Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach

Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex...
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Gespeichert in:

Autor*in:	Swinburne A. J. Augustine [verfasserIn] Tarsha N. Eason [verfasserIn] Tim Wade [verfasserIn] Shannon M. Griffin [verfasserIn] Elizabeth Sams [verfasserIn] Kaneatra Simmons [verfasserIn] Malini Ramudit [verfasserIn] Kevin Oshima [verfasserIn] Alfred Dufour [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	saliva multiplex immunoassay immunoprevalence immunoconversion incident infection

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 18(2021), 5797, p 5797
Übergeordnetes Werk:	volume:18 ; year:2021 ; number:5797, p 5797

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph18115797

Katalog-ID:	DOAJ016639723

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allfields	10.3390/ijerph18115797 doi (DE-627)DOAJ016639723 (DE-599)DOAJ6e85aff136b34165b1b3befd8f661be8 DE-627 ger DE-627 rakwb eng Swinburne A. J. Augustine verfasserin aut Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies. saliva multiplex immunoassay immunoprevalence immunoconversion incident infection Medicine R Tarsha N. Eason verfasserin aut Tim Wade verfasserin aut Shannon M. Griffin verfasserin aut Elizabeth Sams verfasserin aut Kaneatra Simmons verfasserin aut Malini Ramudit verfasserin aut Kevin Oshima verfasserin aut Alfred Dufour verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 5797, p 5797 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:5797, p 5797 https://doi.org/10.3390/ijerph18115797 kostenfrei https://doaj.org/article/6e85aff136b34165b1b3befd8f661be8 kostenfrei https://www.mdpi.com/1660-4601/18/11/5797 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 5797, p 5797
spelling	10.3390/ijerph18115797 doi (DE-627)DOAJ016639723 (DE-599)DOAJ6e85aff136b34165b1b3befd8f661be8 DE-627 ger DE-627 rakwb eng Swinburne A. J. Augustine verfasserin aut Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies. saliva multiplex immunoassay immunoprevalence immunoconversion incident infection Medicine R Tarsha N. Eason verfasserin aut Tim Wade verfasserin aut Shannon M. Griffin verfasserin aut Elizabeth Sams verfasserin aut Kaneatra Simmons verfasserin aut Malini Ramudit verfasserin aut Kevin Oshima verfasserin aut Alfred Dufour verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 5797, p 5797 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:5797, p 5797 https://doi.org/10.3390/ijerph18115797 kostenfrei https://doaj.org/article/6e85aff136b34165b1b3befd8f661be8 kostenfrei https://www.mdpi.com/1660-4601/18/11/5797 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 5797, p 5797
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allfieldsGer	10.3390/ijerph18115797 doi (DE-627)DOAJ016639723 (DE-599)DOAJ6e85aff136b34165b1b3befd8f661be8 DE-627 ger DE-627 rakwb eng Swinburne A. J. Augustine verfasserin aut Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies. saliva multiplex immunoassay immunoprevalence immunoconversion incident infection Medicine R Tarsha N. Eason verfasserin aut Tim Wade verfasserin aut Shannon M. Griffin verfasserin aut Elizabeth Sams verfasserin aut Kaneatra Simmons verfasserin aut Malini Ramudit verfasserin aut Kevin Oshima verfasserin aut Alfred Dufour verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 5797, p 5797 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:5797, p 5797 https://doi.org/10.3390/ijerph18115797 kostenfrei https://doaj.org/article/6e85aff136b34165b1b3befd8f661be8 kostenfrei https://www.mdpi.com/1660-4601/18/11/5797 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 5797, p 5797
allfieldsSound	10.3390/ijerph18115797 doi (DE-627)DOAJ016639723 (DE-599)DOAJ6e85aff136b34165b1b3befd8f661be8 DE-627 ger DE-627 rakwb eng Swinburne A. J. Augustine verfasserin aut Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies. saliva multiplex immunoassay immunoprevalence immunoconversion incident infection Medicine R Tarsha N. Eason verfasserin aut Tim Wade verfasserin aut Shannon M. Griffin verfasserin aut Elizabeth Sams verfasserin aut Kaneatra Simmons verfasserin aut Malini Ramudit verfasserin aut Kevin Oshima verfasserin aut Alfred Dufour verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 5797, p 5797 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:5797, p 5797 https://doi.org/10.3390/ijerph18115797 kostenfrei https://doaj.org/article/6e85aff136b34165b1b3befd8f661be8 kostenfrei https://www.mdpi.com/1660-4601/18/11/5797 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 5797, p 5797
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author	Swinburne A. J. Augustine
spellingShingle	Swinburne A. J. Augustine misc saliva misc multiplex misc immunoassay misc immunoprevalence misc immunoconversion misc incident infection misc Medicine misc R Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach
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title	Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach
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title_sort	salivary antibodies against multiple environmental pathogens found in individuals recreating at an iowa beach
title_auth	Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach
abstract	Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies.
abstractGer	Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies.
abstract_unstemmed	Detecting environmental exposures and mitigating their impacts are growing global public health challenges. Antibody tests show great promise and have emerged as fundamental tools for large-scale exposure studies. Here, we apply, demonstrate and validate the utility of a salivary antibody multiplex immunoassay in measuring antibody prevalence and immunoconversions to six pathogens commonly found in the environment. The study aimed to assess waterborne infections in consenting beachgoers recreating at an Iowa riverine beach by measuring immunoglobulin G (IgG) antibodies against select pathogens in serially collected saliva samples. Results showed that nearly 80% of beachgoers had prior exposures to at least one of the targeted pathogens at the beginning of the study. Most of these exposures were to norovirus GI.1 (59.41%), norovirus GII.4 (58.79%) and <i<Toxoplasma gondii</i< (22.80%) and over half (56.28%) of beachgoers had evidence of previous exposure to multiple pathogens. Of individuals who returned samples for each collection period, 6.11% immunoconverted to one or more pathogens, largely to noroviruses (GI.1: 3.82% and GII.4: 2.29%) and <i<T. gondii</i< (1.53%). Outcomes of this effort illustrate that the multiplex immunoassay presented here serves as an effective tool for evaluating health risks by providing valuable information on the occurrence of known and emerging pathogens in population surveillance studies.
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title_short	Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach
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author2	Tarsha N. Eason Tim Wade Shannon M. Griffin Elizabeth Sams Kaneatra Simmons Malini Ramudit Kevin Oshima Alfred Dufour
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