Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease

Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-N...
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Autor*in:	Giacomo Giacalone [verfasserIn] Marta Zanoletti [verfasserIn] Rebecca Re [verfasserIn] Davide Contini [verfasserIn] Lorenzo Spinelli [verfasserIn] Alessandro Torricelli [verfasserIn] Luisa Roveri [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS

Übergeordnetes Werk:	In: Applied Sciences - MDPI AG, 2012, 11(2021), 5, p 2407
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:5, p 2407

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/app11052407

Katalog-ID:	DOAJ015713814

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520			\|a Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD.
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allfields_unstemmed	10.3390/app11052407 doi (DE-627)DOAJ015713814 (DE-599)DOAJ3f41e1a7ab4349f3acda584de92eac7a DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Giacomo Giacalone verfasserin aut Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD. microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Marta Zanoletti verfasserin aut Rebecca Re verfasserin aut Davide Contini verfasserin aut Lorenzo Spinelli verfasserin aut Alessandro Torricelli verfasserin aut Luisa Roveri verfasserin aut In Applied Sciences MDPI AG, 2012 11(2021), 5, p 2407 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:11 year:2021 number:5, p 2407 https://doi.org/10.3390/app11052407 kostenfrei https://doaj.org/article/3f41e1a7ab4349f3acda584de92eac7a kostenfrei https://www.mdpi.com/2076-3417/11/5/2407 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 2407
allfieldsGer	10.3390/app11052407 doi (DE-627)DOAJ015713814 (DE-599)DOAJ3f41e1a7ab4349f3acda584de92eac7a DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Giacomo Giacalone verfasserin aut Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD. microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Marta Zanoletti verfasserin aut Rebecca Re verfasserin aut Davide Contini verfasserin aut Lorenzo Spinelli verfasserin aut Alessandro Torricelli verfasserin aut Luisa Roveri verfasserin aut In Applied Sciences MDPI AG, 2012 11(2021), 5, p 2407 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:11 year:2021 number:5, p 2407 https://doi.org/10.3390/app11052407 kostenfrei https://doaj.org/article/3f41e1a7ab4349f3acda584de92eac7a kostenfrei https://www.mdpi.com/2076-3417/11/5/2407 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 2407
allfieldsSound	10.3390/app11052407 doi (DE-627)DOAJ015713814 (DE-599)DOAJ3f41e1a7ab4349f3acda584de92eac7a DE-627 ger DE-627 rakwb eng TA1-2040 QH301-705.5 QC1-999 QD1-999 Giacomo Giacalone verfasserin aut Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD. microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry Marta Zanoletti verfasserin aut Rebecca Re verfasserin aut Davide Contini verfasserin aut Lorenzo Spinelli verfasserin aut Alessandro Torricelli verfasserin aut Luisa Roveri verfasserin aut In Applied Sciences MDPI AG, 2012 11(2021), 5, p 2407 (DE-627)737287640 (DE-600)2704225-X 20763417 nnns volume:11 year:2021 number:5, p 2407 https://doi.org/10.3390/app11052407 kostenfrei https://doaj.org/article/3f41e1a7ab4349f3acda584de92eac7a kostenfrei https://www.mdpi.com/2076-3417/11/5/2407 kostenfrei https://doaj.org/toc/2076-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 2407
language	English
source	In Applied Sciences 11(2021), 5, p 2407 volume:11 year:2021 number:5, p 2407
sourceStr	In Applied Sciences 11(2021), 5, p 2407 volume:11 year:2021 number:5, p 2407
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS Technology T Engineering (General). Civil engineering (General) Biology (General) Physics Chemistry
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container_title	Applied Sciences
authorswithroles_txt_mv	Giacomo Giacalone @@aut@@ Marta Zanoletti @@aut@@ Rebecca Re @@aut@@ Davide Contini @@aut@@ Lorenzo Spinelli @@aut@@ Alessandro Torricelli @@aut@@ Luisa Roveri @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	737287640
id	DOAJ015713814
language_de	englisch
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author	Giacomo Giacalone
spellingShingle	Giacomo Giacalone misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc microcirculation dysfunction in cerebral small vessel disease misc asymptomatic cerebral small vessel disease misc NIRS in cerebrovascular diseases misc oxygen saturation in cerebral small vessel disease misc novel applications of time-domain near-infrared spectroscopy misc TD-NIRS misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
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topic_title	TA1-2040 QH301-705.5 QC1-999 QD1-999 Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease microcirculation dysfunction in cerebral small vessel disease asymptomatic cerebral small vessel disease NIRS in cerebrovascular diseases oxygen saturation in cerebral small vessel disease novel applications of time-domain near-infrared spectroscopy TD-NIRS
topic	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc microcirculation dysfunction in cerebral small vessel disease misc asymptomatic cerebral small vessel disease misc NIRS in cerebrovascular diseases misc oxygen saturation in cerebral small vessel disease misc novel applications of time-domain near-infrared spectroscopy misc TD-NIRS misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
topic_unstemmed	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc microcirculation dysfunction in cerebral small vessel disease misc asymptomatic cerebral small vessel disease misc NIRS in cerebrovascular diseases misc oxygen saturation in cerebral small vessel disease misc novel applications of time-domain near-infrared spectroscopy misc TD-NIRS misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
topic_browse	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc microcirculation dysfunction in cerebral small vessel disease misc asymptomatic cerebral small vessel disease misc NIRS in cerebrovascular diseases misc oxygen saturation in cerebral small vessel disease misc novel applications of time-domain near-infrared spectroscopy misc TD-NIRS misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
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title	Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
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title_full	Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
author_sort	Giacomo Giacalone
journal	Applied Sciences
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author_browse	Giacomo Giacalone Marta Zanoletti Rebecca Re Davide Contini Lorenzo Spinelli Alessandro Torricelli Luisa Roveri
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title_sort	time-domain near-infrared spectroscopy in subjects with asymptomatic cerebral small vessel disease
callnumber	TA1-2040
title_auth	Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
abstract	Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD.
abstractGer	Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD.
abstract_unstemmed	Biomarkers of microcirculation dysfunction may help in the study of cerebral small vessel disease (CSVD). Time-Domain Near-Infrared spectroscopy (TD-NIRS), estimating the oxygenation of microcirculation of cerebral outer layers, might indirectly correlate with CSVD. We retrospectively evaluated TD-NIRS data from healthy subjects with age ≥ 55 years; no history of brain disease; normal neurological examination; absence of stenosis < 50% of extra/intra-cranial arteries; incidental finding of asymptomatic CSVD at brain magnetic resonance imaging (MRI). According to Fazekas scale, subjects were classified by presence of white matter hyperintensities in periventricular region (pvWMHs), deep white matter region (dWMHs), or both (d+pvWMHs). We compared the concentration of hemoglobin species and tissue oxygen saturation (StO<sub<2</sub<) among these groups. The study included 20 subjects, median age 67.5 (IQR 61–78) years old (6 without WMHs, 5 with pvWMHs, 9 with d+pvWMHs). Subjects with d+pvWMHs had significantly lower StO<sub<2</sub< compared to subjects without WMHs (<i<p</i< = 0.022) or with pvWMHs (<i<p</i< = 0.004). StO<sub<2</sub< < 56.7% indicated the presence of d+pvWMHs with 91% sensitivity and 67% specificity [AUC 91% (CI 95% 78–100%)]. In this preliminary study, cerebral TD-NIRS detected significantly lower StO<sub<2</sub< in subjects with radiological signs of asymptomatic CSVD. Further studies are needed to evaluate if StO<sub<2</sub< might represent a marker of asymptomatic CSVD.
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title_short	Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
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