Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review
Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jawaher Ansari [verfasserIn] Yussra Eltigani Mohmmed [verfasserIn] Saad Ghazal-Aswad [verfasserIn] Hidayath Ansari [verfasserIn] Syed M.J. Akhter [verfasserIn] Omar Hassoun Hadid [verfasserIn] Syed Rizwan [verfasserIn] Raya Almazrouei [verfasserIn] Emad Dawoud [verfasserIn] Fathi Azribi [verfasserIn] Heba Elhasin [verfasserIn] Pawan Kumar [verfasserIn] Abdul Rahman Al Sumaida [verfasserIn] Khaled Al-Qawasmeh [verfasserIn] John Glaholm [verfasserIn] M.J. Hochmair [verfasserIn] Syed Hussain [verfasserIn] Khalid Balaraj [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
Vaginal squamous cell carcinoma |
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| Übergeordnetes Werk: |
In: Gynecologic Oncology Reports - Elsevier, 2015, 38(2021), Seite 100878- |
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| Übergeordnetes Werk: |
volume:38 ; year:2021 ; pages:100878- |
| Links: |
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| DOI / URN: |
10.1016/j.gore.2021.100878 |
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| Katalog-ID: |
DOAJ015913716 |
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| 245 | 1 | 0 | |a Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
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| 520 | |a Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. | ||
| 650 | 4 | |a Pembrolizumab | |
| 650 | 4 | |a Vaginal squamous cell carcinoma | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Immune related adverse events | |
| 650 | 4 | |a Wall-eyed internuclear ophthalmoplegia | |
| 650 | 4 | |a Checkpoint inhibitors | |
| 653 | 0 | |a Gynecology and obstetrics | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Yussra Eltigani Mohmmed |e verfasserin |4 aut | |
| 700 | 0 | |a Saad Ghazal-Aswad |e verfasserin |4 aut | |
| 700 | 0 | |a Hidayath Ansari |e verfasserin |4 aut | |
| 700 | 0 | |a Syed M.J. Akhter |e verfasserin |4 aut | |
| 700 | 0 | |a Omar Hassoun Hadid |e verfasserin |4 aut | |
| 700 | 0 | |a Syed Rizwan |e verfasserin |4 aut | |
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| 700 | 0 | |a Fathi Azribi |e verfasserin |4 aut | |
| 700 | 0 | |a Heba Elhasin |e verfasserin |4 aut | |
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| 700 | 0 | |a Abdul Rahman Al Sumaida |e verfasserin |4 aut | |
| 700 | 0 | |a Khaled Al-Qawasmeh |e verfasserin |4 aut | |
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| 700 | 0 | |a M.J. Hochmair |e verfasserin |4 aut | |
| 700 | 0 | |a Syed Hussain |e verfasserin |4 aut | |
| 700 | 0 | |a Khalid Balaraj |e verfasserin |4 aut | |
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10.1016/j.gore.2021.100878 doi (DE-627)DOAJ015913716 (DE-599)DOAJ3036c81e205949458a77884e841d72ef DE-627 ger DE-627 rakwb eng RG1-991 RC254-282 Jawaher Ansari verfasserin aut Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. Pembrolizumab Vaginal squamous cell carcinoma Radiotherapy Immune related adverse events Wall-eyed internuclear ophthalmoplegia Checkpoint inhibitors Gynecology and obstetrics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yussra Eltigani Mohmmed verfasserin aut Saad Ghazal-Aswad verfasserin aut Hidayath Ansari verfasserin aut Syed M.J. Akhter verfasserin aut Omar Hassoun Hadid verfasserin aut Syed Rizwan verfasserin aut Raya Almazrouei verfasserin aut Emad Dawoud verfasserin aut Fathi Azribi verfasserin aut Heba Elhasin verfasserin aut Pawan Kumar verfasserin aut Abdul Rahman Al Sumaida verfasserin aut Khaled Al-Qawasmeh verfasserin aut John Glaholm verfasserin aut M.J. Hochmair verfasserin aut Syed Hussain verfasserin aut Khalid Balaraj verfasserin aut In Gynecologic Oncology Reports Elsevier, 2015 38(2021), Seite 100878- (DE-627)823093204 (DE-600)2818505-5 23525789 nnns volume:38 year:2021 pages:100878- https://doi.org/10.1016/j.gore.2021.100878 kostenfrei https://doaj.org/article/3036c81e205949458a77884e841d72ef kostenfrei http://www.sciencedirect.com/science/article/pii/S235257892100182X kostenfrei https://doaj.org/toc/2352-5789 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 100878- |
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10.1016/j.gore.2021.100878 doi (DE-627)DOAJ015913716 (DE-599)DOAJ3036c81e205949458a77884e841d72ef DE-627 ger DE-627 rakwb eng RG1-991 RC254-282 Jawaher Ansari verfasserin aut Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. Pembrolizumab Vaginal squamous cell carcinoma Radiotherapy Immune related adverse events Wall-eyed internuclear ophthalmoplegia Checkpoint inhibitors Gynecology and obstetrics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yussra Eltigani Mohmmed verfasserin aut Saad Ghazal-Aswad verfasserin aut Hidayath Ansari verfasserin aut Syed M.J. Akhter verfasserin aut Omar Hassoun Hadid verfasserin aut Syed Rizwan verfasserin aut Raya Almazrouei verfasserin aut Emad Dawoud verfasserin aut Fathi Azribi verfasserin aut Heba Elhasin verfasserin aut Pawan Kumar verfasserin aut Abdul Rahman Al Sumaida verfasserin aut Khaled Al-Qawasmeh verfasserin aut John Glaholm verfasserin aut M.J. Hochmair verfasserin aut Syed Hussain verfasserin aut Khalid Balaraj verfasserin aut In Gynecologic Oncology Reports Elsevier, 2015 38(2021), Seite 100878- (DE-627)823093204 (DE-600)2818505-5 23525789 nnns volume:38 year:2021 pages:100878- https://doi.org/10.1016/j.gore.2021.100878 kostenfrei https://doaj.org/article/3036c81e205949458a77884e841d72ef kostenfrei http://www.sciencedirect.com/science/article/pii/S235257892100182X kostenfrei https://doaj.org/toc/2352-5789 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 100878- |
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10.1016/j.gore.2021.100878 doi (DE-627)DOAJ015913716 (DE-599)DOAJ3036c81e205949458a77884e841d72ef DE-627 ger DE-627 rakwb eng RG1-991 RC254-282 Jawaher Ansari verfasserin aut Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. Pembrolizumab Vaginal squamous cell carcinoma Radiotherapy Immune related adverse events Wall-eyed internuclear ophthalmoplegia Checkpoint inhibitors Gynecology and obstetrics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yussra Eltigani Mohmmed verfasserin aut Saad Ghazal-Aswad verfasserin aut Hidayath Ansari verfasserin aut Syed M.J. Akhter verfasserin aut Omar Hassoun Hadid verfasserin aut Syed Rizwan verfasserin aut Raya Almazrouei verfasserin aut Emad Dawoud verfasserin aut Fathi Azribi verfasserin aut Heba Elhasin verfasserin aut Pawan Kumar verfasserin aut Abdul Rahman Al Sumaida verfasserin aut Khaled Al-Qawasmeh verfasserin aut John Glaholm verfasserin aut M.J. Hochmair verfasserin aut Syed Hussain verfasserin aut Khalid Balaraj verfasserin aut In Gynecologic Oncology Reports Elsevier, 2015 38(2021), Seite 100878- (DE-627)823093204 (DE-600)2818505-5 23525789 nnns volume:38 year:2021 pages:100878- https://doi.org/10.1016/j.gore.2021.100878 kostenfrei https://doaj.org/article/3036c81e205949458a77884e841d72ef kostenfrei http://www.sciencedirect.com/science/article/pii/S235257892100182X kostenfrei https://doaj.org/toc/2352-5789 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 100878- |
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10.1016/j.gore.2021.100878 doi (DE-627)DOAJ015913716 (DE-599)DOAJ3036c81e205949458a77884e841d72ef DE-627 ger DE-627 rakwb eng RG1-991 RC254-282 Jawaher Ansari verfasserin aut Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. Pembrolizumab Vaginal squamous cell carcinoma Radiotherapy Immune related adverse events Wall-eyed internuclear ophthalmoplegia Checkpoint inhibitors Gynecology and obstetrics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Yussra Eltigani Mohmmed verfasserin aut Saad Ghazal-Aswad verfasserin aut Hidayath Ansari verfasserin aut Syed M.J. Akhter verfasserin aut Omar Hassoun Hadid verfasserin aut Syed Rizwan verfasserin aut Raya Almazrouei verfasserin aut Emad Dawoud verfasserin aut Fathi Azribi verfasserin aut Heba Elhasin verfasserin aut Pawan Kumar verfasserin aut Abdul Rahman Al Sumaida verfasserin aut Khaled Al-Qawasmeh verfasserin aut John Glaholm verfasserin aut M.J. Hochmair verfasserin aut Syed Hussain verfasserin aut Khalid Balaraj verfasserin aut In Gynecologic Oncology Reports Elsevier, 2015 38(2021), Seite 100878- (DE-627)823093204 (DE-600)2818505-5 23525789 nnns volume:38 year:2021 pages:100878- https://doi.org/10.1016/j.gore.2021.100878 kostenfrei https://doaj.org/article/3036c81e205949458a77884e841d72ef kostenfrei http://www.sciencedirect.com/science/article/pii/S235257892100182X kostenfrei https://doaj.org/toc/2352-5789 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 100878- |
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Jawaher Ansari @@aut@@ Yussra Eltigani Mohmmed @@aut@@ Saad Ghazal-Aswad @@aut@@ Hidayath Ansari @@aut@@ Syed M.J. Akhter @@aut@@ Omar Hassoun Hadid @@aut@@ Syed Rizwan @@aut@@ Raya Almazrouei @@aut@@ Emad Dawoud @@aut@@ Fathi Azribi @@aut@@ Heba Elhasin @@aut@@ Pawan Kumar @@aut@@ Abdul Rahman Al Sumaida @@aut@@ Khaled Al-Qawasmeh @@aut@@ John Glaholm @@aut@@ M.J. Hochmair @@aut@@ Syed Hussain @@aut@@ Khalid Balaraj @@aut@@ |
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Jawaher Ansari |
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Jawaher Ansari misc RG1-991 misc RC254-282 misc Pembrolizumab misc Vaginal squamous cell carcinoma misc Radiotherapy misc Immune related adverse events misc Wall-eyed internuclear ophthalmoplegia misc Checkpoint inhibitors misc Gynecology and obstetrics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
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RG1-991 RC254-282 Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review Pembrolizumab Vaginal squamous cell carcinoma Radiotherapy Immune related adverse events Wall-eyed internuclear ophthalmoplegia Checkpoint inhibitors |
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misc RG1-991 misc RC254-282 misc Pembrolizumab misc Vaginal squamous cell carcinoma misc Radiotherapy misc Immune related adverse events misc Wall-eyed internuclear ophthalmoplegia misc Checkpoint inhibitors misc Gynecology and obstetrics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RG1-991 misc RC254-282 misc Pembrolizumab misc Vaginal squamous cell carcinoma misc Radiotherapy misc Immune related adverse events misc Wall-eyed internuclear ophthalmoplegia misc Checkpoint inhibitors misc Gynecology and obstetrics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RG1-991 misc RC254-282 misc Pembrolizumab misc Vaginal squamous cell carcinoma misc Radiotherapy misc Immune related adverse events misc Wall-eyed internuclear ophthalmoplegia misc Checkpoint inhibitors misc Gynecology and obstetrics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
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Jawaher Ansari Yussra Eltigani Mohmmed Saad Ghazal-Aswad Hidayath Ansari Syed M.J. Akhter Omar Hassoun Hadid Syed Rizwan Raya Almazrouei Emad Dawoud Fathi Azribi Heba Elhasin Pawan Kumar Abdul Rahman Al Sumaida Khaled Al-Qawasmeh John Glaholm M.J. Hochmair Syed Hussain Khalid Balaraj |
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rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
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RG1-991 |
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Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
| abstract |
Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. |
| abstractGer |
Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. |
| abstract_unstemmed |
Primary vaginal cancer is a rare malignancy with a lack of international guidelines and supporting clinical trial evidence to guide decision making. Historical results have shown poor outcomes with chemotherapy for stage IVB vaginal squamous cell carcinoma (SCC). The evolving role of checkpoint inhibitors in rare gynaecological cancers prompted us to investigate the role of pembrolizumab in this setting. The efficacy of pembrolizumab in vaginal SCC has never been investigated in any clinical trial. There is established data to support the use of concurrent chemoradiotherapy in gynaecological cancers, however, the data for concurrent use of immunotherapy and radiotherapy is still lacking but is the subject of several clinical trials. We herein present the first reported case of chemotherapy refractory vaginal SCC with complete response to pembrolizumab and concurrent pelvic radiotherapy. We also present wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) as a rare but new immune related adverse event. |
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Rare case of chemotherapy-refractory metastatic vaginal squamous cell carcinoma with complete response to concurrent pembrolizumab and radiotherapy- case report and literature review |
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