The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Tom Macleod [verfasserIn] Anna Berekmeri [verfasserIn] Charlie Bridgewood [verfasserIn] Martin Stacey [verfasserIn] Dennis McGonagle [verfasserIn] Miriam Wittmann [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2021.808012

Katalog-ID:	DOAJ016500660

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520			\|a The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.
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spelling	10.3389/fimmu.2021.808012 doi (DE-627)DOAJ016500660 (DE-599)DOAJ81b21c05d1f047d4bba0270b9bf448e9 DE-627 ger DE-627 rakwb eng RC581-607 Tom Macleod verfasserin aut The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines. IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta Immunologic diseases. Allergy Tom Macleod verfasserin aut Anna Berekmeri verfasserin aut Charlie Bridgewood verfasserin aut Martin Stacey verfasserin aut Dennis McGonagle verfasserin aut Dennis McGonagle verfasserin aut Miriam Wittmann verfasserin aut Miriam Wittmann verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.808012 kostenfrei https://doaj.org/article/81b21c05d1f047d4bba0270b9bf448e9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.808012/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
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allfieldsGer	10.3389/fimmu.2021.808012 doi (DE-627)DOAJ016500660 (DE-599)DOAJ81b21c05d1f047d4bba0270b9bf448e9 DE-627 ger DE-627 rakwb eng RC581-607 Tom Macleod verfasserin aut The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines. IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta Immunologic diseases. Allergy Tom Macleod verfasserin aut Anna Berekmeri verfasserin aut Charlie Bridgewood verfasserin aut Martin Stacey verfasserin aut Dennis McGonagle verfasserin aut Dennis McGonagle verfasserin aut Miriam Wittmann verfasserin aut Miriam Wittmann verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.808012 kostenfrei https://doaj.org/article/81b21c05d1f047d4bba0270b9bf448e9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.808012/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fimmu.2021.808012 doi (DE-627)DOAJ016500660 (DE-599)DOAJ81b21c05d1f047d4bba0270b9bf448e9 DE-627 ger DE-627 rakwb eng RC581-607 Tom Macleod verfasserin aut The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines. IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta Immunologic diseases. Allergy Tom Macleod verfasserin aut Anna Berekmeri verfasserin aut Charlie Bridgewood verfasserin aut Martin Stacey verfasserin aut Dennis McGonagle verfasserin aut Dennis McGonagle verfasserin aut Miriam Wittmann verfasserin aut Miriam Wittmann verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.808012 kostenfrei https://doaj.org/article/81b21c05d1f047d4bba0270b9bf448e9 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.808012/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Immunology 12(2021) volume:12 year:2021
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topic_facet	IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Tom Macleod @@aut@@ Anna Berekmeri @@aut@@ Charlie Bridgewood @@aut@@ Martin Stacey @@aut@@ Dennis McGonagle @@aut@@ Miriam Wittmann @@aut@@
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callnumber-first	R - Medicine
author	Tom Macleod
spellingShingle	Tom Macleod misc RC581-607 misc IL-36 cytokine family misc IL-1 family cytokines misc IL-33 misc proteolytic regulation misc IL-1alpha misc IL-1beta misc Immunologic diseases. Allergy The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
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topic_title	RC581-607 The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier IL-36 cytokine family IL-1 family cytokines IL-33 proteolytic regulation IL-1alpha IL-1beta
topic	misc RC581-607 misc IL-36 cytokine family misc IL-1 family cytokines misc IL-33 misc proteolytic regulation misc IL-1alpha misc IL-1beta misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc IL-36 cytokine family misc IL-1 family cytokines misc IL-33 misc proteolytic regulation misc IL-1alpha misc IL-1beta misc Immunologic diseases. Allergy
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title	The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
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title_full	The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
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title_sort	immunological impact of il-1 family cytokines on the epidermal barrier
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title_auth	The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
abstract	The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.
abstractGer	The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.
abstract_unstemmed	The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
url	https://doi.org/10.3389/fimmu.2021.808012 https://doaj.org/article/81b21c05d1f047d4bba0270b9bf448e9 https://www.frontiersin.org/articles/10.3389/fimmu.2021.808012/full https://doaj.org/toc/1664-3224
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author2	Tom Macleod Anna Berekmeri Charlie Bridgewood Martin Stacey Dennis McGonagle Miriam Wittmann
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