COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease

Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognitio...
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Autor*in:	Simone Beretta [verfasserIn] Andrea Stabile [verfasserIn] Claudia Balducci [verfasserIn] Jacopo C. DiFrancesco [verfasserIn] Adriana Patruno [verfasserIn] Roberto Rona [verfasserIn] Michela Bombino [verfasserIn] Cristina Capraro [verfasserIn] Francesca Andreetta [verfasserIn] Paola Cavalcante [verfasserIn] Fabio Moda [verfasserIn] Giuseppe Citerio [verfasserIn] Giuseppe Foti [verfasserIn] Graziella Bogliun [verfasserIn] Carlo Ferrarese [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Annals of Clinical and Translational Neurology - Wiley, 2015, 8(2021), 12, Seite 2314-2318
Übergeordnetes Werk:	volume:8 ; year:2021 ; number:12 ; pages:2314-2318

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/acn3.51479

Katalog-ID:	DOAJ016586913

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520			\|a Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up.
653		0	\|a Neurosciences. Biological psychiatry. Neuropsychiatry
653		0	\|a Neurology. Diseases of the nervous system
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700	0		\|a Graziella Bogliun \|e verfasserin \|4 aut
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spelling	10.1002/acn3.51479 doi (DE-627)DOAJ016586913 (DE-599)DOAJ9f185bb5f06b454ba757d5d0d1695e64 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Simone Beretta verfasserin aut COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up. Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Andrea Stabile verfasserin aut Claudia Balducci verfasserin aut Jacopo C. DiFrancesco verfasserin aut Adriana Patruno verfasserin aut Roberto Rona verfasserin aut Michela Bombino verfasserin aut Cristina Capraro verfasserin aut Francesca Andreetta verfasserin aut Paola Cavalcante verfasserin aut Fabio Moda verfasserin aut Giuseppe Citerio verfasserin aut Giuseppe Foti verfasserin aut Graziella Bogliun verfasserin aut Carlo Ferrarese verfasserin aut In Annals of Clinical and Translational Neurology Wiley, 2015 8(2021), 12, Seite 2314-2318 (DE-627)77139649X (DE-600)2740696-9 23289503 nnns volume:8 year:2021 number:12 pages:2314-2318 https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/article/9f185bb5f06b454ba757d5d0d1695e64 kostenfrei https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/toc/2328-9503 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 12 2314-2318
allfields_unstemmed	10.1002/acn3.51479 doi (DE-627)DOAJ016586913 (DE-599)DOAJ9f185bb5f06b454ba757d5d0d1695e64 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Simone Beretta verfasserin aut COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up. Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Andrea Stabile verfasserin aut Claudia Balducci verfasserin aut Jacopo C. DiFrancesco verfasserin aut Adriana Patruno verfasserin aut Roberto Rona verfasserin aut Michela Bombino verfasserin aut Cristina Capraro verfasserin aut Francesca Andreetta verfasserin aut Paola Cavalcante verfasserin aut Fabio Moda verfasserin aut Giuseppe Citerio verfasserin aut Giuseppe Foti verfasserin aut Graziella Bogliun verfasserin aut Carlo Ferrarese verfasserin aut In Annals of Clinical and Translational Neurology Wiley, 2015 8(2021), 12, Seite 2314-2318 (DE-627)77139649X (DE-600)2740696-9 23289503 nnns volume:8 year:2021 number:12 pages:2314-2318 https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/article/9f185bb5f06b454ba757d5d0d1695e64 kostenfrei https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/toc/2328-9503 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 12 2314-2318
allfieldsGer	10.1002/acn3.51479 doi (DE-627)DOAJ016586913 (DE-599)DOAJ9f185bb5f06b454ba757d5d0d1695e64 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Simone Beretta verfasserin aut COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up. Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Andrea Stabile verfasserin aut Claudia Balducci verfasserin aut Jacopo C. DiFrancesco verfasserin aut Adriana Patruno verfasserin aut Roberto Rona verfasserin aut Michela Bombino verfasserin aut Cristina Capraro verfasserin aut Francesca Andreetta verfasserin aut Paola Cavalcante verfasserin aut Fabio Moda verfasserin aut Giuseppe Citerio verfasserin aut Giuseppe Foti verfasserin aut Graziella Bogliun verfasserin aut Carlo Ferrarese verfasserin aut In Annals of Clinical and Translational Neurology Wiley, 2015 8(2021), 12, Seite 2314-2318 (DE-627)77139649X (DE-600)2740696-9 23289503 nnns volume:8 year:2021 number:12 pages:2314-2318 https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/article/9f185bb5f06b454ba757d5d0d1695e64 kostenfrei https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/toc/2328-9503 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 12 2314-2318
allfieldsSound	10.1002/acn3.51479 doi (DE-627)DOAJ016586913 (DE-599)DOAJ9f185bb5f06b454ba757d5d0d1695e64 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 Simone Beretta verfasserin aut COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up. Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Andrea Stabile verfasserin aut Claudia Balducci verfasserin aut Jacopo C. DiFrancesco verfasserin aut Adriana Patruno verfasserin aut Roberto Rona verfasserin aut Michela Bombino verfasserin aut Cristina Capraro verfasserin aut Francesca Andreetta verfasserin aut Paola Cavalcante verfasserin aut Fabio Moda verfasserin aut Giuseppe Citerio verfasserin aut Giuseppe Foti verfasserin aut Graziella Bogliun verfasserin aut Carlo Ferrarese verfasserin aut In Annals of Clinical and Translational Neurology Wiley, 2015 8(2021), 12, Seite 2314-2318 (DE-627)77139649X (DE-600)2740696-9 23289503 nnns volume:8 year:2021 number:12 pages:2314-2318 https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/article/9f185bb5f06b454ba757d5d0d1695e64 kostenfrei https://doi.org/10.1002/acn3.51479 kostenfrei https://doaj.org/toc/2328-9503 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 12 2314-2318
language	English
source	In Annals of Clinical and Translational Neurology 8(2021), 12, Seite 2314-2318 volume:8 year:2021 number:12 pages:2314-2318
sourceStr	In Annals of Clinical and Translational Neurology 8(2021), 12, Seite 2314-2318 volume:8 year:2021 number:12 pages:2314-2318
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Annals of Clinical and Translational Neurology
authorswithroles_txt_mv	Simone Beretta @@aut@@ Andrea Stabile @@aut@@ Claudia Balducci @@aut@@ Jacopo C. DiFrancesco @@aut@@ Adriana Patruno @@aut@@ Roberto Rona @@aut@@ Michela Bombino @@aut@@ Cristina Capraro @@aut@@ Francesca Andreetta @@aut@@ Paola Cavalcante @@aut@@ Fabio Moda @@aut@@ Giuseppe Citerio @@aut@@ Giuseppe Foti @@aut@@ Graziella Bogliun @@aut@@ Carlo Ferrarese @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	77139649X
id	DOAJ016586913
language_de	englisch
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callnumber-first	R - Medicine
author	Simone Beretta
spellingShingle	Simone Beretta misc RC321-571 misc RC346-429 misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
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topic_title	RC321-571 RC346-429 COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
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title	COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
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title_full	COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
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author_browse	Simone Beretta Andrea Stabile Claudia Balducci Jacopo C. DiFrancesco Adriana Patruno Roberto Rona Michela Bombino Cristina Capraro Francesca Andreetta Paola Cavalcante Fabio Moda Giuseppe Citerio Giuseppe Foti Graziella Bogliun Carlo Ferrarese
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title_sort	covid‐19‐associated immune‐mediated encephalitis mimicking acute‐onset creutzfeldt‐jakob disease
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title_auth	COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
abstract	Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up.
abstractGer	Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up.
abstract_unstemmed	Abstract We report a subtype of immune‐mediated encephalitis associated with COVID‐19, which closely mimics acute‐onset sporadic Creutzfeldt–Jakob disease. A 64‐year‐old man presented with confusion, aphasia, myoclonus, and a silent interstitial pneumonia. He tested positive for SARS‐CoV‐2. Cognition and myoclonus rapidly deteriorated, EEG evolved to generalized periodic discharges and brain MRI showed multiple cortical DWI hyperintensities. CSF analysis was normal, except for a positive 14‐3‐3 protein. RT‐QuIC analysis was negative. High levels of pro‐inflammatory cytokines were present in the CSF and serum. Treatment with steroids and intravenous immunoglobulins produced EEG and clinical improvement, with a good neurological outcome at a 6‐month follow‐up.
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title_short	COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease
url	https://doi.org/10.1002/acn3.51479 https://doaj.org/article/9f185bb5f06b454ba757d5d0d1695e64 https://doaj.org/toc/2328-9503
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up_date	2024-07-03T21:54:45.969Z
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COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease

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