Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence....
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Autor*in:	Michèle J. Hoffmann [verfasserIn] Wolfgang A. Schulz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	urothelial carcinoma bladder cancer chromatin regulator epigenetic enzyme differentiation plasticity

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 23, p 6040
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:23, p 6040

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13236040

Katalog-ID:	DOAJ015892263

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520			\|a Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.
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allfieldsSound	10.3390/cancers13236040 doi (DE-627)DOAJ015892263 (DE-599)DOAJ4122921d26fe4a86a70d64295bc4f108 DE-627 ger DE-627 rakwb eng RC254-282 Michèle J. Hoffmann verfasserin aut Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development. urothelial carcinoma bladder cancer chromatin regulator epigenetic enzyme differentiation plasticity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wolfgang A. Schulz verfasserin aut In Cancers MDPI AG, 2010 13(2021), 23, p 6040 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:23, p 6040 https://doi.org/10.3390/cancers13236040 kostenfrei https://doaj.org/article/4122921d26fe4a86a70d64295bc4f108 kostenfrei https://www.mdpi.com/2072-6694/13/23/6040 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 23, p 6040
language	English
source	In Cancers 13(2021), 23, p 6040 volume:13 year:2021 number:23, p 6040
sourceStr	In Cancers 13(2021), 23, p 6040 volume:13 year:2021 number:23, p 6040
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	urothelial carcinoma bladder cancer chromatin regulator epigenetic enzyme differentiation plasticity Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Michèle J. Hoffmann @@aut@@ Wolfgang A. Schulz @@aut@@
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callnumber-first	R - Medicine
author	Michèle J. Hoffmann
spellingShingle	Michèle J. Hoffmann misc RC254-282 misc urothelial carcinoma misc bladder cancer misc chromatin regulator misc epigenetic enzyme misc differentiation misc plasticity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma
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topic_title	RC254-282 Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma urothelial carcinoma bladder cancer chromatin regulator epigenetic enzyme differentiation plasticity
topic	misc RC254-282 misc urothelial carcinoma misc bladder cancer misc chromatin regulator misc epigenetic enzyme misc differentiation misc plasticity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc urothelial carcinoma misc bladder cancer misc chromatin regulator misc epigenetic enzyme misc differentiation misc plasticity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc urothelial carcinoma misc bladder cancer misc chromatin regulator misc epigenetic enzyme misc differentiation misc plasticity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma
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title_sort	alterations of chromatin regulators in the pathogenesis of urinary bladder urothelial carcinoma
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title_auth	Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma
abstract	Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.
abstractGer	Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.
abstract_unstemmed	Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.
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title_short	Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma
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Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

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