Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells

Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campeste...
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Autor*in:	Gabriel López-García [verfasserIn] Antonio Cilla [verfasserIn] Reyes Barberá [verfasserIn] Amparo Alegría [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 39(2017), Seite 84-90
Übergeordnetes Werk:	volume:39 ; year:2017 ; pages:84-90

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2017.10.006

Katalog-ID:	DOAJ015870847

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520			\|a Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer.
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publishDate	2017
allfields	10.1016/j.jff.2017.10.006 doi (DE-627)DOAJ015870847 (DE-599)DOAJ33d6cfc0b8304a60b0e3955be0ed289b DE-627 ger DE-627 rakwb eng TX341-641 Gabriel López-García verfasserin aut Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer. Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply Antonio Cilla verfasserin aut Reyes Barberá verfasserin aut Amparo Alegría verfasserin aut In Journal of Functional Foods Elsevier, 2021 39(2017), Seite 84-90 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:39 year:2017 pages:84-90 https://doi.org/10.1016/j.jff.2017.10.006 kostenfrei https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461730590X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2017 84-90
spelling	10.1016/j.jff.2017.10.006 doi (DE-627)DOAJ015870847 (DE-599)DOAJ33d6cfc0b8304a60b0e3955be0ed289b DE-627 ger DE-627 rakwb eng TX341-641 Gabriel López-García verfasserin aut Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer. Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply Antonio Cilla verfasserin aut Reyes Barberá verfasserin aut Amparo Alegría verfasserin aut In Journal of Functional Foods Elsevier, 2021 39(2017), Seite 84-90 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:39 year:2017 pages:84-90 https://doi.org/10.1016/j.jff.2017.10.006 kostenfrei https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461730590X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2017 84-90
allfields_unstemmed	10.1016/j.jff.2017.10.006 doi (DE-627)DOAJ015870847 (DE-599)DOAJ33d6cfc0b8304a60b0e3955be0ed289b DE-627 ger DE-627 rakwb eng TX341-641 Gabriel López-García verfasserin aut Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer. Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply Antonio Cilla verfasserin aut Reyes Barberá verfasserin aut Amparo Alegría verfasserin aut In Journal of Functional Foods Elsevier, 2021 39(2017), Seite 84-90 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:39 year:2017 pages:84-90 https://doi.org/10.1016/j.jff.2017.10.006 kostenfrei https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461730590X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2017 84-90
allfieldsGer	10.1016/j.jff.2017.10.006 doi (DE-627)DOAJ015870847 (DE-599)DOAJ33d6cfc0b8304a60b0e3955be0ed289b DE-627 ger DE-627 rakwb eng TX341-641 Gabriel López-García verfasserin aut Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer. Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply Antonio Cilla verfasserin aut Reyes Barberá verfasserin aut Amparo Alegría verfasserin aut In Journal of Functional Foods Elsevier, 2021 39(2017), Seite 84-90 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:39 year:2017 pages:84-90 https://doi.org/10.1016/j.jff.2017.10.006 kostenfrei https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461730590X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2017 84-90
allfieldsSound	10.1016/j.jff.2017.10.006 doi (DE-627)DOAJ015870847 (DE-599)DOAJ33d6cfc0b8304a60b0e3955be0ed289b DE-627 ger DE-627 rakwb eng TX341-641 Gabriel López-García verfasserin aut Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer. Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply Antonio Cilla verfasserin aut Reyes Barberá verfasserin aut Amparo Alegría verfasserin aut In Journal of Functional Foods Elsevier, 2021 39(2017), Seite 84-90 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:39 year:2017 pages:84-90 https://doi.org/10.1016/j.jff.2017.10.006 kostenfrei https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461730590X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 39 2017 84-90
language	English
source	In Journal of Functional Foods 39(2017), Seite 84-90 volume:39 year:2017 pages:84-90
sourceStr	In Journal of Functional Foods 39(2017), Seite 84-90 volume:39 year:2017 pages:84-90
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Gabriel López-García @@aut@@ Antonio Cilla @@aut@@ Reyes Barberá @@aut@@ Amparo Alegría @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ015870847
language_de	englisch
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callnumber-first	T - Technology
author	Gabriel López-García
spellingShingle	Gabriel López-García misc TX341-641 misc Plant sterols misc Antiproliferative effect misc Colon cancer misc Caco-2 cells misc Cytostatic effect misc Nutrition. Foods and food supply Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells
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topic_title	TX341-641 Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells Plant sterols Antiproliferative effect Colon cancer Caco-2 cells Cytostatic effect
topic	misc TX341-641 misc Plant sterols misc Antiproliferative effect misc Colon cancer misc Caco-2 cells misc Cytostatic effect misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Plant sterols misc Antiproliferative effect misc Colon cancer misc Caco-2 cells misc Cytostatic effect misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Plant sterols misc Antiproliferative effect misc Colon cancer misc Caco-2 cells misc Cytostatic effect misc Nutrition. Foods and food supply
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title	Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells
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title_full	Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells
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author_browse	Gabriel López-García Antonio Cilla Reyes Barberá Amparo Alegría
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title_sort	antiproliferative effect of plant sterols at colonic concentrations on caco-2 cells
callnumber	TX341-641
title_auth	Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells
abstract	Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer.
abstractGer	Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer.
abstract_unstemmed	Plant sterols (PS) have been incorporated to foods due to their cholesterol-lowering effect. Because of their low intestinal absorption (0.5–2%), they can reach the colon and exert local actions. The aim of this study was to evaluate the antiproliferative effect of individual (β-sitosterol, campesterol and stigmasterol) and combined PS in colon cancer cells (Caco-2) at human colonic concentrations after simulated gastrointestinal digestion of a PS enriched milk-based fruit beverage. β-Sitosterol, campesterol and stigmasterol induced significant cell viability reduction (13–59% vs control), but only stigmasterol produced an overproduction of reactive oxygen species (92% vs control). Individual PS induced reversible arrest in phase G0/G1 of the cell cycle, suggesting that they act as cytostatic agents. Combined PS showed a greater effect than individual PS, inducing also cell necrosis and irreversible cell cycle arrest (G0/G1 phase). The consumption of PS-enriched foods therefore could exert a potential preventive effect against colon cancer.
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title_short	Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells
url	https://doi.org/10.1016/j.jff.2017.10.006 https://doaj.org/article/33d6cfc0b8304a60b0e3955be0ed289b http://www.sciencedirect.com/science/article/pii/S175646461730590X https://doaj.org/toc/1756-4646
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up_date	2024-07-03T17:35:49.648Z
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Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells

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