Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases

Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biom...
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Autor*in:	Qurrat Ul Ain [verfasserIn] Mehak Sarfraz [verfasserIn] Gayuk Kalih Prasesti [verfasserIn] Triwedya Indra Dewi [verfasserIn] Neng Fisheri Kurniati [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	pro-inflammatory biomarkers confounding factors inflammation chemokines cytokines acute-phase proteins

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 11(2021), 10, p 1464
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:10, p 1464

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom11101464

Katalog-ID:	DOAJ016656482

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language	English
source	In Biomolecules 11(2021), 10, p 1464 volume:11 year:2021 number:10, p 1464
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topic_title	QR1-502 Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases pro-inflammatory biomarkers confounding factors inflammation chemokines cytokines acute-phase proteins
topic	misc QR1-502 misc pro-inflammatory biomarkers misc confounding factors misc inflammation misc chemokines misc cytokines misc acute-phase proteins misc Microbiology
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title	Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases
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title_sort	confounders in identification and analysis of inflammatory biomarkers in cardiovascular diseases
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title_auth	Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases
abstract	Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biomarkers and the pathology of various cardiovascular diseases, the mechanisms of the underlying cause are unclear. Identification of pro-inflammatory biomarkers such as cytokines, chemokines, acute phase proteins, and other soluble immune factors can help in the early diagnosis of disease. The presence of certain confounding factors such as variations in age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, as well as inconsistencies in methodological practices such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. The purpose of the review is to identify and summarize the effect of demographic factors, epidemiological factors, medication use, and analytical and pre-analytical factors with a panel of inflammatory biomarkers CRP, IL-1b, IL-6, TNFa, and the soluble TNF receptors on the concentration of these inflammatory biomarkers in serum.
abstractGer	Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biomarkers and the pathology of various cardiovascular diseases, the mechanisms of the underlying cause are unclear. Identification of pro-inflammatory biomarkers such as cytokines, chemokines, acute phase proteins, and other soluble immune factors can help in the early diagnosis of disease. The presence of certain confounding factors such as variations in age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, as well as inconsistencies in methodological practices such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. The purpose of the review is to identify and summarize the effect of demographic factors, epidemiological factors, medication use, and analytical and pre-analytical factors with a panel of inflammatory biomarkers CRP, IL-1b, IL-6, TNFa, and the soluble TNF receptors on the concentration of these inflammatory biomarkers in serum.
abstract_unstemmed	Proinflammatory biomarkers have been increasingly used in epidemiologic and intervention studies over the past decades to evaluate and identify an association of systemic inflammation with cardiovascular diseases. Although there is a strong correlation between the elevated level of inflammatory biomarkers and the pathology of various cardiovascular diseases, the mechanisms of the underlying cause are unclear. Identification of pro-inflammatory biomarkers such as cytokines, chemokines, acute phase proteins, and other soluble immune factors can help in the early diagnosis of disease. The presence of certain confounding factors such as variations in age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, as well as inconsistencies in methodological practices such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. The purpose of the review is to identify and summarize the effect of demographic factors, epidemiological factors, medication use, and analytical and pre-analytical factors with a panel of inflammatory biomarkers CRP, IL-1b, IL-6, TNFa, and the soluble TNF receptors on the concentration of these inflammatory biomarkers in serum.
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title_short	Confounders in Identification and Analysis of Inflammatory Biomarkers in Cardiovascular Diseases
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