Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study

(1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial s...
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Autor*in:	Madonna Salib [verfasserIn] Arnaud Simon [verfasserIn] Nicolas Girerd [verfasserIn] Anna Kearney-Schwartz [verfasserIn] Patrick Rossignol [verfasserIn] Athanase Benetos [verfasserIn] Luc Frimat [verfasserIn] Sophie Girerd [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 5, p 1410
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:5, p 1410

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm11051410

Katalog-ID:	DOAJ016341929

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520			\|a (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients.
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allfields	10.3390/jcm11051410 doi (DE-627)DOAJ016341929 (DE-599)DOAJ7590c7cc3c75479e89f69038147ffd2a DE-627 ger DE-627 rakwb eng Madonna Salib verfasserin aut Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients. arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R Arnaud Simon verfasserin aut Nicolas Girerd verfasserin aut Anna Kearney-Schwartz verfasserin aut Patrick Rossignol verfasserin aut Athanase Benetos verfasserin aut Luc Frimat verfasserin aut Sophie Girerd verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 5, p 1410 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:5, p 1410 https://doi.org/10.3390/jcm11051410 kostenfrei https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a kostenfrei https://www.mdpi.com/2077-0383/11/5/1410 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5, p 1410
spelling	10.3390/jcm11051410 doi (DE-627)DOAJ016341929 (DE-599)DOAJ7590c7cc3c75479e89f69038147ffd2a DE-627 ger DE-627 rakwb eng Madonna Salib verfasserin aut Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients. arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R Arnaud Simon verfasserin aut Nicolas Girerd verfasserin aut Anna Kearney-Schwartz verfasserin aut Patrick Rossignol verfasserin aut Athanase Benetos verfasserin aut Luc Frimat verfasserin aut Sophie Girerd verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 5, p 1410 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:5, p 1410 https://doi.org/10.3390/jcm11051410 kostenfrei https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a kostenfrei https://www.mdpi.com/2077-0383/11/5/1410 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5, p 1410
allfields_unstemmed	10.3390/jcm11051410 doi (DE-627)DOAJ016341929 (DE-599)DOAJ7590c7cc3c75479e89f69038147ffd2a DE-627 ger DE-627 rakwb eng Madonna Salib verfasserin aut Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients. arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R Arnaud Simon verfasserin aut Nicolas Girerd verfasserin aut Anna Kearney-Schwartz verfasserin aut Patrick Rossignol verfasserin aut Athanase Benetos verfasserin aut Luc Frimat verfasserin aut Sophie Girerd verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 5, p 1410 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:5, p 1410 https://doi.org/10.3390/jcm11051410 kostenfrei https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a kostenfrei https://www.mdpi.com/2077-0383/11/5/1410 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5, p 1410
allfieldsGer	10.3390/jcm11051410 doi (DE-627)DOAJ016341929 (DE-599)DOAJ7590c7cc3c75479e89f69038147ffd2a DE-627 ger DE-627 rakwb eng Madonna Salib verfasserin aut Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients. arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R Arnaud Simon verfasserin aut Nicolas Girerd verfasserin aut Anna Kearney-Schwartz verfasserin aut Patrick Rossignol verfasserin aut Athanase Benetos verfasserin aut Luc Frimat verfasserin aut Sophie Girerd verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 5, p 1410 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:5, p 1410 https://doi.org/10.3390/jcm11051410 kostenfrei https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a kostenfrei https://www.mdpi.com/2077-0383/11/5/1410 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5, p 1410
allfieldsSound	10.3390/jcm11051410 doi (DE-627)DOAJ016341929 (DE-599)DOAJ7590c7cc3c75479e89f69038147ffd2a DE-627 ger DE-627 rakwb eng Madonna Salib verfasserin aut Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients. arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R Arnaud Simon verfasserin aut Nicolas Girerd verfasserin aut Anna Kearney-Schwartz verfasserin aut Patrick Rossignol verfasserin aut Athanase Benetos verfasserin aut Luc Frimat verfasserin aut Sophie Girerd verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 5, p 1410 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:5, p 1410 https://doi.org/10.3390/jcm11051410 kostenfrei https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a kostenfrei https://www.mdpi.com/2077-0383/11/5/1410 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5, p 1410
language	English
source	In Journal of Clinical Medicine 11(2022), 5, p 1410 volume:11 year:2022 number:5, p 1410
sourceStr	In Journal of Clinical Medicine 11(2022), 5, p 1410 volume:11 year:2022 number:5, p 1410
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topic_facet	arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity Medicine R
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authorswithroles_txt_mv	Madonna Salib @@aut@@ Arnaud Simon @@aut@@ Nicolas Girerd @@aut@@ Anna Kearney-Schwartz @@aut@@ Patrick Rossignol @@aut@@ Athanase Benetos @@aut@@ Luc Frimat @@aut@@ Sophie Girerd @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Madonna Salib
spellingShingle	Madonna Salib misc arterial stiffness misc cardiovascular diseases misc kidney transplantation misc pulse-wave velocity misc Medicine misc R Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study
authorStr	Madonna Salib
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topic_title	Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study arterial stiffness cardiovascular diseases kidney transplantation pulse-wave velocity
topic	misc arterial stiffness misc cardiovascular diseases misc kidney transplantation misc pulse-wave velocity misc Medicine misc R
topic_unstemmed	misc arterial stiffness misc cardiovascular diseases misc kidney transplantation misc pulse-wave velocity misc Medicine misc R
topic_browse	misc arterial stiffness misc cardiovascular diseases misc kidney transplantation misc pulse-wave velocity misc Medicine misc R
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title	Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study
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title_full	Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study
author_sort	Madonna Salib
journal	Journal of Clinical Medicine
journalStr	Journal of Clinical Medicine
lang_code	eng
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author_browse	Madonna Salib Arnaud Simon Nicolas Girerd Anna Kearney-Schwartz Patrick Rossignol Athanase Benetos Luc Frimat Sophie Girerd
container_volume	11
format_se	Elektronische Aufsätze
author-letter	Madonna Salib
doi_str_mv	10.3390/jcm11051410
author2-role	verfasserin
title_sort	association between long-term change in arterial stiffness and cardiovascular outcomes in kidney transplant recipients: insights from the transarte study
title_auth	Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study
abstract	(1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients.
abstractGer	(1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients.
abstract_unstemmed	(1) Background: Increased arterial stiffness is associated with cardiovascular (CV) diseases in end-stage renal disease (ESRD) patients, and CV mortality remains higher in kidney transplantation (KT) recipients compared to in the general population. KT is associated with an improvement in arterial stiffness in the early post-transplant period, followed by a potential re-worsening in the late period. In a cohort of KT patients, we evaluated the associations of pulse-wave velocity (PWV) measured at different time-points (pre-transplant, and early and late post-transplant periods) with CV morbi-mortality, as well as the evolution between these measurements with CV morbi-mortality. (2) Methods: Forty KT recipients with a 10-year follow-up were included. The association of PWV with CV events was assessed with multivariable cox analysis. Backward linear regressions were conducted to identify the determinants of PWV at 1 year and those of the long-term evolution of PWV after KT (delta PWV at 1 year—latest PWV). (3) Results: The absence of arterial stiffening during the long-term follow-up after KT is associated with a lower CV outcome rate (HR for the delta PWV = 0.76 (0.58–0.98), <i<p</i< = 0.036). Age at KT is associated with the worsening of arterial stiffness in the late post-transplantation period (β for the delta PWV = −0.104, <i<p</i< = 0.031). A high PWV at 1 year was associated with a potential for recovery during follow-up (β = 0.744, <i<p</i< < 0.0001). (4) Conclusions: The absence of PWV worsening in the late post-transplantation period was significantly associated with a lower risk of CV events, whereas early changes in PWV were not. Finding an intervention capable of reducing long-term PWV could improve the prognosis of KT recipients.
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container_issue	5, p 1410
title_short	Association between Long-Term Change in Arterial Stiffness and Cardiovascular Outcomes in Kidney Transplant Recipients: Insights from the TRANSARTE Study
url	https://doi.org/10.3390/jcm11051410 https://doaj.org/article/7590c7cc3c75479e89f69038147ffd2a https://www.mdpi.com/2077-0383/11/5/1410 https://doaj.org/toc/2077-0383
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author2	Arnaud Simon Nicolas Girerd Anna Kearney-Schwartz Patrick Rossignol Athanase Benetos Luc Frimat Sophie Girerd
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up_date	2024-07-03T20:26:02.038Z
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