Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination

Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Andrew P. Maurer [verfasserIn] Sarah A. Johnson [verfasserIn] Abbi R. Hernandez [verfasserIn] Jordan Reasor [verfasserIn] Daniela M. Cossio [verfasserIn] Kaeli E. Fertal [verfasserIn] Jack M. Mizell [verfasserIn] Katelyn N. Lubke [verfasserIn] Benjamin J. Clark [verfasserIn] Sara N. Burke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Arc hippocampus immediate-early gene memory retrograde tracer

Übergeordnetes Werk:	In: Frontiers in Systems Neuroscience - Frontiers Media S.A., 2008, 11(2017)
Übergeordnetes Werk:	volume:11 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnsys.2017.00049

Katalog-ID:	DOAJ015781933

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allfields	10.3389/fnsys.2017.00049 doi (DE-627)DOAJ015781933 (DE-599)DOAJ9498849033014ca3a8318979a37c2842 DE-627 ger DE-627 rakwb eng RC321-571 Andrew P. Maurer verfasserin aut Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry Andrew P. Maurer verfasserin aut Sarah A. Johnson verfasserin aut Abbi R. Hernandez verfasserin aut Jordan Reasor verfasserin aut Daniela M. Cossio verfasserin aut Daniela M. Cossio verfasserin aut Kaeli E. Fertal verfasserin aut Jack M. Mizell verfasserin aut Katelyn N. Lubke verfasserin aut Katelyn N. Lubke verfasserin aut Benjamin J. Clark verfasserin aut Sara N. Burke verfasserin aut Sara N. Burke verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 11(2017) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:11 year:2017 https://doi.org/10.3389/fnsys.2017.00049 kostenfrei https://doaj.org/article/9498849033014ca3a8318979a37c2842 kostenfrei http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017
spelling	10.3389/fnsys.2017.00049 doi (DE-627)DOAJ015781933 (DE-599)DOAJ9498849033014ca3a8318979a37c2842 DE-627 ger DE-627 rakwb eng RC321-571 Andrew P. Maurer verfasserin aut Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry Andrew P. Maurer verfasserin aut Sarah A. Johnson verfasserin aut Abbi R. Hernandez verfasserin aut Jordan Reasor verfasserin aut Daniela M. Cossio verfasserin aut Daniela M. Cossio verfasserin aut Kaeli E. Fertal verfasserin aut Jack M. Mizell verfasserin aut Katelyn N. Lubke verfasserin aut Katelyn N. Lubke verfasserin aut Benjamin J. Clark verfasserin aut Sara N. Burke verfasserin aut Sara N. Burke verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 11(2017) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:11 year:2017 https://doi.org/10.3389/fnsys.2017.00049 kostenfrei https://doaj.org/article/9498849033014ca3a8318979a37c2842 kostenfrei http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017
allfields_unstemmed	10.3389/fnsys.2017.00049 doi (DE-627)DOAJ015781933 (DE-599)DOAJ9498849033014ca3a8318979a37c2842 DE-627 ger DE-627 rakwb eng RC321-571 Andrew P. Maurer verfasserin aut Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry Andrew P. Maurer verfasserin aut Sarah A. Johnson verfasserin aut Abbi R. Hernandez verfasserin aut Jordan Reasor verfasserin aut Daniela M. Cossio verfasserin aut Daniela M. Cossio verfasserin aut Kaeli E. Fertal verfasserin aut Jack M. Mizell verfasserin aut Katelyn N. Lubke verfasserin aut Katelyn N. Lubke verfasserin aut Benjamin J. Clark verfasserin aut Sara N. Burke verfasserin aut Sara N. Burke verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 11(2017) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:11 year:2017 https://doi.org/10.3389/fnsys.2017.00049 kostenfrei https://doaj.org/article/9498849033014ca3a8318979a37c2842 kostenfrei http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017
allfieldsGer	10.3389/fnsys.2017.00049 doi (DE-627)DOAJ015781933 (DE-599)DOAJ9498849033014ca3a8318979a37c2842 DE-627 ger DE-627 rakwb eng RC321-571 Andrew P. Maurer verfasserin aut Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry Andrew P. Maurer verfasserin aut Sarah A. Johnson verfasserin aut Abbi R. Hernandez verfasserin aut Jordan Reasor verfasserin aut Daniela M. Cossio verfasserin aut Daniela M. Cossio verfasserin aut Kaeli E. Fertal verfasserin aut Jack M. Mizell verfasserin aut Katelyn N. Lubke verfasserin aut Katelyn N. Lubke verfasserin aut Benjamin J. Clark verfasserin aut Sara N. Burke verfasserin aut Sara N. Burke verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 11(2017) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:11 year:2017 https://doi.org/10.3389/fnsys.2017.00049 kostenfrei https://doaj.org/article/9498849033014ca3a8318979a37c2842 kostenfrei http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017
allfieldsSound	10.3389/fnsys.2017.00049 doi (DE-627)DOAJ015781933 (DE-599)DOAJ9498849033014ca3a8318979a37c2842 DE-627 ger DE-627 rakwb eng RC321-571 Andrew P. Maurer verfasserin aut Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network. Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry Andrew P. Maurer verfasserin aut Sarah A. Johnson verfasserin aut Abbi R. Hernandez verfasserin aut Jordan Reasor verfasserin aut Daniela M. Cossio verfasserin aut Daniela M. Cossio verfasserin aut Kaeli E. Fertal verfasserin aut Jack M. Mizell verfasserin aut Katelyn N. Lubke verfasserin aut Katelyn N. Lubke verfasserin aut Benjamin J. Clark verfasserin aut Sara N. Burke verfasserin aut Sara N. Burke verfasserin aut In Frontiers in Systems Neuroscience Frontiers Media S.A., 2008 11(2017) (DE-627)579826740 (DE-600)2453005-0 16625137 nnns volume:11 year:2017 https://doi.org/10.3389/fnsys.2017.00049 kostenfrei https://doaj.org/article/9498849033014ca3a8318979a37c2842 kostenfrei http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full kostenfrei https://doaj.org/toc/1662-5137 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017
language	English
source	In Frontiers in Systems Neuroscience 11(2017) volume:11 year:2017
sourceStr	In Frontiers in Systems Neuroscience 11(2017) volume:11 year:2017
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Arc hippocampus immediate-early gene memory retrograde tracer Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Frontiers in Systems Neuroscience
authorswithroles_txt_mv	Andrew P. Maurer @@aut@@ Sarah A. Johnson @@aut@@ Abbi R. Hernandez @@aut@@ Jordan Reasor @@aut@@ Daniela M. Cossio @@aut@@ Kaeli E. Fertal @@aut@@ Jack M. Mizell @@aut@@ Katelyn N. Lubke @@aut@@ Benjamin J. Clark @@aut@@ Sara N. Burke @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	579826740
id	DOAJ015781933
language_de	englisch
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callnumber-first	R - Medicine
author	Andrew P. Maurer
spellingShingle	Andrew P. Maurer misc RC321-571 misc Arc misc hippocampus misc immediate-early gene misc memory misc retrograde tracer misc Neurosciences. Biological psychiatry. Neuropsychiatry Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination
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topic_title	RC321-571 Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination Arc hippocampus immediate-early gene memory retrograde tracer
topic	misc RC321-571 misc Arc misc hippocampus misc immediate-early gene misc memory misc retrograde tracer misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination
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title_full	Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination
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author_browse	Andrew P. Maurer Sarah A. Johnson Abbi R. Hernandez Jordan Reasor Daniela M. Cossio Kaeli E. Fertal Jack M. Mizell Katelyn N. Lubke Benjamin J. Clark Sara N. Burke
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title_sort	age-related changes in lateral entorhinal and ca3 neuron allocation predict poor performance on object discrimination
callnumber	RC321-571
title_auth	Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination
abstract	Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network.
abstractGer	Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network.
abstract_unstemmed	Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change. Furthermore, it is not known the extent to which age-related deficits in sensory discrimination relate to the inability of aged CA3 neurons to update in response to new environments. Young and aged rats were pre-characterized on a LEGO© object discrimination task, comparable to behavioral tests in humans in which CA3 hyperactivity has been linked to impairments. The cellular compartment analysis of temporal activity with fluorescence in situ hybridization for the immediate-early gene Arc was then used to identify the principal cell populations that were active during two distinct epochs of random foraging in different environments. This approach enabled the extent to which rats could discriminate two similar objects to be related to the ability of CA3 neurons to update across different environments. In both young and aged rats, there were animals that performed poorly on the LEGO object discrimination task. In the aged rats only, however, the poor performers had a higher percent of CA3 neurons that were active during random foraging in a novel environment, but this is not related to the ability of CA3 neurons to remap when the environment changed. Afferent neurons to CA3 in LEC, as identified with the retrograde tracer choleratoxin B (CTB), also showed a higher percentage of cells that were positive for Arc mRNA in aged poor performing rats. This suggests that LEC contributes to the hyperactivity seen in CA3 of aged animals with object discrimination deficits and age-related cognitive decline may be the consequence of dysfunction endemic to the larger network.
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title_short	Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination
url	https://doi.org/10.3389/fnsys.2017.00049 https://doaj.org/article/9498849033014ca3a8318979a37c2842 http://journal.frontiersin.org/article/10.3389/fnsys.2017.00049/full https://doaj.org/toc/1662-5137
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Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination

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