Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches

There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed...
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Autor*in:	Magdy Elnashar [verfasserIn] Mauro Vaccarezza [verfasserIn] Hani Al-Salami [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets

Übergeordnetes Werk:	In: Future Science OA - Future Science Ltd, 2015, 7(2021), 3
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:3

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.2144/fsoa-2020-0105

Katalog-ID:	DOAJ016323513

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520			\|a There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids.
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spelling	10.2144/fsoa-2020-0105 doi (DE-627)DOAJ016323513 (DE-599)DOAJb2d7d2e78ba84213840e7146287fadf1 DE-627 ger DE-627 rakwb eng R5-920 Magdy Elnashar verfasserin aut Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids. auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets Medicine R Medicine (General) Mauro Vaccarezza verfasserin aut Hani Al-Salami verfasserin aut In Future Science OA Future Science Ltd, 2015 7(2021), 3 (DE-627)863949525 (DE-600)2863457-3 20565623 nnns volume:7 year:2021 number:3 https://doi.org/10.2144/fsoa-2020-0105 kostenfrei https://doaj.org/article/b2d7d2e78ba84213840e7146287fadf1 kostenfrei https://www.future-science.com/doi/10.2144/fsoa-2020-0105 kostenfrei https://doaj.org/toc/2056-5623 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2086 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3
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allfieldsSound	10.2144/fsoa-2020-0105 doi (DE-627)DOAJ016323513 (DE-599)DOAJb2d7d2e78ba84213840e7146287fadf1 DE-627 ger DE-627 rakwb eng R5-920 Magdy Elnashar verfasserin aut Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids. auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets Medicine R Medicine (General) Mauro Vaccarezza verfasserin aut Hani Al-Salami verfasserin aut In Future Science OA Future Science Ltd, 2015 7(2021), 3 (DE-627)863949525 (DE-600)2863457-3 20565623 nnns volume:7 year:2021 number:3 https://doi.org/10.2144/fsoa-2020-0105 kostenfrei https://doaj.org/article/b2d7d2e78ba84213840e7146287fadf1 kostenfrei https://www.future-science.com/doi/10.2144/fsoa-2020-0105 kostenfrei https://doaj.org/toc/2056-5623 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2086 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 3
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callnumber-first	R - Medicine
author	Magdy Elnashar
spellingShingle	Magdy Elnashar misc R5-920 misc auto-transplantation misc bile acid misc diabetes treatment misc encapsulation misc human pancreas misc pancreatic islets misc Medicine misc R misc Medicine (General) Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
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topic_title	R5-920 Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches auto-transplantation bile acid diabetes treatment encapsulation human pancreas pancreatic islets
topic	misc R5-920 misc auto-transplantation misc bile acid misc diabetes treatment misc encapsulation misc human pancreas misc pancreatic islets misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc auto-transplantation misc bile acid misc diabetes treatment misc encapsulation misc human pancreas misc pancreatic islets misc Medicine misc R misc Medicine (General)
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title	Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
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title_full	Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
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title_sort	cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
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title_auth	Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
abstract	There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids.
abstractGer	There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids.
abstract_unstemmed	There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids.
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title_short	Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches
url	https://doi.org/10.2144/fsoa-2020-0105 https://doaj.org/article/b2d7d2e78ba84213840e7146287fadf1 https://www.future-science.com/doi/10.2144/fsoa-2020-0105 https://doaj.org/toc/2056-5623
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up_date	2024-07-03T20:19:23.881Z
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