Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer

Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and E...
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Autor*in:	Lauren Brady [verfasserIn] Jessica Carlsson [verfasserIn] Anne-Marie Baird [verfasserIn] Orla Casey [verfasserIn] Tatjana Vlajnic [verfasserIn] Pierre Murchan [verfasserIn] David Cormican [verfasserIn] Danielle Costigan [verfasserIn] Steven Gray [verfasserIn] Orla Sheils [verfasserIn] Amanda O'Neill [verfasserIn] R. William Watson [verfasserIn] Ove Andren [verfasserIn] Stephen Finn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Prostate cancer ERG PTEN Biochemical recurrence

Übergeordnetes Werk:	In: Cancer Treatment and Research Communications - Elsevier, 2021, 29(2021), Seite 100451-
Übergeordnetes Werk:	volume:29 ; year:2021 ; pages:100451-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ctarc.2021.100451

Katalog-ID:	DOAJ016539567

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520			\|a Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population.
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650		4	\|a Biochemical recurrence
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.1016/j.ctarc.2021.100451 doi (DE-627)DOAJ016539567 (DE-599)DOAJ869ace08d9a3453a91cb1d1b38d5ae20 DE-627 ger DE-627 rakwb eng RC254-282 Lauren Brady verfasserin aut Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population. Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Carlsson verfasserin aut Anne-Marie Baird verfasserin aut Orla Casey verfasserin aut Tatjana Vlajnic verfasserin aut Pierre Murchan verfasserin aut David Cormican verfasserin aut Danielle Costigan verfasserin aut Steven Gray verfasserin aut Orla Sheils verfasserin aut Amanda O'Neill verfasserin aut R. William Watson verfasserin aut Ove Andren verfasserin aut Stephen Finn verfasserin aut In Cancer Treatment and Research Communications Elsevier, 2021 29(2021), Seite 100451- (DE-627)866455191 (DE-600)2866646-X 24682942 nnns volume:29 year:2021 pages:100451- https://doi.org/10.1016/j.ctarc.2021.100451 kostenfrei https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468294221001489 kostenfrei https://doaj.org/toc/2468-2942 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2021 100451-
spelling	10.1016/j.ctarc.2021.100451 doi (DE-627)DOAJ016539567 (DE-599)DOAJ869ace08d9a3453a91cb1d1b38d5ae20 DE-627 ger DE-627 rakwb eng RC254-282 Lauren Brady verfasserin aut Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population. Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Carlsson verfasserin aut Anne-Marie Baird verfasserin aut Orla Casey verfasserin aut Tatjana Vlajnic verfasserin aut Pierre Murchan verfasserin aut David Cormican verfasserin aut Danielle Costigan verfasserin aut Steven Gray verfasserin aut Orla Sheils verfasserin aut Amanda O'Neill verfasserin aut R. William Watson verfasserin aut Ove Andren verfasserin aut Stephen Finn verfasserin aut In Cancer Treatment and Research Communications Elsevier, 2021 29(2021), Seite 100451- (DE-627)866455191 (DE-600)2866646-X 24682942 nnns volume:29 year:2021 pages:100451- https://doi.org/10.1016/j.ctarc.2021.100451 kostenfrei https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468294221001489 kostenfrei https://doaj.org/toc/2468-2942 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2021 100451-
allfields_unstemmed	10.1016/j.ctarc.2021.100451 doi (DE-627)DOAJ016539567 (DE-599)DOAJ869ace08d9a3453a91cb1d1b38d5ae20 DE-627 ger DE-627 rakwb eng RC254-282 Lauren Brady verfasserin aut Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population. Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Carlsson verfasserin aut Anne-Marie Baird verfasserin aut Orla Casey verfasserin aut Tatjana Vlajnic verfasserin aut Pierre Murchan verfasserin aut David Cormican verfasserin aut Danielle Costigan verfasserin aut Steven Gray verfasserin aut Orla Sheils verfasserin aut Amanda O'Neill verfasserin aut R. William Watson verfasserin aut Ove Andren verfasserin aut Stephen Finn verfasserin aut In Cancer Treatment and Research Communications Elsevier, 2021 29(2021), Seite 100451- (DE-627)866455191 (DE-600)2866646-X 24682942 nnns volume:29 year:2021 pages:100451- https://doi.org/10.1016/j.ctarc.2021.100451 kostenfrei https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468294221001489 kostenfrei https://doaj.org/toc/2468-2942 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2021 100451-
allfieldsGer	10.1016/j.ctarc.2021.100451 doi (DE-627)DOAJ016539567 (DE-599)DOAJ869ace08d9a3453a91cb1d1b38d5ae20 DE-627 ger DE-627 rakwb eng RC254-282 Lauren Brady verfasserin aut Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population. Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Carlsson verfasserin aut Anne-Marie Baird verfasserin aut Orla Casey verfasserin aut Tatjana Vlajnic verfasserin aut Pierre Murchan verfasserin aut David Cormican verfasserin aut Danielle Costigan verfasserin aut Steven Gray verfasserin aut Orla Sheils verfasserin aut Amanda O'Neill verfasserin aut R. William Watson verfasserin aut Ove Andren verfasserin aut Stephen Finn verfasserin aut In Cancer Treatment and Research Communications Elsevier, 2021 29(2021), Seite 100451- (DE-627)866455191 (DE-600)2866646-X 24682942 nnns volume:29 year:2021 pages:100451- https://doi.org/10.1016/j.ctarc.2021.100451 kostenfrei https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468294221001489 kostenfrei https://doaj.org/toc/2468-2942 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2021 100451-
allfieldsSound	10.1016/j.ctarc.2021.100451 doi (DE-627)DOAJ016539567 (DE-599)DOAJ869ace08d9a3453a91cb1d1b38d5ae20 DE-627 ger DE-627 rakwb eng RC254-282 Lauren Brady verfasserin aut Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population. Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Carlsson verfasserin aut Anne-Marie Baird verfasserin aut Orla Casey verfasserin aut Tatjana Vlajnic verfasserin aut Pierre Murchan verfasserin aut David Cormican verfasserin aut Danielle Costigan verfasserin aut Steven Gray verfasserin aut Orla Sheils verfasserin aut Amanda O'Neill verfasserin aut R. William Watson verfasserin aut Ove Andren verfasserin aut Stephen Finn verfasserin aut In Cancer Treatment and Research Communications Elsevier, 2021 29(2021), Seite 100451- (DE-627)866455191 (DE-600)2866646-X 24682942 nnns volume:29 year:2021 pages:100451- https://doi.org/10.1016/j.ctarc.2021.100451 kostenfrei https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 kostenfrei http://www.sciencedirect.com/science/article/pii/S2468294221001489 kostenfrei https://doaj.org/toc/2468-2942 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2021 100451-
language	English
source	In Cancer Treatment and Research Communications 29(2021), Seite 100451- volume:29 year:2021 pages:100451-
sourceStr	In Cancer Treatment and Research Communications 29(2021), Seite 100451- volume:29 year:2021 pages:100451-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Prostate cancer ERG PTEN Biochemical recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancer Treatment and Research Communications
authorswithroles_txt_mv	Lauren Brady @@aut@@ Jessica Carlsson @@aut@@ Anne-Marie Baird @@aut@@ Orla Casey @@aut@@ Tatjana Vlajnic @@aut@@ Pierre Murchan @@aut@@ David Cormican @@aut@@ Danielle Costigan @@aut@@ Steven Gray @@aut@@ Orla Sheils @@aut@@ Amanda O'Neill @@aut@@ R. William Watson @@aut@@ Ove Andren @@aut@@ Stephen Finn @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	866455191
id	DOAJ016539567
language_de	englisch
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callnumber-first	R - Medicine
author	Lauren Brady
spellingShingle	Lauren Brady misc RC254-282 misc Prostate cancer misc ERG misc PTEN misc Biochemical recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer
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topic_title	RC254-282 Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer Prostate cancer ERG PTEN Biochemical recurrence
topic	misc RC254-282 misc Prostate cancer misc ERG misc PTEN misc Biochemical recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Prostate cancer misc ERG misc PTEN misc Biochemical recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Prostate cancer misc ERG misc PTEN misc Biochemical recurrence misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer
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title_full	Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer
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author_browse	Lauren Brady Jessica Carlsson Anne-Marie Baird Orla Casey Tatjana Vlajnic Pierre Murchan David Cormican Danielle Costigan Steven Gray Orla Sheils Amanda O'Neill R. William Watson Ove Andren Stephen Finn
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title_sort	correlation of integrated erg/pten assessment with biochemical recurrence in prostate cancer
callnumber	RC254-282
title_auth	Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer
abstract	Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population.
abstractGer	Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population.
abstract_unstemmed	Introduction: Prostate cancer is a heterogeneous disease, with a complex molecular landscape that evolves throughout disease progression. Common alterations in genes such as ERG and PTEN have been attributed to worse prognosis. This study aimed to further examine the clinical relevance of PTEN and ERG expression in a cohort of patients with prostate cancer post radical prostatectomy. Methods: Tissue microarrays were constructed from 132 patients with prostate cancer from the Irish Prostate Cancer Research Consortium and University Hospital of Orebro, Sweden. Patients were divided into three groups – Group 1: biochemical recurrence, Group 2: no biochemical recurrence and Group 3: immediate progression after surgery. PTEN and ERG immunohistochemical analysis was performed and the association between expression levels and clinical parameters were compared. Results: Pathological stage pT3 tumours were more common at borderline significantly higher levels amongst patients who biochemically recurred when compared to patients who did not recur after radical prostatectomy (p = 0.05). ERG and PTEN expression levels were compared separately and concurrently across all three patient groups. Lack of ERG expression was strongly associated with immediate progression after surgery (p = 0.029). Loss of/low PTEN trended towards an association with immediate progression, however this was not statistically significant (p = 0.066). Conclusion: In this study, negative ERG expression was strongly associated with immediate biochemical progression after radical prostatectomy. Moreover, a trend towards a relationship between aberrant PTEN expression and progression was observed. Additional studies with long-term follow up data may provide further clinical insight into the genomic heterogeneity in this population.
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title_short	Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer
url	https://doi.org/10.1016/j.ctarc.2021.100451 https://doaj.org/article/869ace08d9a3453a91cb1d1b38d5ae20 http://www.sciencedirect.com/science/article/pii/S2468294221001489 https://doaj.org/toc/2468-2942
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Correlation of integrated ERG/PTEN assessment with biochemical recurrence in prostate cancer

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