IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling

Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleio...
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Gespeichert in:

Autor*in:	Zixi Wang [verfasserIn] Di Guan [verfasserIn] Jianxin Huo [verfasserIn] Subhra K. Biswas [verfasserIn] Yuhan Huang [verfasserIn] Yuansheng Yang [verfasserIn] Shengli Xu [verfasserIn] Kong-Peng Lam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	NK cell IL-10 cytotoxicity IFN-γ mTOR metabolism

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2021.619195

Katalog-ID:	DOAJ016175875

Internformat


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allfieldsSound	10.3389/fimmu.2021.619195 doi (DE-627)DOAJ016175875 (DE-599)DOAJf9f6d1be24ff46a7acb99d102b7e248c DE-627 ger DE-627 rakwb eng RC581-607 Zixi Wang verfasserin aut IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleiotropic cytokine, is known to suppress macrophage activation but stimulate NK cells. However, it remains unclear if IL-10 has an effect on the metabolism of human NK cells and if so, what metabolic mechanisms are affected, and how these metabolic changes are regulated and contribute to the effector functions of NK cells. In this study, we demonstrate that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, and these metabolic changes are crucial for the enhanced effector functions of NK cells. Mechanistically, we unravel that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells. NK cell IL-10 cytotoxicity IFN-γ mTOR metabolism Immunologic diseases. Allergy Zixi Wang verfasserin aut Di Guan verfasserin aut Di Guan verfasserin aut Jianxin Huo verfasserin aut Jianxin Huo verfasserin aut Subhra K. Biswas verfasserin aut Yuhan Huang verfasserin aut Yuansheng Yang verfasserin aut Shengli Xu verfasserin aut Shengli Xu verfasserin aut Shengli Xu verfasserin aut Kong-Peng Lam verfasserin aut Kong-Peng Lam verfasserin aut Kong-Peng Lam verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.619195 kostenfrei https://doaj.org/article/f9f6d1be24ff46a7acb99d102b7e248c kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.619195/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Immunology 12(2021) volume:12 year:2021
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topic_facet	NK cell IL-10 cytotoxicity IFN-γ mTOR metabolism Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Zixi Wang @@aut@@ Di Guan @@aut@@ Jianxin Huo @@aut@@ Subhra K. Biswas @@aut@@ Yuhan Huang @@aut@@ Yuansheng Yang @@aut@@ Shengli Xu @@aut@@ Kong-Peng Lam @@aut@@
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callnumber-first	R - Medicine
author	Zixi Wang
spellingShingle	Zixi Wang misc RC581-607 misc NK cell misc IL-10 misc cytotoxicity misc IFN-γ misc mTOR misc metabolism misc Immunologic diseases. Allergy IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling
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topic_title	RC581-607 IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling NK cell IL-10 cytotoxicity IFN-γ mTOR metabolism
topic	misc RC581-607 misc NK cell misc IL-10 misc cytotoxicity misc IFN-γ misc mTOR misc metabolism misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc NK cell misc IL-10 misc cytotoxicity misc IFN-γ misc mTOR misc metabolism misc Immunologic diseases. Allergy
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title	IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling
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title_full	IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling
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title_sort	il-10 enhances human natural killer cell effector functions via metabolic reprogramming regulated by mtorc1 signaling
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title_auth	IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling
abstract	Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleiotropic cytokine, is known to suppress macrophage activation but stimulate NK cells. However, it remains unclear if IL-10 has an effect on the metabolism of human NK cells and if so, what metabolic mechanisms are affected, and how these metabolic changes are regulated and contribute to the effector functions of NK cells. In this study, we demonstrate that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, and these metabolic changes are crucial for the enhanced effector functions of NK cells. Mechanistically, we unravel that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
abstractGer	Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleiotropic cytokine, is known to suppress macrophage activation but stimulate NK cells. However, it remains unclear if IL-10 has an effect on the metabolism of human NK cells and if so, what metabolic mechanisms are affected, and how these metabolic changes are regulated and contribute to the effector functions of NK cells. In this study, we demonstrate that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, and these metabolic changes are crucial for the enhanced effector functions of NK cells. Mechanistically, we unravel that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
abstract_unstemmed	Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis and oxidative phosphorylation in natural killer (NK) cells to support their enhanced effector functions. IL-10, a pleiotropic cytokine, is known to suppress macrophage activation but stimulate NK cells. However, it remains unclear if IL-10 has an effect on the metabolism of human NK cells and if so, what metabolic mechanisms are affected, and how these metabolic changes are regulated and contribute to the effector functions of NK cells. In this study, we demonstrate that IL-10 upregulates both glycolysis and oxidative phosphorylation in human NK cells, and these metabolic changes are crucial for the enhanced effector functions of NK cells. Mechanistically, we unravel that IL-10 activates the mammalian target of rapamycin complex 1 (mTORC1) to regulate metabolic reprogramming in human NK cells.
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title_short	IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling
url	https://doi.org/10.3389/fimmu.2021.619195 https://doaj.org/article/f9f6d1be24ff46a7acb99d102b7e248c https://www.frontiersin.org/articles/10.3389/fimmu.2021.619195/full https://doaj.org/toc/1664-3224
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up_date	2024-07-03T19:26:18.399Z
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IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling

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