Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.

<h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Juan P de-Torres [verfasserIn] David Blanco [verfasserIn] Ana B Alcaide [verfasserIn] Luis M Seijo [verfasserIn] Gorka Bastarrika [verfasserIn] María José Pajares [verfasserIn] Arrate Muñoz-Barrutia [verfasserIn] Carlos Ortiz-de-Solorzano [verfasserIn] Ruben Pio [verfasserIn] Arantza Campo [verfasserIn] Usua Montes [verfasserIn] Victor Segura [verfasserIn] Jesús Pueyo [verfasserIn] Luis M Montuenga [verfasserIn] Javier J Zulueta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 8(2013), 4, p e60260
Übergeordnetes Werk:	volume:8 ; year:2013 ; number:4, p e60260

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0060260

Katalog-ID:	DOAJ015781372

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245	1	0	\|a Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
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520			\|a <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases.
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700	0		\|a Arantza Campo \|e verfasserin \|4 aut
700	0		\|a Usua Montes \|e verfasserin \|4 aut
700	0		\|a Victor Segura \|e verfasserin \|4 aut
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700	0		\|a Luis M Montuenga \|e verfasserin \|4 aut
700	0		\|a Javier J Zulueta \|e verfasserin \|4 aut
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allfields	10.1371/journal.pone.0060260 doi (DE-627)DOAJ015781372 (DE-599)DOAJc2bd8e4dc3cc4fc688fa0329e2742b85 DE-627 ger DE-627 rakwb eng Juan P de-Torres verfasserin aut Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. Medicine R Science Q David Blanco verfasserin aut Ana B Alcaide verfasserin aut Luis M Seijo verfasserin aut Gorka Bastarrika verfasserin aut María José Pajares verfasserin aut Arrate Muñoz-Barrutia verfasserin aut Carlos Ortiz-de-Solorzano verfasserin aut Ruben Pio verfasserin aut Arantza Campo verfasserin aut Usua Montes verfasserin aut Victor Segura verfasserin aut Jesús Pueyo verfasserin aut Luis M Montuenga verfasserin aut Javier J Zulueta verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 4, p e60260 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:4, p e60260 https://doi.org/10.1371/journal.pone.0060260 kostenfrei https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 4, p e60260
spelling	10.1371/journal.pone.0060260 doi (DE-627)DOAJ015781372 (DE-599)DOAJc2bd8e4dc3cc4fc688fa0329e2742b85 DE-627 ger DE-627 rakwb eng Juan P de-Torres verfasserin aut Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. Medicine R Science Q David Blanco verfasserin aut Ana B Alcaide verfasserin aut Luis M Seijo verfasserin aut Gorka Bastarrika verfasserin aut María José Pajares verfasserin aut Arrate Muñoz-Barrutia verfasserin aut Carlos Ortiz-de-Solorzano verfasserin aut Ruben Pio verfasserin aut Arantza Campo verfasserin aut Usua Montes verfasserin aut Victor Segura verfasserin aut Jesús Pueyo verfasserin aut Luis M Montuenga verfasserin aut Javier J Zulueta verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 4, p e60260 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:4, p e60260 https://doi.org/10.1371/journal.pone.0060260 kostenfrei https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 4, p e60260
allfields_unstemmed	10.1371/journal.pone.0060260 doi (DE-627)DOAJ015781372 (DE-599)DOAJc2bd8e4dc3cc4fc688fa0329e2742b85 DE-627 ger DE-627 rakwb eng Juan P de-Torres verfasserin aut Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. Medicine R Science Q David Blanco verfasserin aut Ana B Alcaide verfasserin aut Luis M Seijo verfasserin aut Gorka Bastarrika verfasserin aut María José Pajares verfasserin aut Arrate Muñoz-Barrutia verfasserin aut Carlos Ortiz-de-Solorzano verfasserin aut Ruben Pio verfasserin aut Arantza Campo verfasserin aut Usua Montes verfasserin aut Victor Segura verfasserin aut Jesús Pueyo verfasserin aut Luis M Montuenga verfasserin aut Javier J Zulueta verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 4, p e60260 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:4, p e60260 https://doi.org/10.1371/journal.pone.0060260 kostenfrei https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 4, p e60260
allfieldsGer	10.1371/journal.pone.0060260 doi (DE-627)DOAJ015781372 (DE-599)DOAJc2bd8e4dc3cc4fc688fa0329e2742b85 DE-627 ger DE-627 rakwb eng Juan P de-Torres verfasserin aut Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. Medicine R Science Q David Blanco verfasserin aut Ana B Alcaide verfasserin aut Luis M Seijo verfasserin aut Gorka Bastarrika verfasserin aut María José Pajares verfasserin aut Arrate Muñoz-Barrutia verfasserin aut Carlos Ortiz-de-Solorzano verfasserin aut Ruben Pio verfasserin aut Arantza Campo verfasserin aut Usua Montes verfasserin aut Victor Segura verfasserin aut Jesús Pueyo verfasserin aut Luis M Montuenga verfasserin aut Javier J Zulueta verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 4, p e60260 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:4, p e60260 https://doi.org/10.1371/journal.pone.0060260 kostenfrei https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 4, p e60260
allfieldsSound	10.1371/journal.pone.0060260 doi (DE-627)DOAJ015781372 (DE-599)DOAJc2bd8e4dc3cc4fc688fa0329e2742b85 DE-627 ger DE-627 rakwb eng Juan P de-Torres verfasserin aut Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases. Medicine R Science Q David Blanco verfasserin aut Ana B Alcaide verfasserin aut Luis M Seijo verfasserin aut Gorka Bastarrika verfasserin aut María José Pajares verfasserin aut Arrate Muñoz-Barrutia verfasserin aut Carlos Ortiz-de-Solorzano verfasserin aut Ruben Pio verfasserin aut Arantza Campo verfasserin aut Usua Montes verfasserin aut Victor Segura verfasserin aut Jesús Pueyo verfasserin aut Luis M Montuenga verfasserin aut Javier J Zulueta verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 4, p e60260 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:4, p e60260 https://doi.org/10.1371/journal.pone.0060260 kostenfrei https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 4, p e60260
language	English
source	In PLoS ONE 8(2013), 4, p e60260 volume:8 year:2013 number:4, p e60260
sourceStr	In PLoS ONE 8(2013), 4, p e60260 volume:8 year:2013 number:4, p e60260
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Juan P de-Torres @@aut@@ David Blanco @@aut@@ Ana B Alcaide @@aut@@ Luis M Seijo @@aut@@ Gorka Bastarrika @@aut@@ María José Pajares @@aut@@ Arrate Muñoz-Barrutia @@aut@@ Carlos Ortiz-de-Solorzano @@aut@@ Ruben Pio @@aut@@ Arantza Campo @@aut@@ Usua Montes @@aut@@ Victor Segura @@aut@@ Jesús Pueyo @@aut@@ Luis M Montuenga @@aut@@ Javier J Zulueta @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ015781372
language_de	englisch
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Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. 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author	Juan P de-Torres
spellingShingle	Juan P de-Torres misc Medicine misc R misc Science misc Q Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
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topic_title	Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra
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title	Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
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title_full	Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra
author_sort	Juan P de-Torres
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author_browse	Juan P de-Torres David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta
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author-letter	Juan P de-Torres
doi_str_mv	10.1371/journal.pone.0060260
author2-role	verfasserin
title_sort	smokers with ct detected emphysema and no airway obstruction have decreased plasma levels of egf, il-15, il-8 and il-1ra
title_auth	Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
abstract	<h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases.
abstractGer	<h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases.
abstract_unstemmed	<h4<Rationale</h4<Low-grade inflammation and emphysema have been shown to be associated with an increased risk of lung cancer. However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases.
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title_short	Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.
url	https://doi.org/10.1371/journal.pone.0060260 https://doaj.org/article/c2bd8e4dc3cc4fc688fa0329e2742b85 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577098/?tool=EBI https://doaj.org/toc/1932-6203
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author2	David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta
author2Str	David Blanco Ana B Alcaide Luis M Seijo Gorka Bastarrika María José Pajares Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano Ruben Pio Arantza Campo Usua Montes Victor Segura Jesús Pueyo Luis M Montuenga Javier J Zulueta
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doi_str	10.1371/journal.pone.0060260
up_date	2024-07-03T17:01:58.867Z
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However, the systemic inflammatory response in patients with emphysema is still unknown.<h4<Objective</h4<TO COMPARE THE PLASMA CYTOKINE PROFILES IN TWO GROUPS OF CURRENT OR FORMER SMOKERS WITHOUT AIRWAY OBSTRUCTION: a control group of individuals without computed tomography (CT) detected emphysema vs. a study group of individuals with CT detected emphysema.<h4<Methods</h4<Subjects underwent a chest CT, spirometry, and determination of EGF, IL-15, IL-1ra, IL-8, MCP-1, MIP-1β, TGFα, TNFα, and VEGF levels in plasma. Cytokine levels in each group were compared adjusting for confounding factors.<h4<Results</h4<160 current smokers and former smokers without airway obstruction participated in the study: 80 without emphysema and 80 subjects with emphysema. Adjusted group comparisons revealed significant reductions in EGF (-0.317, p = 0.01), IL-15 (-0.21, p = 0.01), IL-8 (-0.180, p = 0.02) and IL-1ra (-0.220, p = 0.03) in subjects with emphysema and normal spirometry.<h4<Conclusions</h4<Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. 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Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra.

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