Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation

The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable...
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Gespeichert in:

Autor*in:	Xiaoming Sun [verfasserIn] Yi Shi [verfasserIn] Tomohiro Akahoshi [verfasserIn] Mamoru Fujiwara [verfasserIn] Hiroyuki Gatanaga [verfasserIn] Christian Schönbach [verfasserIn] Nozomi Kuse [verfasserIn] Victor Appay [verfasserIn] George F. Gao [verfasserIn] Shinichi Oka [verfasserIn] Masafumi Takiguchi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 15(2016), 10, Seite 2279-2291
Übergeordnetes Werk:	volume:15 ; year:2016 ; number:10 ; pages:2279-2291

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2016.05.017

Katalog-ID:	DOAJ016067428

Internformat


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520			\|a The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level.
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700	0		\|a Hiroyuki Gatanaga \|e verfasserin \|4 aut
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700	0		\|a George F. Gao \|e verfasserin \|4 aut
700	0		\|a Shinichi Oka \|e verfasserin \|4 aut
700	0		\|a Masafumi Takiguchi \|e verfasserin \|4 aut
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912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
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912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
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912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
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912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
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912			\|a GBV_ILN_4323
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
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Indexfelder

author_variant	x s xs y s ys t a ta m f mf h g hg c s cs n k nk v a va g g gg s o so m t mt
matchkey_str	article:22111247:2016----::fetoaigesaeuainncladi
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callnumber-subject-code	QH
publishDate	2016
allfields	10.1016/j.celrep.2016.05.017 doi (DE-627)DOAJ016067428 (DE-599)DOAJ8bc8c09c146b4a2bb6ee5e7745395bca DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoming Sun verfasserin aut Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. Biology (General) Yi Shi verfasserin aut Tomohiro Akahoshi verfasserin aut Mamoru Fujiwara verfasserin aut Hiroyuki Gatanaga verfasserin aut Christian Schönbach verfasserin aut Nozomi Kuse verfasserin aut Victor Appay verfasserin aut George F. Gao verfasserin aut Shinichi Oka verfasserin aut Masafumi Takiguchi verfasserin aut In Cell Reports Elsevier, 2015 15(2016), 10, Seite 2279-2291 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:15 year:2016 number:10 pages:2279-2291 https://doi.org/10.1016/j.celrep.2016.05.017 kostenfrei https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca kostenfrei http://www.sciencedirect.com/science/article/pii/S221112471630585X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2016 10 2279-2291
spelling	10.1016/j.celrep.2016.05.017 doi (DE-627)DOAJ016067428 (DE-599)DOAJ8bc8c09c146b4a2bb6ee5e7745395bca DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoming Sun verfasserin aut Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. Biology (General) Yi Shi verfasserin aut Tomohiro Akahoshi verfasserin aut Mamoru Fujiwara verfasserin aut Hiroyuki Gatanaga verfasserin aut Christian Schönbach verfasserin aut Nozomi Kuse verfasserin aut Victor Appay verfasserin aut George F. Gao verfasserin aut Shinichi Oka verfasserin aut Masafumi Takiguchi verfasserin aut In Cell Reports Elsevier, 2015 15(2016), 10, Seite 2279-2291 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:15 year:2016 number:10 pages:2279-2291 https://doi.org/10.1016/j.celrep.2016.05.017 kostenfrei https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca kostenfrei http://www.sciencedirect.com/science/article/pii/S221112471630585X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2016 10 2279-2291
allfields_unstemmed	10.1016/j.celrep.2016.05.017 doi (DE-627)DOAJ016067428 (DE-599)DOAJ8bc8c09c146b4a2bb6ee5e7745395bca DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoming Sun verfasserin aut Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. Biology (General) Yi Shi verfasserin aut Tomohiro Akahoshi verfasserin aut Mamoru Fujiwara verfasserin aut Hiroyuki Gatanaga verfasserin aut Christian Schönbach verfasserin aut Nozomi Kuse verfasserin aut Victor Appay verfasserin aut George F. Gao verfasserin aut Shinichi Oka verfasserin aut Masafumi Takiguchi verfasserin aut In Cell Reports Elsevier, 2015 15(2016), 10, Seite 2279-2291 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:15 year:2016 number:10 pages:2279-2291 https://doi.org/10.1016/j.celrep.2016.05.017 kostenfrei https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca kostenfrei http://www.sciencedirect.com/science/article/pii/S221112471630585X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2016 10 2279-2291
allfieldsGer	10.1016/j.celrep.2016.05.017 doi (DE-627)DOAJ016067428 (DE-599)DOAJ8bc8c09c146b4a2bb6ee5e7745395bca DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoming Sun verfasserin aut Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. Biology (General) Yi Shi verfasserin aut Tomohiro Akahoshi verfasserin aut Mamoru Fujiwara verfasserin aut Hiroyuki Gatanaga verfasserin aut Christian Schönbach verfasserin aut Nozomi Kuse verfasserin aut Victor Appay verfasserin aut George F. Gao verfasserin aut Shinichi Oka verfasserin aut Masafumi Takiguchi verfasserin aut In Cell Reports Elsevier, 2015 15(2016), 10, Seite 2279-2291 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:15 year:2016 number:10 pages:2279-2291 https://doi.org/10.1016/j.celrep.2016.05.017 kostenfrei https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca kostenfrei http://www.sciencedirect.com/science/article/pii/S221112471630585X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2016 10 2279-2291
allfieldsSound	10.1016/j.celrep.2016.05.017 doi (DE-627)DOAJ016067428 (DE-599)DOAJ8bc8c09c146b4a2bb6ee5e7745395bca DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoming Sun verfasserin aut Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. Biology (General) Yi Shi verfasserin aut Tomohiro Akahoshi verfasserin aut Mamoru Fujiwara verfasserin aut Hiroyuki Gatanaga verfasserin aut Christian Schönbach verfasserin aut Nozomi Kuse verfasserin aut Victor Appay verfasserin aut George F. Gao verfasserin aut Shinichi Oka verfasserin aut Masafumi Takiguchi verfasserin aut In Cell Reports Elsevier, 2015 15(2016), 10, Seite 2279-2291 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:15 year:2016 number:10 pages:2279-2291 https://doi.org/10.1016/j.celrep.2016.05.017 kostenfrei https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca kostenfrei http://www.sciencedirect.com/science/article/pii/S221112471630585X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2016 10 2279-2291
language	English
source	In Cell Reports 15(2016), 10, Seite 2279-2291 volume:15 year:2016 number:10 pages:2279-2291
sourceStr	In Cell Reports 15(2016), 10, Seite 2279-2291 volume:15 year:2016 number:10 pages:2279-2291
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Xiaoming Sun @@aut@@ Yi Shi @@aut@@ Tomohiro Akahoshi @@aut@@ Mamoru Fujiwara @@aut@@ Hiroyuki Gatanaga @@aut@@ Christian Schönbach @@aut@@ Nozomi Kuse @@aut@@ Victor Appay @@aut@@ George F. Gao @@aut@@ Shinichi Oka @@aut@@ Masafumi Takiguchi @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ016067428
language_de	englisch
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callnumber-first	Q - Science
author	Xiaoming Sun
spellingShingle	Xiaoming Sun misc QH301-705.5 misc Biology (General) Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
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topic_title	QH301-705.5 Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
topic	misc QH301-705.5 misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Biology (General)
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title	Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
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title_full	Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
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author_browse	Xiaoming Sun Yi Shi Tomohiro Akahoshi Mamoru Fujiwara Hiroyuki Gatanaga Christian Schönbach Nozomi Kuse Victor Appay George F. Gao Shinichi Oka Masafumi Takiguchi
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author-letter	Xiaoming Sun
doi_str_mv	10.1016/j.celrep.2016.05.017
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title_sort	effects of a single escape mutation on t cell and hiv-1 co-adaptation
callnumber	QH301-705.5
title_auth	Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
abstract	The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level.
abstractGer	The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level.
abstract_unstemmed	The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level.
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container_issue	10
title_short	Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation
url	https://doi.org/10.1016/j.celrep.2016.05.017 https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca http://www.sciencedirect.com/science/article/pii/S221112471630585X https://doaj.org/toc/2211-1247
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author2	Yi Shi Tomohiro Akahoshi Mamoru Fujiwara Hiroyuki Gatanaga Christian Schönbach Nozomi Kuse Victor Appay George F. Gao Shinichi Oka Masafumi Takiguchi
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up_date	2024-07-03T18:47:21.199Z
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Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation

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