Cortical thinning over two years after first-episode psychosis depends on age of onset
Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of...
Ausführliche Beschreibung
Autor*in: |
Laura Pina-Camacho [verfasserIn] Kenia Martinez [verfasserIn] Covadonga M. Diaz-Caneja [verfasserIn] Gisela Mezquida [verfasserIn] Manuel J. Cuesta [verfasserIn] Carmen Moreno [verfasserIn] Silvia Amoretti [verfasserIn] Ana González-Pinto [verfasserIn] Celso Arango [verfasserIn] Eduard Vieta [verfasserIn] Josefina Castro-Fornieles [verfasserIn] Antonio Lobo [verfasserIn] David Fraguas [verfasserIn] Miguel Bernardo [verfasserIn] Joost Janssen [verfasserIn] Mara Parellada [verfasserIn] PEPs Group [verfasserIn] |
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Englisch |
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2022 |
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Übergeordnetes Werk: |
In: npj Schizophrenia - Nature Portfolio, 2016, 8(2022), 1, Seite 9 |
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Übergeordnetes Werk: |
volume:8 ; year:2022 ; number:1 ; pages:9 |
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DOI / URN: |
10.1038/s41537-021-00196-7 |
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Katalog-ID: |
DOAJ016338650 |
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520 | |a Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. | ||
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10.1038/s41537-021-00196-7 doi (DE-627)DOAJ016338650 (DE-599)DOAJ3dea36f302c74c848414a7113dc1a41c DE-627 ger DE-627 rakwb eng RC435-571 Laura Pina-Camacho verfasserin aut Cortical thinning over two years after first-episode psychosis depends on age of onset 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. Psychiatry Kenia Martinez verfasserin aut Covadonga M. Diaz-Caneja verfasserin aut Gisela Mezquida verfasserin aut Manuel J. Cuesta verfasserin aut Carmen Moreno verfasserin aut Silvia Amoretti verfasserin aut Ana González-Pinto verfasserin aut Celso Arango verfasserin aut Eduard Vieta verfasserin aut Josefina Castro-Fornieles verfasserin aut Antonio Lobo verfasserin aut David Fraguas verfasserin aut Miguel Bernardo verfasserin aut Joost Janssen verfasserin aut Mara Parellada verfasserin aut PEPs Group verfasserin aut In npj Schizophrenia Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)820061697 (DE-600)2813844-2 2334265X nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/article/3dea36f302c74c848414a7113dc1a41c kostenfrei https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/toc/2334-265X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 8 2022 1 9 |
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10.1038/s41537-021-00196-7 doi (DE-627)DOAJ016338650 (DE-599)DOAJ3dea36f302c74c848414a7113dc1a41c DE-627 ger DE-627 rakwb eng RC435-571 Laura Pina-Camacho verfasserin aut Cortical thinning over two years after first-episode psychosis depends on age of onset 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. Psychiatry Kenia Martinez verfasserin aut Covadonga M. Diaz-Caneja verfasserin aut Gisela Mezquida verfasserin aut Manuel J. Cuesta verfasserin aut Carmen Moreno verfasserin aut Silvia Amoretti verfasserin aut Ana González-Pinto verfasserin aut Celso Arango verfasserin aut Eduard Vieta verfasserin aut Josefina Castro-Fornieles verfasserin aut Antonio Lobo verfasserin aut David Fraguas verfasserin aut Miguel Bernardo verfasserin aut Joost Janssen verfasserin aut Mara Parellada verfasserin aut PEPs Group verfasserin aut In npj Schizophrenia Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)820061697 (DE-600)2813844-2 2334265X nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/article/3dea36f302c74c848414a7113dc1a41c kostenfrei https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/toc/2334-265X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 8 2022 1 9 |
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10.1038/s41537-021-00196-7 doi (DE-627)DOAJ016338650 (DE-599)DOAJ3dea36f302c74c848414a7113dc1a41c DE-627 ger DE-627 rakwb eng RC435-571 Laura Pina-Camacho verfasserin aut Cortical thinning over two years after first-episode psychosis depends on age of onset 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. Psychiatry Kenia Martinez verfasserin aut Covadonga M. Diaz-Caneja verfasserin aut Gisela Mezquida verfasserin aut Manuel J. Cuesta verfasserin aut Carmen Moreno verfasserin aut Silvia Amoretti verfasserin aut Ana González-Pinto verfasserin aut Celso Arango verfasserin aut Eduard Vieta verfasserin aut Josefina Castro-Fornieles verfasserin aut Antonio Lobo verfasserin aut David Fraguas verfasserin aut Miguel Bernardo verfasserin aut Joost Janssen verfasserin aut Mara Parellada verfasserin aut PEPs Group verfasserin aut In npj Schizophrenia Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)820061697 (DE-600)2813844-2 2334265X nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/article/3dea36f302c74c848414a7113dc1a41c kostenfrei https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/toc/2334-265X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 8 2022 1 9 |
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10.1038/s41537-021-00196-7 doi (DE-627)DOAJ016338650 (DE-599)DOAJ3dea36f302c74c848414a7113dc1a41c DE-627 ger DE-627 rakwb eng RC435-571 Laura Pina-Camacho verfasserin aut Cortical thinning over two years after first-episode psychosis depends on age of onset 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. Psychiatry Kenia Martinez verfasserin aut Covadonga M. Diaz-Caneja verfasserin aut Gisela Mezquida verfasserin aut Manuel J. Cuesta verfasserin aut Carmen Moreno verfasserin aut Silvia Amoretti verfasserin aut Ana González-Pinto verfasserin aut Celso Arango verfasserin aut Eduard Vieta verfasserin aut Josefina Castro-Fornieles verfasserin aut Antonio Lobo verfasserin aut David Fraguas verfasserin aut Miguel Bernardo verfasserin aut Joost Janssen verfasserin aut Mara Parellada verfasserin aut PEPs Group verfasserin aut In npj Schizophrenia Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)820061697 (DE-600)2813844-2 2334265X nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/article/3dea36f302c74c848414a7113dc1a41c kostenfrei https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/toc/2334-265X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 8 2022 1 9 |
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10.1038/s41537-021-00196-7 doi (DE-627)DOAJ016338650 (DE-599)DOAJ3dea36f302c74c848414a7113dc1a41c DE-627 ger DE-627 rakwb eng RC435-571 Laura Pina-Camacho verfasserin aut Cortical thinning over two years after first-episode psychosis depends on age of onset 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. Psychiatry Kenia Martinez verfasserin aut Covadonga M. Diaz-Caneja verfasserin aut Gisela Mezquida verfasserin aut Manuel J. Cuesta verfasserin aut Carmen Moreno verfasserin aut Silvia Amoretti verfasserin aut Ana González-Pinto verfasserin aut Celso Arango verfasserin aut Eduard Vieta verfasserin aut Josefina Castro-Fornieles verfasserin aut Antonio Lobo verfasserin aut David Fraguas verfasserin aut Miguel Bernardo verfasserin aut Joost Janssen verfasserin aut Mara Parellada verfasserin aut PEPs Group verfasserin aut In npj Schizophrenia Nature Portfolio, 2016 8(2022), 1, Seite 9 (DE-627)820061697 (DE-600)2813844-2 2334265X nnns volume:8 year:2022 number:1 pages:9 https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/article/3dea36f302c74c848414a7113dc1a41c kostenfrei https://doi.org/10.1038/s41537-021-00196-7 kostenfrei https://doaj.org/toc/2334-265X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 8 2022 1 9 |
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Cortical thinning over two years after first-episode psychosis depends on age of onset |
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Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. |
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Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. |
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Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. |
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