Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.

Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cell...
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Autor*in:	Olga Antsiferova [verfasserIn] Anne Müller [verfasserIn] Patrick C Rämer [verfasserIn] Obinna Chijioke [verfasserIn] Bithi Chatterjee [verfasserIn] Ana Raykova [verfasserIn] Raquel Planas [verfasserIn] Mireia Sospedra [verfasserIn] Anatoliy Shumilov [verfasserIn] Ming-Han Tsai [verfasserIn] Henri-Jacques Delecluse [verfasserIn] Christian Münz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Übergeordnetes Werk:	In: PLoS Pathogens - Public Library of Science (PLoS), 2005, 10(2014), 8, p e1004333
Übergeordnetes Werk:	volume:10 ; year:2014 ; number:8, p e1004333

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.ppat.1004333

Katalog-ID:	DOAJ016522354

Internformat


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245	1	0	\|a Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
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520			\|a Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
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700	0		\|a Patrick C Rämer \|e verfasserin \|4 aut
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700	0		\|a Ana Raykova \|e verfasserin \|4 aut
700	0		\|a Raquel Planas \|e verfasserin \|4 aut
700	0		\|a Mireia Sospedra \|e verfasserin \|4 aut
700	0		\|a Anatoliy Shumilov \|e verfasserin \|4 aut
700	0		\|a Ming-Han Tsai \|e verfasserin \|4 aut
700	0		\|a Henri-Jacques Delecluse \|e verfasserin \|4 aut
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912			\|a GBV_ILN_170
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912			\|a GBV_ILN_230
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912			\|a GBV_ILN_2006
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
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Indexfelder

author_variant	o a oa a m am p c r pcr o c oc b c bc a r ar r p rp m s ms a s as m h t mht h j d hjd c m cm
matchkey_str	article:15537374:2014----::dpiernfrfbseiic8clcoecnrninlcnrlb
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publishDate	2014
allfields	10.1371/journal.ppat.1004333 doi (DE-627)DOAJ016522354 (DE-599)DOAJe25caa9499d24c2d95619727227fe222 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Olga Antsiferova verfasserin aut Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. Immunologic diseases. Allergy Biology (General) Anne Müller verfasserin aut Patrick C Rämer verfasserin aut Obinna Chijioke verfasserin aut Bithi Chatterjee verfasserin aut Ana Raykova verfasserin aut Raquel Planas verfasserin aut Mireia Sospedra verfasserin aut Anatoliy Shumilov verfasserin aut Ming-Han Tsai verfasserin aut Henri-Jacques Delecluse verfasserin aut Christian Münz verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 10(2014), 8, p e1004333 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:10 year:2014 number:8, p e1004333 https://doi.org/10.1371/journal.ppat.1004333 kostenfrei https://doaj.org/article/e25caa9499d24c2d95619727227fe222 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 8, p e1004333
spelling	10.1371/journal.ppat.1004333 doi (DE-627)DOAJ016522354 (DE-599)DOAJe25caa9499d24c2d95619727227fe222 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Olga Antsiferova verfasserin aut Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. Immunologic diseases. Allergy Biology (General) Anne Müller verfasserin aut Patrick C Rämer verfasserin aut Obinna Chijioke verfasserin aut Bithi Chatterjee verfasserin aut Ana Raykova verfasserin aut Raquel Planas verfasserin aut Mireia Sospedra verfasserin aut Anatoliy Shumilov verfasserin aut Ming-Han Tsai verfasserin aut Henri-Jacques Delecluse verfasserin aut Christian Münz verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 10(2014), 8, p e1004333 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:10 year:2014 number:8, p e1004333 https://doi.org/10.1371/journal.ppat.1004333 kostenfrei https://doaj.org/article/e25caa9499d24c2d95619727227fe222 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 8, p e1004333
allfields_unstemmed	10.1371/journal.ppat.1004333 doi (DE-627)DOAJ016522354 (DE-599)DOAJe25caa9499d24c2d95619727227fe222 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Olga Antsiferova verfasserin aut Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. Immunologic diseases. Allergy Biology (General) Anne Müller verfasserin aut Patrick C Rämer verfasserin aut Obinna Chijioke verfasserin aut Bithi Chatterjee verfasserin aut Ana Raykova verfasserin aut Raquel Planas verfasserin aut Mireia Sospedra verfasserin aut Anatoliy Shumilov verfasserin aut Ming-Han Tsai verfasserin aut Henri-Jacques Delecluse verfasserin aut Christian Münz verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 10(2014), 8, p e1004333 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:10 year:2014 number:8, p e1004333 https://doi.org/10.1371/journal.ppat.1004333 kostenfrei https://doaj.org/article/e25caa9499d24c2d95619727227fe222 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 8, p e1004333
allfieldsGer	10.1371/journal.ppat.1004333 doi (DE-627)DOAJ016522354 (DE-599)DOAJe25caa9499d24c2d95619727227fe222 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Olga Antsiferova verfasserin aut Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. Immunologic diseases. Allergy Biology (General) Anne Müller verfasserin aut Patrick C Rämer verfasserin aut Obinna Chijioke verfasserin aut Bithi Chatterjee verfasserin aut Ana Raykova verfasserin aut Raquel Planas verfasserin aut Mireia Sospedra verfasserin aut Anatoliy Shumilov verfasserin aut Ming-Han Tsai verfasserin aut Henri-Jacques Delecluse verfasserin aut Christian Münz verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 10(2014), 8, p e1004333 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:10 year:2014 number:8, p e1004333 https://doi.org/10.1371/journal.ppat.1004333 kostenfrei https://doaj.org/article/e25caa9499d24c2d95619727227fe222 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 8, p e1004333
allfieldsSound	10.1371/journal.ppat.1004333 doi (DE-627)DOAJ016522354 (DE-599)DOAJe25caa9499d24c2d95619727227fe222 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Olga Antsiferova verfasserin aut Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development. Immunologic diseases. Allergy Biology (General) Anne Müller verfasserin aut Patrick C Rämer verfasserin aut Obinna Chijioke verfasserin aut Bithi Chatterjee verfasserin aut Ana Raykova verfasserin aut Raquel Planas verfasserin aut Mireia Sospedra verfasserin aut Anatoliy Shumilov verfasserin aut Ming-Han Tsai verfasserin aut Henri-Jacques Delecluse verfasserin aut Christian Münz verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 10(2014), 8, p e1004333 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:10 year:2014 number:8, p e1004333 https://doi.org/10.1371/journal.ppat.1004333 kostenfrei https://doaj.org/article/e25caa9499d24c2d95619727227fe222 kostenfrei https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 8, p e1004333
language	English
source	In PLoS Pathogens 10(2014), 8, p e1004333 volume:10 year:2014 number:8, p e1004333
sourceStr	In PLoS Pathogens 10(2014), 8, p e1004333 volume:10 year:2014 number:8, p e1004333
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immunologic diseases. Allergy Biology (General)
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container_title	PLoS Pathogens
authorswithroles_txt_mv	Olga Antsiferova @@aut@@ Anne Müller @@aut@@ Patrick C Rämer @@aut@@ Obinna Chijioke @@aut@@ Bithi Chatterjee @@aut@@ Ana Raykova @@aut@@ Raquel Planas @@aut@@ Mireia Sospedra @@aut@@ Anatoliy Shumilov @@aut@@ Ming-Han Tsai @@aut@@ Henri-Jacques Delecluse @@aut@@ Christian Münz @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
hierarchy_top_id	501074422
id	DOAJ016522354
language_de	englisch
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callnumber-first	R - Medicine
author	Olga Antsiferova
spellingShingle	Olga Antsiferova misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General) Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
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topic_title	RC581-607 QH301-705.5 Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice
topic	misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General)
topic_unstemmed	misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General)
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title	Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
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title_full	Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice
author_sort	Olga Antsiferova
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author_browse	Olga Antsiferova Anne Müller Patrick C Rämer Obinna Chijioke Bithi Chatterjee Ana Raykova Raquel Planas Mireia Sospedra Anatoliy Shumilov Ming-Han Tsai Henri-Jacques Delecluse Christian Münz
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author-letter	Olga Antsiferova
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title_sort	adoptive transfer of ebv specific cd8+ t cell clones can transiently control ebv infection in humanized mice
callnumber	RC581-607
title_auth	Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
abstract	Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
abstractGer	Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
abstract_unstemmed	Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
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title_short	Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
url	https://doi.org/10.1371/journal.ppat.1004333 https://doaj.org/article/e25caa9499d24c2d95619727227fe222 https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165855/?tool=EBI https://doaj.org/toc/1553-7366 https://doaj.org/toc/1553-7374
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author2	Anne Müller Patrick C Rämer Obinna Chijioke Bithi Chatterjee Ana Raykova Raquel Planas Mireia Sospedra Anatoliy Shumilov Ming-Han Tsai Henri-Jacques Delecluse Christian Münz
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up_date	2024-07-03T21:32:16.579Z
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Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.

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