Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current stu...
Ausführliche Beschreibung
Autor*in: |
Bishwo N. Adhikari [verfasserIn] Kenneth A. Callicott [verfasserIn] Peter J. Cotty [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Microorganisms - MDPI AG, 2013, 9(2021), 1, p 137 |
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Übergeordnetes Werk: |
volume:9 ; year:2021 ; number:1, p 137 |
Links: |
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DOI / URN: |
10.3390/microorganisms9010137 |
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Katalog-ID: |
DOAJ016378660 |
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520 | |a Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. | ||
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10.3390/microorganisms9010137 doi (DE-627)DOAJ016378660 (DE-599)DOAJd921905bd5004d8dbd02207e46bbd8e1 DE-627 ger DE-627 rakwb eng QH301-705.5 Bishwo N. Adhikari verfasserin aut Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution Biology (General) Kenneth A. Callicott verfasserin aut Peter J. Cotty verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 1, p 137 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:1, p 137 https://doi.org/10.3390/microorganisms9010137 kostenfrei https://doaj.org/article/d921905bd5004d8dbd02207e46bbd8e1 kostenfrei https://www.mdpi.com/2076-2607/9/1/137 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1, p 137 |
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10.3390/microorganisms9010137 doi (DE-627)DOAJ016378660 (DE-599)DOAJd921905bd5004d8dbd02207e46bbd8e1 DE-627 ger DE-627 rakwb eng QH301-705.5 Bishwo N. Adhikari verfasserin aut Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution Biology (General) Kenneth A. Callicott verfasserin aut Peter J. Cotty verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 1, p 137 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:1, p 137 https://doi.org/10.3390/microorganisms9010137 kostenfrei https://doaj.org/article/d921905bd5004d8dbd02207e46bbd8e1 kostenfrei https://www.mdpi.com/2076-2607/9/1/137 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1, p 137 |
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10.3390/microorganisms9010137 doi (DE-627)DOAJ016378660 (DE-599)DOAJd921905bd5004d8dbd02207e46bbd8e1 DE-627 ger DE-627 rakwb eng QH301-705.5 Bishwo N. Adhikari verfasserin aut Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution Biology (General) Kenneth A. Callicott verfasserin aut Peter J. Cotty verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 1, p 137 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:1, p 137 https://doi.org/10.3390/microorganisms9010137 kostenfrei https://doaj.org/article/d921905bd5004d8dbd02207e46bbd8e1 kostenfrei https://www.mdpi.com/2076-2607/9/1/137 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1, p 137 |
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10.3390/microorganisms9010137 doi (DE-627)DOAJ016378660 (DE-599)DOAJd921905bd5004d8dbd02207e46bbd8e1 DE-627 ger DE-627 rakwb eng QH301-705.5 Bishwo N. Adhikari verfasserin aut Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution Biology (General) Kenneth A. Callicott verfasserin aut Peter J. Cotty verfasserin aut In Microorganisms MDPI AG, 2013 9(2021), 1, p 137 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:9 year:2021 number:1, p 137 https://doi.org/10.3390/microorganisms9010137 kostenfrei https://doaj.org/article/d921905bd5004d8dbd02207e46bbd8e1 kostenfrei https://www.mdpi.com/2076-2607/9/1/137 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 1, p 137 |
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Bishwo N. Adhikari |
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Bishwo N. Adhikari misc QH301-705.5 misc iron misc gene cluster misc deletion misc <i<Aspergillus flavus</i< misc iron utilization gene cluster misc evolution misc Biology (General) Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< |
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QH301-705.5 Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution |
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conservation and loss of a putative iron utilization gene cluster among genotypes of <i<aspergillus flavus</i< |
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Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< |
abstract |
Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. |
abstractGer |
Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. |
abstract_unstemmed |
Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability. |
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Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< |
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