Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements

Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. Fo...
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Autor*in:	María Isabel Iñiguez-Luna [verfasserIn] Jorge Cadena-Iñiguez [verfasserIn] Ramón Marcos Soto-Hernández [verfasserIn] Francisco Javier Morales-Flores [verfasserIn] Moisés Cortes-Cruz [verfasserIn] Kazuo N. Watanabe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cucurbitacins flavonoids fruit cancer diabetes endemic species

Übergeordnetes Werk:	In: Frontiers in Plant Science - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpls.2021.772389

Katalog-ID:	DOAJ016542762

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callnumber-first	S - Agriculture
author	María Isabel Iñiguez-Luna
spellingShingle	María Isabel Iñiguez-Luna misc SB1-1110 misc cucurbitacins misc flavonoids misc fruit misc cancer misc diabetes misc endemic species misc Plant culture Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements
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topic_title	SB1-1110 Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements cucurbitacins flavonoids fruit cancer diabetes endemic species
topic	misc SB1-1110 misc cucurbitacins misc flavonoids misc fruit misc cancer misc diabetes misc endemic species misc Plant culture
topic_unstemmed	misc SB1-1110 misc cucurbitacins misc flavonoids misc fruit misc cancer misc diabetes misc endemic species misc Plant culture
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title	Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements
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title_full	Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements
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title_sort	natural bioactive compounds of sechium spp. for therapeutic and nutraceutical supplements
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title_auth	Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements
abstract	Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. For Sechium spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting Sechium genotypes. The obtained data were analyzed via a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. Therefore, genotypes can be feasibly selected based on fruit flavor for gross-breeding, and cytotoxicity can be reduced without losing possible therapeutic effects.
abstractGer	Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. For Sechium spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting Sechium genotypes. The obtained data were analyzed via a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. Therefore, genotypes can be feasibly selected based on fruit flavor for gross-breeding, and cytotoxicity can be reduced without losing possible therapeutic effects.
abstract_unstemmed	Natural products are in great demand because certain secondary metabolites (SMs) are sources of antioxidants, flavorings, active substances, or anticancer agents with less aggressiveness and selectivity, among which triterpenes and flavonoids are of importance because they inhibit carcinogenesis. For Sechium spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting Sechium genotypes. The obtained data were analyzed via a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. Therefore, genotypes can be feasibly selected based on fruit flavor for gross-breeding, and cytotoxicity can be reduced without losing possible therapeutic effects.
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title_short	Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements
url	https://doi.org/10.3389/fpls.2021.772389 https://doaj.org/article/f96601293b2f49cf9e75de2ba2776283 https://www.frontiersin.org/articles/10.3389/fpls.2021.772389/full https://doaj.org/toc/1664-462X
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author2	María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe
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up_date	2024-07-03T21:39:24.374Z
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For Sechium spp. P. Br. (chayotes), there is scientific evidence of antiproliferative activity that has occurred when cancer cell lines have been treated with this fruit. In order to compare future therapeutic designs and identify new and ancestral characteristics, triterpenes and flavonoids were determined in contrasting Sechium genotypes. The obtained data were analyzed via a cladistics approach, with the aim of identifying the characteristics and state of phytochemicals and genetic variables. The concentrations of flavonoids and triterpenes were determined, and a more complex composition of secondary metabolites was found in the wild types as compared to their domesticated genotypes. Bitter fruits contained a higher number of SMs, followed by those with a neutral and sweet flavor. A cladogram showed the differentiation of the three groups based on the flavor of the fruits. The diversity of SMs decreases in evolutionary terms, in response to domestication and environmental adaptation. 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Natural Bioactive Compounds of Sechium spp. for Therapeutic and Nutraceutical Supplements

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