Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications

In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuseppe Cirillo [verfasserIn] Elvira Pantuso [verfasserIn] Manuela Curcio [verfasserIn] Orazio Vittorio [verfasserIn] Antonella Leggio [verfasserIn] Francesca Iemma [verfasserIn] Giovanni De Filpo [verfasserIn] Fiore Pasquale Nicoletta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hybrid hydrogels controlled drug delivery protein crystallization lysozyme

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 5, p 1355
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:5, p 1355

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26051355

Katalog-ID:	DOAJ016604598

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allfields	10.3390/molecules26051355 doi (DE-627)DOAJ016604598 (DE-599)DOAJb5930e82f92d44e6910cbda11dca8ef8 DE-627 ger DE-627 rakwb eng QD241-441 Giuseppe Cirillo verfasserin aut Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure. hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry Elvira Pantuso verfasserin aut Manuela Curcio verfasserin aut Orazio Vittorio verfasserin aut Antonella Leggio verfasserin aut Francesca Iemma verfasserin aut Giovanni De Filpo verfasserin aut Fiore Pasquale Nicoletta verfasserin aut In Molecules MDPI AG, 2003 26(2021), 5, p 1355 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:5, p 1355 https://doi.org/10.3390/molecules26051355 kostenfrei https://doaj.org/article/b5930e82f92d44e6910cbda11dca8ef8 kostenfrei https://www.mdpi.com/1420-3049/26/5/1355 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 5, p 1355
spelling	10.3390/molecules26051355 doi (DE-627)DOAJ016604598 (DE-599)DOAJb5930e82f92d44e6910cbda11dca8ef8 DE-627 ger DE-627 rakwb eng QD241-441 Giuseppe Cirillo verfasserin aut Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure. hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry Elvira Pantuso verfasserin aut Manuela Curcio verfasserin aut Orazio Vittorio verfasserin aut Antonella Leggio verfasserin aut Francesca Iemma verfasserin aut Giovanni De Filpo verfasserin aut Fiore Pasquale Nicoletta verfasserin aut In Molecules MDPI AG, 2003 26(2021), 5, p 1355 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:5, p 1355 https://doi.org/10.3390/molecules26051355 kostenfrei https://doaj.org/article/b5930e82f92d44e6910cbda11dca8ef8 kostenfrei https://www.mdpi.com/1420-3049/26/5/1355 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 5, p 1355
allfields_unstemmed	10.3390/molecules26051355 doi (DE-627)DOAJ016604598 (DE-599)DOAJb5930e82f92d44e6910cbda11dca8ef8 DE-627 ger DE-627 rakwb eng QD241-441 Giuseppe Cirillo verfasserin aut Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure. hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry Elvira Pantuso verfasserin aut Manuela Curcio verfasserin aut Orazio Vittorio verfasserin aut Antonella Leggio verfasserin aut Francesca Iemma verfasserin aut Giovanni De Filpo verfasserin aut Fiore Pasquale Nicoletta verfasserin aut In Molecules MDPI AG, 2003 26(2021), 5, p 1355 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:5, p 1355 https://doi.org/10.3390/molecules26051355 kostenfrei https://doaj.org/article/b5930e82f92d44e6910cbda11dca8ef8 kostenfrei https://www.mdpi.com/1420-3049/26/5/1355 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 5, p 1355
allfieldsGer	10.3390/molecules26051355 doi (DE-627)DOAJ016604598 (DE-599)DOAJb5930e82f92d44e6910cbda11dca8ef8 DE-627 ger DE-627 rakwb eng QD241-441 Giuseppe Cirillo verfasserin aut Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure. hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry Elvira Pantuso verfasserin aut Manuela Curcio verfasserin aut Orazio Vittorio verfasserin aut Antonella Leggio verfasserin aut Francesca Iemma verfasserin aut Giovanni De Filpo verfasserin aut Fiore Pasquale Nicoletta verfasserin aut In Molecules MDPI AG, 2003 26(2021), 5, p 1355 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:5, p 1355 https://doi.org/10.3390/molecules26051355 kostenfrei https://doaj.org/article/b5930e82f92d44e6910cbda11dca8ef8 kostenfrei https://www.mdpi.com/1420-3049/26/5/1355 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 5, p 1355
allfieldsSound	10.3390/molecules26051355 doi (DE-627)DOAJ016604598 (DE-599)DOAJb5930e82f92d44e6910cbda11dca8ef8 DE-627 ger DE-627 rakwb eng QD241-441 Giuseppe Cirillo verfasserin aut Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure. hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry Elvira Pantuso verfasserin aut Manuela Curcio verfasserin aut Orazio Vittorio verfasserin aut Antonella Leggio verfasserin aut Francesca Iemma verfasserin aut Giovanni De Filpo verfasserin aut Fiore Pasquale Nicoletta verfasserin aut In Molecules MDPI AG, 2003 26(2021), 5, p 1355 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:5, p 1355 https://doi.org/10.3390/molecules26051355 kostenfrei https://doaj.org/article/b5930e82f92d44e6910cbda11dca8ef8 kostenfrei https://www.mdpi.com/1420-3049/26/5/1355 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 5, p 1355
language	English
source	In Molecules 26(2021), 5, p 1355 volume:26 year:2021 number:5, p 1355
sourceStr	In Molecules 26(2021), 5, p 1355 volume:26 year:2021 number:5, p 1355
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topic_facet	hybrid hydrogels controlled drug delivery protein crystallization lysozyme Organic chemistry
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authorswithroles_txt_mv	Giuseppe Cirillo @@aut@@ Elvira Pantuso @@aut@@ Manuela Curcio @@aut@@ Orazio Vittorio @@aut@@ Antonella Leggio @@aut@@ Francesca Iemma @@aut@@ Giovanni De Filpo @@aut@@ Fiore Pasquale Nicoletta @@aut@@
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callnumber-first	Q - Science
author	Giuseppe Cirillo
spellingShingle	Giuseppe Cirillo misc QD241-441 misc hybrid hydrogels misc controlled drug delivery misc protein crystallization misc lysozyme misc Organic chemistry Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications
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topic_title	QD241-441 Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications hybrid hydrogels controlled drug delivery protein crystallization lysozyme
topic	misc QD241-441 misc hybrid hydrogels misc controlled drug delivery misc protein crystallization misc lysozyme misc Organic chemistry
topic_unstemmed	misc QD241-441 misc hybrid hydrogels misc controlled drug delivery misc protein crystallization misc lysozyme misc Organic chemistry
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title	Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications
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title_full	Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications
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title_auth	Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications
abstract	In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure.
abstractGer	In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure.
abstract_unstemmed	In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure.
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container_issue	5, p 1355
title_short	Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications
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