Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats

Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, t...
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Autor*in:	Shota Yamamoto [verfasserIn] Hiroki Noguchi [verfasserIn] Asuka Takeda [verfasserIn] Ryosuke Arakaki [verfasserIn] Maimi Uchishiba [verfasserIn] Junki Imaizumi [verfasserIn] Saki Minato [verfasserIn] Shuhei Kamada [verfasserIn] Tomohiro Kagawa [verfasserIn] Atsuko Yoshida [verfasserIn] Takako Kawakita [verfasserIn] Yuri Yamamoto [verfasserIn] Kanako Yoshida [verfasserIn] Masafumi Kon [verfasserIn] Nobuo Shinohara [verfasserIn] Takeshi Iwasa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	PCOS body weight food intake metabolic oxytocin DHT

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 15, p 8207
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:15, p 8207

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23158207

Katalog-ID:	DOAJ016745892

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allfields	10.3390/ijms23158207 doi (DE-627)DOAJ016745892 (DE-599)DOAJac23b7fc9a9a41c4b5f060715af6bc9f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shota Yamamoto verfasserin aut Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry Hiroki Noguchi verfasserin aut Asuka Takeda verfasserin aut Ryosuke Arakaki verfasserin aut Maimi Uchishiba verfasserin aut Junki Imaizumi verfasserin aut Saki Minato verfasserin aut Shuhei Kamada verfasserin aut Tomohiro Kagawa verfasserin aut Atsuko Yoshida verfasserin aut Takako Kawakita verfasserin aut Yuri Yamamoto verfasserin aut Kanako Yoshida verfasserin aut Masafumi Kon verfasserin aut Nobuo Shinohara verfasserin aut Takeshi Iwasa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 15, p 8207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:15, p 8207 https://doi.org/10.3390/ijms23158207 kostenfrei https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f kostenfrei https://www.mdpi.com/1422-0067/23/15/8207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 15, p 8207
spelling	10.3390/ijms23158207 doi (DE-627)DOAJ016745892 (DE-599)DOAJac23b7fc9a9a41c4b5f060715af6bc9f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shota Yamamoto verfasserin aut Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry Hiroki Noguchi verfasserin aut Asuka Takeda verfasserin aut Ryosuke Arakaki verfasserin aut Maimi Uchishiba verfasserin aut Junki Imaizumi verfasserin aut Saki Minato verfasserin aut Shuhei Kamada verfasserin aut Tomohiro Kagawa verfasserin aut Atsuko Yoshida verfasserin aut Takako Kawakita verfasserin aut Yuri Yamamoto verfasserin aut Kanako Yoshida verfasserin aut Masafumi Kon verfasserin aut Nobuo Shinohara verfasserin aut Takeshi Iwasa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 15, p 8207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:15, p 8207 https://doi.org/10.3390/ijms23158207 kostenfrei https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f kostenfrei https://www.mdpi.com/1422-0067/23/15/8207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 15, p 8207
allfields_unstemmed	10.3390/ijms23158207 doi (DE-627)DOAJ016745892 (DE-599)DOAJac23b7fc9a9a41c4b5f060715af6bc9f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shota Yamamoto verfasserin aut Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry Hiroki Noguchi verfasserin aut Asuka Takeda verfasserin aut Ryosuke Arakaki verfasserin aut Maimi Uchishiba verfasserin aut Junki Imaizumi verfasserin aut Saki Minato verfasserin aut Shuhei Kamada verfasserin aut Tomohiro Kagawa verfasserin aut Atsuko Yoshida verfasserin aut Takako Kawakita verfasserin aut Yuri Yamamoto verfasserin aut Kanako Yoshida verfasserin aut Masafumi Kon verfasserin aut Nobuo Shinohara verfasserin aut Takeshi Iwasa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 15, p 8207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:15, p 8207 https://doi.org/10.3390/ijms23158207 kostenfrei https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f kostenfrei https://www.mdpi.com/1422-0067/23/15/8207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 15, p 8207
allfieldsGer	10.3390/ijms23158207 doi (DE-627)DOAJ016745892 (DE-599)DOAJac23b7fc9a9a41c4b5f060715af6bc9f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shota Yamamoto verfasserin aut Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry Hiroki Noguchi verfasserin aut Asuka Takeda verfasserin aut Ryosuke Arakaki verfasserin aut Maimi Uchishiba verfasserin aut Junki Imaizumi verfasserin aut Saki Minato verfasserin aut Shuhei Kamada verfasserin aut Tomohiro Kagawa verfasserin aut Atsuko Yoshida verfasserin aut Takako Kawakita verfasserin aut Yuri Yamamoto verfasserin aut Kanako Yoshida verfasserin aut Masafumi Kon verfasserin aut Nobuo Shinohara verfasserin aut Takeshi Iwasa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 15, p 8207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:15, p 8207 https://doi.org/10.3390/ijms23158207 kostenfrei https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f kostenfrei https://www.mdpi.com/1422-0067/23/15/8207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 15, p 8207
allfieldsSound	10.3390/ijms23158207 doi (DE-627)DOAJ016745892 (DE-599)DOAJac23b7fc9a9a41c4b5f060715af6bc9f DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shota Yamamoto verfasserin aut Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry Hiroki Noguchi verfasserin aut Asuka Takeda verfasserin aut Ryosuke Arakaki verfasserin aut Maimi Uchishiba verfasserin aut Junki Imaizumi verfasserin aut Saki Minato verfasserin aut Shuhei Kamada verfasserin aut Tomohiro Kagawa verfasserin aut Atsuko Yoshida verfasserin aut Takako Kawakita verfasserin aut Yuri Yamamoto verfasserin aut Kanako Yoshida verfasserin aut Masafumi Kon verfasserin aut Nobuo Shinohara verfasserin aut Takeshi Iwasa verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 15, p 8207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:15, p 8207 https://doi.org/10.3390/ijms23158207 kostenfrei https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f kostenfrei https://www.mdpi.com/1422-0067/23/15/8207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 15, p 8207
language	English
source	In International Journal of Molecular Sciences 23(2022), 15, p 8207 volume:23 year:2022 number:15, p 8207
sourceStr	In International Journal of Molecular Sciences 23(2022), 15, p 8207 volume:23 year:2022 number:15, p 8207
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	PCOS body weight food intake metabolic oxytocin DHT Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Shota Yamamoto @@aut@@ Hiroki Noguchi @@aut@@ Asuka Takeda @@aut@@ Ryosuke Arakaki @@aut@@ Maimi Uchishiba @@aut@@ Junki Imaizumi @@aut@@ Saki Minato @@aut@@ Shuhei Kamada @@aut@@ Tomohiro Kagawa @@aut@@ Atsuko Yoshida @@aut@@ Takako Kawakita @@aut@@ Yuri Yamamoto @@aut@@ Kanako Yoshida @@aut@@ Masafumi Kon @@aut@@ Nobuo Shinohara @@aut@@ Takeshi Iwasa @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ016745892
language_de	englisch
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callnumber-first	Q - Science
author	Shota Yamamoto
spellingShingle	Shota Yamamoto misc QH301-705.5 misc QD1-999 misc PCOS misc body weight misc food intake misc metabolic misc oxytocin misc DHT misc Biology (General) misc Chemistry Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats
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topic_title	QH301-705.5 QD1-999 Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats PCOS body weight food intake metabolic oxytocin DHT
topic	misc QH301-705.5 misc QD1-999 misc PCOS misc body weight misc food intake misc metabolic misc oxytocin misc DHT misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc PCOS misc body weight misc food intake misc metabolic misc oxytocin misc DHT misc Biology (General) misc Chemistry
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title	Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats
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title_full	Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats
author_sort	Shota Yamamoto
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author_browse	Shota Yamamoto Hiroki Noguchi Asuka Takeda Ryosuke Arakaki Maimi Uchishiba Junki Imaizumi Saki Minato Shuhei Kamada Tomohiro Kagawa Atsuko Yoshida Takako Kawakita Yuri Yamamoto Kanako Yoshida Masafumi Kon Nobuo Shinohara Takeshi Iwasa
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title_sort	changes in endogenous oxytocin levels and the effects of exogenous oxytocin administration on body weight changes and food intake in polycystic ovary syndrome model rats
callnumber	QH301-705.5
title_auth	Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats
abstract	Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients.
abstractGer	Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients.
abstract_unstemmed	Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients.
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title_short	Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats
url	https://doi.org/10.3390/ijms23158207 https://doaj.org/article/ac23b7fc9a9a41c4b5f060715af6bc9f https://www.mdpi.com/1422-0067/23/15/8207 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2	Hiroki Noguchi Asuka Takeda Ryosuke Arakaki Maimi Uchishiba Junki Imaizumi Saki Minato Shuhei Kamada Tomohiro Kagawa Atsuko Yoshida Takako Kawakita Yuri Yamamoto Kanako Yoshida Masafumi Kon Nobuo Shinohara Takeshi Iwasa
author2Str	Hiroki Noguchi Asuka Takeda Ryosuke Arakaki Maimi Uchishiba Junki Imaizumi Saki Minato Shuhei Kamada Tomohiro Kagawa Atsuko Yoshida Takako Kawakita Yuri Yamamoto Kanako Yoshida Masafumi Kon Nobuo Shinohara Takeshi Iwasa
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Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats

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