Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress
Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not wel...
Ausführliche Beschreibung
Autor*in: |
Leila Hosseinmardi [verfasserIn] Gholam Hossein Meftahi [verfasserIn] Abdolhossein Shiravi [verfasserIn] Hossein Shirvani [verfasserIn] Shahram Sharafi [verfasserIn] |
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E-Artikel |
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Englisch |
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In: Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar), 2004 |
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DOI / URN: |
10.1590/1678-4324-2020190113 |
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Katalog-ID: |
DOAJ016590333 |
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520 | |a Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. | ||
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10.1590/1678-4324-2020190113 doi (DE-627)DOAJ016590333 (DE-599)DOAJ0bd576c7cf7041b5a2bc5317a232adb2 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Leila Hosseinmardi verfasserin aut Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress Biotechnology Gholam Hossein Meftahi verfasserin aut Abdolhossein Shiravi verfasserin aut Hossein Shirvani verfasserin aut Shahram Sharafi verfasserin aut In Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar), 2004 (DE-627)372352324 (DE-600)2122231-9 16784324 nnns https://doi.org/10.1590/1678-4324-2020190113 kostenfrei https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 kostenfrei http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en kostenfrei https://doaj.org/toc/1678-4324 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1678-4324-2020190113 doi (DE-627)DOAJ016590333 (DE-599)DOAJ0bd576c7cf7041b5a2bc5317a232adb2 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Leila Hosseinmardi verfasserin aut Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress Biotechnology Gholam Hossein Meftahi verfasserin aut Abdolhossein Shiravi verfasserin aut Hossein Shirvani verfasserin aut Shahram Sharafi verfasserin aut In Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar), 2004 (DE-627)372352324 (DE-600)2122231-9 16784324 nnns https://doi.org/10.1590/1678-4324-2020190113 kostenfrei https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 kostenfrei http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en kostenfrei https://doaj.org/toc/1678-4324 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1678-4324-2020190113 doi (DE-627)DOAJ016590333 (DE-599)DOAJ0bd576c7cf7041b5a2bc5317a232adb2 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Leila Hosseinmardi verfasserin aut Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress Biotechnology Gholam Hossein Meftahi verfasserin aut Abdolhossein Shiravi verfasserin aut Hossein Shirvani verfasserin aut Shahram Sharafi verfasserin aut In Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar), 2004 (DE-627)372352324 (DE-600)2122231-9 16784324 nnns https://doi.org/10.1590/1678-4324-2020190113 kostenfrei https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 kostenfrei http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en kostenfrei https://doaj.org/toc/1678-4324 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1678-4324-2020190113 doi (DE-627)DOAJ016590333 (DE-599)DOAJ0bd576c7cf7041b5a2bc5317a232adb2 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Leila Hosseinmardi verfasserin aut Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress Biotechnology Gholam Hossein Meftahi verfasserin aut Abdolhossein Shiravi verfasserin aut Hossein Shirvani verfasserin aut Shahram Sharafi verfasserin aut In Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar), 2004 (DE-627)372352324 (DE-600)2122231-9 16784324 nnns https://doi.org/10.1590/1678-4324-2020190113 kostenfrei https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 kostenfrei http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en kostenfrei https://doaj.org/toc/1678-4324 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1590/1678-4324-2020190113 doi (DE-627)DOAJ016590333 (DE-599)DOAJ0bd576c7cf7041b5a2bc5317a232adb2 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Leila Hosseinmardi verfasserin aut Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress Biotechnology Gholam Hossein Meftahi verfasserin aut Abdolhossein Shiravi verfasserin aut Hossein Shirvani verfasserin aut Shahram Sharafi verfasserin aut In Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar), 2004 (DE-627)372352324 (DE-600)2122231-9 16784324 nnns https://doi.org/10.1590/1678-4324-2020190113 kostenfrei https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 kostenfrei http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en kostenfrei https://doaj.org/toc/1678-4324 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. 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Leila Hosseinmardi misc TP248.13-248.65 misc barnes maze misc BLA misc β1-adrenergic receptors misc CA1 misc passive avoidance test misc stress misc Biotechnology Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress |
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TP248.13-248.65 Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress barnes maze BLA β1-adrenergic receptors CA1 passive avoidance test stress |
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Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress |
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Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress |
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Leila Hosseinmardi Gholam Hossein Meftahi Abdolhossein Shiravi Hossein Shirvani Shahram Sharafi |
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effects of β1-adrenoceptors in the basolateral amygdala on spatial memory, passive avoidance, long-term potentiation and neuronal arborization in the hippocampal ca1 region in response to unavoidable stress |
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TP248.13-248.65 |
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Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress |
abstract |
Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. |
abstractGer |
Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. |
abstract_unstemmed |
Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not well understood. In the present study the role of β1-adrenoreceptor in the BLA on memory, neuronal arborization and long-term potentiation (LTP) in the CA1 region of hippocampus was examined by infusion the β1-adrenoreceptor agonist (Dobutamine; 0.5µl/side) or antagonist (Atenolol; 0.25µL/side) bilaterally into the BLA before foot-shock stress. Passive avoidance test results showed that Step-through latency time was significantly decreased in the stress group rats one, four and seven days after the stress, which intra-BLA injection of Atenolol or Dobutamine before stress couldn’t attenuate this reduction. Barnes-maze results revealed that infusion of Dobutamine and Atenolol significantly reduced spatial memory indicators such as increased latency time, the number of errors and the distance traveling to achieve the target hole in the stress group. These learning impairments in stress rats correlated with a reduction of LTP in hippocampal CA1 synapses in-vivo, which infusion of Dobutamine and Atenolol couldn’t attenuate the population spike amplitude and mean-field excitatory postsynaptic potentials (fEPSP) slope reduction induced by stress. Also, the Golgi-Cox staining demonstrated that infusion of Atenolol attenuated stress decreased CA1 region dendritic and axonal arborization. These results suggest that β1-adrenergic receptors activation or block seem to exacerbate stress-induced hippocampal memory deficits and this effect is independent of CA1 LTP modulation. |
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Effects of β1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress |
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https://doi.org/10.1590/1678-4324-2020190113 https://doaj.org/article/0bd576c7cf7041b5a2bc5317a232adb2 http://www.scielo.br/pdf/babt/v63/1516-8913-babt-63-e20190113.pdf http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100305&tlng=en https://doaj.org/toc/1678-4324 |
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