An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?

Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated succ...
Ausführliche Beschreibung

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Autor*in:	Hui Liu [verfasserIn] Jiajia Zhao [verfasserIn] Liu Yang [verfasserIn] Chuwei Yang [verfasserIn] Yufei Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS)

Übergeordnetes Werk:	In: International Journal of Infectious Diseases - Elsevier, 2015, 115(2022), Seite 26-29
Übergeordnetes Werk:	volume:115 ; year:2022 ; pages:26-29

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ijid.2021.11.041

Katalog-ID:	DOAJ015873161

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520			\|a Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms.
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700	0		\|a Yufei Liu \|e verfasserin \|4 aut
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allfields	10.1016/j.ijid.2021.11.041 doi (DE-627)DOAJ015873161 (DE-599)DOAJa9f4d09fdcca43aca6f2d673393b84f7 DE-627 ger DE-627 rakwb eng RC109-216 Hui Liu verfasserin aut An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms. X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases Jiajia Zhao verfasserin aut Liu Yang verfasserin aut Chuwei Yang verfasserin aut Yufei Liu verfasserin aut In International Journal of Infectious Diseases Elsevier, 2015 115(2022), Seite 26-29 (DE-627)341907669 (DE-600)2070533-5 18783511 nnns volume:115 year:2022 pages:26-29 https://doi.org/10.1016/j.ijid.2021.11.041 kostenfrei https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1201971221008900 kostenfrei https://doaj.org/toc/1201-9712 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 115 2022 26-29
spelling	10.1016/j.ijid.2021.11.041 doi (DE-627)DOAJ015873161 (DE-599)DOAJa9f4d09fdcca43aca6f2d673393b84f7 DE-627 ger DE-627 rakwb eng RC109-216 Hui Liu verfasserin aut An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms. X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases Jiajia Zhao verfasserin aut Liu Yang verfasserin aut Chuwei Yang verfasserin aut Yufei Liu verfasserin aut In International Journal of Infectious Diseases Elsevier, 2015 115(2022), Seite 26-29 (DE-627)341907669 (DE-600)2070533-5 18783511 nnns volume:115 year:2022 pages:26-29 https://doi.org/10.1016/j.ijid.2021.11.041 kostenfrei https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1201971221008900 kostenfrei https://doaj.org/toc/1201-9712 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 115 2022 26-29
allfields_unstemmed	10.1016/j.ijid.2021.11.041 doi (DE-627)DOAJ015873161 (DE-599)DOAJa9f4d09fdcca43aca6f2d673393b84f7 DE-627 ger DE-627 rakwb eng RC109-216 Hui Liu verfasserin aut An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms. X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases Jiajia Zhao verfasserin aut Liu Yang verfasserin aut Chuwei Yang verfasserin aut Yufei Liu verfasserin aut In International Journal of Infectious Diseases Elsevier, 2015 115(2022), Seite 26-29 (DE-627)341907669 (DE-600)2070533-5 18783511 nnns volume:115 year:2022 pages:26-29 https://doi.org/10.1016/j.ijid.2021.11.041 kostenfrei https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1201971221008900 kostenfrei https://doaj.org/toc/1201-9712 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 115 2022 26-29
allfieldsGer	10.1016/j.ijid.2021.11.041 doi (DE-627)DOAJ015873161 (DE-599)DOAJa9f4d09fdcca43aca6f2d673393b84f7 DE-627 ger DE-627 rakwb eng RC109-216 Hui Liu verfasserin aut An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms. X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases Jiajia Zhao verfasserin aut Liu Yang verfasserin aut Chuwei Yang verfasserin aut Yufei Liu verfasserin aut In International Journal of Infectious Diseases Elsevier, 2015 115(2022), Seite 26-29 (DE-627)341907669 (DE-600)2070533-5 18783511 nnns volume:115 year:2022 pages:26-29 https://doi.org/10.1016/j.ijid.2021.11.041 kostenfrei https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1201971221008900 kostenfrei https://doaj.org/toc/1201-9712 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 115 2022 26-29
allfieldsSound	10.1016/j.ijid.2021.11.041 doi (DE-627)DOAJ015873161 (DE-599)DOAJa9f4d09fdcca43aca6f2d673393b84f7 DE-627 ger DE-627 rakwb eng RC109-216 Hui Liu verfasserin aut An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms. X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases Jiajia Zhao verfasserin aut Liu Yang verfasserin aut Chuwei Yang verfasserin aut Yufei Liu verfasserin aut In International Journal of Infectious Diseases Elsevier, 2015 115(2022), Seite 26-29 (DE-627)341907669 (DE-600)2070533-5 18783511 nnns volume:115 year:2022 pages:26-29 https://doi.org/10.1016/j.ijid.2021.11.041 kostenfrei https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 kostenfrei http://www.sciencedirect.com/science/article/pii/S1201971221008900 kostenfrei https://doaj.org/toc/1201-9712 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 115 2022 26-29
language	English
source	In International Journal of Infectious Diseases 115(2022), Seite 26-29 volume:115 year:2022 pages:26-29
sourceStr	In International Journal of Infectious Diseases 115(2022), Seite 26-29 volume:115 year:2022 pages:26-29
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS) Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	International Journal of Infectious Diseases
authorswithroles_txt_mv	Hui Liu @@aut@@ Jiajia Zhao @@aut@@ Liu Yang @@aut@@ Chuwei Yang @@aut@@ Yufei Liu @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	341907669
id	DOAJ015873161
language_de	englisch
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callnumber-first	R - Medicine
author	Hui Liu
spellingShingle	Hui Liu misc RC109-216 misc X-linked agammaglobulinemia (XLA) misc Torque teno virus (TTV) misc meningoencephalitis misc high-throughput sequencing (HTS) misc Infectious and parasitic diseases An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?
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topic_title	RC109-216 An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus? X-linked agammaglobulinemia (XLA) Torque teno virus (TTV) meningoencephalitis high-throughput sequencing (HTS)
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title	An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?
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title_full	An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?
author_sort	Hui Liu
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title_sort	x-linked agammaglobulinemia (xla) patient with fever and disturbance of consciousness: infection with torque teno virus?
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title_auth	An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?
abstract	Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms.
abstractGer	Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms.
abstract_unstemmed	Summary: This is the first report of meningoencephalitis in an adult male with X-linked agammaglobulinemia caused by a probable Torque teno virus (TTV) infection. TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. This case suggests that TTV can have a pathogenic effect on patients with severe immunodeficiency disease, and can produce severe clinical symptoms.
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title_short	An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?
url	https://doi.org/10.1016/j.ijid.2021.11.041 https://doaj.org/article/a9f4d09fdcca43aca6f2d673393b84f7 http://www.sciencedirect.com/science/article/pii/S1201971221008900 https://doaj.org/toc/1201-9712
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up_date	2024-07-03T17:36:44.042Z
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TTV was detected in the cerebrospinal fluid samples of the patient by high-throughput sequencing technology. The patient was treated successfully.AbstractX-linked agammaglobulinemia (XLA) is a rare primary immunodeficiency disease caused by mutations in the Bruton's tyrosine kinase (Btk) gene, characterized by recurrent infections and low or undetectable immunoglobulin levels. The most recommended treatment for XLA is lifelong intravenous immunoglobulin (IVIG) replacement therapy. Without treatment, XLA patients are vulnerable to bacterial and viral infections. Meningoencephalitis is a common complication in patients with XLA. Torque teno viruses (TTVs) are ubiquitous in various tissues of healthy people, while TTV infections have been reported only recently. This case study presents the first reported case on the Chinese mainland of meningoencephalitis in an adult male with XLA, most likely caused by TTV. A 27-year-old male presented with fever and severe disturbance of consciousness. Conventional tests, including blood culture and cerebrospinal fluid (CSF) culture, did not reveal any bacterial infections. The clinical presentation, neuroimaging findings, and results of CSF were suggestive of viral meningoencephalitis. Next, TTV was detected in CSF by high-throughput sequencing (HTS) technology. 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An X-linked agammaglobulinemia (XLA) patient with fever and disturbance of consciousness: infection with Torque teno virus?

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