Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<

Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current stu...
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Autor*in:	Bishwo N. Adhikari [verfasserIn] Kenneth A. Callicott [verfasserIn] Peter J. Cotty [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	iron gene cluster deletion iron utilization gene cluster evolution

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 9(2021), 1, p 137
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:1, p 137

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms9010137

Katalog-ID:	DOAJ016378660

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520			\|a Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability.
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callnumber-first	Q - Science
author	Bishwo N. Adhikari
spellingShingle	Bishwo N. Adhikari misc QH301-705.5 misc iron misc gene cluster misc deletion misc <i<Aspergillus flavus</i< misc iron utilization gene cluster misc evolution misc Biology (General) Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
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topic_title	QH301-705.5 Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i< iron gene cluster deletion <i<Aspergillus flavus</i< iron utilization gene cluster evolution
topic	misc QH301-705.5 misc iron misc gene cluster misc deletion misc <i<Aspergillus flavus</i< misc iron utilization gene cluster misc evolution misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc iron misc gene cluster misc deletion misc <i<Aspergillus flavus</i< misc iron utilization gene cluster misc evolution misc Biology (General)
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title	Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
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title_full	Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
author_sort	Bishwo N. Adhikari
journal	Microorganisms
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author_browse	Bishwo N. Adhikari Kenneth A. Callicott Peter J. Cotty
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title_sort	conservation and loss of a putative iron utilization gene cluster among genotypes of <i<aspergillus flavus</i<
callnumber	QH301-705.5
title_auth	Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
abstract	Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability.
abstractGer	Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability.
abstract_unstemmed	Iron is an essential component for growth and development. Despite relative abundance in the environment, bioavailability of iron is limited due to oxidation by atmospheric oxygen into insoluble ferric iron. Filamentous fungi have developed diverse pathways to uptake and use iron. In the current study, a putative iron utilization gene cluster (IUC) in <i<Aspergillus flavus</i< was identified and characterized. Gene analyses indicate <i<A. flavus</i< may use reductive as well as siderophore-mediated iron uptake and utilization pathways. The ferroxidation and iron permeation process, in which iron transport depends on the coupling of these two activities, mediates the reductive pathway. The IUC identified in this work includes six genes and is located in a highly polymorphic region of the genome. Diversity among <i<A. flavus</i< genotypes is manifested in the structure of the IUC, which ranged from complete deletion to a region disabled by multiple indels. Molecular profiling of <i<A. flavus</i< populations suggests lineage-specific loss of IUC. The observed variation among A. flavus genotypes in iron utilization and the lineage-specific loss of the iron utilization genes in several <i<A. flavus</i< clonal lineages provide insight on evolution of iron acquisition and utilization within <i<Aspergillus</i< section <i<Flavi</i<. The potential divergence in capacity to acquire iron should be taken into account when selecting <i<A. flavus</i< active ingredients for biocontrol in niches where climate change may alter iron availability.
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title_short	Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<
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Conservation and Loss of a Putative Iron Utilization Gene Cluster among Genotypes of <i<Aspergillus flavus</i<

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