Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is <i<Sechiu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Graciela Gavia-García [verfasserIn] Juana Rosado-Pérez [verfasserIn] Itzen Aguiñiga-Sánchez [verfasserIn] Edelmiro Santiago-Osorio [verfasserIn] Víctor Manuel Mendoza-Núñez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	metabolic syndrome telomerase oxidative stress antioxidants ageing

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 7, p 634
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:7, p 634

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9070634

Katalog-ID:	DOAJ016259092

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language	English
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authorswithroles_txt_mv	Graciela Gavia-García @@aut@@ Juana Rosado-Pérez @@aut@@ Itzen Aguiñiga-Sánchez @@aut@@ Edelmiro Santiago-Osorio @@aut@@ Víctor Manuel Mendoza-Núñez @@aut@@
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callnumber-first	R - Medicine
author	Graciela Gavia-García
spellingShingle	Graciela Gavia-García misc RM1-950 misc metabolic syndrome misc telomerase misc oxidative stress misc antioxidants misc ageing misc <i<S. edule</i< misc Therapeutics. Pharmacology Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome
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topic_title	RM1-950 Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome metabolic syndrome telomerase oxidative stress antioxidants ageing <i<S. edule</i<
topic	misc RM1-950 misc metabolic syndrome misc telomerase misc oxidative stress misc antioxidants misc ageing misc <i<S. edule</i< misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc metabolic syndrome misc telomerase misc oxidative stress misc antioxidants misc ageing misc <i<S. edule</i< misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc metabolic syndrome misc telomerase misc oxidative stress misc antioxidants misc ageing misc <i<S. edule</i< misc Therapeutics. Pharmacology
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title	Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome
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title_full	Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome
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title_sort	effect of <i<sechium edule</i< var. <i<nigrum spinosum</i< (chayote) on telomerase levels and antioxidant capacity in older adults with metabolic syndrome
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title_auth	Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome
abstract	Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is <i<Sechium edule</i< and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (<i<n</i< = 30) and experimental group (<i<n</i< = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed <i<Sechium edule</i<. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.
abstractGer	Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is <i<Sechium edule</i< and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (<i<n</i< = 30) and experimental group (<i<n</i< = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed <i<Sechium edule</i<. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.
abstract_unstemmed	Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is <i<Sechium edule</i< and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (<i<n</i< = 30) and experimental group (<i<n</i< = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed <i<Sechium edule</i<. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.
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container_issue	7, p 634
title_short	Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome
url	https://doi.org/10.3390/antiox9070634 https://doaj.org/article/08a3bedcc6ef4fbc8b49881c263828b1 https://www.mdpi.com/2076-3921/9/7/634 https://doaj.org/toc/2076-3921
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author2	Juana Rosado-Pérez Itzen Aguiñiga-Sánchez Edelmiro Santiago-Osorio Víctor Manuel Mendoza-Núñez
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up_date	2024-07-03T19:55:58.449Z
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There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed <i<Sechium edule</i<. 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Effect of <i<Sechium edule</i< var. <i<nigrum spinosum</i< (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

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