Bilirubin Cohort study Hypertension Medicine R
isfreeaccess_bool	true
container_title	Journal of Translational Medicine
authorswithroles_txt_mv	Chen Tang @@aut@@ Hanxiang Jiang @@aut@@ Bin Zhao @@aut@@ Yi Lin @@aut@@ Shengnan Lin @@aut@@ Tianmu Chen @@aut@@ Yanhua Su @@aut@@ Yiqin Zhang @@aut@@ Lina Zhou @@aut@@ Lianmeng Li @@aut@@ Jincheng Lin @@aut@@ Zhonghua Lu @@aut@@ Yao Wang @@aut@@ Zeyu Zhao @@aut@@ Longjian Liu @@aut@@ Yuxin Wang @@aut@@ Jie Zhang @@aut@@ Heqing Shen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	369084136
id	DOAJ015407101
language_de	englisch
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Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. 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author	Chen Tang
spellingShingle	Chen Tang misc Ageing misc Bilirubin misc Cohort study misc Hypertension misc Medicine misc R The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
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topic_title	The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study Ageing Bilirubin Cohort study Hypertension
topic	misc Ageing misc Bilirubin misc Cohort study misc Hypertension misc Medicine misc R
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title	The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
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title_full	The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
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author_browse	Chen Tang Hanxiang Jiang Bin Zhao Yi Lin Shengnan Lin Tianmu Chen Yanhua Su Yiqin Zhang Lina Zhou Lianmeng Li Jincheng Lin Zhonghua Lu Yao Wang Zeyu Zhao Longjian Liu Yuxin Wang Jie Zhang Heqing Shen
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title_sort	association between bilirubin and hypertension among a chinese ageing cohort: a prospective follow-up study
title_auth	The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
abstract	Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.
abstractGer	Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.
abstract_unstemmed	Abstract Background Hypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities among adults. Although the correlation between bilirubin and hypertension has been reported, the observation in quinquagenarian population is scarce. We aimed to examine bilirubin-hypertension association in Guankou Ageing Cohort Study. Methods Participants ≥ 55 years were recruited and their questionnaires and physical examination data were collected. Kaplan–Meier survival analysis and Cox proportional hazards regression were implemented to assess the hypertension risk. The non-liner dose–response relationships of bilirubin-hypertension were determined by restricted cubic spline (RCS) models. Receiver operating characteristic (ROC) curves and multiple factors analysis (MFA) were performed to evaluate the predictive abilities. Results 1881 eligible participants (male 43.75%, female 56.25%) with the median age of 61.00 (59.00–66.00) were included. The hazard ratio (HR, 95% CI) of serum total bilirubin (STB) and unconjugated bilirubin (UCB) were 1.03 (1.01–1.05) and 1.05 (1.03–1.07), while conjugated bilirubin (CB) showed a weak protective effect with the HR of 0.96 (0.92–0.99), and the associations remained significant in all models. RCS analyses further indicated the similar bidirectional effects of STB and UCB with the cut-off of 12.17 μmol/L and 8.59 μmol/L, while CB exhibited inverse bidirectional dose–response relationship with a cut-off of 3.47 μmol/L. ROC curves and MFA showed baseline STB combined with age, BMI, and waist circumference could well discriminate the low and high of hypertension risk. Conclusions Our findings suggested the higher levels of total and unconjugated bilirubin were hazardous factors of hypertension, while an inverse effect presented when more bilirubin was conjugated.
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title_short	The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
url	https://doi.org/10.1186/s12967-022-03309-7 https://doaj.org/article/aa02167d15c64acf9fcad3c1f4ce95db https://doaj.org/toc/1479-5876
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The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study

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