The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia

Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Marianna Riello [verfasserIn] Andreia V. Faria [verfasserIn] Bronte Ficek [verfasserIn] Kimberly Webster [verfasserIn] Chiadi U. Onyike [verfasserIn] John Desmond [verfasserIn] Constantine Frangakis [verfasserIn] Kyrana Tsapkini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	primary progressive aphasia object naming action naming atlas-based analysis gray matter volumes education

Übergeordnetes Werk:	In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 10(2018)
Übergeordnetes Werk:	volume:10 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnagi.2018.00346

Katalog-ID:	DOAJ015876047

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authorswithroles_txt_mv	Marianna Riello @@aut@@ Andreia V. Faria @@aut@@ Bronte Ficek @@aut@@ Kimberly Webster @@aut@@ Chiadi U. Onyike @@aut@@ John Desmond @@aut@@ Constantine Frangakis @@aut@@ Kyrana Tsapkini @@aut@@
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author	Marianna Riello
spellingShingle	Marianna Riello misc RC321-571 misc primary progressive aphasia misc object naming misc action naming misc atlas-based analysis misc gray matter volumes misc education misc Neurosciences. Biological psychiatry. Neuropsychiatry The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
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topic_title	RC321-571 The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia primary progressive aphasia object naming action naming atlas-based analysis gray matter volumes education
topic	misc RC321-571 misc primary progressive aphasia misc object naming misc action naming misc atlas-based analysis misc gray matter volumes misc education misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
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title_full	The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
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title_sort	role of language severity and education in explaining performance on object and action naming in primary progressive aphasia
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title_auth	The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
abstract	Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy. In the present study, we asked how much variance of the object and action naming impairments observed in PPA may be attributed to atrophy in the language network alone vs. additional clinical and demographic factors including language severity and education. Thirty-nine participants with PPA underwent magnetic resonance imaging (MRI) for volumetric analysis and a complete neuropsychological examination, including standardized tests of object and action naming. We used stepwise regression models to compare atrophy (volumetric model) to clinical/demographic variables (clinical-demographic model) for naming objects and actions. The clinical-demographic model was the best-fit model that explained the largest amount of variance in both object and action naming. Brain volume measurements alone explained little variance in both object and action naming. Clinical factors, particularly language severity, and demographic factors, particularly education, need to be considered in conjunction with brain volumes in PPA. The present study emphasizes the complexity of PPA as a syndrome and provides an example of how volumetric, clinical and demographic factors may interact in determining naming performance/deterioration.
abstractGer	Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy. In the present study, we asked how much variance of the object and action naming impairments observed in PPA may be attributed to atrophy in the language network alone vs. additional clinical and demographic factors including language severity and education. Thirty-nine participants with PPA underwent magnetic resonance imaging (MRI) for volumetric analysis and a complete neuropsychological examination, including standardized tests of object and action naming. We used stepwise regression models to compare atrophy (volumetric model) to clinical/demographic variables (clinical-demographic model) for naming objects and actions. The clinical-demographic model was the best-fit model that explained the largest amount of variance in both object and action naming. Brain volume measurements alone explained little variance in both object and action naming. Clinical factors, particularly language severity, and demographic factors, particularly education, need to be considered in conjunction with brain volumes in PPA. The present study emphasizes the complexity of PPA as a syndrome and provides an example of how volumetric, clinical and demographic factors may interact in determining naming performance/deterioration.
abstract_unstemmed	Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy. In the present study, we asked how much variance of the object and action naming impairments observed in PPA may be attributed to atrophy in the language network alone vs. additional clinical and demographic factors including language severity and education. Thirty-nine participants with PPA underwent magnetic resonance imaging (MRI) for volumetric analysis and a complete neuropsychological examination, including standardized tests of object and action naming. We used stepwise regression models to compare atrophy (volumetric model) to clinical/demographic variables (clinical-demographic model) for naming objects and actions. The clinical-demographic model was the best-fit model that explained the largest amount of variance in both object and action naming. Brain volume measurements alone explained little variance in both object and action naming. Clinical factors, particularly language severity, and demographic factors, particularly education, need to be considered in conjunction with brain volumes in PPA. The present study emphasizes the complexity of PPA as a syndrome and provides an example of how volumetric, clinical and demographic factors may interact in determining naming performance/deterioration.
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title_short	The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia
url	https://doi.org/10.3389/fnagi.2018.00346 https://doaj.org/article/796e3427dead49feb254c0ceb8c9a354 https://www.frontiersin.org/article/10.3389/fnagi.2018.00346/full https://doaj.org/toc/1663-4365
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author2	Andreia V. Faria Bronte Ficek Kimberly Webster Chiadi U. Onyike John Desmond Constantine Frangakis Kyrana Tsapkini
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The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia

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